BacMap

Definition	Chlorobium tepidum TLS, complete genome.
Accession	NC_002932
Length	2,154,946

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The map label for this gene is gdhB [H]

Identifier: 21674585

GI number: 21674585

Start: 1677121

End: 1677945

Strand: Reverse

Name: gdhB [H]

Synonym: CT1771

Alternate gene names: 21674585

Gene position: 1677945-1677121 (Counterclockwise)

Preceding gene: 21674586

Following gene: 21674584

Centisome position: 77.86

GC content: 56.48

Gene sequence:

>825_bases
ATGAAACAGCTTGAGAACAGGGTCGCCGTTATCACCGGCTCGACCAAAGGCATCGGCAGGGCAATTGCCCGCGAGTTCGT
CCGGCAGGGAGCCAAGGTGGTTATTACCTCCAGCCGTCAGGAGAATGTCGAAGCCGCCCTCCGCGAATATCCCAAAGATT
TGGTTCATGGCCACGTCAGTGACGTGTCGTCATATGCCAGCGTCGAGTCGCTCGTCGATGCCGCCGTTCGGCGGTTCGGC
GCGCTTGACTGCTTTATCAACAACGCCGGAATCTCCGACCCTTTCACCAGCGTCTGCGACAGCGATCCGGCGGTGTGGAG
CCGCGTGATCGACACCAACCTCAAGGGTACCTACAATGGCAGCCGGGCCGCCGCCCGCTACTTCCTGTCGGTAGGCAGGC
GCGGCAAAATTATCAATATGGCTGGATCGGGCACCGACAAAGGTTCGAACACCCCTTTTATTTCGGCCTACGGCTCGACC
AAGGCGGCCATTGCTCGCTTCACCTTTGCCATGGCTGAAGAGTACCGCAACGCCGGTCTTTCGATCATGCTGCTCCATCC
AGGCCTGGTCAGGACAGAGATCAATCATCCGGAGCGGACGACGCCCGAACTGCAAAAGCAGCTCAAAACCTTCAATATCA
TTCTCGACATCTTCGCACAAAGCCCCGATCTGGCCGTGCGATATGCTGTCAAAATGGCATCTTCGTGGAGCGACGGCAAG
ACGGGACTCTATCTCTCCGCGCTTGACGGAAAACGCAAGAAGATGATGCTTCTGAGCTATCCGTTTCGTAAACTGTTCAA
CAGAATCGACCGGCAAACTTATTAA

Upstream 100 bases:

>100_bases
TGGGCCGAGACCCATCCCGAACTCCAGGCCATGGTCGATCAAAGCTTGCTGAAGAAGCAGGACTGAAACGCGGCGCTGCC
GGGGGCTGAAACGTGTCGTC

Downstream 100 bases:

>100_bases
TCACGACAGCCATGCGCAAGACGACCGGAACTCTTTTCGTGCTTCTTACACTTGTGACGCTCATTTTGCAGGGATGCTAC
AGCTTTTCTGGCGGAGCGCT

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MKQLENRVAVITGSTKGIGRAIAREFVRQGAKVVITSSRQENVEAALREYPKDLVHGHVSDVSSYASVESLVDAAVRRFG
ALDCFINNAGISDPFTSVCDSDPAVWSRVIDTNLKGTYNGSRAAARYFLSVGRRGKIINMAGSGTDKGSNTPFISAYGST
KAAIARFTFAMAEEYRNAGLSIMLLHPGLVRTEINHPERTTPELQKQLKTFNIILDIFAQSPDLAVRYAVKMASSWSDGK
TGLYLSALDGKRKKMMLLSYPFRKLFNRIDRQTY

Sequences:

>Translated_274_residues
MKQLENRVAVITGSTKGIGRAIAREFVRQGAKVVITSSRQENVEAALREYPKDLVHGHVSDVSSYASVESLVDAAVRRFG
ALDCFINNAGISDPFTSVCDSDPAVWSRVIDTNLKGTYNGSRAAARYFLSVGRRGKIINMAGSGTDKGSNTPFISAYGST
KAAIARFTFAMAEEYRNAGLSIMLLHPGLVRTEINHPERTTPELQKQLKTFNIILDIFAQSPDLAVRYAVKMASSWSDGK
TGLYLSALDGKRKKMMLLSYPFRKLFNRIDRQTY
>Mature_274_residues
MKQLENRVAVITGSTKGIGRAIAREFVRQGAKVVITSSRQENVEAALREYPKDLVHGHVSDVSSYASVESLVDAAVRRFG
ALDCFINNAGISDPFTSVCDSDPAVWSRVIDTNLKGTYNGSRAAARYFLSVGRRGKIINMAGSGTDKGSNTPFISAYGST
KAAIARFTFAMAEEYRNAGLSIMLLHPGLVRTEINHPERTTPELQKQLKTFNIILDIFAQSPDLAVRYAVKMASSWSDGK
TGLYLSALDGKRKKMMLLSYPFRKLFNRIDRQTY

