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The map label for this gene is adhA [H]

Identifier: 21674098

GI number: 21674098

Start: 1193454

End: 1194470

Strand: Reverse

Name: adhA [H]

Synonym: CT1275

Alternate gene names: 21674098

Gene position: 1194470-1193454 (Counterclockwise)

Preceding gene: 21674099

Following gene: 21674096

Centisome position: 55.43

GC content: 63.03

Gene sequence:

>1017_bases
ATGGTGCTGGAGCGGGTTGTCGATCTTTTGCACGAGACGCAACCGCTGGTTCTGCGGGAGTTGCCCGTTCCCGAGCCGGG
GCCGGGGGAGATTCTGTTGAGGGTCGCCACCTGTGGCGTCTGCCACACGGAGCTTGACGAAATCGAGGGGCGCACGCCGC
CGCCGCGATTTCCGGTGATTCCGGGACATCAGGTCATTGGGCGGGTTGTTGCCTGCGGCGATGGCGTCGCGGGCATCGAA
ACCGGCAGTCGACGCGGGGTGGCGTGGATTTACTCTTCGTGTGGTCACTGCGACCTCTGCCGCTCCGGTAACGAAAACCT
CTGCGCGGAGTTCAGCGCGACAGGCCGCGACGCCGATGGAGGCTACGCGGAGTATATGGTGGCTCCGGCGGCCTTCACCT
ATTCCATTCCCGATGTGTTCTCCGACGCCGAGGCCGCTCCGCTCCTCTGCGGCGGCGCGATCGGCTACCGTTCGCTGATG
CTCGCAAACCTCAAAGATGGTCAGATTCTCGGCCTGACCGGGTTCGGCGCATCGGGCCATCAGGTGCTCAAACTCGCTCG
CTATCTCTATCCAAAATCTCCGGTCTTCGTCTTCGCCCGAAGCGAAAAAGACTGCGATTTCGCCCGCTCGCTTGGCGCGG
ACTGGGCTGGCGGTACCACAGACAACTCGCCGTCGCCCTGTGATTCCATTATCGATACGACGCCCGCCTGGTTGCCAGTG
CTTTCGGCGCTCGAACGGCTTCGGCCCGGCGGACGGCTCGTCATCAATGCGATCCGCAAGGAGTCGCACGATAGCGAGTT
GCTCGCGGGCATTTCCTACGAACGGCACCTCTGGATGGAGAAGGAGATCAAAAGCGTGGCCAACATTACGCGGGCCGATG
TGTCGGCGTTCCTCGACATCGCCGCCCGCATGGGGCTGAAGCCGGAGGTGCGGAGCTATCCGCTCGAAGAGGCCAACCGT
GTGCTGCTCGATCTGCGTCACGGAAAAGCCCGCGGTGCTGCGGTACTCATTCCATAA

Upstream 100 bases:

>100_bases
ATGAATTGAAGATTCAATAGGGCGGACTTTTGTGTCCGCCCTTTGCTTTTTTGCATGGCTTTTGTGAATTTGCGGAAAAG
GGAGAGCCATGATGAACGCG

Downstream 100 bases:

>100_bases
TCAGGAGGTTTTGGCAACCTCCATTCCGACAGTGGTTGACGGACTGAGCATTTTGTGCCCGGTATCGAGCAATGTGCTGA
CCGCTCCGCTGTCGGTGCTG

Product: alcohol dehydrogenase, zinc-containing

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MVLERVVDLLHETQPLVLRELPVPEPGPGEILLRVATCGVCHTELDEIEGRTPPPRFPVIPGHQVIGRVVACGDGVAGIE
TGSRRGVAWIYSSCGHCDLCRSGNENLCAEFSATGRDADGGYAEYMVAPAAFTYSIPDVFSDAEAAPLLCGGAIGYRSLM
LANLKDGQILGLTGFGASGHQVLKLARYLYPKSPVFVFARSEKDCDFARSLGADWAGGTTDNSPSPCDSIIDTTPAWLPV
LSALERLRPGGRLVINAIRKESHDSELLAGISYERHLWMEKEIKSVANITRADVSAFLDIAARMGLKPEVRSYPLEEANR
VLLDLRHGKARGAAVLIP

Sequences:

>Translated_338_residues
MVLERVVDLLHETQPLVLRELPVPEPGPGEILLRVATCGVCHTELDEIEGRTPPPRFPVIPGHQVIGRVVACGDGVAGIE
TGSRRGVAWIYSSCGHCDLCRSGNENLCAEFSATGRDADGGYAEYMVAPAAFTYSIPDVFSDAEAAPLLCGGAIGYRSLM
LANLKDGQILGLTGFGASGHQVLKLARYLYPKSPVFVFARSEKDCDFARSLGADWAGGTTDNSPSPCDSIIDTTPAWLPV
LSALERLRPGGRLVINAIRKESHDSELLAGISYERHLWMEKEIKSVANITRADVSAFLDIAARMGLKPEVRSYPLEEANR
VLLDLRHGKARGAAVLIP
>Mature_338_residues
MVLERVVDLLHETQPLVLRELPVPEPGPGEILLRVATCGVCHTELDEIEGRTPPPRFPVIPGHQVIGRVVACGDGVAGIE
TGSRRGVAWIYSSCGHCDLCRSGNENLCAEFSATGRDADGGYAEYMVAPAAFTYSIPDVFSDAEAAPLLCGGAIGYRSLM
LANLKDGQILGLTGFGASGHQVLKLARYLYPKSPVFVFARSEKDCDFARSLGADWAGGTTDNSPSPCDSIIDTTPAWLPV
LSALERLRPGGRLVINAIRKESHDSELLAGISYERHLWMEKEIKSVANITRADVSAFLDIAARMGLKPEVRSYPLEEANR
VLLDLRHGKARGAAVLIP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=196, Percent_Identity=27.0408163265306, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI262073058, Length=196, Percent_Identity=27.0408163265306, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI156627571, Length=340, Percent_Identity=26.1764705882353, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI71565154, Length=192, Percent_Identity=28.125, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87081918, Length=344, Percent_Identity=29.3604651162791, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI87082401, Length=332, Percent_Identity=28.9156626506024, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1786518, Length=210, Percent_Identity=34.2857142857143, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787863, Length=223, Percent_Identity=28.6995515695067, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788073, Length=259, Percent_Identity=28.957528957529, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI226510992, Length=174, Percent_Identity=30.4597701149425, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790045, Length=209, Percent_Identity=29.6650717703349, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87082125, Length=180, Percent_Identity=30, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786552, Length=223, Percent_Identity=30.0448430493274, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788075, Length=262, Percent_Identity=24.0458015267176, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=324, Percent_Identity=25.6172839506173, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=27.6785714285714, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=336, Percent_Identity=26.4880952380952, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=273, Percent_Identity=25.6410256410256, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=346, Percent_Identity=27.1676300578035, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=347, Percent_Identity=27.0893371757925, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323961, Length=350, Percent_Identity=26.2857142857143, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324486, Length=168, Percent_Identity=35.1190476190476, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=193, Percent_Identity=30.5699481865285, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=311, Percent_Identity=24.7588424437299, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=224, Percent_Identity=28.125, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737895, Length=191, Percent_Identity=27.7486910994764, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737897, Length=218, Percent_Identity=29.3577981651376, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137530, Length=218, Percent_Identity=27.5229357798165, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36403; Mature: 36403

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLERVVDLLHETQPLVLRELPVPEPGPGEILLRVATCGVCHTELDEIEGRTPPPRFPVI
CHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEHHCCCHHHHHHHHCCCCCCCCCCCC
PGHQVIGRVVACGDGVAGIETGSRRGVAWIYSSCGHCDLCRSGNENLCAEFSATGRDADG
CCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCEEEEECCCCCCCCC
GYAEYMVAPAAFTYSIPDVFSDAEAAPLLCGGAIGYRSLMLANLKDGQILGLTGFGASGH
CHHHEEEECHHEEEECCHHHCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEECCCCCHH
QVLKLARYLYPKSPVFVFARSEKDCDFARSLGADWAGGTTDNSPSPCDSIIDTTPAWLPV
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHH
LSALERLRPGGRLVINAIRKESHDSELLAGISYERHLWMEKEIKSVANITRADVSAFLDI
HHHHHHHCCCCCEEHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARMGLKPEVRSYPLEEANRVLLDLRHGKARGAAVLIP
HHHCCCCCHHHCCCHHHHCEEEEEECCCCCCCCEEECC
>Mature Secondary Structure
MVLERVVDLLHETQPLVLRELPVPEPGPGEILLRVATCGVCHTELDEIEGRTPPPRFPVI
CHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEEHHCCCHHHHHHHHCCCCCCCCCCCC
PGHQVIGRVVACGDGVAGIETGSRRGVAWIYSSCGHCDLCRSGNENLCAEFSATGRDADG
CCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCCCEEEEECCCCCCCCC
GYAEYMVAPAAFTYSIPDVFSDAEAAPLLCGGAIGYRSLMLANLKDGQILGLTGFGASGH
CHHHEEEECHHEEEECCHHHCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEECCCCCHH
QVLKLARYLYPKSPVFVFARSEKDCDFARSLGADWAGGTTDNSPSPCDSIIDTTPAWLPV
HHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHH
LSALERLRPGGRLVINAIRKESHDSELLAGISYERHLWMEKEIKSVANITRADVSAFLDI
HHHHHHHCCCCCEEHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARMGLKPEVRSYPLEEANRVLLDLRHGKARGAAVLIP
HHHCCCCCHHHCCCHHHHCEEEEEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]