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The map label for this gene is sdhA [H]

Identifier: 21674852

GI number: 21674852

Start: 1940202

End: 1941905

Strand: Reverse

Name: sdhA [H]

Synonym: CT2042

Alternate gene names: 21674852

Gene position: 1941905-1940202 (Counterclockwise)

Preceding gene: 21674853

Following gene: 21674851

Centisome position: 90.11

GC content: 59.68

Gene sequence:

>1704_bases
ATGAAACCATTTGATATCGTCATCGTCGGTGGTGGCGGTGCCGGACTTTATGCGGCCATGGAGGCAATGAAGACCAATCC
GGGCCTGAACATCGCCGTGCTTTCAAAGGTCTATCCGAACCGCTCCCACACCTCGGCAGCGCAGGGCGGAGCCAACGCGG
CGCTGGCCAACAAGGCCAAGGATGACACGGTCGAGATGCATATTTACGATACGATCAAGGGCAGCGACTATCTGGCTGAC
CAGGATGCGGTCGAGGTGCTCTGTTCCGAAGCTCCGAAGATTATCCGCGAACTCGACAACATGGGCACACCGTGGTCGAG
GATGGATGACAAGACCATCGCCCAGCGTCCCTTTGGCGGCGCGGGCCGTCCCCGCTGTTGCTATTGCGCAGACAAGACAG
GCCACACCATTCTCCAGACCCTGTACGAACAGTGCCTGCGCAAGGGCGTGTTTTTCTTCAACGAATATTTCGCGCTCGCT
CTTTCGGTTGACGGCAGCCGTTCGCGGGGTCTCATCGCCATGAACATCAAGACCGGCAAGGTCGAGGCGTTTCCGGCCAA
GACGGTGATTTTCGCCACCGGCGGTTACGCCAAGATGTACTGGAACCGTTCCAGCAACGCGGCGGGCAATACCGGTGACG
GTCAGGCCATTGCCTACCGTGCGGGCATTCCACTCAAGGACATGGAGTTCGTGCAGTTCCATCCCACCGGTTTGCGCAAA
AGCGGCCTGCTTGTGACCGAGGGTGCCCGCGGCGAGGGTGGTTATCTGGTCAACGCGCTCGGCGAGCGCTTCATGTCGCG
CTACGCTCCAGAAAAGATGGAGCTTGGCCCGCGTGACCTCGTCTCCCGTTCGCTTGAAACCGAAATTCTCGAAGGTCGCG
GCTTCGACAGCCCGGCAGGCAAATATTTGCATCTCGATCTCCGCCATCTCGGCGCCGACCTCATCAAGTCGCGCCTCCCG
CAGATTCGCGAGATGTGCATGTACTTCGAAGGCGTCGATCCGATTGAGGAGCCGGTGCCGGTCAGGCCGACGGCTCACTA
TTCGATGGGCGGCATTGATACCGACAACTTCGGACGCACCATCATGGAGGGTGTCTATGCCGCCGGTGAGTGCGGCTGCG
TGTCGGTGCATGGCGCGAACCGCCTTGGCGGCAACTCGCTGCTCGACATTCTGGTCTTTGGACGCATCGCCGGAAGGGCC
GCTGCCGAAGAGTGCGGCAAATTCAATCCATCCGCCATTCCCGCATCCGAGGTGGCCGAAAAAGAGCATGAGCTGCGCAG
CTTCATGCAGCCGCGCGGTCACTACGAACGCTACGGCACGTTGCGCGAAGAACTGGGCCATACGCTCGGCGCGAACGTCG
GCATCTTCCGCGATTCCTCGAAAATCAAGCAGGGAATCGCCGATATCGAAAGCCTCCAGGAGCGCTTCCGGCACGTCAGG
GTTTTCGATACGAGCGACATCTACAACACCAATCTGCTTCAGGTGCTCGAACTGAAGAACATGCTCGACCTGTCCGAAAC
CGTGGCCGCGGGCGCGCTTGCCAGGGAGGAGAGCCGCGGCTCGCACACCAGGACCGATTTCCCGACGCGTGACGACGAGA
AGTGGCACAAGCATACCATTTATACATACGAGAATGGCCGCCCGAAGCTTGCATACAAACCGGTCACGATGGGCCGCTAC
GAGCTTCAGGAACGAACCTATTAA

