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The map label for this gene is pepP [H]

Identifier: 21674426

GI number: 21674426

Start: 1514689

End: 1515783

Strand: Reverse

Name: pepP [H]

Synonym: CT1608

Alternate gene names: 21674426

Gene position: 1515783-1514689 (Counterclockwise)

Preceding gene: 21674432

Following gene: 21674425

Centisome position: 70.34

GC content: 59.91

Gene sequence:

>1095_bases
ATGTCGCAAGACCTTCTTCATACCTATCGCAGTAGCCTGCGCGCTAAAATTTTCAGAAAAATGGCCGCTGCCGGCCTGGA
CTCTCTTCTGGTGACCGATCTGGCGACCATTCGCTGGCTGACCGGTTTCAGTGGTTCCAACGCCAAACTGCTCTTCGCCG
GAGATTCAACCTCCGTGCTTTTTACCGATTTCCGGTATCAGGAGCAGGTTCGTCAGGAGACGAGTGGCATTGCTACGGTG
ATTCTCAAAGACCCGCTTCCGGTCGAGCTGGCGTCAGGTTTGTTCCGGCTCGGAGATCGCATGGCGTTGCAGGCCGACCA
CGTTACCTGGCACGAGCAGCAGCAGCTTTCGGAGAAGATGGGTAACCGTGAGTTTACGCCCGTTTCGTCATTTTTCGACG
AGTTTCGCGAGATCAAAGACATCGAGGAGCTCGACCGGATGCGTCGCGCTGTCGCCCTCAGCGAAACCGTGCTCGAAGCG
GTGATCGGCATGATCGGCCCCGGCGTCACCGAAATCGACATCGCTGCTGAAATTACCTATCGCCACCGCAAGCTCGGTGC
GGAGAAGGACTCGTTCGACCCCATTGTGGCTGGAGGCATCCGTGGTGCGATGCCGCACGCCAAGCCGACCGCAGTTGCCT
TCGAGCCGGGGGCCCTGATCGTTATCGACATGGGCTGCATTGTCGATGGCTACGCCTCAGACCAGACTCGCACAGTCGCC
TTCGGCAAGGTTTCCGAGGAGCAGCGGACGGTCTATCGCATTGTGCAGGAGGCGCAGCAGCTTGGTATCGACGCAGCGAA
AGCCGGAATGGCCGCCCGCGACCTCGATGCTGAGGTGCGTAACTTCATCGCCGCTGCAGGCTACGGCGAAGCGTTCGGTC
ATGGCCTTGGCCACGGTGTTGGCGTCGAAGTGCACGAAGCCCCGCGTGTCGGCACAGCCTCTACCGGCACACTCCGCGAA
GGCACGCTTTTCACCATCGAACCGGGCATCTACCTTCCGGGCCGCTTCGGCGTGCGCATCGAAGACATGGTAGCCCTCGG
CCCCAACGGCGCGGAACCGTTGCAGCGGTTTACCAAGGAGCTTATCGAACTTTAA

Upstream 100 bases:

>100_bases
TACTAACTGTCGGCCCCTTTAGCAACAAAAGCCCTTTTGCACAAAGCAGATGAGCGTTTCGTGGCGGCTGACGCGATTTT
TTCATTCTGTTTTCCGATTC

Downstream 100 bases:

>100_bases
TTGCGTGGTGAATTATGAGCGAATCAAAATCCGGCGGCTATTGCATGGTCATTACGACGGCCCCAAGCCGTGAGGAGGCT
GAAAAGCTGGCGCAAGGTAT

Product: aminopeptidase P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSQDLLHTYRSSLRAKIFRKMAAAGLDSLLVTDLATIRWLTGFSGSNAKLLFAGDSTSVLFTDFRYQEQVRQETSGIATV
ILKDPLPVELASGLFRLGDRMALQADHVTWHEQQQLSEKMGNREFTPVSSFFDEFREIKDIEELDRMRRAVALSETVLEA
VIGMIGPGVTEIDIAAEITYRHRKLGAEKDSFDPIVAGGIRGAMPHAKPTAVAFEPGALIVIDMGCIVDGYASDQTRTVA
FGKVSEEQRTVYRIVQEAQQLGIDAAKAGMAARDLDAEVRNFIAAAGYGEAFGHGLGHGVGVEVHEAPRVGTASTGTLRE
GTLFTIEPGIYLPGRFGVRIEDMVALGPNGAEPLQRFTKELIEL

Sequences:

>Translated_364_residues
MSQDLLHTYRSSLRAKIFRKMAAAGLDSLLVTDLATIRWLTGFSGSNAKLLFAGDSTSVLFTDFRYQEQVRQETSGIATV
ILKDPLPVELASGLFRLGDRMALQADHVTWHEQQQLSEKMGNREFTPVSSFFDEFREIKDIEELDRMRRAVALSETVLEA
VIGMIGPGVTEIDIAAEITYRHRKLGAEKDSFDPIVAGGIRGAMPHAKPTAVAFEPGALIVIDMGCIVDGYASDQTRTVA
FGKVSEEQRTVYRIVQEAQQLGIDAAKAGMAARDLDAEVRNFIAAAGYGEAFGHGLGHGVGVEVHEAPRVGTASTGTLRE
GTLFTIEPGIYLPGRFGVRIEDMVALGPNGAEPLQRFTKELIEL
>Mature_363_residues
SQDLLHTYRSSLRAKIFRKMAAAGLDSLLVTDLATIRWLTGFSGSNAKLLFAGDSTSVLFTDFRYQEQVRQETSGIATVI
LKDPLPVELASGLFRLGDRMALQADHVTWHEQQQLSEKMGNREFTPVSSFFDEFREIKDIEELDRMRRAVALSETVLEAV
IGMIGPGVTEIDIAAEITYRHRKLGAEKDSFDPIVAGGIRGAMPHAKPTAVAFEPGALIVIDMGCIVDGYASDQTRTVAF
GKVSEEQRTVYRIVQEAQQLGIDAAKAGMAARDLDAEVRNFIAAAGYGEAFGHGLGHGVGVEVHEAPRVGTASTGTLREG
TLFTIEPGIYLPGRFGVRIEDMVALGPNGAEPLQRFTKELIEL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=251, Percent_Identity=28.2868525896414, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI164420681, Length=198, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI264681563, Length=229, Percent_Identity=31.0043668122271, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI93141226, Length=159, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788728, Length=366, Percent_Identity=35.2459016393443, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1789275, Length=249, Percent_Identity=28.9156626506024, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786364, Length=207, Percent_Identity=29.951690821256, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=253, Percent_Identity=27.6679841897233, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321118, Length=297, Percent_Identity=26.2626262626263, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920384, Length=300, Percent_Identity=27.3333333333333, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39672; Mature: 39541

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDLLHTYRSSLRAKIFRKMAAAGLDSLLVTDLATIRWLTGFSGSNAKLLFAGDSTSVL
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEE
FTDFRYQEQVRQETSGIATVILKDPLPVELASGLFRLGDRMALQADHVTWHEQQQLSEKM
EEHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHH
GNREFTPVSSFFDEFREIKDIEELDRMRRAVALSETVLEAVIGMIGPGVTEIDIAAEITY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
RHRKLGAEKDSFDPIVAGGIRGAMPHAKPTAVAFEPGALIVIDMGCIVDGYASDQTRTVA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCEEECCCCCCEEEEE
FGKVSEEQRTVYRIVQEAQQLGIDAAKAGMAARDLDAEVRNFIAAAGYGEAFGHGLGHGV
ECCCCHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
GVEVHEAPRVGTASTGTLREGTLFTIEPGIYLPGRFGVRIEDMVALGPNGAEPLQRFTKE
CEEEECCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCEEEHEEEECCCCHHHHHHHHHH
LIEL
HHCC
>Mature Secondary Structure 
SQDLLHTYRSSLRAKIFRKMAAAGLDSLLVTDLATIRWLTGFSGSNAKLLFAGDSTSVL
CHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEE
FTDFRYQEQVRQETSGIATVILKDPLPVELASGLFRLGDRMALQADHVTWHEQQQLSEKM
EEHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHH
GNREFTPVSSFFDEFREIKDIEELDRMRRAVALSETVLEAVIGMIGPGVTEIDIAAEITY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
RHRKLGAEKDSFDPIVAGGIRGAMPHAKPTAVAFEPGALIVIDMGCIVDGYASDQTRTVA
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCEEECCCCCCEEEEE
FGKVSEEQRTVYRIVQEAQQLGIDAAKAGMAARDLDAEVRNFIAAAGYGEAFGHGLGHGV
ECCCCHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
GVEVHEAPRVGTASTGTLREGTLFTIEPGIYLPGRFGVRIEDMVALGPNGAEPLQRFTKE
CEEEECCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCEEEHEEEECCCCHHHHHHHHHH
LIEL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]