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The map label for this gene is coaX

Identifier: 21674229

GI number: 21674229

Start: 1320137

End: 1320949

Strand: Reverse

Name: coaX

Synonym: CT1408

Alternate gene names: 21674229

Gene position: 1320949-1320137 (Counterclockwise)

Preceding gene: 21674230

Following gene: 21674224

Centisome position: 61.3

GC content: 59.66

Gene sequence:

>813_bases
ATGCAGAGTTCCCGGGGCGCACGAGCTGCCGACGTGCCTGTGCGGCTGGTCGTTGACATCGGCAATACCAGCACGACGTT
GGCGATTTTCACCGGTGATGAAGAGCCGTCGGTCGAGTCGGTACCGAGTGCGTTGTTTGCCGATTCCAGCACAATGCGCG
AAGTGTTTGGCAACATGGCCCGGAAGCACGGCGAGCCACAGGCCATCGCCATTTGCAGCGTGGTGCCTTCCGCTACCGCC
GTCGGTTCGGCGCTTCTCGAATCACTTTTCTCCGTACCGGTGCTGACCATCTGCTGTAAGCTCCGTTTTCCTTTTCGTCT
CGACTACGCAACCCCGCACACCTTCGGCGCGGATCGCCTTGCCCTGTGCGCATGGAGCCGACATCTCTTTTCTGAAAAAC
CGGTTATCGCCGTCGATATCGGCACGGCCATCACCTTCGACGTGCTCGACACGGTGGGGAATTATCGCGGTGGTCTCATC
ATGCCGGGTATCGACATGATGGCCGGAGCGCTTCATTCGAGAACCGCCCAGCTTCCCCAGGTGCGCATCGACAGGCCGGA
GAGCCTTCTCGGGCGCTCGACGACCGAATGCATCAAAAGCGGAGTTTTCTGGGGAGTGGTCAAACAGATCGGCGGCCTCG
TGGACGCCATTCGCGGCGACCTTGTACGCGACTTTGGCGAGTCAACGGTCGAAGTGATTGTCACCGGCGGCAATAGCAGG
ATTATCGTTCCGGAGATCGGCCCTGTCAGTGTTATCGACGAACTCGCTGTCCTGCGCGGCAGCGATCTTTTGCTGCGGAT
GAATATGCCGTGA

Upstream 100 bases:

>100_bases
AATACGGCCTTCCGGACGTTGACAAGCTGCTTGCAGCGCTGTCGGCCAGGACGGGCTTGCAGATCAAACGGCCCTAAACA
CGGTATCCGGCGCATTTCCC

Downstream 100 bases:

>100_bases
ATCCCGCCGCTACAAAGTTTCGACCTTGAGGCTTACCTTTTCTCTTCTCACCCCGGCTTGAAAGCCGGGACAACAGAAAA
GAATGTAACGATCGAGTGGC

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MQSSRGARAADVPVRLVVDIGNTSTTLAIFTGDEEPSVESVPSALFADSSTMREVFGNMARKHGEPQAIAICSVVPSATA
VGSALLESLFSVPVLTICCKLRFPFRLDYATPHTFGADRLALCAWSRHLFSEKPVIAVDIGTAITFDVLDTVGNYRGGLI
MPGIDMMAGALHSRTAQLPQVRIDRPESLLGRSTTECIKSGVFWGVVKQIGGLVDAIRGDLVRDFGESTVEVIVTGGNSR
IIVPEIGPVSVIDELAVLRGSDLLLRMNMP

Sequences:

>Translated_270_residues
MQSSRGARAADVPVRLVVDIGNTSTTLAIFTGDEEPSVESVPSALFADSSTMREVFGNMARKHGEPQAIAICSVVPSATA
VGSALLESLFSVPVLTICCKLRFPFRLDYATPHTFGADRLALCAWSRHLFSEKPVIAVDIGTAITFDVLDTVGNYRGGLI
MPGIDMMAGALHSRTAQLPQVRIDRPESLLGRSTTECIKSGVFWGVVKQIGGLVDAIRGDLVRDFGESTVEVIVTGGNSR
IIVPEIGPVSVIDELAVLRGSDLLLRMNMP
>Mature_270_residues
MQSSRGARAADVPVRLVVDIGNTSTTLAIFTGDEEPSVESVPSALFADSSTMREVFGNMARKHGEPQAIAICSVVPSATA
VGSALLESLFSVPVLTICCKLRFPFRLDYATPHTFGADRLALCAWSRHLFSEKPVIAVDIGTAITFDVLDTVGNYRGGLI
MPGIDMMAGALHSRTAQLPQVRIDRPESLLGRSTTECIKSGVFWGVVKQIGGLVDAIRGDLVRDFGESTVEVIVTGGNSR
IIVPEIGPVSVIDELAVLRGSDLLLRMNMP

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_CHLTE (Q8KCK7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662294.1
- ProteinModelPortal:   Q8KCK7
- GeneID:   1006817
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1408
- NMPDR:   fig|194439.1.peg.1388
- TIGR:   CT1408
- HOGENOM:   HBG634537
- OMA:   GTACTIF
- ProtClustDB:   PRK13320
- BioCyc:   CTEP194439:CT_1408-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 28826; Mature: 28826

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: ACT_SITE 118-118 BINDING 109-109 BINDING 142-142 BINDING 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSSRGARAADVPVRLVVDIGNTSTTLAIFTGDEEPSVESVPSALFADSSTMREVFGNMA
CCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHH
RKHGEPQAIAICSVVPSATAVGSALLESLFSVPVLTICCKLRFPFRLDYATPHTFGADRL
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
ALCAWSRHLFSEKPVIAVDIGTAITFDVLDTVGNYRGGLIMPGIDMMAGALHSRTAQLPQ
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCC
VRIDRPESLLGRSTTECIKSGVFWGVVKQIGGLVDAIRGDLVRDFGESTVEVIVTGGNSR
EECCCCHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCE
IIVPEIGPVSVIDELAVLRGSDLLLRMNMP
EEEECCCCHHHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure
MQSSRGARAADVPVRLVVDIGNTSTTLAIFTGDEEPSVESVPSALFADSSTMREVFGNMA
CCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHH
RKHGEPQAIAICSVVPSATAVGSALLESLFSVPVLTICCKLRFPFRLDYATPHTFGADRL
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHH
ALCAWSRHLFSEKPVIAVDIGTAITFDVLDTVGNYRGGLIMPGIDMMAGALHSRTAQLPQ
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCC
VRIDRPESLLGRSTTECIKSGVFWGVVKQIGGLVDAIRGDLVRDFGESTVEVIVTGGNSR
EECCCCHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCE
IIVPEIGPVSVIDELAVLRGSDLLLRMNMP
EEEECCCCHHHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901