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The map label for this gene is fabH

Identifier: 21674923

GI number: 21674923

Start: 2000561

End: 2001550

Strand: Direct

Name: fabH

Synonym: CT2114

Alternate gene names: 21674923

Gene position: 2000561-2001550 (Clockwise)

Preceding gene: 21674922

Following gene: 21674924

Centisome position: 92.84

GC content: 58.08

Gene sequence:

>990_bases
ATGAAAGCAGCCATAACGACGACCGCCAAGTATCTGCCTGAAGAGATAATGTCCAATCAGGACCTCGAACGAATTCTTGA
TACAAACGACGAGTGGATAACGACCCGGACCGGCATCAAGGAGCGGAGAATTCTCCGGGATCCGAAAAAGGCCACATCAT
ATATGTGCACCGAGGTTGCCCGGCAGTTGCTTGAAAAGCGGGGCATCTCCGCCGACGAGATCGATCTGATCATCGTGGCG
ACCATGTCTCCCGACATGCTCTTTCCCTCGACGGCATGTCTGGTTCAGGGCAATATCCAGGCAAAAAACGCCTGGGGCTT
CGACCTTTCCGCCGCCTGCTCGGGTTTCGTCTATGGCCTCTACACCGGCGCCCAGTTCATTGAATCGGGCAACTGCAAGA
AGGTGATGGTGATCGGCGCGGACAAGATGTCCTCCATTCTCGATTACGAAGACCGGACGACCGCCATCCTGTTTGGTGAC
GGAGCGGGCGGCGTTATTCTCGAAGCTGCGAATGAAGAGGGGTACGGCGTGCTCGACGCCCGTCTCTACTCCGACGGCCT
CAATGGCAGGGAGCACCTCCTGATGCCGGGCGGCGGAAGCCTTCATCCGGCGTCGCATGAAACGGTCGATCAGCACATGC
ACTTCATCCAGCAGGATGGCAAGCAGGTCTTCAAGGCTGCGGTCATAGCCATGGCCGATGTGGCCGAAGAGATCATGCAG
CGCAACAATCTGACTGCGGAAACCATCGACTGGCTCGTGCCACACCAGGCCAACCAGCGTATCATTCACGCCACCGCCGA
GCGTATGGGGATCACCGAAGAAAAGGTAATGATGAACATCGCGCGCTATGGCAACACCACGGCAGGCACGGTGCCGATCT
GCCTCGCCGAGCTGGACGAGCAGGGCAAACTGCACAAAGGCTCGAACCTCGTGCTGGTGAGCTTCGGAGCAGGCTACACC
TGGGGCGGCGTTTACGTCCGCTGGCAGTAA

Upstream 100 bases:

>100_bases
AGATGCTCCTGAATGTCTATTCCCTGTCCTTTGCTATTGGCCGAAGAGACTCCGATACAATCTTCGCATTTTCCGTCCGC
TTATCAAGAGAAACCACACT

Downstream 100 bases:

>100_bases
GCCAAACCATTCAAAGGAATTACAGGATATGAAAGCATTTGTTTTCCCCGGTCAGGGTTCGCAGTACTGCGGCATGGGCC
GCGATCTGTACGAGCGCTTC

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKAAITTTAKYLPEEIMSNQDLERILDTNDEWITTRTGIKERRILRDPKKATSYMCTEVARQLLEKRGISADEIDLIIVA
TMSPDMLFPSTACLVQGNIQAKNAWGFDLSAACSGFVYGLYTGAQFIESGNCKKVMVIGADKMSSILDYEDRTTAILFGD
GAGGVILEAANEEGYGVLDARLYSDGLNGREHLLMPGGGSLHPASHETVDQHMHFIQQDGKQVFKAAVIAMADVAEEIMQ
RNNLTAETIDWLVPHQANQRIIHATAERMGITEEKVMMNIARYGNTTAGTVPICLAELDEQGKLHKGSNLVLVSFGAGYT
WGGVYVRWQ

Sequences:

