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The map label for this gene is moaC

Identifier: 21674152

GI number: 21674152

Start: 1251527

End: 1252465

Strand: Direct

Name: moaC

Synonym: CT1330

Alternate gene names: 21674152

Gene position: 1251527-1252465 (Clockwise)

Preceding gene: 21674144

Following gene: 21674153

Centisome position: 58.08

GC content: 61.87

Gene sequence:

>939_bases
ATGGAATTCACCCACCTCGATGAAAACGGCATGGTTCGCATGGCGGACGTTTCCGGCAAACCGCCAACACGGCGTAAAGC
TTGCGCTTCGGGACGCATCGTTATGCTGCCGGAAACCATCGCGCTGCTCCGCCGAAAGGAACTCCCGAAGGGCAACGTAC
TCGCCGCAGCCAAGATCGCTGGCATCCAGGCGGCCAAACAGACCTCGACACTCATCCCTCTCTGTCACCAGCTTAACCTT
TCGTGGATCGACATCGAATTCGAGATCGGCGACGACTCGATCGGTATTGCAGCAACCGTCATCACGCGCGAATCGACCGG
CGTCGAGATGGAGGCACTCGCCGCCGTCTCTGTAGCGGCGCTGACCATTTACGACATGTGCAAGGCGGTGGACAAGACGA
TGGAGATTTCCGCCATCCGACTCGACCACAAAACCGGCGGCAAGTCGTCGGCAGCAGAGTATCACCCGCGCACGGCTATT
CTCGTCATGTCGGACTCCATCGCAGCAGGCACGGCGACCGACCATTCCGGTGCGATTTTGCGCGAAGGTCTTCAAAAAGC
TGGATGCGCGGTCGAGGCACTAACCATCACTCCCGACGAACCGGTCGAGATCGCCGCGACGGTCGAGGCCTGGATCGGCG
AGGGCATCGAGTTCATCGTTACCTCCGGCGGCACCGGCCTCGGCCCGCGCGACCTCGCCATCGACACGCTTGCCCCGAAG
TTCACCCGACGACTGCCCGGCGTGGAGCAGGAGCTGCTTCGGTGGGGGCAAACGAAAACGCGAACTGCGATGCTTTCGCG
CCTCGCCGCCGGCGTAATCGGCAACACGGTGGTCGTCTGCCTGCCGGGTAGTACGAGCGCGGCCAAAGACGCACTCGAAG
TGCTCGTTCCCGCCATCTTCCACGCATTCCCGATGCTCAAAGGGGATGGCCACGCATGA

Upstream 100 bases:

>100_bases
AAGAACAGAATAGAGGACCGGCCTCGACGCTGCATTGTCAATCCCGGAGCCTGAACGCACAACTGGTATGGTTTTCCGGT
CGAACGAAATCTTGCTAATC

Downstream 100 bases:

>100_bases
TGACCGTCGTTCACGAAGCTCACGAAAGTAAACAAAAACAGGCCAAAACAATGACGACCGTTCACGAAGCTCACGAAATT
ATCGCCACGACGACACCCCT

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEFTHLDENGMVRMADVSGKPPTRRKACASGRIVMLPETIALLRRKELPKGNVLAAAKIAGIQAAKQTSTLIPLCHQLNL
SWIDIEFEIGDDSIGIAATVITRESTGVEMEALAAVSVAALTIYDMCKAVDKTMEISAIRLDHKTGGKSSAAEYHPRTAI
LVMSDSIAAGTATDHSGAILREGLQKAGCAVEALTITPDEPVEIAATVEAWIGEGIEFIVTSGGTGLGPRDLAIDTLAPK
FTRRLPGVEQELLRWGQTKTRTAMLSRLAAGVIGNTVVVCLPGSTSAAKDALEVLVPAIFHAFPMLKGDGHA

Sequences:

>Translated_312_residues
MEFTHLDENGMVRMADVSGKPPTRRKACASGRIVMLPETIALLRRKELPKGNVLAAAKIAGIQAAKQTSTLIPLCHQLNL
SWIDIEFEIGDDSIGIAATVITRESTGVEMEALAAVSVAALTIYDMCKAVDKTMEISAIRLDHKTGGKSSAAEYHPRTAI
LVMSDSIAAGTATDHSGAILREGLQKAGCAVEALTITPDEPVEIAATVEAWIGEGIEFIVTSGGTGLGPRDLAIDTLAPK
FTRRLPGVEQELLRWGQTKTRTAMLSRLAAGVIGNTVVVCLPGSTSAAKDALEVLVPAIFHAFPMLKGDGHA
>Mature_312_residues
MEFTHLDENGMVRMADVSGKPPTRRKACASGRIVMLPETIALLRRKELPKGNVLAAAKIAGIQAAKQTSTLIPLCHQLNL
SWIDIEFEIGDDSIGIAATVITRESTGVEMEALAAVSVAALTIYDMCKAVDKTMEISAIRLDHKTGGKSSAAEYHPRTAI
LVMSDSIAAGTATDHSGAILREGLQKAGCAVEALTITPDEPVEIAATVEAWIGEGIEFIVTSGGTGLGPRDLAIDTLAPK
FTRRLPGVEQELLRWGQTKTRTAMLSRLAAGVIGNTVVVCLPGSTSAAKDALEVLVPAIFHAFPMLKGDGHA

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family

Homologues:

Organism=Homo sapiens, GI66932975, Length=159, Percent_Identity=32.7044025157233, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI10880983, Length=159, Percent_Identity=32.7044025157233, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1787001, Length=150, Percent_Identity=48.6666666666667, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787000, Length=170, Percent_Identity=34.1176470588235, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI32566331, Length=150, Percent_Identity=42.6666666666667, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17564954, Length=166, Percent_Identity=32.5301204819277, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574490, Length=162, Percent_Identity=43.2098765432099, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28574492, Length=150, Percent_Identity=44, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI17136978, Length=152, Percent_Identity=29.6052631578947, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24638841, Length=152, Percent_Identity=29.6052631578947, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOACB_CHLTE (P59014)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662217.1
- ProteinModelPortal:   P59014
- GeneID:   1006700
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1330
- NMPDR:   fig|194439.1.peg.1311
- TIGR:   CT1330
- HOGENOM:   HBG289233
- OMA:   RTAMLSR
- ProtClustDB:   PRK03604
- BioCyc:   CTEP194439:CT_1330-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- Gene3D:   G3DSA:3.40.980.10
- PIRSF:   PIRSF036594
- SMART:   SM00852
- TIGRFAMs:   TIGR00581
- TIGRFAMs:   TIGR00177

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth; SSF55040 MoaC; SSF53218 MoCF_biosynth

EC number: NA

Molecular weight: Translated: 32917; Mature: 32917

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFTHLDENGMVRMADVSGKPPTRRKACASGRIVMLPETIALLRRKELPKGNVLAAAKIA
CCCCEECCCCCEEEEECCCCCCCHHHHHHCCCEEECCHHHHHHHHHCCCCCCEEEEHHHH
GIQAAKQTSTLIPLCHQLNLSWIDIEFEIGDDSIGIAATVITRESTGVEMEALAAVSVAA
HHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LTIYDMCKAVDKTMEISAIRLDHKTGGKSSAAEYHPRTAILVMSDSIAAGTATDHSGAIL
HHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCCCCHHH
REGLQKAGCAVEALTITPDEPVEIAATVEAWIGEGIEFIVTSGGTGLGPRDLAIDTLAPK
HHHHHHCCCEEEEEEECCCCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCHH
FTRRLPGVEQELLRWGQTKTRTAMLSRLAAGVIGNTVVVCLPGSTSAAKDALEVLVPAIF
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
HAFPMLKGDGHA
HHHHCCCCCCCC
>Mature Secondary Structure
MEFTHLDENGMVRMADVSGKPPTRRKACASGRIVMLPETIALLRRKELPKGNVLAAAKIA
CCCCEECCCCCEEEEECCCCCCCHHHHHHCCCEEECCHHHHHHHHHCCCCCCEEEEHHHH
GIQAAKQTSTLIPLCHQLNLSWIDIEFEIGDDSIGIAATVITRESTGVEMEALAAVSVAA
HHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LTIYDMCKAVDKTMEISAIRLDHKTGGKSSAAEYHPRTAILVMSDSIAAGTATDHSGAIL
HHHHHHHHHHHHHHEEEEEEEECCCCCCCCCHHCCCCEEEEEEECCCCCCCCCCCCCHHH
REGLQKAGCAVEALTITPDEPVEIAATVEAWIGEGIEFIVTSGGTGLGPRDLAIDTLAPK
HHHHHHCCCEEEEEEECCCCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHCHH
FTRRLPGVEQELLRWGQTKTRTAMLSRLAAGVIGNTVVVCLPGSTSAAKDALEVLVPAIF
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
HAFPMLKGDGHA
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901