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The map label for this gene is aqpZ [H]

Identifier: 21674292

GI number: 21674292

Start: 1378755

End: 1379561

Strand: Reverse

Name: aqpZ [H]

Synonym: CT1472

Alternate gene names: 21674292

Gene position: 1379561-1378755 (Counterclockwise)

Preceding gene: 21674297

Following gene: 21674291

Centisome position: 64.02

GC content: 64.06

Gene sequence:

>807_bases
ATGGTTTCGGGAAACGATAATAACCACCATGCGGCGCAACGCGCCCGGATGCTTCTGACCCAGATTGCGCCCAATTTTCT
CGACCCGAAGCACGAATGGCAGCGGATTTTTGCCGAGTTGTGGGGTACTTTTCTGCTGGTGCTCGTGGCAGCGGGCGGTC
CTGTGGCGGCGACGAGTTCCGGTAACCATGCCGGCGATGCGCTCCTGCCGGTCGCGCCTGGCCTGATGGTGATGGCGATT
ATCTACTTCATGGGCACGGTGAGCGGCGCGCATCTCAATCCTGCCGTTACTCTGGCGTTTGCCATGCGCCGGAACTTCCC
CTGGGTTCGCGTGCCGGGCTACATCCTTGCCCAGGTCGCCGGAGGGTGGCTGGCCGCGCTGTTTCTCGGCTTCATGTTTG
GCAACGCGGCGGTCGCGCCGGGCATGACGTTGCCAGGCCACGAGGTCACGCCGCTAAAGGCGCTCGTCATGGAGATGGTG
CTGACCGCCGCGCTGGTGAACACGATTCTCGGCACCTCGTCGGGCGCGCGTAATATCGGCACCAACGGCGCGATTGCGGT
TGGCGGCTACATTGCGCTGGCAGGGATGTGGGCTGCGCCGGTCAGCGGTGCATCGATGAACCCTGTGCGCTCGCTTGCCC
CCGCGCTGGTGTGCGGCGATACAACGCTTGCCTGGGTCTACGTTGCCGGGCCGATCGCCGGTGCGTTGATCGGCGTGGTA
TTTGAATGGATTCTGAAGGGGCCGCCCACCACCGCCGGAACTGTCGCCGCACAAGGCACGCTCGACATCGACGACAGGGA
AGGGTAG

Upstream 100 bases:

>100_bases
TTATCTTTATTTTAGCTGCAAAGCGAATGCAAAGAAGCAGCCGCTTTGTGAAAGAGCTTTTTTGTTACAAGATTGCTAAC
CGCTTATCCAGAAATGTGAT

Downstream 100 bases:

>100_bases
CCTGCCGGTCATCTTTTACAGCTCGATCTTCCGGTGCTTCTGTCGCTGATGGTGTACAGCAGAAAAACACCGACAGTCAG
GTGTGAGCGAAGCGAGCCGG

Product: major intrinsic protein

Products: glycerol [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MVSGNDNNHHAAQRARMLLTQIAPNFLDPKHEWQRIFAELWGTFLLVLVAAGGPVAATSSGNHAGDALLPVAPGLMVMAI
IYFMGTVSGAHLNPAVTLAFAMRRNFPWVRVPGYILAQVAGGWLAALFLGFMFGNAAVAPGMTLPGHEVTPLKALVMEMV
LTAALVNTILGTSSGARNIGTNGAIAVGGYIALAGMWAAPVSGASMNPVRSLAPALVCGDTTLAWVYVAGPIAGALIGVV
FEWILKGPPTTAGTVAAQGTLDIDDREG

Sequences:

