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The map label for this gene is thiD1 [H]

Identifier: 218232781

GI number: 218232781

Start: 768420

End: 769232

Strand: Direct

Name: thiD1 [H]

Synonym: BCB4264_A0791

Alternate gene names: 218232781

Gene position: 768420-769232 (Clockwise)

Preceding gene: 218232275

Following gene: 218231830

Centisome position: 14.18

GC content: 38.5

Gene sequence:

>813_bases
ATGAAAGTGAATAAAGCTTTAACAATTGCAGGGTCTGATAGCGGCGGCGGTGCTGGAATTCAGGCAGATTTAAAAACATT
CCAAGAGCTTGGTGTATACGGAATGACGGCTATTACGGCAATTACTGCTCAAAACACGCTTGGCGTTCAAGGGGTATATC
CTGTTCCATTAGAAGGTATTACAGAACAGCTGAATTCAATTGGTACGGATGTAACACCAGATGCAGTGAAACTAGGAATG
TTATTTAGTAGTGAAATAATTCAAATTGTTGCAGAACAAATTAAAAAGTTTGGCTGGAATAATATTGTGCTAGATCCCGT
TATGATTGCAAAAGGCGGTGCATCATTATTACAGCAAGAAGCAGTTCAAGCATTAAAAGAATATTTATTACCAGTAGCAA
CTGTTATAACACCGAATGTCCCAGAAGCAGAAGTGTTAACTGGGATGGAGATTCATAATGTTGAAGATAGTAAGGAAGCT
GCAAAAATATTGCATGAATTAGGTGCTAAATATGTGCTTATGAAGGGCGGACATGCAGAATATCAAGGGAATGAAGTAAT
TGATTTCCTCTTTGATGGAGAAAAATTTATTGAGTTTAGAAGCGAGCGAATTCCTTCAAAGCAAACGCATGGAAGTGGGT
GTACATTTGCTTCAGCGGTTACAGCAGGACTTGCGAAAGGATACTCAATTGAAGATGCTGTTCAAGAAGCAAAACGATTT
ATTAGTATAGCAATTGAAGAGCCATTGAATATTGGTAGTGGTCATGGACCGACGAATCATTTTGCGTATAAAGTGAATAG
AACGCGTGTATAG

Upstream 100 bases:

>100_bases
AGCCTTTAAAGATGGCCGTGTGCTCGTACATGGAACGAAAGATATAAGCGAAGCAAAAACGATTTATCATCGCTATTTTG
GATAGAAAAGGATGAGTGGG

Downstream 100 bases:

>100_bases
ATAAGTGAAAAGCCAGTTTTATAACTGGCTTTTTTTCTGTTTACTTTTTCAAAATACAGGAGTAATATATCAGCCAGAAT
ACATTTTTTTGTAAACGCTG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVPLEGITEQLNSIGTDVTPDAVKLGM
LFSSEIIQIVAEQIKKFGWNNIVLDPVMIAKGGASLLQQEAVQALKEYLLPVATVITPNVPEAEVLTGMEIHNVEDSKEA
AKILHELGAKYVLMKGGHAEYQGNEVIDFLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEDAVQEAKRF
ISIAIEEPLNIGSGHGPTNHFAYKVNRTRV

Sequences:

>Translated_270_residues
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVPLEGITEQLNSIGTDVTPDAVKLGM
LFSSEIIQIVAEQIKKFGWNNIVLDPVMIAKGGASLLQQEAVQALKEYLLPVATVITPNVPEAEVLTGMEIHNVEDSKEA
AKILHELGAKYVLMKGGHAEYQGNEVIDFLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEDAVQEAKRF
ISIAIEEPLNIGSGHGPTNHFAYKVNRTRV
>Mature_270_residues
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVPLEGITEQLNSIGTDVTPDAVKLGM
LFSSEIIQIVAEQIKKFGWNNIVLDPVMIAKGGASLLQQEAVQALKEYLLPVATVITPNVPEAEVLTGMEIHNVEDSKEA
AKILHELGAKYVLMKGGHAEYQGNEVIDFLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEDAVQEAKRF
ISIAIEEPLNIGSGHGPTNHFAYKVNRTRV

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=264, Percent_Identity=44.3181818181818, Blast_Score=213, Evalue=9e-57,
Organism=Escherichia coli, GI1788758, Length=249, Percent_Identity=28.1124497991968, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325378, Length=272, Percent_Identity=33.4558823529412, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324997, Length=273, Percent_Identity=34.0659340659341, Blast_Score=135, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324517, Length=273, Percent_Identity=34.4322344322344, Blast_Score=132, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28874; Mature: 28874

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVPLEGI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TEQLNSIGTDVTPDAVKLGMLFSSEIIQIVAEQIKKFGWNNIVLDPVMIAKGGASLLQQE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHH
AVQALKEYLLPVATVITPNVPEAEVLTGMEIHNVEDSKEAAKILHELGAKYVLMKGGHAE
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCC
YQGNEVIDFLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEDAVQEAKRF
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ISIAIEEPLNIGSGHGPTNHFAYKVNRTRV
HHHHHHCCCCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MKVNKALTIAGSDSGGGAGIQADLKTFQELGVYGMTAITAITAQNTLGVQGVYPVPLEGI
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TEQLNSIGTDVTPDAVKLGMLFSSEIIQIVAEQIKKFGWNNIVLDPVMIAKGGASLLQQE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCCHHHHHHH
AVQALKEYLLPVATVITPNVPEAEVLTGMEIHNVEDSKEAAKILHELGAKYVLMKGGHAE
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCC
YQGNEVIDFLFDGEKFIEFRSERIPSKQTHGSGCTFASAVTAGLAKGYSIEDAVQEAKRF
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ISIAIEEPLNIGSGHGPTNHFAYKVNRTRV
HHHHHHCCCCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]