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The map label for this gene is gcvP1 [H]

Identifier: 21674443

GI number: 21674443

Start: 1531555

End: 1532889

Strand: Reverse

Name: gcvP1 [H]

Synonym: CT1625

Alternate gene names: 21674443

Gene position: 1532889-1531555 (Counterclockwise)

Preceding gene: 21674444

Following gene: 21674440

Centisome position: 71.13

GC content: 59.48

Gene sequence:

>1335_bases
ATGCCTTTCATTGTCAATACCGACGCCGAGCGGGCCGAGATGCTGCGCGAAATCGGCGTCGAGAATTTTGAGGCGCTGAT
CGCGGACATTCCCGAAGAGATTCGCCTCAAAAAGGCGCTCGACCTCTTTCCCGCCATGGGCGAGCCTGAGGTGAAGAGTC
TGCTCGAAAAGATGGCCTCAGGCAACGCCGCCACCTGTGACCACGTGAGCTTCCTCGGTGCGGGGGCTTACGACCATTTC
ATTCCTTCGGCGGTCAAGACCATTGCCTCCCGGAGCGAGTTCTACACCGCCTACACGCCTTACCAGGCCGAGGTGTCGCA
GGGTACCCTGCAGGCGATCTACGAATACCAGAGCGTGATGTGCCGTCTCTACGGCATGGATGTGGCCAACGCCTCGATGT
ACGACGGCGCGAGCGCGCTTGCCGAAGCAGCGCTGATTGCCCTGAACGTTACCGGGCGCAACGGCATCGTGGTGGCGGGC
AAGCTGCATCCCTACACCAGTCAGGTGCTTGAAACCTATCTCGAGGCCGCCGGAGACCGGTCTATCGTGCAGAACGGTCT
CGAGAACGGCATCGGCAGCGTCGAGGCGCTCGAAGCGCTGGTTTCTTCCGAAACCGCCGCGGTGATCGTGCAGCAGCCGA
ACTTTTACGGTTGTCTTGAAGAGGTCGAGGCGATCGGCGAAATTGCCAGAAAGAACGGGGCGCTTTTCATCGTCTCTGCC
GATCCGGTCTCGCTCGGCGTGCTCGAAGCGCCGGGTAATTACGGTGCTGACATCGCCGTTGGCGAGGGTCAGTCGGTCGG
TAACGCCCAGAGCTTCGGCGGGCCGTATCTCGGCATTCTGACTGTCAAGCAGGCGCATGTGCGCAAAATTCCGGGCCGTC
TGGTCGGCATGACCAAAGACAAGGATGGCAACGATGGTTTCATCCTGACGCTTCAGACCCGCGAGCAGCACATCCGCCGC
GAAAAGGCCACCTCGAACATCTGTTCCAATCAGGCGCTCTGTGCTCTGCAGTCGGTGGTGCACCTGTCGCTGCTTGGAAA
GGAGGGAATTCGGGATGTCGCCAACCGTTCGATGCAGAAAGCGCACTATCTGGCTGACCGCATCGCCGAACTACCCGGCT
ATTCGATGAAGTTCAGCGCACCCTTTTTCCGTGAATTCGTGGTCGAAACGCCCGTCCCTTCAGCGACGATCATCGAGAAG
ATGCTCGAGAAAAAAGTGTTTGCCGGTGTCGATCTTTCCGCATGGGGAGAAGATGGGCTCTTGGTTGCCGTCACCGAGAA
GCGCACGAAAGAGGAACTTGACAGCTTCGTCAGCGAACTCGCTGCGCTCGGCTGA

Upstream 100 bases:

>100_bases
AGCTCGATAATCCTGCCGATGTCGAGGCACTACTCTCTCCGGCGGACTACAGCGCCCTGATCGGTGAGTAAGATTTTCAA
CTGAATTTCAATACGCAACC

Downstream 100 bases:

>100_bases
AAAGCTTCTTATGCATCGCATAAAAAAAGCCACCGTTTGGGGTGGCTTTTTTGTTTGAAGATCGATCTTTTTGTTCATAC
CAGGCTGAGCTTCTCCAGCT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPFIVNTDAERAEMLREIGVENFEALIADIPEEIRLKKALDLFPAMGEPEVKSLLEKMASGNAATCDHVSFLGAGAYDHF
IPSAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVMCRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAG
KLHPYTSQVLETYLEAAGDRSIVQNGLENGIGSVEALEALVSSETAAVIVQQPNFYGCLEEVEAIGEIARKNGALFIVSA
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKDKDGNDGFILTLQTREQHIRR
EKATSNICSNQALCALQSVVHLSLLGKEGIRDVANRSMQKAHYLADRIAELPGYSMKFSAPFFREFVVETPVPSATIIEK
MLEKKVFAGVDLSAWGEDGLLVAVTEKRTKEELDSFVSELAALG

