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The map label for this gene is pqqL [C]

Identifier: 21674744

GI number: 21674744

Start: 1826768

End: 1828096

Strand: Direct

Name: pqqL [C]

Synonym: CT1932

Alternate gene names: 21674744

Gene position: 1826768-1828096 (Clockwise)

Preceding gene: 21674737

Following gene: 21674746

Centisome position: 84.77

GC content: 56.96

Gene sequence:

>1329_bases
TTGCACCCAAATCCATCCGCAATCGTGAGAAAAAATATCGTATCGCCCTCCATCGGCAACGCCACACACCCTGCAGAACG
CCTCTCAACCGGCATTGTCGAAAGTGGAACCCTTCCCAACGGCCTGCGCATCGTCAGCAATCAGGTGCCCTGGATTCACA
GCGTCACGCTTGGCTTGTGGATCAACGCCGGTTCGCGCGAAGATCCCGAAGGATTCGAGGGTATGGCCCATTTCATCGAA
CACGCACTTTTCAAGGGCACGCAAAAGCGTGACTACGTCGAGATTGCCCGCTGCGTCGAAGAAACCGGTGGCTATATCGA
CGCCTGGACCACCAAGGAGCAGACCTGCCTGTGCGTCAGGTGCCTCCGGGAGCATCTGCATCTGGCTTTTGACCTGCTCG
CCGATCTCTGCTGTAATCCGGTTTTTCCGCCCGACGAGATCGAGAAAGAAAAAGAGGTGGTGCTCGAAGAGATCGCCAGT
GTGAACGACACCCCGGAAGAGCTGATCTTCGAGGATTTCGACCGCCGCGCCTTTTCCCGGCATCCCCTCGGCACAGCGAT
TCTCGGCACCGAAGAGAGCGTCGAAAGGCTCACCGGCAAAGAGATCAGAGACTTCATGCGCCGCCACTACGTGCCATCGA
AAATGCTCGTCACCGCCATCGGCAACATCGAGCACGATGCAGTGACCGGGCTGGCGGAATCGTTTTGGGGCCACCTGAAG
GACTCGCCGCAGGAAGATTCGGTGAGGCGGCTGTTCGATCTATCGGCGTACAGGCCATTTACAAAAACGCTGAAAAAAAG
TGTCTTCCAGTCGCAGATTCTGCTCGGCACGATCTTCCCGCGAGACGACCGTCGCTTCTGGGGACTGATGGTGCTGAACG
CCATGCTGTCGAGCGGCATGAGTTCGATCCTGAACCTCGAACTGCGCGAGAAGCGCGGACTGGTCTATCAGGCGTACTCT
TCGGTCTCTTTCTACGACGAGGTCACTGAATTCAATGTTTATGCGGGCACCGACAAGGGCAAAACCTCGAAAACCCTCGA
CACGATCGCCGAACTCCTGACCGGCAACGTGCTGAAGGAACCCGATCCCTTCGAACTCGCGGCAGCCAAATCGAAGATGC
TCGGTTCGATGATCCTCGGCATGGAAAAGATGACCCGGCGCATGTCGCACATAGCGCAGGATATGTTCTATTTCGGGCGA
TACCTTTCACCTTCTGAAAAGGCTGGAATGATTGATGGGGTGACGGCTGAAGATGTGGCGGTGGCTGCCGCCGCACTCGG
CATCCCCGAGCAAATATCGACTCTGGTCTACAAGCCCGGCGGCAGGTAA

Upstream 100 bases:

>100_bases
TGTGGCGGCACGGGAGATACCGCGGAACCGGCTGGAGCGCAATCCATGCAGATGCGGCCCAGAGCCAATTTGTGCTTAAT
AATAAGAAGAATAACTTACA

Downstream 100 bases:

>100_bases
CTTTCGGCACTTGACGACGAAGTGTGGCCACGTTGAACGAAGTACGGAAAAACCCGTTGAACGATCCGTTTTAAAAAAGC
CTGAAAAAATAGTATAATTC

Product: M16 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MHPNPSAIVRKNIVSPSIGNATHPAERLSTGIVESGTLPNGLRIVSNQVPWIHSVTLGLWINAGSREDPEGFEGMAHFIE
HALFKGTQKRDYVEIARCVEETGGYIDAWTTKEQTCLCVRCLREHLHLAFDLLADLCCNPVFPPDEIEKEKEVVLEEIAS
VNDTPEELIFEDFDRRAFSRHPLGTAILGTEESVERLTGKEIRDFMRRHYVPSKMLVTAIGNIEHDAVTGLAESFWGHLK
DSPQEDSVRRLFDLSAYRPFTKTLKKSVFQSQILLGTIFPRDDRRFWGLMVLNAMLSSGMSSILNLELREKRGLVYQAYS
SVSFYDEVTEFNVYAGTDKGKTSKTLDTIAELLTGNVLKEPDPFELAAAKSKMLGSMILGMEKMTRRMSHIAQDMFYFGR
YLSPSEKAGMIDGVTAEDVAVAAAALGIPEQISTLVYKPGGR

Sequences:

