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The map label for this gene is ciaR [H]

Identifier: 218232940

GI number: 218232940

Start: 588064

End: 588735

Strand: Direct

Name: ciaR [H]

Synonym: BCB4264_A0608

Alternate gene names: 218232940

Gene position: 588064-588735 (Clockwise)

Preceding gene: 218232403

Following gene: 218233596

Centisome position: 10.85

GC content: 35.27

Gene sequence:

>672_bases
ATGCGTTTACTTGTAGTAGAAGATAATGCTTCGTTATTAGAGTCTATCGTACAAATTTTACGTGATGAATTTGAAGTAGA
TACGGCAATAAATGGAGAAGATGGATTGTTTTTAGCTCTTCAAAATATATATGATGCAATTTTGCTGGATGTGATGATGC
CAGGGATGGACGGATTTGAAGTGATTCAAAAAATACGAGATGAAAAGATTGAAACACCAGTCCTGTTTTTGACAGCGAGA
GATTCTTTAGAAGATCGGGTGAAGGGATTGGACTTTGGTGGAGATGACTATATTGTTAAGCCATTTCAGGCCCCTGAATT
AAAAGCGAGAATTCGTGCTTTACTACGCAGAAGTGGTAGTTTAACAACGCAGCAAACAATTCGTTATAAAGGGATTGAAT
TGTTCGGAAAAGATAAAGACGTTCAAGTAGATGGACAAAGTATTAAGTTGACATTGAAACAATATGAGCTACTAGAGTAT
CTCATTCAAAATAGCGGGAAGATTTTAATGCGTGAACAAATTTTTGATCGTGTTTGGGGATTTGATTCAGATACTACAGT
AGCGATTGTAGAAGTATATGTGCATCATTTGCGTAAAAAATTAGAACCATTCGGTTATCAGAAAGATATTCAAACCGTTC
GAGGTATTGGATATATATTAAAAGAACAATGA

Upstream 100 bases:

>100_bases
AGTTAAAAATGAAATTACGTAATGTAACTACATTCTTTTGTTATAAAGAGAAGAAATGTAATAATAAATAGAATTGAACT
ATTTGATGGAAGGTGAGAGC

Downstream 100 bases:

>100_bases
AAAAAGGAAGTATGTTTCAAAAAACACGCATTCGTTTGACTATAGTGAACTCATTAGTATTTATTCTATTAATAGGTATA
TTAGGTAGTATTATTTATTC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLVVEDNASLLESIVQILRDEFEVDTAINGEDGLFLALQNIYDAILLDVMMPGMDGFEVIQKIRDEKIETPVLFLTAR
DSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGSLTTQQTIRYKGIELFGKDKDVQVDGQSIKLTLKQYELLEY
LIQNSGKILMREQIFDRVWGFDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ

Sequences:

>Translated_223_residues
MRLLVVEDNASLLESIVQILRDEFEVDTAINGEDGLFLALQNIYDAILLDVMMPGMDGFEVIQKIRDEKIETPVLFLTAR
DSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGSLTTQQTIRYKGIELFGKDKDVQVDGQSIKLTLKQYELLEY
LIQNSGKILMREQIFDRVWGFDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ
>Mature_223_residues
MRLLVVEDNASLLESIVQILRDEFEVDTAINGEDGLFLALQNIYDAILLDVMMPGMDGFEVIQKIRDEKIETPVLFLTAR
DSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGSLTTQQTIRYKGIELFGKDKDVQVDGQSIKLTLKQYELLEY
LIQNSGKILMREQIFDRVWGFDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=42.2727272727273, Blast_Score=171, Evalue=2e-44,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=39.7321428571429, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=37.5, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.4545454545455, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=36, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.7837837837838, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=35.5855855855856, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.5892857142857, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=28.6343612334802, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=35.0649350649351, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=31.3636363636364, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=27.8761061946903, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787229, Length=190, Percent_Identity=32.6315789473684, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693140, Length=239, Percent_Identity=26.7782426778243, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=36.697247706422, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=142, Percent_Identity=28.8732394366197, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25631; Mature: 25631

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVVEDNASLLESIVQILRDEFEVDTAINGEDGLFLALQNIYDAILLDVMMPGMDGFE
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
VIQKIRDEKIETPVLFLTARDSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGS
HHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCC
LTTQQTIRYKGIELFGKDKDVQVDGQSIKLTLKQYELLEYLIQNSGKILMREQIFDRVWG
CCHHHHHHHCCEEEECCCCCEEECCCEEEEHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
FDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLLVVEDNASLLESIVQILRDEFEVDTAINGEDGLFLALQNIYDAILLDVMMPGMDGFE
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
VIQKIRDEKIETPVLFLTARDSLEDRVKGLDFGGDDYIVKPFQAPELKARIRALLRRSGS
HHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCC
LTTQQTIRYKGIELFGKDKDVQVDGQSIKLTLKQYELLEYLIQNSGKILMREQIFDRVWG
CCHHHHHHHCCEEEECCCCCEEECCCEEEEHHHHHHHHHHHHHCCCCEEHHHHHHHHHHC
FDSDTTVAIVEVYVHHLRKKLEPFGYQKDIQTVRGIGYILKEQ
CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]