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The map label for this gene is pyrB [H]

Identifier: 21674614

GI number: 21674614

Start: 1704506

End: 1705432

Strand: Direct

Name: pyrB [H]

Synonym: CT1800

Alternate gene names: 21674614

Gene position: 1704506-1705432 (Clockwise)

Preceding gene: 21674600

Following gene: 21674615

Centisome position: 79.1

GC content: 63.65

Gene sequence:

>927_bases
TTGAACCACCTCACGGGACTTTTCGGATTACCGGCAAGCACGCTGGTCGAACTGCTCGACCTTGCCACCGGTTACAGGGA
GGGGCTCAACCGAGAGCCTGAAACCTTCGCCCCGCTGCTCTCGAACCGTCGAATCGCCCTTGTTTTCTTCGAGAATTCCA
CCCGCACCCGCTTTTCGTTCGAGCTCGCCGCACGGCACCTCGGCGCGGGGACACTGAGCTTCACGGCGGCGTCGAGCAGC
GTCAGCAAAGGCGAAACGCTCTCGGACACCATCCGGAACCTCGAAGCGATGAAGGTTGATGCCTTCGTTTTGCGCCACCC
GTCGTCGGGCGCGGCGGAGTTCGTAGCCTCGATCACCAAGCGGCCCGTCATCAACGCCGGAGACGGCACGCACGAGCATC
CGACGCAGGCCTTGCTCGACCTCCTCACCCTCCGCGAATATTTCGGAAAGATCGAGGGCCTGAAGATCATGATCCTCGGC
GACATTCTGCACAGCCGCGTTGCGCGGTCGAACATCATCGGCCTGAAAACGCTTGGCGCGGAAATCGCCGTCTGCGCCCC
CACGACGCTTCTGCCGGGCCGCATCGACCAGCTCGGCGTGCGGGTCTTCACCGGCATCGACGAGGCGCTCGCCTGGGCCG
ACGCGGCCATCGTGCTGCGGCTTCAGCTCGAACGCGCCACCGGAGGCTACATTCCGTCGCTCGAAGAGTATTCGGCCTCG
TACGGCCTGACCGACGAAAAGCTCGACCGCCTGAAACGGCTGATGCCGGTGCTCCATCCGGGGCCGATCAACCGCGAAAT
CGAAATCTCGAACCTGGTGGCCGACCGCATCCAGCCACCTGGCTATTCAAGCAGTATGCTGATGGAGCAGGTGACCAACG
GCGTGGCCGTGCGCATGGCCGTGCTGCACCGGCTGCTGGCCAAGTGA

Upstream 100 bases:

>100_bases
CATGGAGTACGTGAGGATTTCGAGCACCACCCAACGCAGCAATCGAGGCGCGCAATAACTTTTTAGCTGTGCCCGCCAAC
ACTTAACCTTTTCTGCACTC

Downstream 100 bases:

>100_bases
CGCGGCGCATCGCTCCGGAGCGATTGACTTTACACACAACGTTCTACACACAACAACATCCGATCAAGGATCACACACCA
TGAATAAAAGCACTTCACTT

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNHLTGLFGLPASTLVELLDLATGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSFELAARHLGAGTLSFTAASSS
VSKGETLSDTIRNLEAMKVDAFVLRHPSSGAAEFVASITKRPVINAGDGTHEHPTQALLDLLTLREYFGKIEGLKIMILG
DILHSRVARSNIIGLKTLGAEIAVCAPTTLLPGRIDQLGVRVFTGIDEALAWADAAIVLRLQLERATGGYIPSLEEYSAS
YGLTDEKLDRLKRLMPVLHPGPINREIEISNLVADRIQPPGYSSSMLMEQVTNGVAVRMAVLHRLLAK

Sequences:

>Translated_308_residues
MNHLTGLFGLPASTLVELLDLATGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSFELAARHLGAGTLSFTAASSS
VSKGETLSDTIRNLEAMKVDAFVLRHPSSGAAEFVASITKRPVINAGDGTHEHPTQALLDLLTLREYFGKIEGLKIMILG
DILHSRVARSNIIGLKTLGAEIAVCAPTTLLPGRIDQLGVRVFTGIDEALAWADAAIVLRLQLERATGGYIPSLEEYSAS
YGLTDEKLDRLKRLMPVLHPGPINREIEISNLVADRIQPPGYSSSMLMEQVTNGVAVRMAVLHRLLAK
>Mature_308_residues
MNHLTGLFGLPASTLVELLDLATGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSFELAARHLGAGTLSFTAASSS
VSKGETLSDTIRNLEAMKVDAFVLRHPSSGAAEFVASITKRPVINAGDGTHEHPTQALLDLLTLREYFGKIEGLKIMILG
DILHSRVARSNIIGLKTLGAEIAVCAPTTLLPGRIDQLGVRVFTGIDEALAWADAAIVLRLQLERATGGYIPSLEEYSAS
YGLTDEKLDRLKRLMPVLHPGPINREIEISNLVADRIQPPGYSSSMLMEQVTNGVAVRMAVLHRLLAK

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=280, Percent_Identity=37.5, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI38788445, Length=148, Percent_Identity=31.7567567567568, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI2367364, Length=296, Percent_Identity=36.4864864864865, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790703, Length=192, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786469, Length=192, Percent_Identity=28.6458333333333, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204318, Length=320, Percent_Identity=34.0625, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322331, Length=279, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24642586, Length=278, Percent_Identity=36.6906474820144, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.2 [H]

Molecular weight: Translated: 33539; Mature: 33539

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLTGLFGLPASTLVELLDLATGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEECCCCCEEHH
ELAARHLGAGTLSFTAASSSVSKGETLSDTIRNLEAMKVDAFVLRHPSSGAAEFVASITK
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEHEEECCCCCHHHHHHHHHC
RPVINAGDGTHEHPTQALLDLLTLREYFGKIEGLKIMILGDILHSRVARSNIIGLKTLGA
CCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCHHHCCC
EIAVCAPTTLLPGRIDQLGVRVFTGIDEALAWADAAIVLRLQLERATGGYIPSLEEYSAS
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHH
YGLTDEKLDRLKRLMPVLHPGPINREIEISNLVADRIQPPGYSSSMLMEQVTNGVAVRMA
CCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
VLHRLLAK
HHHHHHCC
>Mature Secondary Structure
MNHLTGLFGLPASTLVELLDLATGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEEEECCCCCEEHH
ELAARHLGAGTLSFTAASSSVSKGETLSDTIRNLEAMKVDAFVLRHPSSGAAEFVASITK
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEHEEECCCCCHHHHHHHHHC
RPVINAGDGTHEHPTQALLDLLTLREYFGKIEGLKIMILGDILHSRVARSNIIGLKTLGA
CCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCCCCHHHCCC
EIAVCAPTTLLPGRIDQLGVRVFTGIDEALAWADAAIVLRLQLERATGGYIPSLEEYSAS
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHHHH
YGLTDEKLDRLKRLMPVLHPGPINREIEISNLVADRIQPPGYSSSMLMEQVTNGVAVRMA
CCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
VLHRLLAK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA