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The map label for this gene is pepA

Identifier: 21674006

GI number: 21674006

Start: 1109290

End: 1110804

Strand: Reverse

Name: pepA

Synonym: CT1180

Alternate gene names: 21674006

Gene position: 1110804-1109290 (Counterclockwise)

Preceding gene: 21674007

Following gene: 21674004

Centisome position: 51.55

GC content: 55.51

Gene sequence:

>1515_bases
ATGAAATGTACTGTTACGGCTAAAGAGAGCGGCCTGGTTAATGCCGATATTCTCGTCCAGTTTTTCAGCAAAAAAGAGAT
GAAGCGAGATGCAGGCAAAGTTCTCGCAGGTCTGGGTGTTGTTGCGAGCCCTGATGGTGACTTCAAGGCCTCTGCCGGCG
AGATTGCGATGCTCTACCGGCAGGCCTCGGGCAAAGAGGCTTCGAGGGTGATTCTTGCCGGTGTCGGCGAAGGCAAAACC
GCCGAGGATTATCGCAAGGCTGCCGATTCCGTCGCTCGAAAGACGGTTGATCTGCATCTTGGCGTTCTCGCCCTTGATTG
CTCGCCGATCGATGATTGGGCCAAGCAGTCGAAACAGAAGCCGGAAGAGCTGGCAGCCATTCTCGTTGAGGGCGTCCTGT
CCGGAGCTTATCGCTTCGATCGCCTCAAGAGCGGCAAGCTCGACAAGGAGGAGACGAAGGAAGACAAGCCGAAAAACATC
GAAGAGCTGGTGCTTGCCGGATGTGGGAGCAGGCTTGAGGCGATCGAAAAAGGAGCCGGGAAAGGAATGATTATCGGAGC
TTGCCAGAACAGGGCAAGAGACCTGGTCAACCTGCCGGGCAACCATCTTTCTGCCGAAGACCTTGCCGAGGCGGCCATTG
AGGCCGGTAAGCGAGGAGGCTTCGAGGTGACGGTGTTTGATAAAAAGAAAATCGTCGAGCTTGGCATGGGCGGTCTTCTT
GCCGTCAACAAGGGAAGTGAGCAGCCACCGACCTTTGTCATTCTCGACTACAAGCCGAAAGGCAAGGCCAAAAAGACCAT
TGCGCTGGTGGGTAAAGGCGTGACCTTTGATTCGGGCGGCATTTCTCTGAAGCCGGCCCAGGGGATGGACGAGATGAAAT
CGGATATGTCCGGAGCCGCTGTGGTGATTGCCGCAATTGAAGCTGCTGCAAGCCTTGGTCTGCCGCTCAGGGTGGTTGGT
CTGGTTCCCGCTACCGACAACATGCCAGGCGGCTCGGCGCAAAAGCCTGGTGATGTGATCACGACCATGTCGGGCATTAC
GGTCGAGGTTGGCAACACCGATGCCGAGGGACGACTGATTCTTGCTGATGCCCTGTTTTACGCCAAGAAAGAGTATAATC
CTGATGTGATTATTGATTTAGCTACACTGACTGGTGCGTGCATTGTGGCGCTTGGCAACTCGGTGGCCGGACTTTTCAGC
AATGATGAAAAACTGGCTGAGAGTATTTTCGAGGCTGGCCAGTCGTCCGGTGAAAAGGTGTGGCGGTTGCCGCTCTGGGA
TGAGTACGACGAGCTCATCAAGTCCGACGTTGCCGATGTGCACAATACCGGCGGACGCGGCGCGGGTACGATTACTGCGG
CTAAATTTCTCGAGAAGTTTATCGACGGCCACAAGCACTGGGCGCATATCGACATCGCAGGACCGGCTTTTTGGGCAAAA
GGCGGGTCGAAGACGCCGGGAGCAACCGGCTTCGGTGTTCGTCTCTTGCTTGATCTGCTTAAAGGCTGGTCATAA

Upstream 100 bases:

>100_bases
AGAGAAGGCGCAACTTGTGATTCTTGAGGATGTCCGGAAGTTCACCCTCGAACAGGTGGACAGTTAATTTCTTTCAATTA
TTTCCCATTTACGTGCAAGC

Downstream 100 bases:

>100_bases
GACAGATTGACGGTAGATTCACCTGTTCATGCTTCACAACCCGCACAGGAGGCTTTGTTCCAATATGGCAGAGGTCAGGC
AGAATCCGGTGGTGATCGTT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MKCTVTAKESGLVNADILVQFFSKKEMKRDAGKVLAGLGVVASPDGDFKASAGEIAMLYRQASGKEASRVILAGVGEGKT
AEDYRKAADSVARKTVDLHLGVLALDCSPIDDWAKQSKQKPEELAAILVEGVLSGAYRFDRLKSGKLDKEETKEDKPKNI
EELVLAGCGSRLEAIEKGAGKGMIIGACQNRARDLVNLPGNHLSAEDLAEAAIEAGKRGGFEVTVFDKKKIVELGMGGLL
AVNKGSEQPPTFVILDYKPKGKAKKTIALVGKGVTFDSGGISLKPAQGMDEMKSDMSGAAVVIAAIEAAASLGLPLRVVG
LVPATDNMPGGSAQKPGDVITTMSGITVEVGNTDAEGRLILADALFYAKKEYNPDVIIDLATLTGACIVALGNSVAGLFS
NDEKLAESIFEAGQSSGEKVWRLPLWDEYDELIKSDVADVHNTGGRGAGTITAAKFLEKFIDGHKHWAHIDIAGPAFWAK
GGSKTPGATGFGVRLLLDLLKGWS

Sequences:

>Translated_504_residues
MKCTVTAKESGLVNADILVQFFSKKEMKRDAGKVLAGLGVVASPDGDFKASAGEIAMLYRQASGKEASRVILAGVGEGKT
AEDYRKAADSVARKTVDLHLGVLALDCSPIDDWAKQSKQKPEELAAILVEGVLSGAYRFDRLKSGKLDKEETKEDKPKNI
EELVLAGCGSRLEAIEKGAGKGMIIGACQNRARDLVNLPGNHLSAEDLAEAAIEAGKRGGFEVTVFDKKKIVELGMGGLL
AVNKGSEQPPTFVILDYKPKGKAKKTIALVGKGVTFDSGGISLKPAQGMDEMKSDMSGAAVVIAAIEAAASLGLPLRVVG
LVPATDNMPGGSAQKPGDVITTMSGITVEVGNTDAEGRLILADALFYAKKEYNPDVIIDLATLTGACIVALGNSVAGLFS
NDEKLAESIFEAGQSSGEKVWRLPLWDEYDELIKSDVADVHNTGGRGAGTITAAKFLEKFIDGHKHWAHIDIAGPAFWAK
GGSKTPGATGFGVRLLLDLLKGWS
>Mature_504_residues
MKCTVTAKESGLVNADILVQFFSKKEMKRDAGKVLAGLGVVASPDGDFKASAGEIAMLYRQASGKEASRVILAGVGEGKT
AEDYRKAADSVARKTVDLHLGVLALDCSPIDDWAKQSKQKPEELAAILVEGVLSGAYRFDRLKSGKLDKEETKEDKPKNI
EELVLAGCGSRLEAIEKGAGKGMIIGACQNRARDLVNLPGNHLSAEDLAEAAIEAGKRGGFEVTVFDKKKIVELGMGGLL
AVNKGSEQPPTFVILDYKPKGKAKKTIALVGKGVTFDSGGISLKPAQGMDEMKSDMSGAAVVIAAIEAAASLGLPLRVVG
LVPATDNMPGGSAQKPGDVITTMSGITVEVGNTDAEGRLILADALFYAKKEYNPDVIIDLATLTGACIVALGNSVAGLFS
NDEKLAESIFEAGQSSGEKVWRLPLWDEYDELIKSDVADVHNTGGRGAGTITAAKFLEKFIDGHKHWAHIDIAGPAFWAK
GGSKTPGATGFGVRLLLDLLKGWS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=514, Percent_Identity=37.9377431906615, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI47155554, Length=317, Percent_Identity=35.9621451104101, Blast_Score=168, Evalue=9e-42,
Organism=Escherichia coli, GI1790710, Length=377, Percent_Identity=44.0318302387268, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=42.4528301886792, Blast_Score=216, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17556903, Length=318, Percent_Identity=37.1069182389937, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17565172, Length=439, Percent_Identity=27.7904328018223, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24661038, Length=292, Percent_Identity=39.041095890411, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI21355725, Length=292, Percent_Identity=38.3561643835616, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI20129969, Length=308, Percent_Identity=35.0649350649351, Blast_Score=204, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24662227, Length=355, Percent_Identity=31.830985915493, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI161077148, Length=295, Percent_Identity=33.8983050847458, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI20130057, Length=295, Percent_Identity=33.8983050847458, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21355645, Length=295, Percent_Identity=32.5423728813559, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24662223, Length=295, Percent_Identity=32.5423728813559, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI19922386, Length=303, Percent_Identity=34.6534653465347, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI221379063, Length=318, Percent_Identity=35.2201257861635, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI221379062, Length=318, Percent_Identity=35.2201257861635, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21357381, Length=318, Percent_Identity=35.2201257861635, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129963, Length=293, Percent_Identity=35.4948805460751, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24646701, Length=257, Percent_Identity=33.4630350194552, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646703, Length=257, Percent_Identity=33.4630350194552, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358201, Length=257, Percent_Identity=33.4630350194552, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_CHLTE (Q8KD74)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662071.1
- ProteinModelPortal:   Q8KD74
- SMR:   Q8KD74
- MEROPS:   M17.003
- GeneID:   1006544
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1180
- NMPDR:   fig|194439.1.peg.1165
- TIGR:   CT1180
- HOGENOM:   HBG742580
- OMA:   SEGMGEM
- ProtClustDB:   PRK00913
- BioCyc:   CTEP194439:CT_1180-MONOMER
- BRENDA:   3.4.11.1
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52995; Mature: 52995

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 284-284 ACT_SITE 358-358

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCTVTAKESGLVNADILVQFFSKKEMKRDAGKVLAGLGVVASPDGDFKASAGEIAMLYR
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEE
QASGKEASRVILAGVGEGKTAEDYRKAADSVARKTVDLHLGVLALDCSPIDDWAKQSKQK
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHCCC
PEELAAILVEGVLSGAYRFDRLKSGKLDKEETKEDKPKNIEELVLAGCGSRLEAIEKGAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHCCCHHHHHHHCCCC
KGMIIGACQNRARDLVNLPGNHLSAEDLAEAAIEAGKRGGFEVTVFDKKKIVELGMGGLL
CCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCEE
AVNKGSEQPPTFVILDYKPKGKAKKTIALVGKGVTFDSGGISLKPAQGMDEMKSDMSGAA
EECCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCE
VVIAAIEAAASLGLPLRVVGLVPATDNMPGGSAQKPGDVITTMSGITVEVGNTDAEGRLI
EHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCEE
LADALFYAKKEYNPDVIIDLATLTGACIVALGNSVAGLFSNDEKLAESIFEAGQSSGEKV
EEHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHCCCCCCEE
WRLPLWDEYDELIKSDVADVHNTGGRGAGTITAAKFLEKFIDGHKHWAHIDIAGPAFWAK
EECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHCCC
GGSKTPGATGFGVRLLLDLLKGWS
CCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKCTVTAKESGLVNADILVQFFSKKEMKRDAGKVLAGLGVVASPDGDFKASAGEIAMLYR
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEE
QASGKEASRVILAGVGEGKTAEDYRKAADSVARKTVDLHLGVLALDCSPIDDWAKQSKQK
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHCCC
PEELAAILVEGVLSGAYRFDRLKSGKLDKEETKEDKPKNIEELVLAGCGSRLEAIEKGAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHCCCHHHHHHHCCCC
KGMIIGACQNRARDLVNLPGNHLSAEDLAEAAIEAGKRGGFEVTVFDKKKIVELGMGGLL
CCEEEECCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCEE
AVNKGSEQPPTFVILDYKPKGKAKKTIALVGKGVTFDSGGISLKPAQGMDEMKSDMSGAA
EECCCCCCCCEEEEEECCCCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHCCCCCE
VVIAAIEAAASLGLPLRVVGLVPATDNMPGGSAQKPGDVITTMSGITVEVGNTDAEGRLI
EHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCCCEE
LADALFYAKKEYNPDVIIDLATLTGACIVALGNSVAGLFSNDEKLAESIFEAGQSSGEKV
EEHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHCCCCCCEE
WRLPLWDEYDELIKSDVADVHNTGGRGAGTITAAKFLEKFIDGHKHWAHIDIAGPAFWAK
EECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCHHCCC
GGSKTPGATGFGVRLLLDLLKGWS
CCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901