Upstream 100 bases:

>100_bases
GTTTTCATCATGAACGCACGGGTGCCGCAGCAGGCGGTCGGCCCTTTTTCCAACCAGCCAGCCTGCCATTCGGCAGACAG
GCAAGGATTTCCGATTGTTT

Downstream 100 bases:

>100_bases
TCCGAAGGATTTTCAATGAGCGATTCAACGATACAGCATCATGAGGAGAGCCGGGATGTAACCTTCAGGGTTCACCGGTT
CAATCCCCAGGTTGACAGCA

Product: succinate/fumarate oxidoreductase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MKPFDIVIVGGGGAGLYAAMEAMKTNPGLNIAVLSKVYPNRSHTSAAQGGANAALANKAKDDTVEMHIYDTIKGSDYLAD
QDAVEVLCSEAPKIIRELDNMGTPWSRMDDKTIAQRPFGGAGRPRCCYCADKTGHTILQTLYEQCLRKGVFFFNEYFALA
LSVDGSRSRGLIAMNIKTGKVEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
SGLLVTEGARGEGGYLVNALGERFMSRYAPEKMELGPRDLVSRSLETEILEGRGFDSPAGKYLHLDLRHLGADLIKSRLP
QIREMCMYFEGVDPIEEPVPVRPTAHYSMGGIDTDNFGRTIMEGVYAAGECGCVSVHGANRLGGNSLLDILVFGRIAGRA
AAEECGKFNPSAIPASEVAEKEHELRSFMQPRGHYERYGTLREELGHTLGANVGIFRDSSKIKQGIADIESLQERFRHVR
VFDTSDIYNTNLLQVLELKNMLDLSETVAAGALAREESRGSHTRTDFPTRDDEKWHKHTIYTYENGRPKLAYKPVTMGRY
ELQERTY

Sequences:

>Translated_567_residues
MKPFDIVIVGGGGAGLYAAMEAMKTNPGLNIAVLSKVYPNRSHTSAAQGGANAALANKAKDDTVEMHIYDTIKGSDYLAD
QDAVEVLCSEAPKIIRELDNMGTPWSRMDDKTIAQRPFGGAGRPRCCYCADKTGHTILQTLYEQCLRKGVFFFNEYFALA
LSVDGSRSRGLIAMNIKTGKVEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
SGLLVTEGARGEGGYLVNALGERFMSRYAPEKMELGPRDLVSRSLETEILEGRGFDSPAGKYLHLDLRHLGADLIKSRLP
QIREMCMYFEGVDPIEEPVPVRPTAHYSMGGIDTDNFGRTIMEGVYAAGECGCVSVHGANRLGGNSLLDILVFGRIAGRA
AAEECGKFNPSAIPASEVAEKEHELRSFMQPRGHYERYGTLREELGHTLGANVGIFRDSSKIKQGIADIESLQERFRHVR
VFDTSDIYNTNLLQVLELKNMLDLSETVAAGALAREESRGSHTRTDFPTRDDEKWHKHTIYTYENGRPKLAYKPVTMGRY
ELQERTY
>Mature_567_residues
MKPFDIVIVGGGGAGLYAAMEAMKTNPGLNIAVLSKVYPNRSHTSAAQGGANAALANKAKDDTVEMHIYDTIKGSDYLAD
QDAVEVLCSEAPKIIRELDNMGTPWSRMDDKTIAQRPFGGAGRPRCCYCADKTGHTILQTLYEQCLRKGVFFFNEYFALA
LSVDGSRSRGLIAMNIKTGKVEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
SGLLVTEGARGEGGYLVNALGERFMSRYAPEKMELGPRDLVSRSLETEILEGRGFDSPAGKYLHLDLRHLGADLIKSRLP
QIREMCMYFEGVDPIEEPVPVRPTAHYSMGGIDTDNFGRTIMEGVYAAGECGCVSVHGANRLGGNSLLDILVFGRIAGRA
AAEECGKFNPSAIPASEVAEKEHELRSFMQPRGHYERYGTLREELGHTLGANVGIFRDSSKIKQGIADIESLQERFRHVR
VFDTSDIYNTNLLQVLELKNMLDLSETVAAGALAREESRGSHTRTDFPTRDDEKWHKHTIYTYENGRPKLAYKPVTMGRY
ELQERTY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=570, Percent_Identity=42.8070175438597, Blast_Score=441, Evalue=1e-124,
Organism=Escherichia coli, GI1786942, Length=584, Percent_Identity=44.0068493150685, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1790597, Length=555, Percent_Identity=42.5225225225225, Blast_Score=424, Evalue=1e-119,
Organism=Escherichia coli, GI1788928, Length=549, Percent_Identity=32.4225865209472, Blast_Score=234, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=569, Percent_Identity=42.530755711775, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17505833, Length=568, Percent_Identity=41.7253521126761, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71986328, Length=436, Percent_Identity=25.9174311926606, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322701, Length=537, Percent_Identity=45.0651769087523, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6322416, Length=551, Percent_Identity=43.9201451905626, Blast_Score=440, Evalue=1e-124,
Organism=Drosophila melanogaster, GI17137288, Length=570, Percent_Identity=42.9824561403509, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24655642, Length=570, Percent_Identity=42.9824561403509, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24655647, Length=570, Percent_Identity=42.9824561403509, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24663005, Length=573, Percent_Identity=42.0593368237347, Blast_Score=425, Evalue=1e-119,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 62547; Mature: 62547

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFDIVIVGGGGAGLYAAMEAMKTNPGLNIAVLSKVYPNRSHTSAAQGGANAALANKAK
CCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCHHCCCCCHHHHCCCC
DDTVEMHIYDTIKGSDYLADQDAVEVLCSEAPKIIRELDNMGTPWSRMDDKTIAQRPFGG
CCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHCCCCCC
AGRPRCCYCADKTGHTILQTLYEQCLRKGVFFFNEYFALALSVDGSRSRGLIAMNIKTGK
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCEEEEEEECCC
VEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
EEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCC
SGLLVTEGARGEGGYLVNALGERFMSRYAPEKMELGPRDLVSRSLETEILEGRGFDSPAG
CCEEEECCCCCCCCEEHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
KYLHLDLRHLGADLIKSRLPQIREMCMYFEGVDPIEEPVPVRPTAHYSMGGIDTDNFGRT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
IMEGVYAAGECGCVSVHGANRLGGNSLLDILVFGRIAGRAAAEECGKFNPSAIPASEVAE
HHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KEHELRSFMQPRGHYERYGTLREELGHTLGANVGIFRDSSKIKQGIADIESLQERFRHVR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHEE
VFDTSDIYNTNLLQVLELKNMLDLSETVAAGALAREESRGSHTRTDFPTRDDEKWHKHTI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEE
YTYENGRPKLAYKPVTMGRYELQERTY
EEEECCCCEEEECCCCCCHHHHHHCCC
>Mature Secondary Structure
MKPFDIVIVGGGGAGLYAAMEAMKTNPGLNIAVLSKVYPNRSHTSAAQGGANAALANKAK
CCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCHHCCCCCHHHHCCCC
DDTVEMHIYDTIKGSDYLADQDAVEVLCSEAPKIIRELDNMGTPWSRMDDKTIAQRPFGG
CCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHCCCCCC
AGRPRCCYCADKTGHTILQTLYEQCLRKGVFFFNEYFALALSVDGSRSRGLIAMNIKTGK
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCEEEEEEECCC
VEAFPAKTVIFATGGYAKMYWNRSSNAAGNTGDGQAIAYRAGIPLKDMEFVQFHPTGLRK
EEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCC
SGLLVTEGARGEGGYLVNALGERFMSRYAPEKMELGPRDLVSRSLETEILEGRGFDSPAG
CCEEEECCCCCCCCEEHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCC
KYLHLDLRHLGADLIKSRLPQIREMCMYFEGVDPIEEPVPVRPTAHYSMGGIDTDNFGRT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
IMEGVYAAGECGCVSVHGANRLGGNSLLDILVFGRIAGRAAAEECGKFNPSAIPASEVAE
HHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
KEHELRSFMQPRGHYERYGTLREELGHTLGANVGIFRDSSKIKQGIADIESLQERFRHVR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHEE
VFDTSDIYNTNLLQVLELKNMLDLSETVAAGALAREESRGSHTRTDFPTRDDEKWHKHTI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEE
YTYENGRPKLAYKPVTMGRYELQERTY
EEEECCCCEEEECCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA