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The map label for this gene is pgi

Identifier: 21673816

GI number: 21673816

Start: 935305

End: 936984

Strand: Direct

Name: pgi

Synonym: CT0988

Alternate gene names: 21673816

Gene position: 935305-936984 (Clockwise)

Preceding gene: 21673815

Following gene: 21673821

Centisome position: 43.4

GC content: 56.9

Gene sequence:

>1680_bases
ATGTATCTTTCCCGCAGTGCCGAATGGAGCGCCCTCGAGTCACACTATCAGGATATCAGCCACCAGGCGATGATCGATCT
GTTCAGTACCGACCCGAACCGGCATGAACGCTTTTCGCTTTCATTCAACGCCATTCATCTCGATTATTCCAAGAACAGGA
TTTCCGCCCGCACCATGGAGCTTCTCATGGATCTTGTTCGCCGTTCGGGTATCGAGAAGAAGCGTCGGCAGATGTTTGAA
GGGGAGCAGATCAATTTTACCGAACATCGCTCGGTACTTCATACCGCTCTTCGAAGGCCGCCGGGATACACCATGACGAT
TGATGGGAACGATGTCGCTTCCGAGGTTTCGGATGTGCTCGACCAGATGAAAGCGTTTTGCAAAAAGGTTATTTCCGGTG
AGTGGAAAGGCTATACCGGAAAGCGGATCACCGATGTGGTCAATATCGGCATCGGCGGCTCGGATCTCGGGCCTTTCATG
GTTACCGAGGCCCTGAAACCCTTCGCTCACGGAAAGCTGAAGGTACACTTCGTCTCGAACGTCGATGGCTCCCATCTGGT
CGAAACCCTCCGGGGGTTGAATCCCGAAACGACGCTTTTTATCATCGCGTCCAAGACCTTCACCACACAGGAAACCCTTG
CCAACGCTGTCAGCGCCAGAGCGTGGTTTCTGGTCAAGGCGGGCAATCGGGATCACGTCGCGAAGCACTTCGTCGCCGTT
TCGACCAACCGCGAAAAGGTCGAGGAGTTTGGCATCGACCCCGACAACATGTTCCGTTTCTGGGACTGGGTTGGCGGGCG
CTACTCGCTCTGGTCGGCTATCGGTCTTTCCATAGCGCTCTATCTCGGTTTCGACCGCTTCCGTGAGCTGCTTGCCGGAG
CGCACGCGATGGACGAGCACTTCCTGAACGCGCCGCTGGAAGAGAATATGCCGATGATTCTGGCCATGCTCGGCATCTGG
TACAACAACTTTTTCGGAGCGCACTCGCAGGCGATCATTCCCTACGATCAGTACCTGCACCGCTTTCCGGCCTATCTCCA
GCAGCTCGACATGGAGAGCAACGGCAAGCGGGTTGACCGCGCGGGCCACGAAGTCGACTACGCCACCGGGCCGGTGATCT
GGGGCGAGCCGGGCACCAACGCGCAGCACGCCTTCTTCCAACTGCTGCACCAGGGCACGGAGATTGTTCCGGTCGATTTC
ATCGTTTCGCTCAAGAGCCAGAATCCGGTCGGCGAGCATCACGACATGTTGGTTGCCAACTGCTTCGCGCAATCCGAGGC
GCTCATGAAGGGCAAGAGCGAGGCCGAAGCGCGCGCCGAACTCGAAGCTGCGGGCCTGTCGGGTGGCGATCTCGAAAAAC
TACTGCCGCACAAACTTTTTCCCGGAAACCGCCCGACCAACACCATCGTGCTCGACGAGCTAAACCCGTTCAATCTGGGC
AGCCTCATTGCGCTTTACGAGCACAAAGTGTTCGTGCAGGGCGTGGTTTGGAACATCAATTCGTTCGACCAGTGGGGTGT
GGAACTCGGCAAGCAGCTCGCCAAGGCGATTCTGCCGGAGTTCGATGCGGTCGATCCGGTCGAAACCCATGACGCCTCGA
CCAACGCGCTCATCAACCGTTACCGCCAATTCCGCAATGGCTTGAAGTTCCCCAAGAGCAATCAGCTCAAAATGTTCTGA

Upstream 100 bases:

>100_bases
AGGATCGAACAGGCGTCGGGCGGTTGTGTAGTGGTATTGCGTTATATTCCTTACTAATCAATAACGAATAATTGTTTAAC
CTTTTAACGATCTGCTGACC

Downstream 100 bases:

>100_bases
ACGCAAAAAAGGCAGGCCTGGTAAAAAACCGGCCTGCCTTTTTCATCCTCATTTACTTCAGTCCACAGTGTCTTGCATTC
AGAAGGGTTTTAACCCTTTA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MYLSRSAEWSALESHYQDISHQAMIDLFSTDPNRHERFSLSFNAIHLDYSKNRISARTMELLMDLVRRSGIEKKRRQMFE
GEQINFTEHRSVLHTALRRPPGYTMTIDGNDVASEVSDVLDQMKAFCKKVISGEWKGYTGKRITDVVNIGIGGSDLGPFM
VTEALKPFAHGKLKVHFVSNVDGSHLVETLRGLNPETTLFIIASKTFTTQETLANAVSARAWFLVKAGNRDHVAKHFVAV
STNREKVEEFGIDPDNMFRFWDWVGGRYSLWSAIGLSIALYLGFDRFRELLAGAHAMDEHFLNAPLEENMPMILAMLGIW
YNNFFGAHSQAIIPYDQYLHRFPAYLQQLDMESNGKRVDRAGHEVDYATGPVIWGEPGTNAQHAFFQLLHQGTEIVPVDF
IVSLKSQNPVGEHHDMLVANCFAQSEALMKGKSEAEARAELEAAGLSGGDLEKLLPHKLFPGNRPTNTIVLDELNPFNLG
SLIALYEHKVFVQGVVWNINSFDQWGVELGKQLAKAILPEFDAVDPVETHDASTNALINRYRQFRNGLKFPKSNQLKMF

Sequences:

>Translated_559_residues
MYLSRSAEWSALESHYQDISHQAMIDLFSTDPNRHERFSLSFNAIHLDYSKNRISARTMELLMDLVRRSGIEKKRRQMFE
GEQINFTEHRSVLHTALRRPPGYTMTIDGNDVASEVSDVLDQMKAFCKKVISGEWKGYTGKRITDVVNIGIGGSDLGPFM
VTEALKPFAHGKLKVHFVSNVDGSHLVETLRGLNPETTLFIIASKTFTTQETLANAVSARAWFLVKAGNRDHVAKHFVAV
STNREKVEEFGIDPDNMFRFWDWVGGRYSLWSAIGLSIALYLGFDRFRELLAGAHAMDEHFLNAPLEENMPMILAMLGIW
YNNFFGAHSQAIIPYDQYLHRFPAYLQQLDMESNGKRVDRAGHEVDYATGPVIWGEPGTNAQHAFFQLLHQGTEIVPVDF
IVSLKSQNPVGEHHDMLVANCFAQSEALMKGKSEAEARAELEAAGLSGGDLEKLLPHKLFPGNRPTNTIVLDELNPFNLG
SLIALYEHKVFVQGVVWNINSFDQWGVELGKQLAKAILPEFDAVDPVETHDASTNALINRYRQFRNGLKFPKSNQLKMF
>Mature_559_residues
MYLSRSAEWSALESHYQDISHQAMIDLFSTDPNRHERFSLSFNAIHLDYSKNRISARTMELLMDLVRRSGIEKKRRQMFE
GEQINFTEHRSVLHTALRRPPGYTMTIDGNDVASEVSDVLDQMKAFCKKVISGEWKGYTGKRITDVVNIGIGGSDLGPFM
VTEALKPFAHGKLKVHFVSNVDGSHLVETLRGLNPETTLFIIASKTFTTQETLANAVSARAWFLVKAGNRDHVAKHFVAV
STNREKVEEFGIDPDNMFRFWDWVGGRYSLWSAIGLSIALYLGFDRFRELLAGAHAMDEHFLNAPLEENMPMILAMLGIW
YNNFFGAHSQAIIPYDQYLHRFPAYLQQLDMESNGKRVDRAGHEVDYATGPVIWGEPGTNAQHAFFQLLHQGTEIVPVDF
IVSLKSQNPVGEHHDMLVANCFAQSEALMKGKSEAEARAELEAAGLSGGDLEKLLPHKLFPGNRPTNTIVLDELNPFNLG
SLIALYEHKVFVQGVVWNINSFDQWGVELGKQLAKAILPEFDAVDPVETHDASTNALINRYRQFRNGLKFPKSNQLKMF