>Translated_442_residues
MHPNPSAIVRKNIVSPSIGNATHPAERLSTGIVESGTLPNGLRIVSNQVPWIHSVTLGLWINAGSREDPEGFEGMAHFIE
HALFKGTQKRDYVEIARCVEETGGYIDAWTTKEQTCLCVRCLREHLHLAFDLLADLCCNPVFPPDEIEKEKEVVLEEIAS
VNDTPEELIFEDFDRRAFSRHPLGTAILGTEESVERLTGKEIRDFMRRHYVPSKMLVTAIGNIEHDAVTGLAESFWGHLK
DSPQEDSVRRLFDLSAYRPFTKTLKKSVFQSQILLGTIFPRDDRRFWGLMVLNAMLSSGMSSILNLELREKRGLVYQAYS
SVSFYDEVTEFNVYAGTDKGKTSKTLDTIAELLTGNVLKEPDPFELAAAKSKMLGSMILGMEKMTRRMSHIAQDMFYFGR
YLSPSEKAGMIDGVTAEDVAVAAAALGIPEQISTLVYKPGGR
>Mature_442_residues
MHPNPSAIVRKNIVSPSIGNATHPAERLSTGIVESGTLPNGLRIVSNQVPWIHSVTLGLWINAGSREDPEGFEGMAHFIE
HALFKGTQKRDYVEIARCVEETGGYIDAWTTKEQTCLCVRCLREHLHLAFDLLADLCCNPVFPPDEIEKEKEVVLEEIAS
VNDTPEELIFEDFDRRAFSRHPLGTAILGTEESVERLTGKEIRDFMRRHYVPSKMLVTAIGNIEHDAVTGLAESFWGHLK
DSPQEDSVRRLFDLSAYRPFTKTLKKSVFQSQILLGTIFPRDDRRFWGLMVLNAMLSSGMSSILNLELREKRGLVYQAYS
SVSFYDEVTEFNVYAGTDKGKTSKTLDTIAELLTGNVLKEPDPFELAAAKSKMLGSMILGMEKMTRRMSHIAQDMFYFGR
YLSPSEKAGMIDGVTAEDVAVAAAALGIPEQISTLVYKPGGR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=399, Percent_Identity=25.5639097744361, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI46593007, Length=214, Percent_Identity=32.2429906542056, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI24308013, Length=428, Percent_Identity=24.0654205607477, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI50592988, Length=200, Percent_Identity=25, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71999683, Length=419, Percent_Identity=25.0596658711217, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553678, Length=398, Percent_Identity=24.3718592964824, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17510601, Length=417, Percent_Identity=21.1031175059952, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323192, Length=409, Percent_Identity=25.1833740831296, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321813, Length=422, Percent_Identity=19.6682464454976, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323421, Length=200, Percent_Identity=27, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357875, Length=205, Percent_Identity=35.609756097561, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646943, Length=205, Percent_Identity=35.609756097561, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19921772, Length=452, Percent_Identity=21.6814159292035, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667786, Length=209, Percent_Identity=26.7942583732057, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49355; Mature: 49355

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPNPSAIVRKNIVSPSIGNATHPAERLSTGIVESGTLPNGLRIVSNQVPWIHSVTLGLW
CCCCCHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCHHEEEEEEE
INAGSREDPEGFEGMAHFIEHALFKGTQKRDYVEIARCVEETGGYIDAWTTKEQTCLCVR
EECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHH
CLREHLHLAFDLLADLCCNPVFPPDEIEKEKEVVLEEIASVNDTPEELIFEDFDRRAFSR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
HPLGTAILGTEESVERLTGKEIRDFMRRHYVPSKMLVTAIGNIEHDAVTGLAESFWGHLK
CCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
DSPQEDSVRRLFDLSAYRPFTKTLKKSVFQSQILLGTIFPRDDRRFWGLMVLNAMLSSGM
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
SSILNLELREKRGLVYQAYSSVSFYDEVTEFNVYAGTDKGKTSKTLDTIAELLTGNVLKE
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHCCCCCC
PDPFELAAAKSKMLGSMILGMEKMTRRMSHIAQDMFYFGRYLSPSEKAGMIDGVTAEDVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
VAAAALGIPEQISTLVYKPGGR
HHHHHHCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MHPNPSAIVRKNIVSPSIGNATHPAERLSTGIVESGTLPNGLRIVSNQVPWIHSVTLGLW
CCCCCHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCHHEEEEEEE
INAGSREDPEGFEGMAHFIEHALFKGTQKRDYVEIARCVEETGGYIDAWTTKEQTCLCVR
EECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHH
CLREHLHLAFDLLADLCCNPVFPPDEIEKEKEVVLEEIASVNDTPEELIFEDFDRRAFSR
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
HPLGTAILGTEESVERLTGKEIRDFMRRHYVPSKMLVTAIGNIEHDAVTGLAESFWGHLK
CCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
DSPQEDSVRRLFDLSAYRPFTKTLKKSVFQSQILLGTIFPRDDRRFWGLMVLNAMLSSGM
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
SSILNLELREKRGLVYQAYSSVSFYDEVTEFNVYAGTDKGKTSKTLDTIAELLTGNVLKE
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHCCCCCC
PDPFELAAAKSKMLGSMILGMEKMTRRMSHIAQDMFYFGRYLSPSEKAGMIDGVTAEDVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
VAAAALGIPEQISTLVYKPGGR
HHHHHHCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]