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The map label for this gene is obgE

Identifier: 21675022

GI number: 21675022

Start: 2082482

End: 2083489

Strand: Reverse

Name: obgE

Synonym: CT2213

Alternate gene names: 21675022

Gene position: 2083489-2082482 (Counterclockwise)

Preceding gene: 21675024

Following gene: 21675021

Centisome position: 96.68

GC content: 61.21

Gene sequence:

>1008_bases
GTGAAGTTTGTCGATAGTGCGAAAATCTCGGTGAAGGCTGGTGACGGCGGTCGGGGTTGCGTGAGTTTCAGGAGAGAGAA
GTTCGTGCCGAAAGGCGGGCCTGATGGCGGTGACGGTGGCCGTGGTGGCCACGTCTATCTGCGCGCCAACAAGCAGCTTA
CCACTCTGCTCGATTTCAAGTACCGCAAATCCTACATCGCCGGCCGCGGCGGGCATGGGCTTGGCGCTCGCAAGAGCGGC
AAGGATGGCAAGGACGTCATCATTGGCGTGCCGTGCGGCACGGTGGTGCGCAACGTCGAGACCGGCGAGGTGATATGCGA
CATGGTCGAGGACGGGCAGGAGATAATGATCGCCAAGGGCGGACGCGGTGGCTGGGGCAACCAGCACTTCGCCACGGCGA
CCCGGCAGGCTCCGCGATTCGCCCAGCCCGGCGAGCCGGGCGAGGAGTACGAACTCGAAATGGAGCTGAAGCTGATGGCC
GACGTCGGCCTCGTTGGTTTTCCCAACGCAGGCAAATCGACGCTGATCTCGGTACTCAGCGCGGCACGGCCGAAAATCGC
CGACTACCCGTTCACGACGCTGGTGCCGAATCTCGGCATTGTGCGCTATGAGGACTACAAATCCTTCGTCATGGCCGATA
TTCCGGGCATCATCGAAGGGGCGGCGGAAGGGCGCGGCCTGGGCATCCAGTTCCTGCGCCACATCGAGCGCACCAAGACG
CTGCTCATCATGGTTCCGTCCAATACGGAGGATATTGCCGCCGAGTACGCCACGCTCCTGAAGGAGCTGGAGAAGTTCGA
CCCGTCGCTGCTCTCCAAGCCAAGACTCGTGGTGATCACCAAGATGGATATTGCGCCTGAGGATTTCACCATGCCGGAGC
TTGAAAAAGGGGTCAAGGTGCTCGCCATATCGAGTGTGGCGGGACAGGGACTCAAGGCACTCAAGGATGAGCTGTGGCGG
CAGGTCTCTCTCCAGAACCAGTCACCTTCTGAACATGCCGGCAGCTGA

Upstream 100 bases:

>100_bases
CACTTGTGCGGGATTTGCTTGAAGCGGGCATCGGTCGGTCTGGTTTAAAATTGAGAGTAACATAGGTAACGATAGCGATT
ATTACAAAAAGGACGGAAGC

Downstream 100 bases:

>100_bases
TACCTGCGTCAGAAATGCGCGTCTTGCCGACGCTTCGGCCATTTCACGAATCACCGAGGGCTATGCGGGTGAGGGGATCA
TGCTCAAGCGCTCGGTCGAG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKFVDSAKISVKAGDGGRGCVSFRREKFVPKGGPDGGDGGRGGHVYLRANKQLTTLLDFKYRKSYIAGRGGHGLGARKSG
KDGKDVIIGVPCGTVVRNVETGEVICDMVEDGQEIMIAKGGRGGWGNQHFATATRQAPRFAQPGEPGEEYELEMELKLMA
DVGLVGFPNAGKSTLISVLSAARPKIADYPFTTLVPNLGIVRYEDYKSFVMADIPGIIEGAAEGRGLGIQFLRHIERTKT
LLIMVPSNTEDIAAEYATLLKELEKFDPSLLSKPRLVVITKMDIAPEDFTMPELEKGVKVLAISSVAGQGLKALKDELWR
QVSLQNQSPSEHAGS

Sequences:

