Click here to switch to the map view.

The map label for this gene is ampC [C]

Identifier: 218232699

GI number: 218232699

Start: 3089428

End: 3090597

Strand: Reverse

Name: ampC [C]

Synonym: BCB4264_A3206

Alternate gene names: 218232699

Gene position: 3090597-3089428 (Counterclockwise)

Preceding gene: 218235613

Following gene: 218232098

Centisome position: 57.03

GC content: 38.89

Gene sequence:

>1170_bases
TTGATGAAAAAGCATCGTCAAATTACATGTACAGGTTTAGCCCTTTTAATAACTGGAGGTTCCCTGCTTTATACAACTCC
AACCTCAAGTGTAAAAGCGGAGTCCATTCAAAATGTATCTAGTTCGTTACAAACAAGCACCCAAAGAGATCATAATTCCG
TCAAAGAGGCAATGCGGGATACATTGAAACTTGGATATCCAGGGATACTCGCTAAAACTTCCAAAGGTGGAAAAACATGG
AGTTATGCGGCTGGTGTAGCGGATCTAAGTACCAAGAAACCAATGAAAACAGATTTTCGATTTCGAATTGGCAGCGTGAC
AAAGACGTTCACTGCAATAGTTGTACTTCAATTAGCAGGAGAAAACCGCTTGAATTTAGACGATTCTATTGAAAAATGGT
TGCCTGGTGTCATTCAAGGAAATGGATATGATGATAAACAGATTACTATCCGCCAATTATTGAATCACACAAGTGGTATC
GCTAATTACACAAGGTCAAAGGATTTTAATATGATGGATACAAAAAAATCTTATACTGCTGAAGGATTAGTAAAGATGGG
AATATCCATGCCTCCAGATTTTGCCCCAGGAAAGAGCTGGTCGTATTCAAATACAGGATATGTATTACTAGGAATTCTTA
TTGAAAAAGTAACTGGGAACAGCTATGCGGAAGAGATTGAAAATCGAATTATTGAACCACTTGAATTAGCGAATACATTC
TTACCTGGAAATTCAAGCGTCATTCCAGGAACCAAGCATGCCCGTGGATATATCCAATTAGACGGAGCAAGTGAGCCAAA
AGATGTTACTTATTATAACCCAAGTATGGGGAGCTCGGCCGGAGATATGATTTCTACAGCTGATGATTTAAACAAATTCT
TTTCTTATTTACTTGGGGGCAAGTTATTGAAAGAACAGCAACTAAAGCAAATGCTTACAACAGTACCTACAGGAGTAGAT
GAGCTTGGTGATTCCGGGCTTGGAATTTTCAAAATGAAGCTTTCAAACGGTGAATCGATATGGGGGCATGGAGGAACCAT
TCCTGGCTTTTTAACTTTTGCTGGAGGCACACTTGGAGGCAAGCATACATTGGCAGTCAATTTGAACAGCCTTAAAGCTG
ATACTCCTGATCCTTTTAAAAATATTTTACTTGCTGAATTTAGCAAGTAG

Upstream 100 bases:

>100_bases
TCAAACAAAGGATAGACTATTTTTTAGGTCAGAAAGCCATGTGATTAGTTCCAAACAGCAAATAACCATTTATACAATAT
GAATAGGGGAGAGGATTATT

Downstream 100 bases:

>100_bases
TCTAAAAGTAAAAACGGGTAAAATTTATCATAGTTTCATAGTTACACAAATGAATGATGAAAACGATCAATTATTTAAGG
AGGTAATTTCGTGATGAAAA

Product: beta-lactamase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MMKKHRQITCTGLALLITGGSLLYTTPTSSVKAESIQNVSSSLQTSTQRDHNSVKEAMRDTLKLGYPGILAKTSKGGKTW
SYAAGVADLSTKKPMKTDFRFRIGSVTKTFTAIVVLQLAGENRLNLDDSIEKWLPGVIQGNGYDDKQITIRQLLNHTSGI
ANYTRSKDFNMMDTKKSYTAEGLVKMGISMPPDFAPGKSWSYSNTGYVLLGILIEKVTGNSYAEEIENRIIEPLELANTF
LPGNSSVIPGTKHARGYIQLDGASEPKDVTYYNPSMGSSAGDMISTADDLNKFFSYLLGGKLLKEQQLKQMLTTVPTGVD
ELGDSGLGIFKMKLSNGESIWGHGGTIPGFLTFAGGTLGGKHTLAVNLNSLKADTPDPFKNILLAEFSK

Sequences:

>Translated_389_residues
MMKKHRQITCTGLALLITGGSLLYTTPTSSVKAESIQNVSSSLQTSTQRDHNSVKEAMRDTLKLGYPGILAKTSKGGKTW
SYAAGVADLSTKKPMKTDFRFRIGSVTKTFTAIVVLQLAGENRLNLDDSIEKWLPGVIQGNGYDDKQITIRQLLNHTSGI
ANYTRSKDFNMMDTKKSYTAEGLVKMGISMPPDFAPGKSWSYSNTGYVLLGILIEKVTGNSYAEEIENRIIEPLELANTF
LPGNSSVIPGTKHARGYIQLDGASEPKDVTYYNPSMGSSAGDMISTADDLNKFFSYLLGGKLLKEQQLKQMLTTVPTGVD
ELGDSGLGIFKMKLSNGESIWGHGGTIPGFLTFAGGTLGGKHTLAVNLNSLKADTPDPFKNILLAEFSK
>Mature_389_residues
MMKKHRQITCTGLALLITGGSLLYTTPTSSVKAESIQNVSSSLQTSTQRDHNSVKEAMRDTLKLGYPGILAKTSKGGKTW
SYAAGVADLSTKKPMKTDFRFRIGSVTKTFTAIVVLQLAGENRLNLDDSIEKWLPGVIQGNGYDDKQITIRQLLNHTSGI
ANYTRSKDFNMMDTKKSYTAEGLVKMGISMPPDFAPGKSWSYSNTGYVLLGILIEKVTGNSYAEEIENRIIEPLELANTF
LPGNSSVIPGTKHARGYIQLDGASEPKDVTYYNPSMGSSAGDMISTADDLNKFFSYLLGGKLLKEQQLKQMLTTVPTGVD
ELGDSGLGIFKMKLSNGESIWGHGGTIPGFLTFAGGTLGGKHTLAVNLNSLKADTPDPFKNILLAEFSK

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Homo sapiens, GI26051233, Length=142, Percent_Identity=30.2816901408451, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI26051231, Length=142, Percent_Identity=30.2816901408451, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790593, Length=266, Percent_Identity=25.9398496240602, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=351, Percent_Identity=27.9202279202279, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565630, Length=276, Percent_Identity=28.6231884057971, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17550934, Length=324, Percent_Identity=26.5432098765432, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42133; Mature: 42133

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKHRQITCTGLALLITGGSLLYTTPTSSVKAESIQNVSSSLQTSTQRDHNSVKEAMRD
CCCCCCEEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLKLGYPGILAKTSKGGKTWSYAAGVADLSTKKPMKTDFRFRIGSVTKTFTAIVVLQLAG
HHHCCCCCEEEECCCCCCCEEHHCCCHHCCCCCCCCCCCEEEECCHHHHHHHHHEEEECC
ENRLNLDDSIEKWLPGVIQGNGYDDKQITIRQLLNHTSGIANYTRSKDFNMMDTKKSYTA
CCCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
EGLVKMGISMPPDFAPGKSWSYSNTGYVLLGILIEKVTGNSYAEEIENRIIEPLELANTF
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHC
LPGNSSVIPGTKHARGYIQLDGASEPKDVTYYNPSMGSSAGDMISTADDLNKFFSYLLGG
CCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC
KLLKEQQLKQMLTTVPTGVDELGDSGLGIFKMKLSNGESIWGHGGTIPGFLTFAGGTLGG
HHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCEECCCCCCCCCHHEECCCCCCC
KHTLAVNLNSLKADTPDPFKNILLAEFSK
CEEEEEEECCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MMKKHRQITCTGLALLITGGSLLYTTPTSSVKAESIQNVSSSLQTSTQRDHNSVKEAMRD
CCCCCCEEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLKLGYPGILAKTSKGGKTWSYAAGVADLSTKKPMKTDFRFRIGSVTKTFTAIVVLQLAG
HHHCCCCCEEEECCCCCCCEEHHCCCHHCCCCCCCCCCCEEEECCHHHHHHHHHEEEECC
ENRLNLDDSIEKWLPGVIQGNGYDDKQITIRQLLNHTSGIANYTRSKDFNMMDTKKSYTA
CCCCCCCHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
EGLVKMGISMPPDFAPGKSWSYSNTGYVLLGILIEKVTGNSYAEEIENRIIEPLELANTF
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHC
LPGNSSVIPGTKHARGYIQLDGASEPKDVTYYNPSMGSSAGDMISTADDLNKFFSYLLGG
CCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCC
KLLKEQQLKQMLTTVPTGVDELGDSGLGIFKMKLSNGESIWGHGGTIPGFLTFAGGTLGG
HHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCEECCCCCCCCCHHEECCCCCCC
KHTLAVNLNSLKADTPDPFKNILLAEFSK
CEEEEEEECCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]