>Translated_268_residues
MVSGNDNNHHAAQRARMLLTQIAPNFLDPKHEWQRIFAELWGTFLLVLVAAGGPVAATSSGNHAGDALLPVAPGLMVMAI
IYFMGTVSGAHLNPAVTLAFAMRRNFPWVRVPGYILAQVAGGWLAALFLGFMFGNAAVAPGMTLPGHEVTPLKALVMEMV
LTAALVNTILGTSSGARNIGTNGAIAVGGYIALAGMWAAPVSGASMNPVRSLAPALVCGDTTLAWVYVAGPIAGALIGVV
FEWILKGPPTTAGTVAAQGTLDIDDREG
>Mature_268_residues
MVSGNDNNHHAAQRARMLLTQIAPNFLDPKHEWQRIFAELWGTFLLVLVAAGGPVAATSSGNHAGDALLPVAPGLMVMAI
IYFMGTVSGAHLNPAVTLAFAMRRNFPWVRVPGYILAQVAGGWLAALFLGFMFGNAAVAPGMTLPGHEVTPLKALVMEMV
LTAALVNTILGTSSGARNIGTNGAIAVGGYIALAGMWAAPVSGASMNPVRSLAPALVCGDTTLAWVYVAGPIAGALIGVV
FEWILKGPPTTAGTVAAQGTLDIDDREG

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502181, Length=250, Percent_Identity=28.8, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4755125, Length=250, Percent_Identity=28.8, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI6912506, Length=218, Percent_Identity=33.4862385321101, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI37694062, Length=231, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4502179, Length=249, Percent_Identity=30.5220883534137, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI86792455, Length=160, Percent_Identity=35, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4826645, Length=270, Percent_Identity=27.037037037037, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4502183, Length=244, Percent_Identity=28.2786885245902, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI157266307, Length=239, Percent_Identity=28.8702928870293, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI22538420, Length=265, Percent_Identity=28.6792452830189, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790362, Length=238, Percent_Identity=30.2521008403361, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787101, Length=198, Percent_Identity=35.3535353535354, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=238, Percent_Identity=27.7310924369748, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17558372, Length=223, Percent_Identity=28.6995515695067, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=211, Percent_Identity=30.3317535545024, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24652747, Length=225, Percent_Identity=34.2222222222222, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551084, Length=225, Percent_Identity=34.2222222222222, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550503, Length=214, Percent_Identity=31.3084112149533, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24762342, Length=235, Percent_Identity=29.7872340425532, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136672, Length=246, Percent_Identity=26.4227642276423, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24762344, Length=236, Percent_Identity=29.2372881355932, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24762346, Length=236, Percent_Identity=29.2372881355932, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24762348, Length=236, Percent_Identity=29.2372881355932, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20130305, Length=236, Percent_Identity=29.2372881355932, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19922828, Length=214, Percent_Identity=29.4392523364486, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 27665; Mature: 27665

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSGNDNNHHAAQRARMLLTQIAPNFLDPKHEWQRIFAELWGTFLLVLVAAGGPVAATSS
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GNHAGDALLPVAPGLMVMAIIYFMGTVSGAHLNPAVTLAFAMRRNFPWVRVPGYILAQVA
CCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHH
GGWLAALFLGFMFGNAAVAPGMTLPGHEVTPLKALVMEMVLTAALVNTILGTSSGARNIG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TNGAIAVGGYIALAGMWAAPVSGASMNPVRSLAPALVCGDTTLAWVYVAGPIAGALIGVV
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCEEEEEEHHHHHHHHHHHH
FEWILKGPPTTAGTVAAQGTLDIDDREG
HHHHHCCCCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MVSGNDNNHHAAQRARMLLTQIAPNFLDPKHEWQRIFAELWGTFLLVLVAAGGPVAATSS
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GNHAGDALLPVAPGLMVMAIIYFMGTVSGAHLNPAVTLAFAMRRNFPWVRVPGYILAQVA
CCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHH
GGWLAALFLGFMFGNAAVAPGMTLPGHEVTPLKALVMEMVLTAALVNTILGTSSGARNIG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TNGAIAVGGYIALAGMWAAPVSGASMNPVRSLAPALVCGDTTLAWVYVAGPIAGALIGVV
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCCEEEEEEHHHHHHHHHHHH
FEWILKGPPTTAGTVAAQGTLDIDDREG
HHHHHCCCCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]