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The map label for this gene is ahpC [C]

Identifier: 21674312

GI number: 21674312

Start: 1396317

End: 1396904

Strand: Reverse

Name: ahpC [C]

Synonym: CT1492

Alternate gene names: 21674312

Gene position: 1396904-1396317 (Counterclockwise)

Preceding gene: 21674315

Following gene: 21674310

Centisome position: 64.82

GC content: 55.44

Gene sequence:

>588_bases
ATGAGTGTACTCGTAGGCCGTCCAGCCCCAGATTTCAATGCAGCAGCAGTCGTAAACGGCTCGACGTTCGTCGATTCCTG
TCAGCTTTCAGCGTATCGTGGCAAATATGTCGTGCTGTTTTTCTATCCTCTCGACTTCACCTTTGTTTGCCCGACGGAGT
TGCACGCATTTCAGGAGAAGCTCGATGAGTTCAAGAAGCGCAATGTCGAGGTGCTCGGTTGCTCGGTTGACTCCAAATTC
TCGCACTTCGCCTGGCTTAACACCCCGCGCAGCAAAGGCGGCATACAGGGCGTGACCTACCCGCTCATCTCCGACATCAA
CAAGACCATTGCCAAAGACTACGATGTGCTGACTCCCGATGGCAGTGTGGCGCTGAGGGGTCTATTCCTGATTGACAAGG
AGGGCATCGTTCGCCACCAGGTGGTTAACGATCTCGGCATCGGCAGGAACATCGACGAGGTGCTCCGGATCGTCGATGCG
CTTCAGTTCACCGAGGAGTTCGGCGAGGTCTGCCCGGCCAACTGGAACAAGGGCGACAAGACCATGAAGCCGACCGACGA
GGGGCTGAAAGAATACTTCGCGGAATAA

Upstream 100 bases:

>100_bases
AGCAAATAGATGTTTGATACTTGTACCCTGTTTTTTATATTGGATAATATTAGTCTTATTTAAAGGATCACCATCAAACA
AAATTAAAGGAGATACAGTC

Downstream 100 bases:

>100_bases
GTGCGGAATAAGGTATAAGGGCGAGCCCCAGTGTTTGCTCTTTCGTAAGGGCAGTATCGACAGGTATGGGCTGCCCTCGA
TGTAACGACTCCCCTGCAAA

Product: thiolredoxin peroxidase

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSVLVGRPAPDFNAAAVVNGSTFVDSCQLSAYRGKYVVLFFYPLDFTFVCPTELHAFQEKLDEFKKRNVEVLGCSVDSKF
SHFAWLNTPRSKGGIQGVTYPLISDINKTIAKDYDVLTPDGSVALRGLFLIDKEGIVRHQVVNDLGIGRNIDEVLRIVDA
LQFTEEFGEVCPANWNKGDKTMKPTDEGLKEYFAE

Sequences:

>Translated_195_residues
MSVLVGRPAPDFNAAAVVNGSTFVDSCQLSAYRGKYVVLFFYPLDFTFVCPTELHAFQEKLDEFKKRNVEVLGCSVDSKF
SHFAWLNTPRSKGGIQGVTYPLISDINKTIAKDYDVLTPDGSVALRGLFLIDKEGIVRHQVVNDLGIGRNIDEVLRIVDA
LQFTEEFGEVCPANWNKGDKTMKPTDEGLKEYFAE
>Mature_194_residues
SVLVGRPAPDFNAAAVVNGSTFVDSCQLSAYRGKYVVLFFYPLDFTFVCPTELHAFQEKLDEFKKRNVEVLGCSVDSKFS
HFAWLNTPRSKGGIQGVTYPLISDINKTIAKDYDVLTPDGSVALRGLFLIDKEGIVRHQVVNDLGIGRNIDEVLRIVDAL
QFTEEFGEVCPANWNKGDKTMKPTDEGLKEYFAE

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=191, Percent_Identity=53.9267015706806, Blast_Score=227, Evalue=4e-60,
Organism=Homo sapiens, GI4505591, Length=191, Percent_Identity=54.9738219895288, Blast_Score=226, Evalue=9e-60,
Organism=Homo sapiens, GI32455266, Length=191, Percent_Identity=54.9738219895288, Blast_Score=226, Evalue=9e-60,
Organism=Homo sapiens, GI32455264, Length=191, Percent_Identity=54.9738219895288, Blast_Score=226, Evalue=9e-60,
Organism=Homo sapiens, GI5453549, Length=189, Percent_Identity=50.7936507936508, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI5802974, Length=189, Percent_Identity=53.4391534391534, Blast_Score=211, Evalue=4e-55,
Organism=Homo sapiens, GI32483377, Length=185, Percent_Identity=54.0540540540541, Blast_Score=209, Evalue=1e-54,
Organism=Homo sapiens, GI33188454, Length=81, Percent_Identity=61.7283950617284, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI4758638, Length=189, Percent_Identity=32.2751322751323, Blast_Score=92, Evalue=3e-19,
Organism=Escherichia coli, GI1786822, Length=186, Percent_Identity=34.9462365591398, Blast_Score=121, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32565831, Length=190, Percent_Identity=53.1578947368421, Blast_Score=211, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI193204376, Length=190, Percent_Identity=53.1578947368421, Blast_Score=211, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17554494, Length=184, Percent_Identity=50.5434782608696, Blast_Score=198, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25153706, Length=165, Percent_Identity=29.0909090909091, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323613, Length=193, Percent_Identity=49.2227979274611, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320661, Length=193, Percent_Identity=46.1139896373057, Blast_Score=184, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6319407, Length=185, Percent_Identity=36.7567567567568, Blast_Score=111, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17738015, Length=196, Percent_Identity=54.0816326530612, Blast_Score=219, Evalue=8e-58,
Organism=Drosophila melanogaster, GI17157991, Length=187, Percent_Identity=54.0106951871658, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24641739, Length=187, Percent_Identity=54.0106951871658, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24656348, Length=192, Percent_Identity=51.5625, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17864676, Length=192, Percent_Identity=51.5625, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21357347, Length=189, Percent_Identity=51.8518518518518, Blast_Score=210, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24581278, Length=184, Percent_Identity=32.0652173913043, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17975518, Length=204, Percent_Identity=34.8039215686275, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24652434, Length=204, Percent_Identity=34.8039215686275, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24652436, Length=188, Percent_Identity=35.6382978723404, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21765; Mature: 21634

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLVGRPAPDFNAAAVVNGSTFVDSCQLSAYRGKYVVLFFYPLDFTFVCPTELHAFQEK
CCEECCCCCCCCCCEEEECCCHHHHHHHHEEECCCEEEEEEECCCEEEECCHHHHHHHHH
LDEFKKRNVEVLGCSVDSKFSHFAWLNTPRSKGGIQGVTYPLISDINKTIAKDYDVLTPD
HHHHHHCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCC
GSVALRGLFLIDKEGIVRHQVVNDLGIGRNIDEVLRIVDALQFTEEFGEVCPANWNKGDK
CCEEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TMKPTDEGLKEYFAE
CCCCCHHHHHHHHCC
>Mature Secondary Structure 
SVLVGRPAPDFNAAAVVNGSTFVDSCQLSAYRGKYVVLFFYPLDFTFVCPTELHAFQEK
CEECCCCCCCCCCEEEECCCHHHHHHHHEEECCCEEEEEEECCCEEEECCHHHHHHHHH
LDEFKKRNVEVLGCSVDSKFSHFAWLNTPRSKGGIQGVTYPLISDINKTIAKDYDVLTPD
HHHHHHCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCC
GSVALRGLFLIDKEGIVRHQVVNDLGIGRNIDEVLRIVDALQFTEEFGEVCPANWNKGDK
CCEEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TMKPTDEGLKEYFAE
CCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]