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The map label for this gene is moeA [H]

Identifier: 21674153

GI number: 21674153

Start: 1252462

End: 1253742

Strand: Direct

Name: moeA [H]

Synonym: CT1331

Alternate gene names: 21674153

Gene position: 1252462-1253742 (Clockwise)

Preceding gene: 21674152

Following gene: 21674154

Centisome position: 58.12

GC content: 64.09

Gene sequence:

>1281_bases
ATGATGACCGTCGTTCACGAAGCTCACGAAAGTAAACAAAAACAGGCCAAAACAATGACGACCGTTCACGAAGCTCACGA
AATTATCGCCACGACGACACCCCTGATCGAGGCAACCGTCTCCGTTCCGCTGCTCCAGCTCCAGGGCCGGGTGCTTGCCG
AAGATGTCCGTGCCGGATTCGCGATGCCGCGCTTCACCAACGCCGCAATGGACGGCTTCGCCGTGCGATTCGGCGAGATT
GCCGATGCGTCGGACGGCGCTCCCGTGACGCTGCCGGTCTCGCAGGAGCTGGCCGCCGGAGCACTCAACGTTGCGCCACT
CGAAACCGGAACCTGCTGCCGCATCATGACCGGCGCGCCCATTCCCGAAGGCGCTGACACCGTCGTCCCCTTCGAAGAGA
CCAGCGGCTTCGGCAGCGACGCAGTGGAGTTCTACAAAGCCCCGAAAAAGGGCGCGAACATTCGCCACGCGGGCGAGGAA
ATGCAGCCTGGCGCGCTGCTCGCTGCCGCCGGCACCCGCATCACGCCAGCGGAGATCGGCCTGTTCGCCACTTTCGGCAT
CGCCGTGGCGCTCGTGCGGCGGCAGCCGCGCGTCTCGATCATCACGGTTGGCGACGAACTGCGGATGCCAGGCGAACAGA
TCGAACCGCTGGCCATTTACAACAGCAATTTGGCGCTGCTCGCCTCGTGCGTCGAGGGTGCCGGAGCTAAAGTCGTCGGG
ATGCGCCAGTTGCGAGACAACCGGCAAGCGATCCGCGAGGCGCTTGCTTTGGCCATCGCAGAGTCGGACGTCGTCATCAC
CACAGGCGGCATCTCGACGGGCGAGTTCGATTTCATGTACGACGCGCTCAACGAGCTGGGCGTAGAGCAGAAGTTCTGGA
AGGTGGCGCAGAAACCGGGCAAGCCAGTTTACTTTGGCACGACCGGATCGGGCAAGATCGTTTTTTCGTTGCCCGGCAAC
CCGGTCTCGGCGCTCGTCTGCTTCCTCGAATACGGCCTCTCCGCGCTTGCCCGAATGCAGGGCGTGGCGCCAGCCCCAAA
GTTCACTGCGCTGCTCAACGAGCCGTTTCCCACCGACCGCAAGCGCCACCGCTTCCTCTTCGGCCGGCTCAGTGTTGAGG
CGGAAGCGCTCCGCTGCCAGCTCTCGGCGCAGGTCGAGTCGTATATGCTGACGGCGCTCTCCGGTGCGAACTGTCTGGTC
GAAGCGCCGCCCTCCGCCGAACCGCTCCCAGCCGGATCGCTCGTCACCTGCGCCTGGCTTCCGTGGGCAAACGCATGCTG
A

Upstream 100 bases:

>100_bases
TCTGCCTGCCGGGTAGTACGAGCGCGGCCAAAGACGCACTCGAAGTGCTCGTTCCCGCCATCTTCCACGCATTCCCGATG
CTCAAAGGGGATGGCCACGC

Downstream 100 bases:

>100_bases
GCATGTTCCATCCTTTTGAAATCGCGCTCTGCGGCCTCTCCGGCTCAGGAAAAACGACGCTACTCGAAAAGCTGATCCGC
CGCTTCAGCACTGACGGATT

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MMTVVHEAHESKQKQAKTMTTVHEAHEIIATTTPLIEATVSVPLLQLQGRVLAEDVRAGFAMPRFTNAAMDGFAVRFGEI
ADASDGAPVTLPVSQELAAGALNVAPLETGTCCRIMTGAPIPEGADTVVPFEETSGFGSDAVEFYKAPKKGANIRHAGEE
MQPGALLAAAGTRITPAEIGLFATFGIAVALVRRQPRVSIITVGDELRMPGEQIEPLAIYNSNLALLASCVEGAGAKVVG
MRQLRDNRQAIREALALAIAESDVVITTGGISTGEFDFMYDALNELGVEQKFWKVAQKPGKPVYFGTTGSGKIVFSLPGN
PVSALVCFLEYGLSALARMQGVAPAPKFTALLNEPFPTDRKRHRFLFGRLSVEAEALRCQLSAQVESYMLTALSGANCLV
EAPPSAEPLPAGSLVTCAWLPWANAC

Sequences:

>Translated_426_residues
MMTVVHEAHESKQKQAKTMTTVHEAHEIIATTTPLIEATVSVPLLQLQGRVLAEDVRAGFAMPRFTNAAMDGFAVRFGEI
ADASDGAPVTLPVSQELAAGALNVAPLETGTCCRIMTGAPIPEGADTVVPFEETSGFGSDAVEFYKAPKKGANIRHAGEE
MQPGALLAAAGTRITPAEIGLFATFGIAVALVRRQPRVSIITVGDELRMPGEQIEPLAIYNSNLALLASCVEGAGAKVVG
MRQLRDNRQAIREALALAIAESDVVITTGGISTGEFDFMYDALNELGVEQKFWKVAQKPGKPVYFGTTGSGKIVFSLPGN
PVSALVCFLEYGLSALARMQGVAPAPKFTALLNEPFPTDRKRHRFLFGRLSVEAEALRCQLSAQVESYMLTALSGANCLV
EAPPSAEPLPAGSLVTCAWLPWANAC
>Mature_426_residues
MMTVVHEAHESKQKQAKTMTTVHEAHEIIATTTPLIEATVSVPLLQLQGRVLAEDVRAGFAMPRFTNAAMDGFAVRFGEI
ADASDGAPVTLPVSQELAAGALNVAPLETGTCCRIMTGAPIPEGADTVVPFEETSGFGSDAVEFYKAPKKGANIRHAGEE
MQPGALLAAAGTRITPAEIGLFATFGIAVALVRRQPRVSIITVGDELRMPGEQIEPLAIYNSNLALLASCVEGAGAKVVG
MRQLRDNRQAIREALALAIAESDVVITTGGISTGEFDFMYDALNELGVEQKFWKVAQKPGKPVYFGTTGSGKIVFSLPGN
PVSALVCFLEYGLSALARMQGVAPAPKFTALLNEPFPTDRKRHRFLFGRLSVEAEALRCQLSAQVESYMLTALSGANCLV
EAPPSAEPLPAGSLVTCAWLPWANAC

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=413, Percent_Identity=32.4455205811138, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI10880983, Length=383, Percent_Identity=33.6814621409922, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=37.3368146214099, Blast_Score=218, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI25147659, Length=348, Percent_Identity=32.183908045977, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=375, Percent_Identity=26.1333333333333, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136978, Length=414, Percent_Identity=28.0193236714976, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24638841, Length=414, Percent_Identity=28.0193236714976, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45154; Mature: 45154

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTVVHEAHESKQKQAKTMTTVHEAHEIIATTTPLIEATVSVPLLQLQGRVLAEDVRAGF
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHCCHHHHHHHHHCC
AMPRFTNAAMDGFAVRFGEIADASDGAPVTLPVSQELAAGALNVAPLETGTCCRIMTGAP
CCCCHHHHHHCCHHEEECCCCCCCCCCEEEEECCHHHHCCCCEECCCCCCCEEEEEECCC
IPEGADTVVPFEETSGFGSDAVEFYKAPKKGANIRHAGEEMQPGALLAAAGTRITPAEIG
CCCCCCCEEECHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHH
LFATFGIAVALVRRQPRVSIITVGDELRMPGEQIEPLAIYNSNLALLASCVEGAGAKVVG
HHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCEEEECCCHHHHHHHHCCCCCEEEE
MRQLRDNRQAIREALALAIAESDVVITTGGISTGEFDFMYDALNELGVEQKFWKVAQKPG
HHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCC
KPVYFGTTGSGKIVFSLPGNPVSALVCFLEYGLSALARMQGVAPAPKFTALLNEPFPTDR
CCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
KRHRFLFGRLSVEAEALRCQLSAQVESYMLTALSGANCLVEAPPSAEPLPAGSLVTCAWL
HHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEC
PWANAC
CCCCCC
>Mature Secondary Structure
MMTVVHEAHESKQKQAKTMTTVHEAHEIIATTTPLIEATVSVPLLQLQGRVLAEDVRAGF
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHCCHHHHHHHHHCC
AMPRFTNAAMDGFAVRFGEIADASDGAPVTLPVSQELAAGALNVAPLETGTCCRIMTGAP
CCCCHHHHHHCCHHEEECCCCCCCCCCEEEEECCHHHHCCCCEECCCCCCCEEEEEECCC
IPEGADTVVPFEETSGFGSDAVEFYKAPKKGANIRHAGEEMQPGALLAAAGTRITPAEIG
CCCCCCCEEECHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHH
LFATFGIAVALVRRQPRVSIITVGDELRMPGEQIEPLAIYNSNLALLASCVEGAGAKVVG
HHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCEEEECCCHHHHHHHHCCCCCEEEE
MRQLRDNRQAIREALALAIAESDVVITTGGISTGEFDFMYDALNELGVEQKFWKVAQKPG
HHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCC
KPVYFGTTGSGKIVFSLPGNPVSALVCFLEYGLSALARMQGVAPAPKFTALLNEPFPTDR
CCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
KRHRFLFGRLSVEAEALRCQLSAQVESYMLTALSGANCLVEAPPSAEPLPAGSLVTCAWL
HHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEC
PWANAC
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]