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The map label for this gene is ciaH [H]

Identifier: 218233596

GI number: 218233596

Start: 588732

End: 589982

Strand: Direct

Name: ciaH [H]

Synonym: BCB4264_A0609

Alternate gene names: 218233596

Gene position: 588732-589982 (Clockwise)

Preceding gene: 218232940

Following gene: 218234787

Centisome position: 10.86

GC content: 34.13

Gene sequence:

>1251_bases
ATGAAAAAAGGAAGTATGTTTCAAAAAACACGCATTCGTTTGACTATAGTGAACTCATTAGTATTTATTCTATTAATAGG
TATATTAGGTAGTATTATTTATTCATACACATATAAGCGTATTTATAATGAAGTGGATCAATCTATAAAAATGATGGCTC
AGTATAGAGAAAAATTAGATGTTAAAATACCACCAAGAAAACGCATGGAGAATATCCAAATTGGAGATCCGCGAGTAACT
AGAATAACTTGGAATGGAAAAATAGTGAAAATAGAGGGCGATAACCGTAAATTCCGTTCTATTTTTGAAGAGAATTTGGA
AAGTTTTTCTCCCGAAAAATTAGAGGAGTTACAAGATATTGAAATACAAGGACGATATTTTAGAGCATTTTCGCTTCAAA
AAGATGGAGAAATAGTTCAAATCGTGCGAGATATAACAGCGGAAGAAGGAATGTTAAATACTTTATTTTTAATTCTCGTT
ATAGGTTGTAGCATAGGAAGCCTCTGTGCGATAGGTATTGGCTTTTTCCTAGCTGGTAGAGCACTTGTACCTATTCAAAG
TTCATGGGAGAAACAGCAACAATTCGTTTCTGATGCATCACATGAACTCAGGACACCACTTGCAGTTATTCAATCAAAAA
CGGATGTTTTATTCCAGTCACCATCCGCTACGATAGAAGAAAAAGCGATGGATATTTCTACAATTTCAAAAGAATGTAGG
CGGTTATCGAAACTCGTTAGTAATTTATTATTGCTAGCACGTTCTGATTCTAATCAAATTGAGATGGATAAGAAAACATT
TGAACTTGATAAATTGTTAGAAGAAATAGTAGCTCCATATAAAGAGATTGCTTCTTATCAAGAAAAAGAAATGATGCTAA
AAGTAGAACGTGGTGTATCTTTTATGGCTGATAGAGAGCGGATTCATCAAATGATGGTCATACTGTTAGATAATGCGATG
AAGTATACAAACGAAGGTGGGCATATTCAAATTGATTGCACGCAAACGAGTAGTTCAATTCGCATACAGGTGAAAGATGA
CGGGATAGGAGTGAAAGAAGAAGATATTCCGAAATTATTTGATCGTTTTTATCAAGGGGATAAAGCAAGAAGTACGTCAG
AAGGAGCTGGATTAGGTCTTTCAATCGCAAATTGGATTGTAGAAAAGCATTACGGAAAAATATCAGTAGAGAGCAAATGG
GGAGATGGCACTTGTTTTGAAGTGATTTTCCCTAAAAACCAAAAAATATAA

Upstream 100 bases:

>100_bases
TAGAAGTATATGTGCATCATTTGCGTAAAAAATTAGAACCATTCGGTTATCAGAAAGATATTCAAACCGTTCGAGGTATT
GGATATATATTAAAAGAACA

Downstream 100 bases:

>100_bases
GTAAGAAGACGACCTTGTTTTTACAGGGTCGTCTTTTTTTAAGGTAAAGTTAAGAAACTATTTATATTATGTATGGCATA
AAGAAAGTTCGTTACATGAA

Product: Two component system histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKKGSMFQKTRIRLTIVNSLVFILLIGILGSIIYSYTYKRIYNEVDQSIKMMAQYREKLDVKIPPRKRMENIQIGDPRVT
RITWNGKIVKIEGDNRKFRSIFEENLESFSPEKLEELQDIEIQGRYFRAFSLQKDGEIVQIVRDITAEEGMLNTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQSSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECR
RLSKLVSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMMLKVERGVSFMADRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKW
GDGTCFEVIFPKNQKI

