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The map label for this gene is hdrA [H]

Identifier: 21673696

GI number: 21673696

Start: 824466

End: 826718

Strand: Direct

Name: hdrA [H]

Synonym: CT0867

Alternate gene names: 21673696

Gene position: 824466-826718 (Clockwise)

Preceding gene: 21673695

Following gene: 21673697

Centisome position: 38.26

GC content: 57.04

Gene sequence:

>2253_bases
ATGGCTGATGACAAAAAAATAGGCGTATACCTCTGTACCGACTGCGGAATCGGGGAGGCGTTGAATGTGGATGAACTTGA
AGCGGTAGCCAAAAAGGAGTTCAAGGTTCCCGTCTGCAAACAGCATCCCAACCTGTGCAGCAACGAAGGCGTGCAGATCA
TCAAGGATGACCTTAACAACGGAGAGGTCAACAAGATCGTCATTGCCGCCTGTTCGCAGAGGGTGAACAACGATGTATTC
AATTTCGACCCGCTCACCTATGTGACTGAACGGGTTAACCTGCGCGAACAGGTGGTCTGGACGGCTCCGAAAGGGGATGA
CGCTAAAGAGGGGACCCAGTTGATGGCTGCCGACTACCTGAGGATGGGCATTACCAGGGTTCAGAAATCTGAAGTTCCGA
TACCGAAGATCGCCGACGTGAACCGCACCGTACTGGTTGTGGGCGGTGGTGTGACCGGTTTGACTGCGGCGCTTGAAGCT
TCCCAGACCGGCTACAAGGTGGTGCTTGTCGAAAAAGCCCAGGAGCTTGGCGGCTGGGCGAAGAAGATGCACCGCGTGTT
CCCGACCAAGCCGCCGTTCGCCGAAATCGAACAGCCGGCTATCGGTAACAAGATCGAGGCGGTCAAAAAAGATGGTAACA
TCACCGTGCATACCGGCACGACCATCGCCTCCATCGAGGGTGGTCCCGGTGAGTACACGGTGACGATCGACAGGAACGGC
ACAACGGAAACATTCCCAGCGGGAGCTATCGTGCTGGCCGCCGGGTGGAAGCCCTACGATGCGAGCAAACTCGGTCATCT
CGGCTACGGCAAACACCGCAATGTGGTGACCAATCTCGAATTCGAGCAGAACGTTGCCAAAACCGGGGGCAAGGTGACGC
GCCCTTCGGACGGCAAACCGGCCAAGAACGTCGTTTTCCTTCAGTGCGCCGGTCAGCGAGACAAGGATCACGTGCCTTAC
TGTTCGACCGTTTGCTGCAACGTTTCGCTCAAGCAGGCCAAATATGTGCGTGAATCGGATCCCGATGCCGGTGCATTCAT
TGTCTACAAGGACATGCGAACTACCGGCCTGTACGAGAATTTCTACAAGAGCGCGCAGGACGACGAAGGTATCTTTCTCA
CCAAGGGCGAGATTCTTGGCCTCAGTGAAGAGTCCGATGGCAGCCTTGTCATCGAGATCGATAACCAGCTGCTCGGCAGG
AAGATGAAAGTCAAGGCCGACCTGCTTGTGCTTGCCACCGGTATGGTGTCGAACATGGTGCCCGACGGAATGTCAGTCAA
TAACCTGACGCCCGAGTATATTGGCAAGATGGTGCAGAGAGAGACCTCGGACGGCGTGATCGAAGCGCTTGAACCGGAGA
GCCTCATCCTGAACCTCAAGTATCGTCAGGGGCCGGAAATGCCGCATCACAAATGGGGCTTTCCCGATTCCCACTTCATC
TGCTTCCCATATGAAACGCGCAGAACCGGCATCTACTCCGCTGGTGCGGTGCGTCATCCTATGGATGCTGTGCAGGCCTC
GGCCGACGCCACCGGTGCGGCGCTCAAGGCGATCCAGTGCATGGAGCTGACGGCGCAGGGGCGCGCGGTGCATCCGAGAA
CCTGGGACAGAACCTATCCGGAAATCCGCTTCGAGAGCTGCACGCAGTGCCGCCGCTGCACGGTCGAATGTCCGTTTGGC
GCGTACAACGAAAAGGCTGACGGCACGCCGCTCGAATTCCCGTCACGGTGCCGCCGTTGCGGAGTCTGCATGGGAGCCTG
TCCGCAGCGAGTCATCTCGTTCAGGGATTACAGCGTCGATATGATTTCCGCCATGATCAAGTCGATCGAGGTGCCTGACG
AGGGAACCTTCGTGATTGGTTTTGTCTGCGAGAATGACGCCTATCCGGCCTTCGACATGGTGGGGCTGAACAGAATCGGC
ATGAATACCAATTTCCGGTTTATTCCGCTGCGCTGTCTGGGTGGCCTGAACCTGGCGTGGATCGCCGATGCGCTCTCTCG
CGGCGTGGACGGCATTCTGCTGCTCGGCTGCAAATATGGCGACGACTACCAGTGTCACTACGTCAAGGGCAGCCAGATGG
CCAACGAACGCCTCGGCAAGGTTCAGGAGACGCTCGACAGGCTCATGCTCGAAGCCGAGCGCGTCGAGCAGGTGCAGCTC
GCCATCAACGAATGGGACAAGCTGCCGGGTATCCTTGAGGAGTTCTCGAAGAAGATCAAAGATATAGGTGACAATCCGTA
CAAGGGATTCTAA

