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The map label for this gene is tmk

Identifier: 21674136

GI number: 21674136

Start: 1233619

End: 1234263

Strand: Direct

Name: tmk

Synonym: CT1313

Alternate gene names: 21674136

Gene position: 1233619-1234263 (Clockwise)

Preceding gene: 21674135

Following gene: 21674137

Centisome position: 57.25

GC content: 56.12

Gene sequence:

>645_bases
ATGCTCATTTCATTTGAAGGAATCGACGGCGCAGGAAAATCAACCCAGGTCATGAAGCTCAAACGCTATCTTCAAGAGCG
AGGGCGCGAAGTTCTGGCCCTGCGCGAACCGGGTGGCACTCCCGTGGCCGAAGAGATCAGGGAGCTGCTGCTCGAAAGAC
GCAACGACATCACCCCCGTCGGGGAGCTGCTGCTCTTTGCAGCGAGCCGCGCGGAGCTGGTGCAGCAGGTTATCCAGCCG
GCGCTCGAAAACGACAGTGACGTCATTCTCGACCGCTTCTTTGATTCAACGACTGCCTATCAGGGTTACGGGCGGGGCCT
TGACCTGGACATGCTGGCCGAAATCAACCGCATCGCCTCATGCCGCCTCGTGCCGGATGTCACCTTCTATCTCGACCTCA
CCCCGGAAGACGCGCTCATGAGAAAGTTTTCCGAAAAGTCCCTGCCACTGGCGTTCGAATCTGAAGAGCTCGACCGGATG
GAAAACTCAGGGCTTGATTTTTACCGGCGAGTGCGGGAGGGATATCACAAAATCGGCGGCGAAAACCCGAACCGGATCAT
CATCATCGACGCGCTCCTGAGTCCATCGGAAATTCACCGTAAAATTATTTCAAGCATTGACGCGCTCTGCACAAAAACCG
CATAA

Upstream 100 bases:

>100_bases
TAAAGATTGCGGCCACTCTCCAATGCTCGAATATCCGGAACAGTTCAGCACAGCAATCACGGAATTCATTCACCAGGAAC
CACCATTGCCTTAACCTGTT

Downstream 100 bases:

>100_bases
AAAGAGCGCTCCGGAACCGTAAACAGCTTTAGCTTGTTCTCTGACTGACTGATATAGATGTTTATTTTACTGGATTGCTG
TCGGTTTTTGTTGTAAATTT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MLISFEGIDGAGKSTQVMKLKRYLQERGREVLALREPGGTPVAEEIRELLLERRNDITPVGELLLFAASRAELVQQVIQP
ALENDSDVILDRFFDSTTAYQGYGRGLDLDMLAEINRIASCRLVPDVTFYLDLTPEDALMRKFSEKSLPLAFESEELDRM
ENSGLDFYRRVREGYHKIGGENPNRIIIIDALLSPSEIHRKIISSIDALCTKTA

Sequences:

>Translated_214_residues
MLISFEGIDGAGKSTQVMKLKRYLQERGREVLALREPGGTPVAEEIRELLLERRNDITPVGELLLFAASRAELVQQVIQP
ALENDSDVILDRFFDSTTAYQGYGRGLDLDMLAEINRIASCRLVPDVTFYLDLTPEDALMRKFSEKSLPLAFESEELDRM
ENSGLDFYRRVREGYHKIGGENPNRIIIIDALLSPSEIHRKIISSIDALCTKTA
>Mature_214_residues
MLISFEGIDGAGKSTQVMKLKRYLQERGREVLALREPGGTPVAEEIRELLLERRNDITPVGELLLFAASRAELVQQVIQP
ALENDSDVILDRFFDSTTAYQGYGRGLDLDMLAEINRIASCRLVPDVTFYLDLTPEDALMRKFSEKSLPLAFESEELDRM
ENSGLDFYRRVREGYHKIGGENPNRIIIIDALLSPSEIHRKIISSIDALCTKTA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=194, Percent_Identity=41.2371134020619, Blast_Score=124, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28573735, Length=213, Percent_Identity=28.169014084507, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_CHLTE (Q8KCU7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662201.1
- ProteinModelPortal:   Q8KCU7
- SMR:   Q8KCU7
- GeneID:   1006676
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1313
- NMPDR:   fig|194439.1.peg.1295
- TIGR:   CT1313
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   CLSK637698
- BioCyc:   CTEP194439:CT_1313-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24147; Mature: 24147

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISFEGIDGAGKSTQVMKLKRYLQERGREVLALREPGGTPVAEEIRELLLERRNDITPV
CEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHH
GELLLFAASRAELVQQVIQPALENDSDVILDRFFDSTTAYQGYGRGLDLDMLAEINRIAS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHH
CRLVPDVTFYLDLTPEDALMRKFSEKSLPLAFESEELDRMENSGLDFYRRVREGYHKIGG
CEECCCEEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHCCCHHHHHHHHHHHHHCCC
ENPNRIIIIDALLSPSEIHRKIISSIDALCTKTA
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLISFEGIDGAGKSTQVMKLKRYLQERGREVLALREPGGTPVAEEIRELLLERRNDITPV
CEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHH
GELLLFAASRAELVQQVIQPALENDSDVILDRFFDSTTAYQGYGRGLDLDMLAEINRIAS
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHH
CRLVPDVTFYLDLTPEDALMRKFSEKSLPLAFESEELDRMENSGLDFYRRVREGYHKIGG
CEECCCEEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHCCCHHHHHHHHHHHHHCCC
ENPNRIIIIDALLSPSEIHRKIISSIDALCTKTA
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901