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The map label for this gene is macB [H]

Identifier: 21674172

GI number: 21674172

Start: 1268507

End: 1269772

Strand: Direct

Name: macB [H]

Synonym: CT1350

Alternate gene names: 21674172

Gene position: 1268507-1269772 (Clockwise)

Preceding gene: 21674171

Following gene: 21674173

Centisome position: 58.86

GC content: 59.79

Gene sequence:

>1266_bases
ATGAACAGCACTCTGCGGCAGTTCCGGTACGAAACGGTCGAAAGCCTGAATATCGCCGTGTACCAAATCAGGGCCAACAA
GATCCGGTCATTCCTGACGGCGCTTGGCGTCATCATCGGCATCGTGGCGATCACCATGATGGGCACGGCGATCAACGGCA
TCGATATCGGTTTTGACCGGAGCCTCGCCATGCTTGGCTACGATGTGATCTACGTGCAGAAGGGATCGTGGAGCACGATG
GGCTCGTGGTGGCGCTACCGCAACCGGCCTGATATCGAAACCCGGTATGCCACCGAGATCAACCGGATCATCGCAGGCAA
AACGCTCTCCGAGCTGATCGTGGCCGTACCGCAAATGTCCACCATCCAGGCTTCCGCCCGTTACCGTGACCGCGAGATTC
TGCAAATCTTCGCGCTCGGCACCAACCAGGACTACCCGCTCACCGCTTCGGGAGACCTGTCGGCGGGGCGCTTTTTCACA
GCGCAGGAGTCGGCGGCAGGCGACGCTGTCGCGGTCATCGGCAACGACATCGCTACCGGCCTCTTCCCCGACGGACGGGC
AGTCGGCAAGTCGATCCGACTGAGAAATCACAATGTGCGCGTGGTGGGCGTCTTCAAAAAGCAGGGCAAATTCCTCGGAC
TGTTCAGTTTCGACAACCAGCTCATCATGCCGCTCGGCGCGTTCACGAAGGTGTACGGAAAAACCTCGATGGTGACAATC
AGGGTCAAGGTCAGGGATGAAAAACGGATTCCGGAGGCCAAGGAGGAGCTGACCGGACTGATGCGGCGCATCCGGAGGCT
GCCGCCGGGCAAGGCGGACGACTTCGGCATCAACGAGCAGCAGGCGTTCAAAAGCCAGCTCGATCCGATCAAGAACGGCA
TCGCCGTTGCGGGCATCTTCATCACCGGAATGTCGCTGTTTGTTGGAGCCATCGGCATCATGAACATCACCTTCGTGAGC
GTCAAGGAGCGCACCCGCGAAATCGGCCTGCGCAAGGCGCTCGGCGCACGACGGCGCACGATTCTGTTGCAGTTTCTCAT
CGAATCGGTGATGATCTGCCTTGTCGGCGGCGTGATTGGCCTCGTCACGGCGCTGTCGATCACCGTGCTGATTCAGAATC
TGCTACCCGATTTCCCGGTCAGCTTCTCACCGATGCTCGTCCTGGCGAGCCTCGTGGTGTCGGTGGCAACCGGTATCATC
TCCGGCCTCGCTCCGGCGATTTCGGCATCGAGGCTCGATCCGGCCGTTTCACTCAGGTACGAATAG

Upstream 100 bases:

>100_bases
GCAACACCATCATCCTCATCACCCACGAAGAGGACATCGCCCGCTTCACCCGCCGCATCATCCGCCTGCGAGACGGCAGA
ATCGAAAGCGACTCGGCGCC

Downstream 100 bases:

>100_bases
CCATGACGCTCCCGATCCGTGAAACCGTGATACAAGCCGCAACATCGCTGGCAGTCAACAAGCTTCGTTCAGCCTTGACC
ACGCTCGGCGTGGCGGTAGG

Product: ABC transporter efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNSTLRQFRYETVESLNIAVYQIRANKIRSFLTALGVIIGIVAITMMGTAINGIDIGFDRSLAMLGYDVIYVQKGSWSTM
GSWWRYRNRPDIETRYATEINRIIAGKTLSELIVAVPQMSTIQASARYRDREILQIFALGTNQDYPLTASGDLSAGRFFT
AQESAAGDAVAVIGNDIATGLFPDGRAVGKSIRLRNHNVRVVGVFKKQGKFLGLFSFDNQLIMPLGAFTKVYGKTSMVTI
RVKVRDEKRIPEAKEELTGLMRRIRRLPPGKADDFGINEQQAFKSQLDPIKNGIAVAGIFITGMSLFVGAIGIMNITFVS
VKERTREIGLRKALGARRRTILLQFLIESVMICLVGGVIGLVTALSITVLIQNLLPDFPVSFSPMLVLASLVVSVATGII
SGLAPAISASRLDPAVSLRYE