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=208, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI5031737, Length=226, Percent_Identity=29.2035398230088, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI33667109, Length=200, Percent_Identity=30, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=31.0526315789474, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI209862901, Length=245, Percent_Identity=27.7551020408163, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19923983, Length=245, Percent_Identity=27.7551020408163, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19923817, Length=198, Percent_Identity=26.2626262626263, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4758504, Length=223, Percent_Identity=29.1479820627803, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI109715829, Length=235, Percent_Identity=30.2127659574468, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI59889578, Length=173, Percent_Identity=28.3236994219653, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI20149619, Length=204, Percent_Identity=28.921568627451, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7705925, Length=207, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI31542939, Length=202, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=194, Percent_Identity=29.8969072164948, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87082100, Length=226, Percent_Identity=30.0884955752212, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082160, Length=206, Percent_Identity=29.126213592233, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787820, Length=186, Percent_Identity=29.5698924731183, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=27.5590551181102, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790717, Length=195, Percent_Identity=26.1538461538462, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788459, Length=194, Percent_Identity=27.8350515463918, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367365, Length=197, Percent_Identity=27.4111675126904, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787526, Length=220, Percent_Identity=24.0909090909091, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=199, Percent_Identity=29.6482412060301, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562906, Length=200, Percent_Identity=28.5, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560220, Length=219, Percent_Identity=29.6803652968037, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=289, Percent_Identity=27.681660899654, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562908, Length=201, Percent_Identity=29.3532338308458, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=198, Percent_Identity=28.2828282828283, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=220, Percent_Identity=29.5454545454545, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=202, Percent_Identity=27.7227722772277, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=200, Percent_Identity=27, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=228, Percent_Identity=25.4385964912281, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=202, Percent_Identity=29.2079207920792, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86565303, Length=216, Percent_Identity=27.3148148148148, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=202, Percent_Identity=25.7425742574257, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=201, Percent_Identity=24.3781094527363, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17555612, Length=213, Percent_Identity=28.6384976525822, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997099, Length=209, Percent_Identity=30.622009569378, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=205, Percent_Identity=26.3414634146341, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=199, Percent_Identity=28.643216080402, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=205, Percent_Identity=28.780487804878, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=202, Percent_Identity=26.7326732673267, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=201, Percent_Identity=24.3781094527363, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=199, Percent_Identity=26.6331658291457, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=198, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=219, Percent_Identity=22.8310502283105, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=217, Percent_Identity=24.4239631336406, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32563809, Length=217, Percent_Identity=24.4239631336406, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=203, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322227, Length=201, Percent_Identity=25.3731343283582, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322226, Length=270, Percent_Identity=28.1481481481481, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=229, Percent_Identity=29.2576419213974, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355319, Length=196, Percent_Identity=33.6734693877551, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24641232, Length=204, Percent_Identity=30.3921568627451, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI23397609, Length=194, Percent_Identity=30.4123711340206, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640442, Length=229, Percent_Identity=29.2576419213974, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571526, Length=202, Percent_Identity=26.7326732673267, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281364494, Length=206, Percent_Identity=30.5825242718447, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737361, Length=217, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28571387, Length=215, Percent_Identity=29.7674418604651, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24644339, Length=257, Percent_Identity=26.4591439688716, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357673, Length=209, Percent_Identity=29.6650717703349, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24665247, Length=194, Percent_Identity=29.3814432989691, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007236, Length=242, Percent_Identity=30.1652892561983, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221331216, Length=206, Percent_Identity=29.6116504854369, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24665243, Length=194, Percent_Identity=29.8969072164948, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357041, Length=201, Percent_Identity=24.3781094527363, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221331218, Length=206, Percent_Identity=30.0970873786408, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648693, Length=208, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21355889, Length=208, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24641388, Length=209, Percent_Identity=30.1435406698565, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007234, Length=204, Percent_Identity=26.9607843137255, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24663911, Length=208, Percent_Identity=29.8076923076923, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076933, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584748, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24584752, Length=196, Percent_Identity=27.0408163265306, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24639444, Length=193, Percent_Identity=29.0155440414508, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358495, Length=207, Percent_Identity=27.0531400966184, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 30230; Mature: 30230

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLENRVAVITGSTKGIGRAIAREFVRQGAKVVITSSRQENVEAALREYPKDLVHGHVS
CCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHHCCCHH
DVSSYASVESLVDAAVRRFGALDCFINNAGISDPFTSVCDSDPAVWSRVIDTNLKGTYNG
HHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCC
SRAAARYFLSVGRRGKIINMAGSGTDKGSNTPFISAYGSTKAAIARFTFAMAEEYRNAGL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCC
SIMLLHPGLVRTEINHPERTTPELQKQLKTFNIILDIFAQSPDLAVRYAVKMASSWSDGK
EEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TGLYLSALDGKRKKMMLLSYPFRKLFNRIDRQTY
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQLENRVAVITGSTKGIGRAIAREFVRQGAKVVITSSRQENVEAALREYPKDLVHGHVS
CCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCHHHHCCCHH
DVSSYASVESLVDAAVRRFGALDCFINNAGISDPFTSVCDSDPAVWSRVIDTNLKGTYNG
HHHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCC
SRAAARYFLSVGRRGKIINMAGSGTDKGSNTPFISAYGSTKAAIARFTFAMAEEYRNAGL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCC
SIMLLHPGLVRTEINHPERTTPELQKQLKTFNIILDIFAQSPDLAVRYAVKMASSWSDGK
EEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
TGLYLSALDGKRKKMMLLSYPFRKLFNRIDRQTY
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6420184; 3134196; 6413208; 6432532 [H]