>Translated_335_residues
MKFVDSAKISVKAGDGGRGCVSFRREKFVPKGGPDGGDGGRGGHVYLRANKQLTTLLDFKYRKSYIAGRGGHGLGARKSG
KDGKDVIIGVPCGTVVRNVETGEVICDMVEDGQEIMIAKGGRGGWGNQHFATATRQAPRFAQPGEPGEEYELEMELKLMA
DVGLVGFPNAGKSTLISVLSAARPKIADYPFTTLVPNLGIVRYEDYKSFVMADIPGIIEGAAEGRGLGIQFLRHIERTKT
LLIMVPSNTEDIAAEYATLLKELEKFDPSLLSKPRLVVITKMDIAPEDFTMPELEKGVKVLAISSVAGQGLKALKDELWR
QVSLQNQSPSEHAGS
>Mature_335_residues
MKFVDSAKISVKAGDGGRGCVSFRREKFVPKGGPDGGDGGRGGHVYLRANKQLTTLLDFKYRKSYIAGRGGHGLGARKSG
KDGKDVIIGVPCGTVVRNVETGEVICDMVEDGQEIMIAKGGRGGWGNQHFATATRQAPRFAQPGEPGEEYELEMELKLMA
DVGLVGFPNAGKSTLISVLSAARPKIADYPFTTLVPNLGIVRYEDYKSFVMADIPGIIEGAAEGRGLGIQFLRHIERTKT
LLIMVPSNTEDIAAEYATLLKELEKFDPSLLSKPRLVVITKMDIAPEDFTMPELEKGVKVLAISSVAGQGLKALKDELWR
QVSLQNQSPSEHAGS

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=315, Percent_Identity=41.5873015873016, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI111955139, Length=363, Percent_Identity=35.2617079889807, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI111955063, Length=199, Percent_Identity=39.6984924623116, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4557537, Length=123, Percent_Identity=37.3983739837398, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4758796, Length=115, Percent_Identity=40.8695652173913, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789574, Length=347, Percent_Identity=48.7031700288184, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1787454, Length=96, Percent_Identity=36.4583333333333, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=326, Percent_Identity=38.9570552147239, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17552324, Length=339, Percent_Identity=31.2684365781711, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17555344, Length=116, Percent_Identity=40.5172413793103, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71981008, Length=131, Percent_Identity=33.587786259542, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=164, Percent_Identity=40.8536585365854, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319281, Length=87, Percent_Identity=48.2758620689655, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321612, Length=105, Percent_Identity=39.0476190476191, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129375, Length=332, Percent_Identity=39.1566265060241, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24585318, Length=329, Percent_Identity=37.0820668693009, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21356473, Length=91, Percent_Identity=41.7582417582418, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17981711, Length=115, Percent_Identity=41.7391304347826, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_CHLTE (Q8KAF0)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_663087.1
- HSSP:   P20964
- ProteinModelPortal:   Q8KAF0
- SMR:   Q8KAF0
- GeneID:   1007347
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2213
- NMPDR:   fig|194439.1.peg.2181
- TIGR:   CT2213
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- ProtClustDB:   PRK12299
- BioCyc:   CTEP194439:CT_2213-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36120; Mature: 36120

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDSAKISVKAGDGGRGCVSFRREKFVPKGGPDGGDGGRGGHVYLRANKQLTTLLDFK
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEHHHHHH
YRKSYIAGRGGHGLGARKSGKDGKDVIIGVPCGTVVRNVETGEVICDMVEDGQEIMIAKG
HHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCHHHHHHHHHCCCEEEEEEC
GRGGWGNQHFATATRQAPRFAQPGEPGEEYELEMELKLMADVGLVGFPNAGKSTLISVLS
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHHHH
AARPKIADYPFTTLVPNLGIVRYEDYKSFVMADIPGIIEGAAEGRGLGIQFLRHIERTKT
HCCCCCCCCCHHHHCCCCCEEEECCHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHCCE
LLIMVPSNTEDIAAEYATLLKELEKFDPSLLSKPRLVVITKMDIAPEDFTMPELEKGVKV
EEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCEE
LAISSVAGQGLKALKDELWRQVSLQNQSPSEHAGS
EEEECHHCCCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKFVDSAKISVKAGDGGRGCVSFRREKFVPKGGPDGGDGGRGGHVYLRANKQLTTLLDFK
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCEEHHHHHH
YRKSYIAGRGGHGLGARKSGKDGKDVIIGVPCGTVVRNVETGEVICDMVEDGQEIMIAKG
HHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCCCCHHHHHHHHHCCCEEEEEEC
GRGGWGNQHFATATRQAPRFAQPGEPGEEYELEMELKLMADVGLVGFPNAGKSTLISVLS
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHHHH
AARPKIADYPFTTLVPNLGIVRYEDYKSFVMADIPGIIEGAAEGRGLGIQFLRHIERTKT
HCCCCCCCCCHHHHCCCCCEEEECCHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHCCE
LLIMVPSNTEDIAAEYATLLKELEKFDPSLLSKPRLVVITKMDIAPEDFTMPELEKGVKV
EEEEECCCCHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCEE
LAISSVAGQGLKALKDELWRQVSLQNQSPSEHAGS
EEEECHHCCCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901