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The map label for this gene is macB [H]

Identifier: 21674173

GI number: 21674173

Start: 1269775

End: 1271019

Strand: Direct

Name: macB [H]

Synonym: CT1351

Alternate gene names: 21674173

Gene position: 1269775-1271019 (Clockwise)

Preceding gene: 21674172

Following gene: 21674175

Centisome position: 58.92

GC content: 59.28

Gene sequence:

>1245_bases
ATGACGCTCCCGATCCGTGAAACCGTGATACAAGCCGCAACATCGCTGGCAGTCAACAAGCTTCGTTCAGCCTTGACCAC
GCTCGGCGTGGCGGTAGGCGTTTTCTCCATCATCGCAGTCATGACGGCGCTTGACGCGGTTGACCGCTCGATTGCCTCTG
GCCTGTCGAGCCTCGGCGCGAACACCTTTCAGATCCAGAAAAATCCGGCCACGGTGTTCGGCGAAGGCCACAACCGGAAT
CTGTACGCCAACCGCAAGGACATCACCTGGCAGGAGGCGCAGCTCTTTAAAAAATACATGGGCCAGAGCGCGCGCAACAT
TGGATTGATCATCACGAGCCAGGCTGCGCAGGCCAGTTACGGCAACGAAATCACCAATCCCGACGTCACGCTGACCGGAG
GCGACGAAAGCTTCGCTCCGGCCAATGGCTTTGATGTCATCGAGGGCAGGAACCTGAACGACGGCGACCTCCGTTATGCC
TCCGACACCGCCGTTATCGGCAGCGATGTCGCCGCGTACCTTTTCCAGCAGGGACAGAATCCGGTTGGCAAACAGATCAG
GGTCAATGGCAAGGCCTACACGGTCATCGGCGTGTTCAGCAAAAAAGGGCCGGCGTTCGGTCAGAGCCAGGACAACTTCG
TGCTCATCCCGATCACCCGCTTCCTCGAAGAGGTCAATCAGGAATCCAGCATAGCCATCAGCGTTGAGGCCACCTCACAG
AAAACCTACCAGCAAACCATCGATCAGGCCATCGGCGCAATGCGGCTGGCGCGGGGGCTGACGGTGAAAATGCCGAACGA
TTTCGAGATCAGAACCAATGAATCGCTGGTCGATTCGTTCCGCGACATCCAGCGAATCGTCAGCATCGGAGCATTTATCA
TCAGCTTTATGGCGCTGTTGACCGCCGGCGTGGGCATCATGAACATCATGCTGGTCAGTGTGACGGAGCGAACACGGGAG
ATCGGCATCCGCATGTCGGTCGGCGCGCCGCGGCGCTCGATTTTGCAGCAGTTCCTGCTCGAAGCGCTGCTGCTCTCGAT
CGGCGGCGGCGTCCTCGGCATCGTGGCCGGAGCAGCGGCAGGCAACCTGGTGGCGGTCAAATTCAACCTGCCGGTGATGT
TTCCGTGGCTGTGGGTCGTCGTGTCGCTGACAGTATGCTCGGTCATCGGCATCTCGTTCGGACTTTTCCCGGCCTGGAAA
GCCTCCAGCCTTGACCCGGTCACTGCACTCCGCGCTTCGAGGTAA

Upstream 100 bases:

>100_bases
GCCTCGTGGTGTCGGTGGCAACCGGTATCATCTCCGGCCTCGCTCCGGCGATTTCGGCATCGAGGCTCGATCCGGCCGTT
TCACTCAGGTACGAATAGCC

Downstream 100 bases:

>100_bases
ATGAGCAGCTCACTGCTCACAGGCAGCCATTTTCTGCAACGCGTTTCTGGTCGGGCACGGCGCGCTCATCTGTCGCTCTG
CCGCCTGCCATGAGGGGATG

Product: ABC transporter efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTLPIRETVIQAATSLAVNKLRSALTTLGVAVGVFSIIAVMTALDAVDRSIASGLSSLGANTFQIQKNPATVFGEGHNRN
LYANRKDITWQEAQLFKKYMGQSARNIGLIITSQAAQASYGNEITNPDVTLTGGDESFAPANGFDVIEGRNLNDGDLRYA
SDTAVIGSDVAAYLFQQGQNPVGKQIRVNGKAYTVIGVFSKKGPAFGQSQDNFVLIPITRFLEEVNQESSIAISVEATSQ
KTYQQTIDQAIGAMRLARGLTVKMPNDFEIRTNESLVDSFRDIQRIVSIGAFIISFMALLTAGVGIMNIMLVSVTERTRE
IGIRMSVGAPRRSILQQFLLEALLLSIGGGVLGIVAGAAAGNLVAVKFNLPVMFPWLWVVVSLTVCSVIGISFGLFPAWK
ASSLDPVTALRASR

Sequences:

>Translated_414_residues
MTLPIRETVIQAATSLAVNKLRSALTTLGVAVGVFSIIAVMTALDAVDRSIASGLSSLGANTFQIQKNPATVFGEGHNRN
LYANRKDITWQEAQLFKKYMGQSARNIGLIITSQAAQASYGNEITNPDVTLTGGDESFAPANGFDVIEGRNLNDGDLRYA
SDTAVIGSDVAAYLFQQGQNPVGKQIRVNGKAYTVIGVFSKKGPAFGQSQDNFVLIPITRFLEEVNQESSIAISVEATSQ
KTYQQTIDQAIGAMRLARGLTVKMPNDFEIRTNESLVDSFRDIQRIVSIGAFIISFMALLTAGVGIMNIMLVSVTERTRE
IGIRMSVGAPRRSILQQFLLEALLLSIGGGVLGIVAGAAAGNLVAVKFNLPVMFPWLWVVVSLTVCSVIGISFGLFPAWK
ASSLDPVTALRASR
>Mature_413_residues
TLPIRETVIQAATSLAVNKLRSALTTLGVAVGVFSIIAVMTALDAVDRSIASGLSSLGANTFQIQKNPATVFGEGHNRNL
YANRKDITWQEAQLFKKYMGQSARNIGLIITSQAAQASYGNEITNPDVTLTGGDESFAPANGFDVIEGRNLNDGDLRYAS
DTAVIGSDVAAYLFQQGQNPVGKQIRVNGKAYTVIGVFSKKGPAFGQSQDNFVLIPITRFLEEVNQESSIAISVEATSQK
TYQQTIDQAIGAMRLARGLTVKMPNDFEIRTNESLVDSFRDIQRIVSIGAFIISFMALLTAGVGIMNIMLVSVTERTREI
GIRMSVGAPRRSILQQFLLEALLLSIGGGVLGIVAGAAAGNLVAVKFNLPVMFPWLWVVVSLTVCSVIGISFGLFPAWKA
SSLDPVTALRASR

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG0577

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787105, Length=418, Percent_Identity=29.9043062200957, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44372; Mature: 44241

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPIRETVIQAATSLAVNKLRSALTTLGVAVGVFSIIAVMTALDAVDRSIASGLSSLGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTFQIQKNPATVFGEGHNRNLYANRKDITWQEAQLFKKYMGQSARNIGLIITSQAAQASY
CEEEEECCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHC
GNEITNPDVTLTGGDESFAPANGFDVIEGRNLNDGDLRYASDTAVIGSDVAAYLFQQGQN
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCC
PVGKQIRVNGKAYTVIGVFSKKGPAFGQSQDNFVLIPITRFLEEVNQESSIAISVEATSQ
CCCCEEEECCEEEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCEEEEEECCCH
KTYQQTIDQAIGAMRLARGLTVKMPNDFEIRTNESLVDSFRDIQRIVSIGAFIISFMALL
HHHHHHHHHHHHHHHHHCCCEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAGVGIMNIMLVSVTERTREIGIRMSVGAPRRSILQQFLLEALLLSIGGGVLGIVAGAAA
HHCHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GNLVAVKFNLPVMFPWLWVVVSLTVCSVIGISFGLFPAWKASSLDPVTALRASR
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
TLPIRETVIQAATSLAVNKLRSALTTLGVAVGVFSIIAVMTALDAVDRSIASGLSSLGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTFQIQKNPATVFGEGHNRNLYANRKDITWQEAQLFKKYMGQSARNIGLIITSQAAQASY
CEEEEECCCCEEEECCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHC
GNEITNPDVTLTGGDESFAPANGFDVIEGRNLNDGDLRYASDTAVIGSDVAAYLFQQGQN
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCC
PVGKQIRVNGKAYTVIGVFSKKGPAFGQSQDNFVLIPITRFLEEVNQESSIAISVEATSQ
CCCCEEEECCEEEEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCEEEEEECCCH
KTYQQTIDQAIGAMRLARGLTVKMPNDFEIRTNESLVDSFRDIQRIVSIGAFIISFMALL
HHHHHHHHHHHHHHHHHCCCEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAGVGIMNIMLVSVTERTREIGIRMSVGAPRRSILQQFLLEALLLSIGGGVLGIVAGAAA
HHCHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
GNLVAVKFNLPVMFPWLWVVVSLTVCSVIGISFGLFPAWKASSLDPVTALRASR
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA