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The map label for this gene is dsbD [H]

Identifier: 21673901

GI number: 21673901

Start: 1015661

End: 1017484

Strand: Direct

Name: dsbD [H]

Synonym: CT1075

Alternate gene names: 21673901

Gene position: 1015661-1017484 (Clockwise)

Preceding gene: 21673900

Following gene: 21673906

Centisome position: 47.13

GC content: 57.95

Gene sequence:

>1824_bases
ATGCTTTTCATGAGAAGTGCTTCGGCTATGGCCGCGGACTTTCTCGATCCCGAACAGGCTTTCGTGCCAAGCGCAGAGCT
GACCGCAAATCGCTCCATCGCGGTGCACTGGAAGATTGCCAAGTCGTACAAGCTCTACCGAGACCAGATCAAGGTGGGCG
TCTCAGGTGGAAAGGCGAGCCTTGGCGAACCGGTCTTTCCCGAAGGCATCCTCTTCACCGATCCATCGACTGGCGAAAAG
CAGGTTATCTATCATGACGAGCTGAGGCTCGAGGTTCCGGTCAAGCAGGCATCAGCTCCATTCACCGTGAAGGTCGAATA
CCAGGGGTGTGCCGAAGACGGGTTGTGCTATCCGCCGATAAGCAAGTCGTTCAAAGTCGATCCATCCAGGCCCGGAGCAC
TGGCGGCCGTCGAGAGCACGCCGGACACTGGCGCATCGACCGGATTGCAGCCAGCAGCCTCAGATGCCGCGCCTGCTGTA
GCCGCATCATCAGCGAACGCCGTGGATAACGGCGGCAAGAACGATCTGTCGCTCGCCCAATCGACCCTTGAAAGCGGCAG
TTTGTGGAAAGTATTCGCAGCGTTCCTGCTCTTCGGTCTTCTGCTTTCGTTCACGCCCTGCGTGCTGCCTATGGTGCCGA
TTCTTTCGTCGATCATCGTTGGAGAAGGGGAGACCACCAAGGCGAAAAGCTTCCTCATGGCGCTGGCCTACTGCCTCGGT
ATGGCACTCGTTTACACCTCCCTCGGTGTGGCGGCGGGCCTCGCTGGCGAGGGCCTTGCCGGAGCACTGCAAAAGCCGTG
GGTGCTCGTGATGTTCAGCCTGCTGCTGATTGGCCTTTCGCTCTCGATGTTTGATGTCTACCAGCTTCAGGCGCCTGCTT
CGTTGCAGAACAGCCTGAGCAAGACCTCCAGCAAACTCAAAGGCGGCCGTTTCGTTGGTGTTTTCTTCATGGGAGCCATT
TCGGCACTGATTGTCGGCCCATGCGTCGCTGCGCCACTGGCCGGAACACTGGTTTACATCAGCCAGACGAAGGATGTTGT
TATCGGCGGTCTGGCACTCTTTTCGATGGCGATGGGCATGAGCGTACCGTTGCTCCTGATCGGCCTGTCGGCGGGCAGCC
TTCTACCGAAGGCCGGAGCGTGGATGATTGGGGTCAAATATGTGTTCGGTCTGATGCTGATCGCTGTGGCGATCTGGATG
GTCACGCCGGTGCTGCCGCCACAGGCGCTGATGGTTGCCTGGGGCGCACTCGGCATCCTTTGCGCAGTTTTCGCAGGAGT
ATTCGGCCATCTGCCGGAGAAGCTCACCGTCGGGGGCAAGTTCAAGAAAGCGCTCGGCTTGGTGCTCTTCATCATCGGCG
TGATGGAGCTGGCCGGAGCCGCTTCGGGCGGAACCAATCCGCTCGAACCACTGGCCGGACTGCGCGGTGGTTCATCGGTT
GCGGCTGCGAACAATGGCAAAACTGCTGAACTGGCGTTCAAAAAAATCCGCACCGTCGAAGACCTTGACCGCGAGCTGCA
TGCCTCGGCAGGCAAGAAGCCGGTGATGCTCGACTTTTACGCGGACTGGTGCGTCTCTTGCAAGGAGTTCGAAAAGTTCA
CCTTCAGCAATGCGAAGGTTCAGCAGGGCCTCGCCGACGTCACCCTTTTGCAGGTTGACGTGACCGCGAACACCGCGGAC
GACAAAGCGCTGATGAAACGCTTCAACCTTTTCGGCCCTCCCGGCATTATCTTTTTTGACAAGTCTGGCAATGAGCAAGT
GGACAATCGCATCGTCGGTTTTGTCGAAGCAGAGGAATTTCTGAAGCACCTTGAAAAATTATGA

