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The map label for this gene is ilvC1 [H]

Identifier: 218233670

GI number: 218233670

Start: 1393702

End: 1394712

Strand: Direct

Name: ilvC1 [H]

Synonym: BCB4264_A1452

Alternate gene names: 218233670

Gene position: 1393702-1394712 (Clockwise)

Preceding gene: 218234465

Following gene: 218231353

Centisome position: 25.72

GC content: 41.15

Gene sequence:

>1011_bases
ATGGCAAAAGTTTATTATGAGAAAGATGTAACAGTAAATGTATTAAAGGAAAAGAAAGTAGCAATCATCGGATATGGCTC
GCAAGGTCATGCGCATGCGCAAAATTTACGTGATAACGGATTTGATGTAGTAGTAGGTTTAAGAAAAGGTAAGTCTTGGG
ATAAAGCGAATGAAGATGGGTTTTCTGTATATACAGTAGCAGAAGCTGCGGAAAAAGCTGATGTAGTAATGATTCTATTG
CCTGATGAATTACAACCAGAAGTATATGAAGCTGAAATTGCACCAAATTTACAGGCTGGAAACTCTCTCGTGTTCGCACA
TGGATTTAATGTTCACTTTGATCAAGTAAAACCACCAGCTAATGTAGATGTATTTCTAGTAGCGCCAAAAGGACCAGGGC
ATCTCGTACGCCGTACGTTCGCCGAGGGCGGGGCTGTTCCTGCATTATTTGCAGTATATCAAGATGCAACAGGAGTTGCG
ACTGAAAAAGCACTTTCTTATGCTGACGGAATTGGAGCAACGAGAGCTGGTGTACTAGAAACGACGTTTAAAGAAGAAAC
AGAAACAGATTTGTTTGGAGAGCAAGCTGTACTTTGCGGCGGAGTGACTGCACTTGTAAAAGCAGGGTTTGAAACGTTAG
TTGATGCGGGATATCAGCCTGAACTTGCATATTTTGAATGTTTACATGAATTGAAGCTAATCGTTGACCTTATGTACGAA
GGTGGACTTGAAAATATGAGATATTCAGTTTCAGATACAGCGCAGTGGGGAGACTTCGTATCAGGACCACGCGTTGTGAC
TGAAGATACGAAGAAAGCGATGGGGGCAGTATTAGCAGAAATTCAAGATGGTACATTTGCAAGAGGGTGGATTGCAGAAC
ATAAAGCAGGAAGACCAAATTTCCATGCGACAAATGAGAAAGAGAATAAACATGAAATCGAAGTAGTTGGACGTAAATTA
CGTGAAATGATGCCTTTCGTACAGCCGCGAGTAAAGGTAGGGGTTAAATAA

Upstream 100 bases:

>100_bases
TTGCTAGAACAGGTGTAACAGCATTTACACGTAGTATGAAAAAACAAGATAAGCAAGTTATGTTAATTCAATAATCATTT
AAATATAGGGGGAAATGAAA

Downstream 100 bases:

>100_bases
TATGAAGCAGGTTTTGTTCATGGATACAACGCTTCGTGATGGCGAACAATCACCAGGAGTAAATTTAAATGAACAAGAGA
AATTACAAATTGCTAGGCAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 1; Alpha-keto-beta-hydroxylacil reductoisomerase 1 [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKANEDGFSVYTVAEAAEKADVVMILL
PDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPANVDVFLVAPKGPGHLVRRTFAEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENKHEIEVVGRKL
REMMPFVQPRVKVGVK

Sequences:

>Translated_336_residues
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKANEDGFSVYTVAEAAEKADVVMILL
PDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPANVDVFLVAPKGPGHLVRRTFAEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENKHEIEVVGRKL
REMMPFVQPRVKVGVK
>Mature_335_residues
AKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKANEDGFSVYTVAEAAEKADVVMILLP
DELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPANVDVFLVAPKGPGHLVRRTFAEGGAVPALFAVYQDATGVAT
EKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEG
GLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENKHEIEVVGRKLR
EMMPFVQPRVKVGVK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=34.4709897610922, Blast_Score=142, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=34.8348348348348, Blast_Score=161, Evalue=2e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36649; Mature: 36518

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKANEDG
CCEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
FSVYTVAEAAEKADVVMILLPDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPA
EEEEEEEHHHCCCCEEEEEECCCCCCCCEEHHCCCCCCCCCEEEEEECCEEECCCCCCCC
NVDVFLVAPKGPGHLVRRTFAEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPN
CCCCCCEECCCCCHHHCHHCCCCEEEEHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCC
FHATNEKENKHEIEVVGRKLREMMPFVQPRVKVGVK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure 
AKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKANEDG
CEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
FSVYTVAEAAEKADVVMILLPDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPA
EEEEEEEHHHCCCCEEEEEECCCCCCCCEEHHCCCCCCCCCEEEEEECCEEECCCCCCCC
NVDVFLVAPKGPGHLVRRTFAEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPN
CCCCCCEECCCCCHHHCHHCCCCEEEEHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCC
FHATNEKENKHEIEVVGRKLREMMPFVQPRVKVGVK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]