Sequences:

>Translated_444_residues
MPFIVNTDAERAEMLREIGVENFEALIADIPEEIRLKKALDLFPAMGEPEVKSLLEKMASGNAATCDHVSFLGAGAYDHF
IPSAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVMCRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAG
KLHPYTSQVLETYLEAAGDRSIVQNGLENGIGSVEALEALVSSETAAVIVQQPNFYGCLEEVEAIGEIARKNGALFIVSA
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKDKDGNDGFILTLQTREQHIRR
EKATSNICSNQALCALQSVVHLSLLGKEGIRDVANRSMQKAHYLADRIAELPGYSMKFSAPFFREFVVETPVPSATIIEK
MLEKKVFAGVDLSAWGEDGLLVAVTEKRTKEELDSFVSELAALG
>Mature_443_residues
PFIVNTDAERAEMLREIGVENFEALIADIPEEIRLKKALDLFPAMGEPEVKSLLEKMASGNAATCDHVSFLGAGAYDHFI
PSAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVMCRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAGK
LHPYTSQVLETYLEAAGDRSIVQNGLENGIGSVEALEALVSSETAAVIVQQPNFYGCLEEVEAIGEIARKNGALFIVSAD
PVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKDKDGNDGFILTLQTREQHIRRE
KATSNICSNQALCALQSVVHLSLLGKEGIRDVANRSMQKAHYLADRIAELPGYSMKFSAPFFREFVVETPVPSATIIEKM
LEKKVFAGVDLSAWGEDGLLVAVTEKRTKEELDSFVSELAALG

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=351, Percent_Identity=34.1880341880342, Blast_Score=213, Evalue=2e-55,
Organism=Escherichia coli, GI1789269, Length=393, Percent_Identity=34.3511450381679, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=363, Percent_Identity=37.1900826446281, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323843, Length=438, Percent_Identity=30.5936073059361, Blast_Score=200, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24645648, Length=345, Percent_Identity=38.5507246376812, Blast_Score=244, Evalue=9e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 47740; Mature: 47609

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFIVNTDAERAEMLREIGVENFEALIADIPEEIRLKKALDLFPAMGEPEVKSLLEKMAS
CCEEECCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GNAATCDHVSFLGAGAYDHFIPSAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVM
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHH
CRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAGKLHPYTSQVLETYLEAAGDR
HHHHCCCCCCCCHHCCHHHHHHHEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCH
SIVQNGLENGIGSVEALEALVSSETAAVIVQQPNFYGCLEEVEAIGEIARKNGALFIVSA
HHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEC
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKD
CCCEEEEEECCCCCCCEEEECCCCCCCCCHHCCCCEEEEEEEHHHHHHHCCCHHEECCCC
KDGNDGFILTLQTREQHIRREKATSNICSNQALCALQSVVHLSLLGKEGIRDVANRSMQK
CCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHYLADRIAELPGYSMKFSAPFFREFVVETPVPSATIIEKMLEKKVFAGVDLSAWGEDGL
HHHHHHHHHHCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCE
LVAVTEKRTKEELDSFVSELAALG
EEEEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFIVNTDAERAEMLREIGVENFEALIADIPEEIRLKKALDLFPAMGEPEVKSLLEKMAS
CEEECCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GNAATCDHVSFLGAGAYDHFIPSAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVM
CCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHH
CRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAGKLHPYTSQVLETYLEAAGDR
HHHHCCCCCCCCHHCCHHHHHHHEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCH
SIVQNGLENGIGSVEALEALVSSETAAVIVQQPNFYGCLEEVEAIGEIARKNGALFIVSA
HHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEC
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKD
CCCEEEEEECCCCCCCEEEECCCCCCCCCHHCCCCEEEEEEEHHHHHHHCCCHHEECCCC
KDGNDGFILTLQTREQHIRREKATSNICSNQALCALQSVVHLSLLGKEGIRDVANRSMQK
CCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHYLADRIAELPGYSMKFSAPFFREFVVETPVPSATIIEKMLEKKVFAGVDLSAWGEDGL
HHHHHHHHHHCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCE
LVAVTEKRTKEELDSFVSELAALG
EEEEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA