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The map label for this gene is pbp [H]

Identifier: 218232098

GI number: 218232098

Start: 3087250

End: 3089334

Strand: Reverse

Name: pbp [H]

Synonym: BCB4264_A3205

Alternate gene names: 218232098

Gene position: 3089334-3087250 (Counterclockwise)

Preceding gene: 218232699

Following gene: 218231154

Centisome position: 57.01

GC content: 42.4

Gene sequence:

>2085_bases
ATGAAAAATAAGCTAACTGGTGTGTTAGCCACTGCATTAGCGGTAACTATGATTCTACCAACAGGAGCGAAAGCACTTTC
TGAAAGTAAGACTACTGTTGTGACTGGTGAAGAAGTAGTTAGTCAGGAACTGAAGAAGATTGCAGCAGAGAAGGCGGAGC
TACTTACGAAGTCCCATGGGGCAGCTAGCGTGCAGTATGCACTAATTGATAATGGAAAACTTATTTTGTCGGGTCAGGCT
GGCAAGAACGATATGGAAGGGGAAAAGCCGCTAACCAAAGATACTTTATACGGGATTGGTTCAGTTAGTAAAATGTATGC
AACAGCGGCTGTAATGAAATTGGTCGATGAAGGAAAAGTCGATTTGGATGCTCCTGTTGTCCGCTATGTTCCTGATTTTA
AGATGAAGGACGGTCGATACAAACGTATTACACCGCGTATGTTATTGAATCACTCCTCTGGATTGCAAGGTTCTATGTTA
GGTAATGCATTTTTATTTAACGATAATGATACCTATGCCCATGATACCTTGTTACAGCAATTGTCAAATCAAAACTTGAA
GGCGGACCCTGGTGCTTTCTCGGTATATTGTAACGATGGTTTTACGCTGGCCGAAATTTTGGTGGAAAGAGTTAGTAGTA
TGAGCTTTACTGAATTTCTACATCAAAACTTTACAGGGCCTTTAAAAATGAATCATACGAAAACGCCGCAGGACAAATGG
AGGGATGAAAATCGGGCTGGACTATATTACCCGGCGTACCAAGGGCAACTTCCAATTGAATCGGTGAATGTTATTGGTAC
GGGAGGTATATCTTCCACGGCAGAAGATATGGTGCGATTCTCACAACTATTTATGGGACAGGGAAAAGGAATCCTCTCTG
ATAAGGTAGTTAAGGCAATGGAGCAAGAGGAATATAAAAAAGGAATGTGGCCGGGGGCTGGCGAGAATATTTTTAACTAT
GGTCTTGGCTGGGATAGTGTGAAACTATACCCATTCAGTGAATATGGGATCAAAGCTTTGGCTAAGGGCGGCGATACGGC
ATTGCAACATGCTATATTAGTCGTGCTTCCGGAACAGAAAATAGCAGCGGCTGTATTGACATCTGGTGGACGGAGCTCTA
CAAATCAGCTAATGGCAACTGAATTGCTGCTCGCTACGCTTAAAGAAAAAGGTACGATTAAGGAAATCAAGCCGAACAAA
TCCTTTGGTAAGCCGGTCAAAGTCAAAATGCCTCAAGGCGTAGCAAAGAAAGCTGGATTTTATGGTAATAGCGAAACTCA
TTTCAAGATTGAAATTACGAAGAACGGTGAGCTATTCTTACCATCTAATTCAGAAGAAAAATATGTATATACTGCTGATG
GAAGCTTTATTAATGAGGGGGGTACTTCCAAGTTCAACTTCGTAACCGAGAAGAATGGAAGAACTTATTTGAAGGAGAGC
GCATATAAATCTCATCCAGGTTTAGGGCAAAGTGTGATGACCCACTATTTAGCTGAGAAACTAGAAGATAACGTGCTTTC
GAAGAAAACCGCTGCTGCATGGGCAAAGAGGGAAGGTGTCAAGTTTTATCGTGTAAACGAGAAATTTAGTTCTATTCAAT
ATCTTGTTCAGTCGAAACATCTTAGTACTCAAATTACTCGCAAGGAAGGCCCAGCAGGCTATTGGGATGGCAGAAAAATT
ACAGGTCCGAACACCGCGGTGCATCAGATCCAAGTACCCGTGATGAATGGTCGTGATACGACGGAAACGCATTTCTATAC
AGAAGGCGGCAATGAATATATGGAGATGGCTGGATTGTTATACGTAAGTGAATCTAATGTAAAACCAATTGATGTAGACC
GATCATCTAAAGTTACGTTGGATGCAAATGGGTATGCGAAATGGTTTACAATTCCACAAGCGGCAACAGACAAAAGGATG
ACCGTGACGCTGCCATCAAATGGTTCATTTGCGGTGTATGATGAGAAGGGAGTTTGCGTCAACTTCACCATTGTGAGTGG
CAATAACAATGTGGAACTTCCCAAGAACGGAACAATCGTATTCGCTGGGGCACCGAAATCGGAATTTGCAATCTCGGTGA
ACTAG

Upstream 100 bases:

>100_bases
CAAGTAGTCTAAAAGTAAAAACGGGTAAAATTTATCATAGTTTCATAGTTACACAAATGAATGATGAAAACGATCAATTA
TTTAAGGAGGTAATTTCGTG

Downstream 100 bases:

>100_bases
CTATAATTTAAGATGATCTTAAACAAAACCAGTACGGTACAGAAAAGATGTATTACTGGTTTTGTTTGTATTTATGCATT
CTCAATGAAAAAACTTGAAT

Product: putative penicillin-binding protein

Products: NA

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MKNKLTGVLATALAVTMILPTGAKALSESKTTVVTGEEVVSQELKKIAAEKAELLTKSHGAASVQYALIDNGKLILSGQA
GKNDMEGEKPLTKDTLYGIGSVSKMYATAAVMKLVDEGKVDLDAPVVRYVPDFKMKDGRYKRITPRMLLNHSSGLQGSML
GNAFLFNDNDTYAHDTLLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSSMSFTEFLHQNFTGPLKMNHTKTPQDKW
RDENRAGLYYPAYQGQLPIESVNVIGTGGISSTAEDMVRFSQLFMGQGKGILSDKVVKAMEQEEYKKGMWPGAGENIFNY
GLGWDSVKLYPFSEYGIKALAKGGDTALQHAILVVLPEQKIAAAVLTSGGRSSTNQLMATELLLATLKEKGTIKEIKPNK
SFGKPVKVKMPQGVAKKAGFYGNSETHFKIEITKNGELFLPSNSEEKYVYTADGSFINEGGTSKFNFVTEKNGRTYLKES
AYKSHPGLGQSVMTHYLAEKLEDNVLSKKTAAAWAKREGVKFYRVNEKFSSIQYLVQSKHLSTQITRKEGPAGYWDGRKI
TGPNTAVHQIQVPVMNGRDTTETHFYTEGGNEYMEMAGLLYVSESNVKPIDVDRSSKVTLDANGYAKWFTIPQAATDKRM
TVTLPSNGSFAVYDEKGVCVNFTIVSGNNNVELPKNGTIVFAGAPKSEFAISVN

Sequences:

>Translated_694_residues
MKNKLTGVLATALAVTMILPTGAKALSESKTTVVTGEEVVSQELKKIAAEKAELLTKSHGAASVQYALIDNGKLILSGQA
GKNDMEGEKPLTKDTLYGIGSVSKMYATAAVMKLVDEGKVDLDAPVVRYVPDFKMKDGRYKRITPRMLLNHSSGLQGSML
GNAFLFNDNDTYAHDTLLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSSMSFTEFLHQNFTGPLKMNHTKTPQDKW
RDENRAGLYYPAYQGQLPIESVNVIGTGGISSTAEDMVRFSQLFMGQGKGILSDKVVKAMEQEEYKKGMWPGAGENIFNY
GLGWDSVKLYPFSEYGIKALAKGGDTALQHAILVVLPEQKIAAAVLTSGGRSSTNQLMATELLLATLKEKGTIKEIKPNK
SFGKPVKVKMPQGVAKKAGFYGNSETHFKIEITKNGELFLPSNSEEKYVYTADGSFINEGGTSKFNFVTEKNGRTYLKES
AYKSHPGLGQSVMTHYLAEKLEDNVLSKKTAAAWAKREGVKFYRVNEKFSSIQYLVQSKHLSTQITRKEGPAGYWDGRKI
TGPNTAVHQIQVPVMNGRDTTETHFYTEGGNEYMEMAGLLYVSESNVKPIDVDRSSKVTLDANGYAKWFTIPQAATDKRM
TVTLPSNGSFAVYDEKGVCVNFTIVSGNNNVELPKNGTIVFAGAPKSEFAISVN
>Mature_694_residues
MKNKLTGVLATALAVTMILPTGAKALSESKTTVVTGEEVVSQELKKIAAEKAELLTKSHGAASVQYALIDNGKLILSGQA
GKNDMEGEKPLTKDTLYGIGSVSKMYATAAVMKLVDEGKVDLDAPVVRYVPDFKMKDGRYKRITPRMLLNHSSGLQGSML
GNAFLFNDNDTYAHDTLLQQLSNQNLKADPGAFSVYCNDGFTLAEILVERVSSMSFTEFLHQNFTGPLKMNHTKTPQDKW
RDENRAGLYYPAYQGQLPIESVNVIGTGGISSTAEDMVRFSQLFMGQGKGILSDKVVKAMEQEEYKKGMWPGAGENIFNY
GLGWDSVKLYPFSEYGIKALAKGGDTALQHAILVVLPEQKIAAAVLTSGGRSSTNQLMATELLLATLKEKGTIKEIKPNK
SFGKPVKVKMPQGVAKKAGFYGNSETHFKIEITKNGELFLPSNSEEKYVYTADGSFINEGGTSKFNFVTEKNGRTYLKES
AYKSHPGLGQSVMTHYLAEKLEDNVLSKKTAAAWAKREGVKFYRVNEKFSSIQYLVQSKHLSTQITRKEGPAGYWDGRKI
TGPNTAVHQIQVPVMNGRDTTETHFYTEGGNEYMEMAGLLYVSESNVKPIDVDRSSKVTLDANGYAKWFTIPQAATDKRM
TVTLPSNGSFAVYDEKGVCVNFTIVSGNNNVELPKNGTIVFAGAPKSEFAISVN

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1786574, Length=362, Percent_Identity=24.585635359116, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533026, Length=341, Percent_Identity=25.8064516129032, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17550934, Length=291, Percent_Identity=25.085910652921, Blast_Score=70, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 75967; Mature: 75967

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKLTGVLATALAVTMILPTGAKALSESKTTVVTGEEVVSQELKKIAAEKAELLTKSHG
CCCCHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCC
AASVQYALIDNGKLILSGQAGKNDMEGEKPLTKDTLYGIGSVSKMYATAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCC
DLDAPVVRYVPDFKMKDGRYKRITPRMLLNHSSGLQGSMLGNAFLFNDNDTYAHDTLLQQ
CCCCCHHHHCCCCCCCCCCEEECCHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSSMSFTEFLHQNFTGPLKMNHTKTPQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCCCHHHH
RDENRAGLYYPAYQGQLPIESVNVIGTGGISSTAEDMVRFSQLFMGQGKGILSDKVVKAM
CCCCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EQEEYKKGMWPGAGENIFNYGLGWDSVKLYPFSEYGIKALAKGGDTALQHAILVVLPEQK
HHHHHHHCCCCCCCCCCEECCCCCCCEEEEECHHHCHHHHHCCCCHHHCCEEEEEECCHH
IAAAVLTSGGRSSTNQLMATELLLATLKEKGTIKEIKPNKSFGKPVKVKMPQGVAKKAGF
HEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCCHHHHCCC
YGNSETHFKIEITKNGELFLPSNSEEKYVYTADGSFINEGGTSKFNFVTEKNGRTYLKES
CCCCCEEEEEEEECCCCEEECCCCCCCEEEEECCCEECCCCCCEEEEEECCCCCCHHHHH
AYKSHPGLGQSVMTHYLAEKLEDNVLSKKTAAAWAKREGVKFYRVNEKFSSIQYLVQSKH
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
LSTQITRKEGPAGYWDGRKITGPNTAVHQIQVPVMNGRDTTETHFYTEGGNEYMEMAGLL
HHEEEECCCCCCCCCCCEEECCCCCEEEEEEEEEECCCCCCCEEEEECCCHHHHHHHEEE
YVSESNVKPIDVDRSSKVTLDANGYAKWFTIPQAATDKRMTVTLPSNGSFAVYDEKGVCV
EEECCCCCEEECCCCCEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEECCCEEE
NFTIVSGNNNVELPKNGTIVFAGAPKSEFAISVN
EEEEEECCCCEECCCCCEEEEECCCCCCEEEEEC
>Mature Secondary Structure
MKNKLTGVLATALAVTMILPTGAKALSESKTTVVTGEEVVSQELKKIAAEKAELLTKSHG
CCCCHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCC
AASVQYALIDNGKLILSGQAGKNDMEGEKPLTKDTLYGIGSVSKMYATAAVMKLVDEGKV
CCEEEEEEEECCEEEEECCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCC
DLDAPVVRYVPDFKMKDGRYKRITPRMLLNHSSGLQGSMLGNAFLFNDNDTYAHDTLLQQ
CCCCCHHHHCCCCCCCCCCEEECCHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHH
LSNQNLKADPGAFSVYCNDGFTLAEILVERVSSMSFTEFLHQNFTGPLKMNHTKTPQDKW
HCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCCCHHHH
RDENRAGLYYPAYQGQLPIESVNVIGTGGISSTAEDMVRFSQLFMGQGKGILSDKVVKAM
CCCCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EQEEYKKGMWPGAGENIFNYGLGWDSVKLYPFSEYGIKALAKGGDTALQHAILVVLPEQK
HHHHHHHCCCCCCCCCCEECCCCCCCEEEEECHHHCHHHHHCCCCHHHCCEEEEEECCHH
IAAAVLTSGGRSSTNQLMATELLLATLKEKGTIKEIKPNKSFGKPVKVKMPQGVAKKAGF
HEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCCHHHHCCC
YGNSETHFKIEITKNGELFLPSNSEEKYVYTADGSFINEGGTSKFNFVTEKNGRTYLKES
CCCCCEEEEEEEECCCCEEECCCCCCCEEEEECCCEECCCCCCEEEEEECCCCCCHHHHH
AYKSHPGLGQSVMTHYLAEKLEDNVLSKKTAAAWAKREGVKFYRVNEKFSSIQYLVQSKH
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
LSTQITRKEGPAGYWDGRKITGPNTAVHQIQVPVMNGRDTTETHFYTEGGNEYMEMAGLL
HHEEEECCCCCCCCCCCEEECCCCCEEEEEEEEEECCCCCCCEEEEECCCHHHHHHHEEE
YVSESNVKPIDVDRSSKVTLDANGYAKWFTIPQAATDKRMTVTLPSNGSFAVYDEKGVCV
EEECCCCCEEECCCCCEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCEEEEECCCEEE
NFTIVSGNNNVELPKNGTIVFAGAPKSEFAISVN
EEEEEECCCCEECCCCCEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]