Sequences:

>Translated_416_residues
MKKGSMFQKTRIRLTIVNSLVFILLIGILGSIIYSYTYKRIYNEVDQSIKMMAQYREKLDVKIPPRKRMENIQIGDPRVT
RITWNGKIVKIEGDNRKFRSIFEENLESFSPEKLEELQDIEIQGRYFRAFSLQKDGEIVQIVRDITAEEGMLNTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQSSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECR
RLSKLVSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMMLKVERGVSFMADRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKW
GDGTCFEVIFPKNQKI
>Mature_416_residues
MKKGSMFQKTRIRLTIVNSLVFILLIGILGSIIYSYTYKRIYNEVDQSIKMMAQYREKLDVKIPPRKRMENIQIGDPRVT
RITWNGKIVKIEGDNRKFRSIFEENLESFSPEKLEELQDIEIQGRYFRAFSLQKDGEIVQIVRDITAEEGMLNTLFLILV
IGCSIGSLCAIGIGFFLAGRALVPIQSSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECR
RLSKLVSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMMLKVERGVSFMADRERIHQMMVILLDNAM
KYTNEGGHIQIDCTQTSSSIRIQVKDDGIGVKEEDIPKLFDRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKW
GDGTCFEVIFPKNQKI

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=32.618025751073, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.1479820627803, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1786783, Length=228, Percent_Identity=29.3859649122807, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=32.4444444444444, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=29.004329004329, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=30, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=27.5109170305677, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=24.8868778280543, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=27.6785714285714, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=28.0851063829787, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790346, Length=229, Percent_Identity=27.5109170305677, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=26.0504201680672, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=25.6521739130435, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787374, Length=226, Percent_Identity=26.1061946902655, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790861, Length=209, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=23.1818181818182, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081816, Length=225, Percent_Identity=24.8888888888889, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=26.8181818181818, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47541; Mature: 47541

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGSMFQKTRIRLTIVNSLVFILLIGILGSIIYSYTYKRIYNEVDQSIKMMAQYREKLD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKIPPRKRMENIQIGDPRVTRITWNGKIVKIEGDNRKFRSIFEENLESFSPEKLEELQDI
CCCCCHHHHCCCCCCCCEEEEEEECCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCC
EIQGRYFRAFSLQKDGEIVQIVRDITAEEGMLNTLFLILVIGCSIGSLCAIGIGFFLAGR
EECCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
ALVPIQSSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECR
EEECCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHH
RLSKLVSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMMLKVERGVS
HHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
FMADRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTSSSIRIQVKDDGIGVKEEDIPKLF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHH
DRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKWGDGTCFEVIFPKNQKI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKKGSMFQKTRIRLTIVNSLVFILLIGILGSIIYSYTYKRIYNEVDQSIKMMAQYREKLD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKIPPRKRMENIQIGDPRVTRITWNGKIVKIEGDNRKFRSIFEENLESFSPEKLEELQDI
CCCCCHHHHCCCCCCCCEEEEEEECCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCC
EIQGRYFRAFSLQKDGEIVQIVRDITAEEGMLNTLFLILVIGCSIGSLCAIGIGFFLAGR
EECCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
ALVPIQSSWEKQQQFVSDASHELRTPLAVIQSKTDVLFQSPSATIEEKAMDISTISKECR
EEECCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHEEECCCCHHHHHHHHHHHHHHHHH
RLSKLVSNLLLLARSDSNQIEMDKKTFELDKLLEEIVAPYKEIASYQEKEMMLKVERGVS
HHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
FMADRERIHQMMVILLDNAMKYTNEGGHIQIDCTQTSSSIRIQVKDDGIGVKEEDIPKLF
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHH
DRFYQGDKARSTSEGAGLGLSIANWIVEKHYGKISVESKWGDGTCFEVIFPKNQKI
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]