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The map label for this gene is lepB1 [H]

Identifier: 218233559

GI number: 218233559

Start: 464086

End: 464619

Strand: Direct

Name: lepB1 [H]

Synonym: BCB4264_A0478

Alternate gene names: 218233559

Gene position: 464086-464619 (Clockwise)

Preceding gene: 218233841

Following gene: 218235024

Centisome position: 8.56

GC content: 30.34

Gene sequence:

>534_bases
ATGCAAAAGAAAAAATGTTGGCGTGAATTCTTTGGAACTATTGCAATTGCATGTTTATTGGTGTTTTTGGCGAAAATTTT
TGTGTTTTTCCCTACGACTGTAAAAGGAGCATCTATGAGGCCAACGTTGCAAGATGGAGATAAGGTGATTGTTAATAAGT
TAGCAAAACAATTTGAAAGCTATGGGAGAGAAGATATTATTGTTGTGAAAACAGATAATTTTTATGTCAAAAGAGTGATT
GGATTATCTGGAGATATAATTGAGATGAGAAATGATCAATTATATGTAAATTCTGAAGTGAAAGATGAAGAGTATTTGGA
TAGTAATAAAAAACAAGCAGAAAAAAAACTTATGAATTTAACAGAGGACTTTGGACCAATTACAGTTCCCGAAAATAAGA
TTTTTGTTATGGGAGATAATCGCTTAATAAGTAAAGATAGTAGAAATGGTTTAGGTTTTATTGATAGAGAAGATGTGTTA
GGAAAGTTAGCAGGCATTTATTATCCGTTTGAACATATGAAAATAATAAAGTAA

Upstream 100 bases:

>100_bases
GAAATTTCTAATATTATAATTTTATAATTCAGAATTTTGTAGAAAAATATCGGTTGTATTATTTATAATAAAAGTAAAAA
GATGATGAGATGGTGAAATG

Downstream 100 bases:

>100_bases
AAAACCAAGCAAATTTTAGTTTGCTTGGTTTTTTTGTTAAACAGTAGGAGATTCGTTTGATACAAAAATATCTTCATGTT
TCTTTGTAGTACTTAAAACG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MQKKKCWREFFGTIAIACLLVFLAKIFVFFPTTVKGASMRPTLQDGDKVIVNKLAKQFESYGREDIIVVKTDNFYVKRVI
GLSGDIIEMRNDQLYVNSEVKDEEYLDSNKKQAEKKLMNLTEDFGPITVPENKIFVMGDNRLISKDSRNGLGFIDREDVL
GKLAGIYYPFEHMKIIK

Sequences:

>Translated_177_residues
MQKKKCWREFFGTIAIACLLVFLAKIFVFFPTTVKGASMRPTLQDGDKVIVNKLAKQFESYGREDIIVVKTDNFYVKRVI
GLSGDIIEMRNDQLYVNSEVKDEEYLDSNKKQAEKKLMNLTEDFGPITVPENKIFVMGDNRLISKDSRNGLGFIDREDVL
GKLAGIYYPFEHMKIIK
>Mature_177_residues
MQKKKCWREFFGTIAIACLLVFLAKIFVFFPTTVKGASMRPTLQDGDKVIVNKLAKQFESYGREDIIVVKTDNFYVKRVI
GLSGDIIEMRNDQLYVNSEVKDEEYLDSNKKQAEKKLMNLTEDFGPITVPENKIFVMGDNRLISKDSRNGLGFIDREDVL
GKLAGIYYPFEHMKIIK

Specific function: Not essential for cell viability, but required for efficient secretion of many proteins [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20374; Mature: 20374

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKKCWREFFGTIAIACLLVFLAKIFVFFPTTVKGASMRPTLQDGDKVIVNKLAKQFES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YGREDIIVVKTDNFYVKRVIGLSGDIIEMRNDQLYVNSEVKDEEYLDSNKKQAEKKLMNL
CCCCCEEEEECCCEEEEHHHCCCCCEEEECCCEEEECCCCCCHHHHCCCHHHHHHHHHHH
TEDFGPITVPENKIFVMGDNRLISKDSRNGLGFIDREDVLGKLAGIYYPFEHMKIIK
HHHCCCEECCCCEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHEECC
>Mature Secondary Structure
MQKKKCWREFFGTIAIACLLVFLAKIFVFFPTTVKGASMRPTLQDGDKVIVNKLAKQFES
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YGREDIIVVKTDNFYVKRVIGLSGDIIEMRNDQLYVNSEVKDEEYLDSNKKQAEKKLMNL
CCCCCEEEEECCCEEEEHHHCCCCCEEEECCCEEEECCCCCCHHHHCCCHHHHHHHHHHH
TEDFGPITVPENKIFVMGDNRLISKDSRNGLGFIDREDVLGKLAGIYYPFEHMKIIK
HHHCCCEECCCCEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1639057; 7934829; 7876097; 9384377; 8951809; 9823656 [H]