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The map label for this gene is eriC [C]

Identifier: 21674213

GI number: 21674213

Start: 1303909

End: 1305798

Strand: Direct

Name: eriC [C]

Synonym: CT1391

Alternate gene names: 21674213

Gene position: 1303909-1305798 (Clockwise)

Preceding gene: 21674212

Following gene: 21674216

Centisome position: 60.51

GC content: 54.87

Gene sequence:

>1890_bases
ATGAGCTGGCTTTTTAAGAACAGCCGCATCAAGCGGCGTGTTATTGTCTTGACCTATCTGATCCTTCGCAAAAGCCGTTA
TTTCAAAGGTTCTTCACAGCAGTTCGTCCGCATGACCTGGGCTTCGTTCCTCGCCCAGCTCAACCTCAATCAGGATCTTC
CGTTTCTTCTCGTTGCCGTTTTCGTTGGACTGGTCACGGGCTACGTCGCCGTTATTTTTCACGACGCCATCAAGATCATC
AGCTCATACCTTTTCTACGGCACAACCGCGCTCGGGTTGCCGACTTTCAACAATTATCTCAGAATTTTTCTGCTTCCGCT
CATTCCTGCTCTGGGCGGCCTGATTGTCGGGCTGTATAATGCTTTTGTCGTCAAGGCGAGGCCGGAGCACGGCTTACCTT
CGGTCATCAAGGCGGTCGCACAGAAAAATGGCAAAATTCCCACGAAAAACTGGATACACAAAACCATCACCTCGGTGGTC
AGCATCGGAACCGGGGGCGGCGGCGGACGCGAGGCGCCGATCGCGCAGGTAGGCGCATCGATCGGTTCAACCGTGGCGCA
GTGGCTCAAGTTTTCGCCGGGCAGAACCCGGACACTCCTCGGTTGTGGCGCGGCAGCGGGTCTTGCCGCCGTGTTCAACG
CGCCCATCGGTGGCGTGATGTTCGCCGTGGAGGTGATTCTCGGCGATTTCAGCGTCAAGACATTCAGCCCTATCGTGGTG
GCTGCCGTGGTGGGAACCGTACTTTCGAGAAGCTATCTCGGCAATTACCCGACTTTTCAGGTTCCCGAATACAGTCTCGT
TTCAAATACCGAACTGGTGTTCTACTTCATTCTCGGCGTCCTTGCCGGTCTCACCGCAGTCCTGTTCATCAGAACCTTTT
ACTTCATTGAAGAGCATATTCAGAAAATTGAAAAGCGCTTTCGCATTCCCGCGTGGTTGATGCCCGCTATCGGTGGCCTT
TTGTGCGGTTTGATCAGTATGTGGGTGCCGGAACTGTACGGTTTCAGCTATGAGGTTATCAACAAGGCACTGATCGGGCA
GGAGAGCTGGGAGAACATGGTTGCCGTCTACCTGCTCAAGCCGGTGGTCGTGGCGCTGACGGTCGGCTCTGGCGGTTCGG
GCGGCATGTTCGCACCGACCATGAAGATGGGCGCGATGCTCGGCGGCATGTTCGGCAAGGTCGTGAACAATCTCTTTCCG
GCAATCACCGCCGCATCAGGGGCTTACGCGCTGGTTGGCATGGGCGCCGTGACCGCCGGAATCATGCGCGCACCGTTGAC
TGTTATCCTCATTTTGTTTGAAGTCACCGGTCAGTACGAGATCGTCTTGCCCATCATGTTTGCGGCGGTTACTTCGGCGC
TGGTGGCACGGCTGGCTTATCCCTACACCATGGAAACCTACGTGCTCGAAAAGGAGAATGTGCGTGTCGGCTTCGGCATT
GCACTGACCATTGCCGGAAATATCAGCGTGCTGGAGGTGATGCAGCGCAAATTCGTCAAGTTCTTCGATGTCACCAAGGT
GGAGAACATCATCGATGCGTTCTACAACACCCGCGATTCGCACTTTTTCATCACGACGCCAGAGGGAACGTTCGTCGGCA
TCATCGGCCTCGACGAGATGAGCCTCGTGCTGAAGGATGGTATCTTCCCCGGCATGATCGCTGATGATCTGGTCAAAAAG
AATGTGACCGTCTTGTACGACACCTCCAAGCTCGACGAGGCGCTGAAGATTTTCGAGATTTCCGAATACTCGACACTGCC
GGTGGTCGAATATCATTCACGCAAGCTGCTCGGGATTCTCAAGCAGGACGAGGCGTTTTCCTATTACCGCAAACAGATGA
ACCTCATCGGTGAAGATGCCGGTGAGCTGGCCGACCAGCGAACAGCGTAA

Upstream 100 bases:

>100_bases
CCATCGAAAGCCTTGCGAAATCAGCGTTTGTTTGGTATCCACATACAGAAAAAATACATTGCAAGTATTGCCATGATTAC
CAATCCACTGACCCGATTCA

Downstream 100 bases:

>100_bases
TGGCCGTCCGTGACGATTCATTTGTCACAAGAATCAAAAGCCGCTTGCATTAACGGCAACTGATGCGTATGGTTTTGTGA
TGTGCTCCCTGAATCGCTTG

Product: chloride channel, putative

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MSWLFKNSRIKRRVIVLTYLILRKSRYFKGSSQQFVRMTWASFLAQLNLNQDLPFLLVAVFVGLVTGYVAVIFHDAIKII
SSYLFYGTTALGLPTFNNYLRIFLLPLIPALGGLIVGLYNAFVVKARPEHGLPSVIKAVAQKNGKIPTKNWIHKTITSVV
SIGTGGGGGREAPIAQVGASIGSTVAQWLKFSPGRTRTLLGCGAAAGLAAVFNAPIGGVMFAVEVILGDFSVKTFSPIVV
AAVVGTVLSRSYLGNYPTFQVPEYSLVSNTELVFYFILGVLAGLTAVLFIRTFYFIEEHIQKIEKRFRIPAWLMPAIGGL
LCGLISMWVPELYGFSYEVINKALIGQESWENMVAVYLLKPVVVALTVGSGGSGGMFAPTMKMGAMLGGMFGKVVNNLFP
AITAASGAYALVGMGAVTAGIMRAPLTVILILFEVTGQYEIVLPIMFAAVTSALVARLAYPYTMETYVLEKENVRVGFGI
ALTIAGNISVLEVMQRKFVKFFDVTKVENIIDAFYNTRDSHFFITTPEGTFVGIIGLDEMSLVLKDGIFPGMIADDLVKK
NVTVLYDTSKLDEALKIFEISEYSTLPVVEYHSRKLLGILKQDEAFSYYRKQMNLIGEDAGELADQRTA

Sequences:

>Translated_629_residues
MSWLFKNSRIKRRVIVLTYLILRKSRYFKGSSQQFVRMTWASFLAQLNLNQDLPFLLVAVFVGLVTGYVAVIFHDAIKII
SSYLFYGTTALGLPTFNNYLRIFLLPLIPALGGLIVGLYNAFVVKARPEHGLPSVIKAVAQKNGKIPTKNWIHKTITSVV
SIGTGGGGGREAPIAQVGASIGSTVAQWLKFSPGRTRTLLGCGAAAGLAAVFNAPIGGVMFAVEVILGDFSVKTFSPIVV
AAVVGTVLSRSYLGNYPTFQVPEYSLVSNTELVFYFILGVLAGLTAVLFIRTFYFIEEHIQKIEKRFRIPAWLMPAIGGL
LCGLISMWVPELYGFSYEVINKALIGQESWENMVAVYLLKPVVVALTVGSGGSGGMFAPTMKMGAMLGGMFGKVVNNLFP
AITAASGAYALVGMGAVTAGIMRAPLTVILILFEVTGQYEIVLPIMFAAVTSALVARLAYPYTMETYVLEKENVRVGFGI
ALTIAGNISVLEVMQRKFVKFFDVTKVENIIDAFYNTRDSHFFITTPEGTFVGIIGLDEMSLVLKDGIFPGMIADDLVKK
NVTVLYDTSKLDEALKIFEISEYSTLPVVEYHSRKLLGILKQDEAFSYYRKQMNLIGEDAGELADQRTA
>Mature_628_residues
SWLFKNSRIKRRVIVLTYLILRKSRYFKGSSQQFVRMTWASFLAQLNLNQDLPFLLVAVFVGLVTGYVAVIFHDAIKIIS
SYLFYGTTALGLPTFNNYLRIFLLPLIPALGGLIVGLYNAFVVKARPEHGLPSVIKAVAQKNGKIPTKNWIHKTITSVVS
IGTGGGGGREAPIAQVGASIGSTVAQWLKFSPGRTRTLLGCGAAAGLAAVFNAPIGGVMFAVEVILGDFSVKTFSPIVVA
AVVGTVLSRSYLGNYPTFQVPEYSLVSNTELVFYFILGVLAGLTAVLFIRTFYFIEEHIQKIEKRFRIPAWLMPAIGGLL
CGLISMWVPELYGFSYEVINKALIGQESWENMVAVYLLKPVVVALTVGSGGSGGMFAPTMKMGAMLGGMFGKVVNNLFPA
ITAASGAYALVGMGAVTAGIMRAPLTVILILFEVTGQYEIVLPIMFAAVTSALVARLAYPYTMETYVLEKENVRVGFGIA
LTIAGNISVLEVMQRKFVKFFDVTKVENIIDAFYNTRDSHFFITTPEGTFVGIIGLDEMSLVLKDGIFPGMIADDLVKKN
VTVLYDTSKLDEALKIFEISEYSTLPVVEYHSRKLLGILKQDEAFSYYRKQMNLIGEDAGELADQRTA

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=360, Percent_Identity=28.6111111111111, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI189217923, Length=360, Percent_Identity=28.6111111111111, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI189217921, Length=360, Percent_Identity=28.6111111111111, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI153252026, Length=361, Percent_Identity=28.808864265928, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786350, Length=417, Percent_Identity=29.4964028776978, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI87081943, Length=343, Percent_Identity=27.6967930029155, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71996452, Length=511, Percent_Identity=24.26614481409, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71996455, Length=511, Percent_Identity=24.26614481409, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 68702; Mature: 68571

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWLFKNSRIKRRVIVLTYLILRKSRYFKGSSQQFVRMTWASFLAQLNLNQDLPFLLVAV
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
FVGLVTGYVAVIFHDAIKIISSYLFYGTTALGLPTFNNYLRIFLLPLIPALGGLIVGLYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AFVVKARPEHGLPSVIKAVAQKNGKIPTKNWIHKTITSVVSIGTGGGGGREAPIAQVGAS
HHEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
IGSTVAQWLKFSPGRTRTLLGCGAAAGLAAVFNAPIGGVMFAVEVILGDFSVKTFSPIVV
HHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHH
AAVVGTVLSRSYLGNYPTFQVPEYSLVSNTELVFYFILGVLAGLTAVLFIRTFYFIEEHI
HHHHHHHHHHHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKIEKRFRIPAWLMPAIGGLLCGLISMWVPELYGFSYEVINKALIGQESWENMVAVYLLK
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHH
PVVVALTVGSGGSGGMFAPTMKMGAMLGGMFGKVVNNLFPAITAASGAYALVGMGAVTAG
HHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IMRAPLTVILILFEVTGQYEIVLPIMFAAVTSALVARLAYPYTMETYVLEKENVRVGFGI
HHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEE
ALTIAGNISVLEVMQRKFVKFFDVTKVENIIDAFYNTRDSHFFITTPEGTFVGIIGLDEM
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCHH
SLVLKDGIFPGMIADDLVKKNVTVLYDTSKLDEALKIFEISEYSTLPVVEYHSRKLLGIL
HHHHHCCCCCCHHHHHHHHCCCEEEEECHHHHHHHHHHEECCCCCCCCHHHCCHHHHHHH
KQDEAFSYYRKQMNLIGEDAGELADQRTA
HCCHHHHHHHHHHHHHCCCHHHHHHCCCC
>Mature Secondary Structure 
SWLFKNSRIKRRVIVLTYLILRKSRYFKGSSQQFVRMTWASFLAQLNLNQDLPFLLVAV
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH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HCCHHHHHHHHHHHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]