Upstream 100 bases:

>100_bases
CAGTCGGGCGAAATGTATTATCAAGATTGAACCAACGCTGAAAAAAATGATAAAAAAATCAACCCCAAGAAGCTTTTTCG
CAGTTGTCGGAATCCTGCTG

Downstream 100 bases:

>100_bases
CTGACGAAATGACGAGAACAGTGGTGACCTACAATCCCTCGAAAAATCCCTCCAGCGAGGTCTGCGTTACCTCTTCATCT
CCAGCCTTGATCAGCTCGAA

Product: thiol:disulfide interchange protein DsbD

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MLFMRSASAMAADFLDPEQAFVPSAELTANRSIAVHWKIAKSYKLYRDQIKVGVSGGKASLGEPVFPEGILFTDPSTGEK
QVIYHDELRLEVPVKQASAPFTVKVEYQGCAEDGLCYPPISKSFKVDPSRPGALAAVESTPDTGASTGLQPAASDAAPAV
AASSANAVDNGGKNDLSLAQSTLESGSLWKVFAAFLLFGLLLSFTPCVLPMVPILSSIIVGEGETTKAKSFLMALAYCLG
MALVYTSLGVAAGLAGEGLAGALQKPWVLVMFSLLLIGLSLSMFDVYQLQAPASLQNSLSKTSSKLKGGRFVGVFFMGAI
SALIVGPCVAAPLAGTLVYISQTKDVVIGGLALFSMAMGMSVPLLLIGLSAGSLLPKAGAWMIGVKYVFGLMLIAVAIWM
VTPVLPPQALMVAWGALGILCAVFAGVFGHLPEKLTVGGKFKKALGLVLFIIGVMELAGAASGGTNPLEPLAGLRGGSSV
AAANNGKTAELAFKKIRTVEDLDRELHASAGKKPVMLDFYADWCVSCKEFEKFTFSNAKVQQGLADVTLLQVDVTANTAD
DKALMKRFNLFGPPGIIFFDKSGNEQVDNRIVGFVEAEEFLKHLEKL

Sequences:

>Translated_607_residues
MLFMRSASAMAADFLDPEQAFVPSAELTANRSIAVHWKIAKSYKLYRDQIKVGVSGGKASLGEPVFPEGILFTDPSTGEK
QVIYHDELRLEVPVKQASAPFTVKVEYQGCAEDGLCYPPISKSFKVDPSRPGALAAVESTPDTGASTGLQPAASDAAPAV
AASSANAVDNGGKNDLSLAQSTLESGSLWKVFAAFLLFGLLLSFTPCVLPMVPILSSIIVGEGETTKAKSFLMALAYCLG
MALVYTSLGVAAGLAGEGLAGALQKPWVLVMFSLLLIGLSLSMFDVYQLQAPASLQNSLSKTSSKLKGGRFVGVFFMGAI
SALIVGPCVAAPLAGTLVYISQTKDVVIGGLALFSMAMGMSVPLLLIGLSAGSLLPKAGAWMIGVKYVFGLMLIAVAIWM
VTPVLPPQALMVAWGALGILCAVFAGVFGHLPEKLTVGGKFKKALGLVLFIIGVMELAGAASGGTNPLEPLAGLRGGSSV
AAANNGKTAELAFKKIRTVEDLDRELHASAGKKPVMLDFYADWCVSCKEFEKFTFSNAKVQQGLADVTLLQVDVTANTAD
DKALMKRFNLFGPPGIIFFDKSGNEQVDNRIVGFVEAEEFLKHLEKL
>Mature_607_residues
MLFMRSASAMAADFLDPEQAFVPSAELTANRSIAVHWKIAKSYKLYRDQIKVGVSGGKASLGEPVFPEGILFTDPSTGEK
QVIYHDELRLEVPVKQASAPFTVKVEYQGCAEDGLCYPPISKSFKVDPSRPGALAAVESTPDTGASTGLQPAASDAAPAV
AASSANAVDNGGKNDLSLAQSTLESGSLWKVFAAFLLFGLLLSFTPCVLPMVPILSSIIVGEGETTKAKSFLMALAYCLG
MALVYTSLGVAAGLAGEGLAGALQKPWVLVMFSLLLIGLSLSMFDVYQLQAPASLQNSLSKTSSKLKGGRFVGVFFMGAI
SALIVGPCVAAPLAGTLVYISQTKDVVIGGLALFSMAMGMSVPLLLIGLSAGSLLPKAGAWMIGVKYVFGLMLIAVAIWM
VTPVLPPQALMVAWGALGILCAVFAGVFGHLPEKLTVGGKFKKALGLVLFIIGVMELAGAASGGTNPLEPLAGLRGGSSV
AAANNGKTAELAFKKIRTVEDLDRELHASAGKKPVMLDFYADWCVSCKEFEKFTFSNAKVQQGLADVTLLQVDVTANTAD
DKALMKRFNLFGPPGIIFFDKSGNEQVDNRIVGFVEAEEFLKHLEKL

