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The map label for this gene is coaE

Identifier: 21674034

GI number: 21674034

Start: 1135835

End: 1136461

Strand: Reverse

Name: coaE

Synonym: CT1209

Alternate gene names: 21674034

Gene position: 1136461-1135835 (Counterclockwise)

Preceding gene: 21674035

Following gene: 21674031

Centisome position: 52.74

GC content: 59.81

Gene sequence:

>627_bases
ATGAAGGCGCGCCTGCCATTGCTCGTCGGGGTGACCGGCGGCATCGGGAGCGGCAAGAGTACGGTTTGCGCCATGCTTGC
CGAAATGGGATGCGAACTGTTCGAGGCCGACCGGATTGCCAAAGAACTGCAAGTTGAAGATCCCGAGGTAATCAGGGGGA
TTGAAAAACTTTTTGGCCCGGATGTTTACTCGCGCGATGCATCAGGCAAACTTCTCATCGACCGTAAAGCCATTGCTGCG
ATTGTCTTTTCCGAGCCGGAAAAGCTTGCCGCTCTCAACCGGCTCATCCATCCGAAGGTCAGGGAGGCCTTTGTCAACGA
AGTGAAGCGTTGCGCACGCGAAGGCAAACGGATTCTCTGCAAGGAGGCGGCGATTCTGTTCGAGGCGGGCGCGGATCGCG
ATCTCGACCGTATCATCGTGGTGGCGGCAAACGACGGCCTGCGGCTCGCTCGCGCCGTCGCTCGAGGTCTCGCTTGCGAG
GAGGCTCGCAAGCGGATGCAGGCGCAGTGGCCGCAGGAGAAGCTCGTCGAGCGGGCGCACTACGTAATTTTCAACGACGG
CACCCTCGACGAGTTGCGGTCGCAGGTCGAGCAGGTATACCAGAGCCTTCTCACGGTGGTTGAGTAG

Upstream 100 bases:

>100_bases
AAACCTTTGACGCGCGGCTGGACGCTTATTCTCGCAATCCCGAGCTTTGGCGCAAAGTGCTGCTGGAGGTGCGCCGCAAT
CTTGATCAAGAAAGCCGTAA

Downstream 100 bases:

>100_bases
CAAAATGACCTTTCCAGCGTTTTCCTCGAAATCGATTTGGATGAGTTTTTCGCGGGTCTTCAGATGAAGGTCGTGAGGCA
GATCGTCTTACTCTGAAATC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKARLPLLVGVTGGIGSGKSTVCAMLAEMGCELFEADRIAKELQVEDPEVIRGIEKLFGPDVYSRDASGKLLIDRKAIAA
IVFSEPEKLAALNRLIHPKVREAFVNEVKRCAREGKRILCKEAAILFEAGADRDLDRIIVVAANDGLRLARAVARGLACE
EARKRMQAQWPQEKLVERAHYVIFNDGTLDELRSQVEQVYQSLLTVVE

Sequences:

>Translated_208_residues
MKARLPLLVGVTGGIGSGKSTVCAMLAEMGCELFEADRIAKELQVEDPEVIRGIEKLFGPDVYSRDASGKLLIDRKAIAA
IVFSEPEKLAALNRLIHPKVREAFVNEVKRCAREGKRILCKEAAILFEAGADRDLDRIIVVAANDGLRLARAVARGLACE
EARKRMQAQWPQEKLVERAHYVIFNDGTLDELRSQVEQVYQSLLTVVE
>Mature_208_residues
MKARLPLLVGVTGGIGSGKSTVCAMLAEMGCELFEADRIAKELQVEDPEVIRGIEKLFGPDVYSRDASGKLLIDRKAIAA
IVFSEPEKLAALNRLIHPKVREAFVNEVKRCAREGKRILCKEAAILFEAGADRDLDRIIVVAANDGLRLARAVARGLACE
EARKRMQAQWPQEKLVERAHYVIFNDGTLDELRSQVEQVYQSLLTVVE

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=199, Percent_Identity=28.1407035175879, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI191252795, Length=199, Percent_Identity=28.1407035175879, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI110227607, Length=194, Percent_Identity=26.8041237113402, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI110227605, Length=194, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI110227603, Length=194, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI110227601, Length=194, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI205277394, Length=194, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=9e-15,
Organism=Escherichia coli, GI1786292, Length=198, Percent_Identity=26.7676767676768, Blast_Score=70, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17554944, Length=198, Percent_Identity=32.8282828282828, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25143409, Length=203, Percent_Identity=27.5862068965517, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320402, Length=201, Percent_Identity=32.8358208955224, Blast_Score=91, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24644728, Length=197, Percent_Identity=29.9492385786802, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24658602, Length=204, Percent_Identity=28.921568627451, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_CHLTE (Q8KD46)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662099.1
- ProteinModelPortal:   Q8KD46
- SMR:   Q8KD46
- GeneID:   1006569
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1209
- NMPDR:   fig|194439.1.peg.1193
- TIGR:   CT1209
- HOGENOM:   HBG650290
- OMA:   ARPGMTE
- ProtClustDB:   PRK14731
- BioCyc:   CTEP194439:CT_1209-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 23057; Mature: 23057

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKARLPLLVGVTGGIGSGKSTVCAMLAEMGCELFEADRIAKELQVEDPEVIRGIEKLFGP
CCCCCCEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
DVYSRDASGKLLIDRKAIAAIVFSEPEKLAALNRLIHPKVREAFVNEVKRCAREGKRILC
CCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
KEAAILFEAGADRDLDRIIVVAANDGLRLARAVARGLACEEARKRMQAQWPQEKLVERAH
HHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHC
YVIFNDGTLDELRSQVEQVYQSLLTVVE
EEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKARLPLLVGVTGGIGSGKSTVCAMLAEMGCELFEADRIAKELQVEDPEVIRGIEKLFGP
CCCCCCEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
DVYSRDASGKLLIDRKAIAAIVFSEPEKLAALNRLIHPKVREAFVNEVKRCAREGKRILC
CCCCCCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
KEAAILFEAGADRDLDRIIVVAANDGLRLARAVARGLACEEARKRMQAQWPQEKLVERAH
HHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHC
YVIFNDGTLDELRSQVEQVYQSLLTVVE
EEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901