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The map label for this gene is purQ

Identifier: 21674160

GI number: 21674160

Start: 1258895

End: 1259599

Strand: Reverse

Name: purQ

Synonym: CT1338

Alternate gene names: 21674160

Gene position: 1259599-1258895 (Counterclockwise)

Preceding gene: 21674161

Following gene: 21674159

Centisome position: 58.45

GC content: 59.29

Gene sequence:

>705_bases
ATGGCTGATGTTACCGTTGGAATCGTGGTTTTCCCCGGTTCGAACTGCGATCACGACACCGAATATGCCGTTGCTTCGTT
TCCGGGCGTCAAGCCGGTGATGCTCTGGCACAACGATCACGACCTTAAGGGATGTGACGCTGTTATTCTCCCTGGGGGTT
TCTCCTACGGAGATTATCTCCGTTGCGGTGCCATCGCCCGGTTCTCGCCAATCATGCGCGAGGTAATCGATTTTGCAGGC
AAGGGGCGTCCGGTGCTCGGCATCTGTAACGGCTTTCAGGTGCTCGTTGAGTGCGGCCTGCTCGAAGGTGCCCTGATCCG
CAACGCCGGACGGAGGTTCGTTTCACGCCAGACCACCATCAGCGTCGCCAACAACGCCACGATCTTCACCGACCGTTACC
AAAAAGGTGAGGTGCTGCGCGTGCCGGTTGCGCACGGCGAGGGCAACTATTACGCTTCGCCCGAGACCATCGAGAGCCTC
GAATCGAACGGGCAGGTGGTGTTCCGCTACACCGACGCCTGGGGCAACGCAACTGCCGAGGCCAACTTCAACGGCTCGAT
GAACAACATCGCCGGTATCGTCAACAAGCAGGGTAACGTGCTTGGCCTGATGCCGCATCCTGAACGCGCCAGCGAGAAGC
TGCTCGGCTCGGAGGATGGCAGGCGGCTGTTCGAATCGCTTTTCGCGCATCTTGCTGGAGCGTAA

Upstream 100 bases:

>100_bases
GCAAGTCTGCACTGAAATCTGTCAGAAGCTCCTGTCCAATCCGATTATGGAGGACTTCAGCTTCGAACTGGTACCCGTCA
ACTAAATTTCTCACCCTCCT

Downstream 100 bases:

>100_bases
CCCAGCCTTCTGATGGGCATGAACGACACATCGCAGAAGGCCCGGATTTTCTCATGGCTGCTGTTCGATTTCGCGAATAC
ATCGTTCAGCGTCATGATGG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MADVTVGIVVFPGSNCDHDTEYAVASFPGVKPVMLWHNDHDLKGCDAVILPGGFSYGDYLRCGAIARFSPIMREVIDFAG
KGRPVLGICNGFQVLVECGLLEGALIRNAGRRFVSRQTTISVANNATIFTDRYQKGEVLRVPVAHGEGNYYASPETIESL
ESNGQVVFRYTDAWGNATAEANFNGSMNNIAGIVNKQGNVLGLMPHPERASEKLLGSEDGRRLFESLFAHLAGA

Sequences:

>Translated_234_residues
MADVTVGIVVFPGSNCDHDTEYAVASFPGVKPVMLWHNDHDLKGCDAVILPGGFSYGDYLRCGAIARFSPIMREVIDFAG
KGRPVLGICNGFQVLVECGLLEGALIRNAGRRFVSRQTTISVANNATIFTDRYQKGEVLRVPVAHGEGNYYASPETIESL
ESNGQVVFRYTDAWGNATAEANFNGSMNNIAGIVNKQGNVLGLMPHPERASEKLLGSEDGRRLFESLFAHLAGA
>Mature_233_residues
ADVTVGIVVFPGSNCDHDTEYAVASFPGVKPVMLWHNDHDLKGCDAVILPGGFSYGDYLRCGAIARFSPIMREVIDFAGK
GRPVLGICNGFQVLVECGLLEGALIRNAGRRFVSRQTTISVANNATIFTDRYQKGEVLRVPVAHGEGNYYASPETIESLE
SNGQVVFRYTDAWGNATAEANFNGSMNNIAGIVNKQGNVLGLMPHPERASEKLLGSEDGRRLFESLFAHLAGA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI31657129, Length=190, Percent_Identity=34.2105263157895, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI48994899, Length=183, Percent_Identity=32.2404371584699, Blast_Score=78, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17553022, Length=234, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321498, Length=186, Percent_Identity=33.8709677419355, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24582111, Length=190, Percent_Identity=33.1578947368421, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24582109, Length=190, Percent_Identity=33.1578947368421, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137292, Length=190, Percent_Identity=33.1578947368421, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_CHLTE (Q8KCS5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662225.1
- ProteinModelPortal:   Q8KCS5
- SMR:   Q8KCS5
- GeneID:   1006708
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1338
- NMPDR:   fig|194439.1.peg.1319
- TIGR:   CT1338
- HOGENOM:   HBG302712
- OMA:   HPENHVE
- ProtClustDB:   PRK03619
- BioCyc:   CTEP194439:CT_1338-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.3

Molecular weight: Translated: 25269; Mature: 25138

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 89-89 ACT_SITE 206-206 ACT_SITE 208-208

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVTVGIVVFPGSNCDHDTEYAVASFPGVKPVMLWHNDHDLKGCDAVILPGGFSYGDYL
CCCEEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCHH
RCGAIARFSPIMREVIDFAGKGRPVLGICNGFQVLVECGLLEGALIRNAGRRFVSRQTTI
HHCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEE
SVANNATIFTDRYQKGEVLRVPVAHGEGNYYASPETIESLESNGQVVFRYTDAWGNATAE
EECCCEEEEEECCCCCCEEEEEEEECCCCEEECHHHHHHHHCCCEEEEEEECCCCCCEEE
ANFNGSMNNIAGIVNKQGNVLGLMPHPERASEKLLGSEDGRRLFESLFAHLAGA
CCCCCCHHHHHHEEECCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADVTVGIVVFPGSNCDHDTEYAVASFPGVKPVMLWHNDHDLKGCDAVILPGGFSYGDYL
CCEEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCHH
RCGAIARFSPIMREVIDFAGKGRPVLGICNGFQVLVECGLLEGALIRNAGRRFVSRQTTI
HHCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEE
SVANNATIFTDRYQKGEVLRVPVAHGEGNYYASPETIESLESNGQVVFRYTDAWGNATAE
EECCCEEEEEECCCCCCEEEEEEEECCCCEEECHHHHHHHHCCCEEEEEEECCCCCCEEE
ANFNGSMNNIAGIVNKQGNVLGLMPHPERASEKLLGSEDGRRLFESLFAHLAGA
CCCCCCHHHHHHEEECCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901