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The map label for this gene is folK [H]

Identifier: 21674750

GI number: 21674750

Start: 1831519

End: 1832034

Strand: Direct

Name: folK [H]

Synonym: CT1938

Alternate gene names: 21674750

Gene position: 1831519-1832034 (Clockwise)

Preceding gene: 21674749

Following gene: 21674753

Centisome position: 84.99

GC content: 58.33

Gene sequence:

>516_bases
ATGGCGCCAGTTACCGCCTATATCGGCATCGGCTCGAATGTCGGAGACCGGCTCGGCTACCTTCAGCAGGCCGTTGACCA
CCTTGCACAACTGCCTGGCATGAGGGTGAGCGGAGCCTCACGGGTGTATATGACCGAGCCGTTCGGTGATCCCAACCAGG
AACGCTATTTCAACGCCGTCATTGCAGTGCAGACATCGCTCGATCCGACTGACCTTCGCACCCGCTGCAAAGCAATCGAG
CATGACCTGGGCCGCCCCGACCGGTACCAGCGCTGGAGTCCGAGAACCATCGATCTCGATATCCTGCTCTACAGCGATCT
CTGCATCGAAAGCGATCTGCTCGTTATTCCTCATGCCGAGATGCACCACCGGAAATTCGTCCTTATACCACTGCTCGACC
TCGCCAATCCGGTTCACCCCCGCCTGCGCCACTCCATCGCCGAGCTACTGAAAAGCTGCGAAGATCACTCGGTTCCTGTA
CGACTGGTGCAAGAGTTGAAGATCAGGCCGACCTGA

Upstream 100 bases:

>100_bases
CGCGGAGAAAGTCACCGTGAAGGTGCGCAAGCGAGCGCTGCCTCTCGGCGGGCTGTGCGATTATGCTGAAGCCGAACACG
TGATTGAAAGGCACTGAACA

Downstream 100 bases:

>100_bases
CTGACCCGGCTGATCTTCCAATAAAAAAAGCGGACCACCGTGAAGTAGCCCGCTTTTATATTAAAACCTCGCTTTCCGCT
CAGTTCGCGAAAGTGATATT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MAPVTAYIGIGSNVGDRLGYLQQAVDHLAQLPGMRVSGASRVYMTEPFGDPNQERYFNAVIAVQTSLDPTDLRTRCKAIE
HDLGRPDRYQRWSPRTIDLDILLYSDLCIESDLLVIPHAEMHHRKFVLIPLLDLANPVHPRLRHSIAELLKSCEDHSVPV
RLVQELKIRPT

Sequences:

>Translated_171_residues
MAPVTAYIGIGSNVGDRLGYLQQAVDHLAQLPGMRVSGASRVYMTEPFGDPNQERYFNAVIAVQTSLDPTDLRTRCKAIE
HDLGRPDRYQRWSPRTIDLDILLYSDLCIESDLLVIPHAEMHHRKFVLIPLLDLANPVHPRLRHSIAELLKSCEDHSVPV
RLVQELKIRPT
>Mature_170_residues
APVTAYIGIGSNVGDRLGYLQQAVDHLAQLPGMRVSGASRVYMTEPFGDPNQERYFNAVIAVQTSLDPTDLRTRCKAIEH
DLGRPDRYQRWSPRTIDLDILLYSDLCIESDLLVIPHAEMHHRKFVLIPLLDLANPVHPRLRHSIAELLKSCEDHSVPVR
LVQELKIRPT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=150, Percent_Identity=36.6666666666667, Blast_Score=105, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324073, Length=157, Percent_Identity=33.7579617834395, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19397; Mature: 19265

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPVTAYIGIGSNVGDRLGYLQQAVDHLAQLPGMRVSGASRVYMTEPFGDPNQERYFNAV
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCHHHHEEEE
IAVQTSLDPTDLRTRCKAIEHDLGRPDRYQRWSPRTIDLDILLYSDLCIESDLLVIPHAE
EEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCHHCCCCEEEECCCH
MHHRKFVLIPLLDLANPVHPRLRHSIAELLKSCEDHSVPVRLVQELKIRPT
HHCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
APVTAYIGIGSNVGDRLGYLQQAVDHLAQLPGMRVSGASRVYMTEPFGDPNQERYFNAV
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCHHHHEEEE
IAVQTSLDPTDLRTRCKAIEHDLGRPDRYQRWSPRTIDLDILLYSDLCIESDLLVIPHAE
EEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCHHCCCCEEEECCCH
MHHRKFVLIPLLDLANPVHPRLRHSIAELLKSCEDHSVPVRLVQELKIRPT
HHCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]