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The map label for this gene is ribA [H]

Identifier: 218232489

GI number: 218232489

Start: 3278280

End: 3279017

Strand: Reverse

Name: ribA [H]

Synonym: BCB4264_A3398

Alternate gene names: 218232489

Gene position: 3279017-3278280 (Counterclockwise)

Preceding gene: 218231318

Following gene: 218232159

Centisome position: 60.51

GC content: 34.15

Gene sequence:

>738_bases
ATGGTTACAACAGATACAATTCATATGTTAGAAGATAAAATTCAATTTATACATCAAGATGGAAAGGATATTTATTTAGT
AGGCCCTATCAAATTGCCAATTAATTTATATGGGGAGACTAAAGTTTTTCAATGGTATTCTTGGTTACAATGTAGTGAGG
TTACAAATAGTGTAGAAGGAATTATCGAAAAACTCTCATCTATTAATTTAGCTGATATGCAGCAATCTAGTGTACTTGTA
TATGGTGATTTTGAGAATTCTGAAGATGCCCTAATTCGTATGCATAGTATTTGTCACACCGGTGATATCTTTGGTAGTAA
ACGTTGTGACTGTGGATTCCAATTAAAGCAGTCTTTACAAATGATTACAGAACATGGTTCAGGTGCTTTATTTTACTTAG
CGAATCATGAAGGAAGAGGAATTGGCTTGTTTAGTAAAGCTATGACGTACCTCTTGCAAGAAAATGGGTTAGATACAGTA
GAAGCTAATCTGAACCTAGGTTTTGAAGATGATGTTCGAAACTATGATGATACAATTGAAGTATTAAAAGCGCTACGCTC
AAAACCTGTAAAACTTATTACAAATAATCCGAAAAAATTAGAAGCGTTACAAAAAGCTGGATTAAATGTTACGAGTCGTG
AACCGTTATGGGGTGATGTCTCAGAGTTTAATGAGAAATATTTGCAAACGAAGATTCAGCGTTCTGGACATTTTGAAGGG
GGACACTTACATGCTTGA

Upstream 100 bases:

>100_bases
GAATAGCATCTGTAAAAACACTTACGTTGTGTAAGTTAAACAATAAAAAATATAACAATGGAAGAGAATTTTAGAGATTC
TCTATACTAGGAGGTACCTA

Downstream 100 bases:

>100_bases
GCATGAATTGTATATGAAGCTAGCACTAGAAAATGCCAAGGCTATGAAGGGACAAACGACTCCAAATCCATTGGTTGGAT
CTGTAATTGTAAATGATAAT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MVTTDTIHMLEDKIQFIHQDGKDIYLVGPIKLPINLYGETKVFQWYSWLQCSEVTNSVEGIIEKLSSINLADMQQSSVLV
YGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQMITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTV
EANLNLGFEDDVRNYDDTIEVLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
GHLHA

Sequences:

>Translated_245_residues
MVTTDTIHMLEDKIQFIHQDGKDIYLVGPIKLPINLYGETKVFQWYSWLQCSEVTNSVEGIIEKLSSINLADMQQSSVLV
YGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQMITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTV
EANLNLGFEDDVRNYDDTIEVLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
GHLHA
>Mature_245_residues
MVTTDTIHMLEDKIQFIHQDGKDIYLVGPIKLPINLYGETKVFQWYSWLQCSEVTNSVEGIIEKLSSINLADMQQSSVLV
YGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQMITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTV
EANLNLGFEDDVRNYDDTIEVLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
GHLHA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=169, Percent_Identity=46.7455621301775, Blast_Score=146, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=38.5964912280702, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 27645; Mature: 27645

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTDTIHMLEDKIQFIHQDGKDIYLVGPIKLPINLYGETKVFQWYSWLQCSEVTNSVEG
CCCCHHHHHHHHHHHHHHCCCCEEEEEECEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
IIEKLSSINLADMQQSSVLVYGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQ
HHHHHHCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
MITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTVEANLNLGFEDDVRNYDDTIE
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHCCHHHHHH
VLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
HHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GHLHA
CCCCC
>Mature Secondary Structure
MVTTDTIHMLEDKIQFIHQDGKDIYLVGPIKLPINLYGETKVFQWYSWLQCSEVTNSVEG
CCCCHHHHHHHHHHHHHHCCCCEEEEEECEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
IIEKLSSINLADMQQSSVLVYGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQ
HHHHHHCCCHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
MITEHGSGALFYLANHEGRGIGLFSKAMTYLLQENGLDTVEANLNLGFEDDVRNYDDTIE
HHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHCCHHHHHH
VLKALRSKPVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHFEG
HHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GHLHA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA