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The map label for this gene is hisC

Identifier: 21674079

GI number: 21674079

Start: 1180157

End: 1181203

Strand: Reverse

Name: hisC

Synonym: CT1256

Alternate gene names: 21674079

Gene position: 1181203-1180157 (Counterclockwise)

Preceding gene: 21674085

Following gene: 21674078

Centisome position: 54.81

GC content: 57.21

Gene sequence:

>1047_bases
ATGCTCAATCCTGCCCTGGAGCATATCGAGACTTATAAGGTCGAGGGTGGCCAGGAGGCTGAGGTCAAGCTGAACCAGAA
CGAGAACCCCTTCGATCTGCCCTCGTGGCTCAAGGACAAGATTCTCGACCAGTTCCGCCATGAGCCCTGGAACCGCTATC
CGGATATTCTGCCGTACCGGGGCATGGCGGCCTATGCATCGTTTCTCGGCGTGAAGCCGGAGTTGGTGATCATGAGCAAT
GGTTCGAACGAGATGCTCTACACCATCTTCATGGCCTGCCTCGGCGCTGGTCGCAAGGTGCTTATTCCAGAGCCTTCGTT
TTCGCTTTACGACAAGCTTGCACGTCTTCAGCAGGCTGGGGTTGTCGAGGTGCCGATGCATGACGATCTCTCCTTTGACG
TCGATGCGATCATCGAAGCCGCCAGGCGCGAGAAGGTCGATTTTATCGTGCTCTCCACGCCGAACAATCCGACCAGCAAG
TCGCTGTCCCACGACGAGATCGAACGCATTGTCGAAGCTGCCGACGCCATTGTGCTGGTCGATGAAGCGTATGTCGAGTT
TTCGCGTGAGCAATCGGCGCTCGACCTGATCGACCGCTACCCGAACCTGATCGTGTTGCGCACCATGTCCAAGGCGCTTG
CGCTGGCCGGAATGCGTATCGGCTTTGCGATTGCCAATCCGGAGCTGCTGGCCGAAATCTCCAAGCCGAAGATTCCCTTC
GCGTCGAGCCGACTGGCGGAAATCACTCTCATGGCTGTGCTCGAAAACTACTCACTCGTGACCGACGCCGTGCAGTACAT
CCTCGCCGAGCGCGGGCGCATCGAGGCGGAGCTGACAGAAATTCCTGGCATCCATACCTTCGAGAGCGACACCAACTTCC
TCATCATTCGCGTCGCCAACGCATCCGAGGTGTTCAGGAAGCTCAAAAATGCCGGAGTGCTGGTTCGGAACGTGTCGGGA
TACCCGCTTATGGAGAACTGCCTCCGCTTCAATGTTGGTCTCAGGGAGGAGAACGACCGCCTGTTGGAACTGCTGAAAAA
GCTCTGA

Upstream 100 bases:

>100_bases
TCGTTTCTTGGATGGTGTTGCGACCAGTTTTATACTGGCACCACCTCTTAAGACGTCGAAAACCGGTAAATCAAGCATCA
TGAAAAGAGATCTCAGGACC

Downstream 100 bases:

>100_bases
GATGTCGGGTTTCAGGCAGTTGACGGGAGACGAGATGGGGCGGCTGACGCCCGAGGCCTATGCTGATTCAGCGCGGCATC
CGGTGACGCTCATGCTGTAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MLNPALEHIETYKVEGGQEAEVKLNQNENPFDLPSWLKDKILDQFRHEPWNRYPDILPYRGMAAYASFLGVKPELVIMSN
GSNEMLYTIFMACLGAGRKVLIPEPSFSLYDKLARLQQAGVVEVPMHDDLSFDVDAIIEAARREKVDFIVLSTPNNPTSK
SLSHDEIERIVEAADAIVLVDEAYVEFSREQSALDLIDRYPNLIVLRTMSKALALAGMRIGFAIANPELLAEISKPKIPF
ASSRLAEITLMAVLENYSLVTDAVQYILAERGRIEAELTEIPGIHTFESDTNFLIIRVANASEVFRKLKNAGVLVRNVSG
YPLMENCLRFNVGLREENDRLLELLKKL

Sequences:

>Translated_348_residues
MLNPALEHIETYKVEGGQEAEVKLNQNENPFDLPSWLKDKILDQFRHEPWNRYPDILPYRGMAAYASFLGVKPELVIMSN
GSNEMLYTIFMACLGAGRKVLIPEPSFSLYDKLARLQQAGVVEVPMHDDLSFDVDAIIEAARREKVDFIVLSTPNNPTSK
SLSHDEIERIVEAADAIVLVDEAYVEFSREQSALDLIDRYPNLIVLRTMSKALALAGMRIGFAIANPELLAEISKPKIPF
ASSRLAEITLMAVLENYSLVTDAVQYILAERGRIEAELTEIPGIHTFESDTNFLIIRVANASEVFRKLKNAGVLVRNVSG
YPLMENCLRFNVGLREENDRLLELLKKL
>Mature_348_residues
MLNPALEHIETYKVEGGQEAEVKLNQNENPFDLPSWLKDKILDQFRHEPWNRYPDILPYRGMAAYASFLGVKPELVIMSN
GSNEMLYTIFMACLGAGRKVLIPEPSFSLYDKLARLQQAGVVEVPMHDDLSFDVDAIIEAARREKVDFIVLSTPNNPTSK
SLSHDEIERIVEAADAIVLVDEAYVEFSREQSALDLIDRYPNLIVLRTMSKALALAGMRIGFAIANPELLAEISKPKIPF
ASSRLAEITLMAVLENYSLVTDAVQYILAERGRIEAELTEIPGIHTFESDTNFLIIRVANASEVFRKLKNAGVLVRNVSG
YPLMENCLRFNVGLREENDRLLELLKKL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=336, Percent_Identity=32.7380952380952, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1788722, Length=171, Percent_Identity=29.8245614035088, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994476, Length=171, Percent_Identity=29.2397660818713, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=171, Percent_Identity=29.2397660818713, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=186, Percent_Identity=27.9569892473118, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=327, Percent_Identity=31.4984709480122, Blast_Score=133, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_CHLTE (Q8KD01)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662144.1
- ProteinModelPortal:   Q8KD01
- SMR:   Q8KD01
- GeneID:   1006613
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1256
- NMPDR:   fig|194439.1.peg.1238
- TIGR:   CT1256
- HOGENOM:   HBG646350
- OMA:   RDFSKEP
- ProtClustDB:   CLSK637673
- BioCyc:   CTEP194439:CT_1256-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39183; Mature: 39183

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNPALEHIETYKVEGGQEAEVKLNQNENPFDLPSWLKDKILDQFRHEPWNRYPDILPYR
CCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
GMAAYASFLGVKPELVIMSNGSNEMLYTIFMACLGAGRKVLIPEPSFSLYDKLARLQQAG
CHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCC
VVEVPMHDDLSFDVDAIIEAARREKVDFIVLSTPNNPTSKSLSHDEIERIVEAADAIVLV
EEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEE
DEAYVEFSREQSALDLIDRYPNLIVLRTMSKALALAGMRIGFAIANPELLAEISKPKIPF
EHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEEEECCHHHHHHHCCCCCCC
ASSRLAEITLMAVLENYSLVTDAVQYILAERGRIEAELTEIPGIHTFESDTNFLIIRVAN
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEHHHCCCCEEECCCCCEEEEEECC
ASEVFRKLKNAGVLVRNVSGYPLMENCLRFNVGLREENDRLLELLKKL
HHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MLNPALEHIETYKVEGGQEAEVKLNQNENPFDLPSWLKDKILDQFRHEPWNRYPDILPYR
CCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
GMAAYASFLGVKPELVIMSNGSNEMLYTIFMACLGAGRKVLIPEPSFSLYDKLARLQQAG
CHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCC
VVEVPMHDDLSFDVDAIIEAARREKVDFIVLSTPNNPTSKSLSHDEIERIVEAADAIVLV
EEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEEE
DEAYVEFSREQSALDLIDRYPNLIVLRTMSKALALAGMRIGFAIANPELLAEISKPKIPF
EHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHEEEECCHHHHHHHCCCCCCC
ASSRLAEITLMAVLENYSLVTDAVQYILAERGRIEAELTEIPGIHTFESDTNFLIIRVAN
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEHHHCCCCEEECCCCCEEEEEECC
ASEVFRKLKNAGVLVRNVSGYPLMENCLRFNVGLREENDRLLELLKKL
HHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901