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=614, Percent_Identity=36.6449511400651, Blast_Score=357, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 63812; Mature: 63812

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFMRSASAMAADFLDPEQAFVPSAELTANRSIAVHWKIAKSYKLYRDQIKVGVSGGKAS
CCEECCCHHHHHHCCCCHHHHCCCCHHCCCCEEEEEEEEHHHHHHHHHHHEEEECCCCCC
LGEPVFPEGILFTDPSTGEKQVIYHDELRLEVPVKQASAPFTVKVEYQGCAEDGLCYPPI
CCCCCCCCCEEECCCCCCCCEEEEECCEEEEECHHHCCCCEEEEEEECCCCCCCCCCCCC
SKSFKVDPSRPGALAAVESTPDTGASTGLQPAASDAAPAVAASSANAVDNGGKNDLSLAQ
CCCEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHH
STLESGSLWKVFAAFLLFGLLLSFTPCVLPMVPILSSIIVGEGETTKAKSFLMALAYCLG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
MALVYTSLGVAAGLAGEGLAGALQKPWVLVMFSLLLIGLSLSMFDVYQLQAPASLQNSLS
HHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KTSSKLKGGRFVGVFFMGAISALIVGPCVAAPLAGTLVYISQTKDVVIGGLALFSMAMGM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCC
SVPLLLIGLSAGSLLPKAGAWMIGVKYVFGLMLIAVAIWMVTPVLPPQALMVAWGALGIL
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
CAVFAGVFGHLPEKLTVGGKFKKALGLVLFIIGVMELAGAASGGTNPLEPLAGLRGGSSV
HHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCE
AAANNGKTAELAFKKIRTVEDLDRELHASAGKKPVMLDFYADWCVSCKEFEKFTFSNAKV
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCHHHHHHHHCCCHHH
QQGLADVTLLQVDVTANTADDKALMKRFNLFGPPGIIFFDKSGNEQVDNRIVGFVEAEEF
HCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHEEHCCHHHH
LKHLEKL
HHHHHCC
>Mature Secondary Structure
MLFMRSASAMAADFLDPEQAFVPSAELTANRSIAVHWKIAKSYKLYRDQIKVGVSGGKAS
CCEECCCHHHHHHCCCCHHHHCCCCHHCCCCEEEEEEEEHHHHHHHHHHHEEEECCCCCC
LGEPVFPEGILFTDPSTGEKQVIYHDELRLEVPVKQASAPFTVKVEYQGCAEDGLCYPPI
CCCCCCCCCEEECCCCCCCCEEEEECCEEEEECHHHCCCCEEEEEEECCCCCCCCCCCCC
SKSFKVDPSRPGALAAVESTPDTGASTGLQPAASDAAPAVAASSANAVDNGGKNDLSLAQ
CCCEECCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHH
STLESGSLWKVFAAFLLFGLLLSFTPCVLPMVPILSSIIVGEGETTKAKSFLMALAYCLG
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
MALVYTSLGVAAGLAGEGLAGALQKPWVLVMFSLLLIGLSLSMFDVYQLQAPASLQNSLS
HHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KTSSKLKGGRFVGVFFMGAISALIVGPCVAAPLAGTLVYISQTKDVVIGGLALFSMAMGM
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCC
SVPLLLIGLSAGSLLPKAGAWMIGVKYVFGLMLIAVAIWMVTPVLPPQALMVAWGALGIL
CCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
CAVFAGVFGHLPEKLTVGGKFKKALGLVLFIIGVMELAGAASGGTNPLEPLAGLRGGSSV
HHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCE
AAANNGKTAELAFKKIRTVEDLDRELHASAGKKPVMLDFYADWCVSCKEFEKFTFSNAKV
EECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCHHHHHHHHCCCHHH
QQGLADVTLLQVDVTANTADDKALMKRFNLFGPPGIIFFDKSGNEQVDNRIVGFVEAEEF
HCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHEEHCCHHHH
LKHLEKL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]