Sequences:

>Translated_421_residues
MNSTLRQFRYETVESLNIAVYQIRANKIRSFLTALGVIIGIVAITMMGTAINGIDIGFDRSLAMLGYDVIYVQKGSWSTM
GSWWRYRNRPDIETRYATEINRIIAGKTLSELIVAVPQMSTIQASARYRDREILQIFALGTNQDYPLTASGDLSAGRFFT
AQESAAGDAVAVIGNDIATGLFPDGRAVGKSIRLRNHNVRVVGVFKKQGKFLGLFSFDNQLIMPLGAFTKVYGKTSMVTI
RVKVRDEKRIPEAKEELTGLMRRIRRLPPGKADDFGINEQQAFKSQLDPIKNGIAVAGIFITGMSLFVGAIGIMNITFVS
VKERTREIGLRKALGARRRTILLQFLIESVMICLVGGVIGLVTALSITVLIQNLLPDFPVSFSPMLVLASLVVSVATGII
SGLAPAISASRLDPAVSLRYE
>Mature_421_residues
MNSTLRQFRYETVESLNIAVYQIRANKIRSFLTALGVIIGIVAITMMGTAINGIDIGFDRSLAMLGYDVIYVQKGSWSTM
GSWWRYRNRPDIETRYATEINRIIAGKTLSELIVAVPQMSTIQASARYRDREILQIFALGTNQDYPLTASGDLSAGRFFT
AQESAAGDAVAVIGNDIATGLFPDGRAVGKSIRLRNHNVRVVGVFKKQGKFLGLFSFDNQLIMPLGAFTKVYGKTSMVTI
RVKVRDEKRIPEAKEELTGLMRRIRRLPPGKADDFGINEQQAFKSQLDPIKNGIAVAGIFITGMSLFVGAIGIMNITFVS
VKERTREIGLRKALGARRRTILLQFLIESVMICLVGGVIGLVTALSITVLIQNLLPDFPVSFSPMLVLASLVVSVATGII
SGLAPAISASRLDPAVSLRYE

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG0577

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787105, Length=424, Percent_Identity=32.0754716981132, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46117; Mature: 46117

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTLRQFRYETVESLNIAVYQIRANKIRSFLTALGVIIGIVAITMMGTAINGIDIGFDR
CCCHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
SLAMLGYDVIYVQKGSWSTMGSWWRYRNRPDIETRYATEINRIIAGKTLSELIVAVPQMS
CHHHHCEEEEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCH
TIQASARYRDREILQIFALGTNQDYPLTASGDLSAGRFFTAQESAAGDAVAVIGNDIATG
HHHHHHHHCHHHEEEEEEECCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEECCCHHCC
LFPDGRAVGKSIRLRNHNVRVVGVFKKQGKFLGLFSFDNQLIMPLGAFTKVYGKTSMVTI
CCCCCHHHCCEEEEECCCEEEEEEEECCCCEEEEEECCCCEEECHHHHHHHHCCCEEEEE
RVKVRDEKRIPEAKEELTGLMRRIRRLPPGKADDFGINEQQAFKSQLDPIKNGIAVAGIF
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
ITGMSLFVGAIGIMNITFVSVKERTREIGLRKALGARRRTILLQFLIESVMICLVGGVIG
HHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTALSITVLIQNLLPDFPVSFSPMLVLASLVVSVATGIISGLAPAISASRLDPAVSLRY
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
E
C
>Mature Secondary Structure
MNSTLRQFRYETVESLNIAVYQIRANKIRSFLTALGVIIGIVAITMMGTAINGIDIGFDR
CCCHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
SLAMLGYDVIYVQKGSWSTMGSWWRYRNRPDIETRYATEINRIIAGKTLSELIVAVPQMS
CHHHHCEEEEEEECCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCH
TIQASARYRDREILQIFALGTNQDYPLTASGDLSAGRFFTAQESAAGDAVAVIGNDIATG
HHHHHHHHCHHHEEEEEEECCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEECCCHHCC
LFPDGRAVGKSIRLRNHNVRVVGVFKKQGKFLGLFSFDNQLIMPLGAFTKVYGKTSMVTI
CCCCCHHHCCEEEEECCCEEEEEEEECCCCEEEEEECCCCEEECHHHHHHHHCCCEEEEE
RVKVRDEKRIPEAKEELTGLMRRIRRLPPGKADDFGINEQQAFKSQLDPIKNGIAVAGIF
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHH
ITGMSLFVGAIGIMNITFVSVKERTREIGLRKALGARRRTILLQFLIESVMICLVGGVIG
HHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVTALSITVLIQNLLPDFPVSFSPMLVLASLVVSVATGIISGLAPAISASRLDPAVSLRY
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA