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The map label for this gene is cobD [H]

Identifier: 21673767

GI number: 21673767

Start: 887616

End: 888725

Strand: Direct

Name: cobD [H]

Synonym: CT0939

Alternate gene names: 21673767

Gene position: 887616-888725 (Clockwise)

Preceding gene: 21673766

Following gene: 21673768

Centisome position: 41.19

GC content: 61.62

Gene sequence:

>1110_bases
ATGAATCACGATCATCTGCTGGCACATCGCCACGGCGACCGTTCGGGCGACAGGCTTGCGAGTGCCATTTCGCTCGACTT
CAGCGTCAATCTCGCACCGATCGAACCTCCGTTGCAGGAGCTGTTCTCAACCTCCATTCCGCTTGCGCCCTATCCCTCGA
TGGATGGACACGGAGTGCGTGAGTTCTACGCGGCTCGATTCGGCCTCGATCCGGTGTGTGTGCTCTCGACGAATGGCGCA
ATCGAGGGCTTGTACCTGATTCCGAGAGCGCTTGGGATCAAGCGTGTGCTCGTTCCCCAACCCTCGTTTTTTGATTACGG
ACGCGCCTGCCGCCTTGCGGGAGCGGAGGTCGTCCCGCTTGCACTGAGCGAGTCTGGCAGCTTCGCCTTTCCCGGCATCG
ACAAGCTTGCCGATGCGCTTGCCGGATGCGACGCGCTCCTGGCCGGAAGCCCGAACAACCCGACCGGCACGCTGATTCCC
AAGGAGTTGCTGCTGGCGCTGGCCTGCCGCTTTCCGGAGAAGCGGTTCATCGTCGATGAGGCGTTCATCCAGTTCACGGA
GGCCTTCCCGTCAAACTCCCTGATGACCGAAATCAAGGCGTTCCGGAACATCGCTGTGGTGCATTCGCTGACCAAGTTCT
ACGCCATCGCCGGGTTGCGTCTTGGTGCGGTGATCGCGCATCCCTCGATGATCCGCCAGCTTTACGGTTACAAGGAGCCG
TGGACGGTCAACGCCGTCGCGGAGCATGTCGCCGGGCAACTGCTGCACTGCGGCGAGTACGAGCGGGAGGTTCACGCCAT
CGTCCGCGAAGGACGCAAACAGATTGCCGACGGCCTTGCCGGGAACTCCGTGATCACGCTGCACGGCGGCGCGGCGAACT
TCTTTTTCGCCTCCGTCGCGGACGAATTCAGCCTTGACGCGCTGTTCGATGTTCTCGCCGAACGCGGCATTCTCGTCCGG
GACTGCCGGAATTTCGAGGGCGTTCCGCCGAAGTATTTCCGCTTCTGCATTCGCACCTCCGACGAAAACCGGCGTCTCAT
CGAGGCGCTGAACGATTTCGCCGAGTTGTCGAGGATCGCGAAAGCTGCCGTCGAGGAGGCGGTGTCGTGA

Upstream 100 bases:

>100_bases
CTGATCCATTCGAGCTGCTTGCCAAGCATTTCTCGGAAAATCTCGATCTTGAGAAGTTGTTTGCTATTGCCGGTCTTTCG
GTCAAAGGGGAGAAAGAGTC

Downstream 100 bases:

>100_bases
CCTGGTTGCTGATGCCAGCGGCGTTCCTGCTCGATCTGCTGCTTGGCGATCCGCAGTGGTTTCCGCATCCGGTGCGGCTG
GTCGGCAAGCTTGCGTCCGG

Product: aminotransferase, class II

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNHDHLLAHRHGDRSGDRLASAISLDFSVNLAPIEPPLQELFSTSIPLAPYPSMDGHGVREFYAARFGLDPVCVLSTNGA
IEGLYLIPRALGIKRVLVPQPSFFDYGRACRLAGAEVVPLALSESGSFAFPGIDKLADALAGCDALLAGSPNNPTGTLIP
KELLLALACRFPEKRFIVDEAFIQFTEAFPSNSLMTEIKAFRNIAVVHSLTKFYAIAGLRLGAVIAHPSMIRQLYGYKEP
WTVNAVAEHVAGQLLHCGEYEREVHAIVREGRKQIADGLAGNSVITLHGGAANFFFASVADEFSLDALFDVLAERGILVR
DCRNFEGVPPKYFRFCIRTSDENRRLIEALNDFAELSRIAKAAVEEAVS

Sequences:

>Translated_369_residues
MNHDHLLAHRHGDRSGDRLASAISLDFSVNLAPIEPPLQELFSTSIPLAPYPSMDGHGVREFYAARFGLDPVCVLSTNGA
IEGLYLIPRALGIKRVLVPQPSFFDYGRACRLAGAEVVPLALSESGSFAFPGIDKLADALAGCDALLAGSPNNPTGTLIP
KELLLALACRFPEKRFIVDEAFIQFTEAFPSNSLMTEIKAFRNIAVVHSLTKFYAIAGLRLGAVIAHPSMIRQLYGYKEP
WTVNAVAEHVAGQLLHCGEYEREVHAIVREGRKQIADGLAGNSVITLHGGAANFFFASVADEFSLDALFDVLAERGILVR
DCRNFEGVPPKYFRFCIRTSDENRRLIEALNDFAELSRIAKAAVEEAVS
>Mature_369_residues
MNHDHLLAHRHGDRSGDRLASAISLDFSVNLAPIEPPLQELFSTSIPLAPYPSMDGHGVREFYAARFGLDPVCVLSTNGA
IEGLYLIPRALGIKRVLVPQPSFFDYGRACRLAGAEVVPLALSESGSFAFPGIDKLADALAGCDALLAGSPNNPTGTLIP
KELLLALACRFPEKRFIVDEAFIQFTEAFPSNSLMTEIKAFRNIAVVHSLTKFYAIAGLRLGAVIAHPSMIRQLYGYKEP
WTVNAVAEHVAGQLLHCGEYEREVHAIVREGRKQIADGLAGNSVITLHGGAANFFFASVADEFSLDALFDVLAERGILVR
DCRNFEGVPPKYFRFCIRTSDENRRLIEALNDFAELSRIAKAAVEEAVS

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=323, Percent_Identity=28.4829721362229, Blast_Score=98, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322075, Length=287, Percent_Identity=25.4355400696864, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40255; Mature: 40255

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHDHLLAHRHGDRSGDRLASAISLDFSVNLAPIEPPLQELFSTSIPLAPYPSMDGHGVR
CCCCCEEEECCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHH
EFYAARFGLDPVCVLSTNGAIEGLYLIPRALGIKRVLVPQPSFFDYGRACRLAGAEVVPL
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHCCCCEEEE
ALSESGSFAFPGIDKLADALAGCDALLAGSPNNPTGTLIPKELLLALACRFPEKRFIVDE
EECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
AFIQFTEAFPSNSLMTEIKAFRNIAVVHSLTKFYAIAGLRLGAVIAHPSMIRQLYGYKEP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
WTVNAVAEHVAGQLLHCGEYEREVHAIVREGRKQIADGLAGNSVITLHGGAANFFFASVA
EEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
DEFSLDALFDVLAERGILVRDCRNFEGVPPKYFRFCIRTSDENRRLIEALNDFAELSRIA
HHHHHHHHHHHHHHCCEEEEHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KAAVEEAVS
HHHHHHHCC
>Mature Secondary Structure
MNHDHLLAHRHGDRSGDRLASAISLDFSVNLAPIEPPLQELFSTSIPLAPYPSMDGHGVR
CCCCCEEEECCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHH
EFYAARFGLDPVCVLSTNGAIEGLYLIPRALGIKRVLVPQPSFFDYGRACRLAGAEVVPL
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHCCCCEEEE
ALSESGSFAFPGIDKLADALAGCDALLAGSPNNPTGTLIPKELLLALACRFPEKRFIVDE
EECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
AFIQFTEAFPSNSLMTEIKAFRNIAVVHSLTKFYAIAGLRLGAVIAHPSMIRQLYGYKEP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCC
WTVNAVAEHVAGQLLHCGEYEREVHAIVREGRKQIADGLAGNSVITLHGGAANFFFASVA
EEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHH
DEFSLDALFDVLAERGILVRDCRNFEGVPPKYFRFCIRTSDENRRLIEALNDFAELSRIA
HHHHHHHHHHHHHHCCEEEEHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KAAVEEAVS
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]