>Translated_329_residues
MKAAITTTAKYLPEEIMSNQDLERILDTNDEWITTRTGIKERRILRDPKKATSYMCTEVARQLLEKRGISADEIDLIIVA
TMSPDMLFPSTACLVQGNIQAKNAWGFDLSAACSGFVYGLYTGAQFIESGNCKKVMVIGADKMSSILDYEDRTTAILFGD
GAGGVILEAANEEGYGVLDARLYSDGLNGREHLLMPGGGSLHPASHETVDQHMHFIQQDGKQVFKAAVIAMADVAEEIMQ
RNNLTAETIDWLVPHQANQRIIHATAERMGITEEKVMMNIARYGNTTAGTVPICLAELDEQGKLHKGSNLVLVSFGAGYT
WGGVYVRWQ
>Mature_329_residues
MKAAITTTAKYLPEEIMSNQDLERILDTNDEWITTRTGIKERRILRDPKKATSYMCTEVARQLLEKRGISADEIDLIIVA
TMSPDMLFPSTACLVQGNIQAKNAWGFDLSAACSGFVYGLYTGAQFIESGNCKKVMVIGADKMSSILDYEDRTTAILFGD
GAGGVILEAANEEGYGVLDARLYSDGLNGREHLLMPGGGSLHPASHETVDQHMHFIQQDGKQVFKAAVIAMADVAEEIMQ
RNNLTAETIDWLVPHQANQRIIHATAERMGITEEKVMMNIARYGNTTAGTVPICLAELDEQGKLHKGSNLVLVSFGAGYT
WGGVYVRWQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=328, Percent_Identity=41.4634146341463, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CHLTE (Q8KAP2)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662988.1
- ProteinModelPortal:   Q8KAP2
- SMR:   Q8KAP2
- GeneID:   1007447
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2114
- NMPDR:   fig|194439.1.peg.2082
- TIGR:   CT2114
- HOGENOM:   HBG649927
- OMA:   NATAERM
- ProtClustDB:   PRK09352
- BioCyc:   CTEP194439:CT_2114-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 36141; Mature: 36141

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 255-255 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAITTTAKYLPEEIMSNQDLERILDTNDEWITTRTGIKERRILRDPKKATSYMCTEVA
CCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHH
RQLLEKRGISADEIDLIIVATMSPDMLFPSTACLVQGNIQAKNAWGFDLSAACSGFVYGL
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHH
YTGAQFIESGNCKKVMVIGADKMSSILDYEDRTTAILFGDGAGGVILEAANEEGYGVLDA
HHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEE
RLYSDGLNGREHLLMPGGGSLHPASHETVDQHMHFIQQDGKQVFKAAVIAMADVAEEIMQ
EEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNNLTAETIDWLVPHQANQRIIHATAERMGITEEKVMMNIARYGNTTAGTVPICLAELDE
HCCCCHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHEECCCC
QGKLHKGSNLVLVSFGAGYTWGGVYVRWQ
CCCEECCCCEEEEEECCCCEECCEEEEEC
>Mature Secondary Structure
MKAAITTTAKYLPEEIMSNQDLERILDTNDEWITTRTGIKERRILRDPKKATSYMCTEVA
CCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHH
RQLLEKRGISADEIDLIIVATMSPDMLFPSTACLVQGNIQAKNAWGFDLSAACSGFVYGL
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEECCEEECCCCCCCHHHHHHHHHHHH
YTGAQFIESGNCKKVMVIGADKMSSILDYEDRTTAILFGDGAGGVILEAANEEGYGVLDA
HHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEE
RLYSDGLNGREHLLMPGGGSLHPASHETVDQHMHFIQQDGKQVFKAAVIAMADVAEEIMQ
EEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNNLTAETIDWLVPHQANQRIIHATAERMGITEEKVMMNIARYGNTTAGTVPICLAELDE
HCCCCHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHEECCCC
QGKLHKGSNLVLVSFGAGYTWGGVYVRWQ
CCCEECCCCEEEEEECCCCEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901