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=552, Percent_Identity=59.7826086956522, Blast_Score=706, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=552, Percent_Identity=55.6159420289855, Blast_Score=642, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=543, Percent_Identity=59.3001841620626, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=545, Percent_Identity=59.2660550458716, Blast_Score=681, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=59.2660550458716, Blast_Score=681, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=545, Percent_Identity=54.8623853211009, Blast_Score=613, Evalue=1e-176,
Organism=Drosophila melanogaster, GI24651916, Length=545, Percent_Identity=59.0825688073395, Blast_Score=666, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=545, Percent_Identity=59.0825688073395, Blast_Score=666, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=545, Percent_Identity=59.0825688073395, Blast_Score=666, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CHLTE (Q8KDQ7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661881.1
- ProteinModelPortal:   Q8KDQ7
- SMR:   Q8KDQ7
- GeneID:   1007039
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0988
- NMPDR:   fig|194439.1.peg.975
- TIGR:   CT0988
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- BioCyc:   CTEP194439:CT_0988-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 63089; Mature: 63089

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: ACT_SITE 352-352 ACT_SITE 383-383 ACT_SITE 511-511

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLSRSAEWSALESHYQDISHQAMIDLFSTDPNRHERFSLSFNAIHLDYSKNRISARTME
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHH
LLMDLVRRSGIEKKRRQMFEGEQINFTEHRSVLHTALRRPPGYTMTIDGNDVASEVSDVL
HHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
DQMKAFCKKVISGEWKGYTGKRITDVVNIGIGGSDLGPFMVTEALKPFAHGKLKVHFVSN
HHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECC
VDGSHLVETLRGLNPETTLFIIASKTFTTQETLANAVSARAWFLVKAGNRDHVAKHFVAV
CCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCEEEEEECCCHHHHHHHHEEE
STNREKVEEFGIDPDNMFRFWDWVGGRYSLWSAIGLSIALYLGFDRFRELLAGAHAMDEH
CCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FLNAPLEENMPMILAMLGIWYNNFFGAHSQAIIPYDQYLHRFPAYLQQLDMESNGKRVDR
HHCCCHHCCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCHHH
AGHEVDYATGPVIWGEPGTNAQHAFFQLLHQGTEIVPVDFIVSLKSQNPVGEHHDMLVAN
CCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHH
CFAQSEALMKGKSEAEARAELEAAGLSGGDLEKLLPHKLFPGNRPTNTIVLDELNPFNLG
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHCCHHCCCCCCCCCEEEEECCCCCCHH
SLIALYEHKVFVQGVVWNINSFDQWGVELGKQLAKAILPEFDAVDPVETHDASTNALINR
HHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YRQFRNGLKFPKSNQLKMF
HHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MYLSRSAEWSALESHYQDISHQAMIDLFSTDPNRHERFSLSFNAIHLDYSKNRISARTME
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCHHHHHHHH
LLMDLVRRSGIEKKRRQMFEGEQINFTEHRSVLHTALRRPPGYTMTIDGNDVASEVSDVL
HHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
DQMKAFCKKVISGEWKGYTGKRITDVVNIGIGGSDLGPFMVTEALKPFAHGKLKVHFVSN
HHHHHHHHHHHCCCCCCCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECC
VDGSHLVETLRGLNPETTLFIIASKTFTTQETLANAVSARAWFLVKAGNRDHVAKHFVAV
CCHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHCEEEEEECCCHHHHHHHHEEE
STNREKVEEFGIDPDNMFRFWDWVGGRYSLWSAIGLSIALYLGFDRFRELLAGAHAMDEH
CCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
FLNAPLEENMPMILAMLGIWYNNFFGAHSQAIIPYDQYLHRFPAYLQQLDMESNGKRVDR
HHCCCHHCCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCHHH
AGHEVDYATGPVIWGEPGTNAQHAFFQLLHQGTEIVPVDFIVSLKSQNPVGEHHDMLVAN
CCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHH
CFAQSEALMKGKSEAEARAELEAAGLSGGDLEKLLPHKLFPGNRPTNTIVLDELNPFNLG
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHCCHHCCCCCCCCCEEEEECCCCCCHH
SLIALYEHKVFVQGVVWNINSFDQWGVELGKQLAKAILPEFDAVDPVETHDASTNALINR
HHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
YRQFRNGLKFPKSNQLKMF
HHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901