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The map label for this gene is imp [H]

Identifier: 21674251

GI number: 21674251

Start: 1342057

End: 1342842

Strand: Reverse

Name: imp [H]

Synonym: CT1430

Alternate gene names: 21674251

Gene position: 1342842-1342057 (Counterclockwise)

Preceding gene: 21674254

Following gene: 21674250

Centisome position: 62.31

GC content: 59.54

Gene sequence:

>786_bases
TTGCCTATGACTCCCGACCTTCAGCTTGCGCTTGAACTGGCTGAAAAGGCCGGCAAACTGACGCTCGATTATTTCGGGCG
CAGGTCGCTTCAGGTTTTTTCAAAACGCGATGATACCCCGGTGACCGAGGCCGACCGCAAGGCCGAGGAGTTGATCCGGC
AGGGCATCTCGGCAAAGTTTCCCGGTGACGGCCTGTTCGGCGAAGAGTTTAACGAGCGTCCATCCGGTAACGGCCGGCGC
TGGATCATCGATCCGATCGATGGCACCCGTTCCTTTATTCATGGCGTGCCGTTGTATGGCGTGATGATCGCGCTTGAAGT
GGACGGTGTACTTCGTCTCGGCGTTATCAATTTCCCAGCTCTCGGCGAGCTTTATCATGCCGAGATCGGCGCCGGGGCCT
TCATGAATGGCTCCTCTGTGCAGGTTTCAGCTATCGCAGAAACGGCGGCGGCCACGGTGGTCTTCACCGAGAAAGAGTAT
CTACTCGATCCACCATCGACCCATCCGGTCGATCTTTTGCGTTCGAGTGCCGGACTGGTGCGCGGATGGGGCGACTGCTA
CGGCCACATGTTGGTCGCGTCGGGCCGGGCCGAGGTTGCTGTGGACAAGATCATGAGTCCGTGGGATTGCGCGGCGGTCA
TTCCTATCGTCACCGAAGCTGGAGGTTGTTGCTTCGATTATCGAGGCCGTCGGTCGATCATCGATGGCGAGGGTCTCGTC
AGCGCGAACCGCTCGATGGGCGAAGCGCTCATCGAGGCGATCGGCAAAGGGGAGCGCGCCCGATGA

Upstream 100 bases:

>100_bases
GTGAAGGCGCCCTTGTGTTTTTCAGCCTATATCGTTAGGTTCGGCCTCAGTTGATTATCTTACGTCATCATTTGCAGCAT
CAATCATTTGACAGAACCGT

Downstream 100 bases:

>100_bases
ACCTGCTGATTCTGCTGCTGGCGGTCATCATTCTGCTGCTTCTCGTCATCATCACGATGCTTGCGACCGGATGGCCCGGC
AAGCAACGCGAGGAGGTCGA

Product: myo-inositol-1(or 4)-monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MPMTPDLQLALELAEKAGKLTLDYFGRRSLQVFSKRDDTPVTEADRKAEELIRQGISAKFPGDGLFGEEFNERPSGNGRR
WIIDPIDGTRSFIHGVPLYGVMIALEVDGVLRLGVINFPALGELYHAEIGAGAFMNGSSVQVSAIAETAAATVVFTEKEY
LLDPPSTHPVDLLRSSAGLVRGWGDCYGHMLVASGRAEVAVDKIMSPWDCAAVIPIVTEAGGCCFDYRGRRSIIDGEGLV
SANRSMGEALIEAIGKGERAR

Sequences:

>Translated_261_residues
MPMTPDLQLALELAEKAGKLTLDYFGRRSLQVFSKRDDTPVTEADRKAEELIRQGISAKFPGDGLFGEEFNERPSGNGRR
WIIDPIDGTRSFIHGVPLYGVMIALEVDGVLRLGVINFPALGELYHAEIGAGAFMNGSSVQVSAIAETAAATVVFTEKEY
LLDPPSTHPVDLLRSSAGLVRGWGDCYGHMLVASGRAEVAVDKIMSPWDCAAVIPIVTEAGGCCFDYRGRRSIIDGEGLV
SANRSMGEALIEAIGKGERAR
>Mature_260_residues
PMTPDLQLALELAEKAGKLTLDYFGRRSLQVFSKRDDTPVTEADRKAEELIRQGISAKFPGDGLFGEEFNERPSGNGRRW
IIDPIDGTRSFIHGVPLYGVMIALEVDGVLRLGVINFPALGELYHAEIGAGAFMNGSSVQVSAIAETAAATVVFTEKEYL
LDPPSTHPVDLLRSSAGLVRGWGDCYGHMLVASGRAEVAVDKIMSPWDCAAVIPIVTEAGGCCFDYRGRRSIIDGEGLVS
ANRSMGEALIEAIGKGERAR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=244, Percent_Identity=30.7377049180328, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI221625487, Length=271, Percent_Identity=29.8892988929889, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI7657236, Length=243, Percent_Identity=30.8641975308642, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI221625507, Length=152, Percent_Identity=32.2368421052632, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1788882, Length=255, Percent_Identity=28.6274509803922, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790659, Length=131, Percent_Identity=34.3511450381679, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193202572, Length=243, Percent_Identity=31.6872427983539, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193202570, Length=239, Percent_Identity=30.9623430962343, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320493, Length=234, Percent_Identity=29.9145299145299, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664918, Length=224, Percent_Identity=32.5892857142857, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357957, Length=223, Percent_Identity=34.5291479820628, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357329, Length=233, Percent_Identity=31.7596566523605, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24664922, Length=263, Percent_Identity=28.1368821292776, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24664926, Length=260, Percent_Identity=28.8461538461538, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357303, Length=236, Percent_Identity=30.5084745762712, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28114; Mature: 27983

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMTPDLQLALELAEKAGKLTLDYFGRRSLQVFSKRDDTPVTEADRKAEELIRQGISAKF
CCCCCHHHHHHHHHHHCCCEEEHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
PGDGLFGEEFNERPSGNGRRWIIDPIDGTRSFIHGVPLYGVMIALEVDGVLRLGVINFPA
CCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHCCCHHHEEEEEEECCEEEEEEECCCC
LGELYHAEIGAGAFMNGSSVQVSAIAETAAATVVFTEKEYLLDPPSTHPVDLLRSSAGLV
CCHHHHHHCCCCEEECCCCEEEEEHHHHHEEEEEEECCHHCCCCCCCCHHHHHHHCCCCE
RGWGDCYGHMLVASGRAEVAVDKIMSPWDCAAVIPIVTEAGGCCFDYRGRRSIIDGEGLV
ECHHHHHCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCCCCCCEECCCCCC
SANRSMGEALIEAIGKGERAR
CCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PMTPDLQLALELAEKAGKLTLDYFGRRSLQVFSKRDDTPVTEADRKAEELIRQGISAKF
CCCCHHHHHHHHHHHCCCEEEHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
PGDGLFGEEFNERPSGNGRRWIIDPIDGTRSFIHGVPLYGVMIALEVDGVLRLGVINFPA
CCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHCCCHHHEEEEEEECCEEEEEEECCCC
LGELYHAEIGAGAFMNGSSVQVSAIAETAAATVVFTEKEYLLDPPSTHPVDLLRSSAGLV
CCHHHHHHCCCCEEECCCCEEEEEHHHHHEEEEEEECCHHCCCCCCCCHHHHHHHCCCCE
RGWGDCYGHMLVASGRAEVAVDKIMSPWDCAAVIPIVTEAGGCCFDYRGRRSIIDGEGLV
ECHHHHHCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEECCCCCCCEECCCCCC
SANRSMGEALIEAIGKGERAR
CCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]