Upstream 100 bases:

>100_bases
GACCGGTGTCGCCAAGAGGCCGTCCGATGTGACCACCGCCATCCAGGATGCGACCGGCATGGCATTGAAAAGCATTCAAA
GTCTCGTGAGGAGTTAAACT

Downstream 100 bases:

>100_bases
ATCAACCACCGCGGTCAGCAGGGCAACGCCGCTTTCTTGAGCGATCAGGGAGTTTGCCGTTCTCCTGCTGTCCGGGTTTA
TACCGCTGTTAATTCTGGAG

Product: heterodisulfide reductase, subunit A/hydrogenase, delta subunit, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MADDKKIGVYLCTDCGIGEALNVDELEAVAKKEFKVPVCKQHPNLCSNEGVQIIKDDLNNGEVNKIVIAACSQRVNNDVF
NFDPLTYVTERVNLREQVVWTAPKGDDAKEGTQLMAADYLRMGITRVQKSEVPIPKIADVNRTVLVVGGGVTGLTAALEA
SQTGYKVVLVEKAQELGGWAKKMHRVFPTKPPFAEIEQPAIGNKIEAVKKDGNITVHTGTTIASIEGGPGEYTVTIDRNG
TTETFPAGAIVLAAGWKPYDASKLGHLGYGKHRNVVTNLEFEQNVAKTGGKVTRPSDGKPAKNVVFLQCAGQRDKDHVPY
CSTVCCNVSLKQAKYVRESDPDAGAFIVYKDMRTTGLYENFYKSAQDDEGIFLTKGEILGLSEESDGSLVIEIDNQLLGR
KMKVKADLLVLATGMVSNMVPDGMSVNNLTPEYIGKMVQRETSDGVIEALEPESLILNLKYRQGPEMPHHKWGFPDSHFI
CFPYETRRTGIYSAGAVRHPMDAVQASADATGAALKAIQCMELTAQGRAVHPRTWDRTYPEIRFESCTQCRRCTVECPFG
AYNEKADGTPLEFPSRCRRCGVCMGACPQRVISFRDYSVDMISAMIKSIEVPDEGTFVIGFVCENDAYPAFDMVGLNRIG
MNTNFRFIPLRCLGGLNLAWIADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLEAERVEQVQL
AINEWDKLPGILEEFSKKIKDIGDNPYKGF

Sequences:

>Translated_750_residues
MADDKKIGVYLCTDCGIGEALNVDELEAVAKKEFKVPVCKQHPNLCSNEGVQIIKDDLNNGEVNKIVIAACSQRVNNDVF
NFDPLTYVTERVNLREQVVWTAPKGDDAKEGTQLMAADYLRMGITRVQKSEVPIPKIADVNRTVLVVGGGVTGLTAALEA
SQTGYKVVLVEKAQELGGWAKKMHRVFPTKPPFAEIEQPAIGNKIEAVKKDGNITVHTGTTIASIEGGPGEYTVTIDRNG
TTETFPAGAIVLAAGWKPYDASKLGHLGYGKHRNVVTNLEFEQNVAKTGGKVTRPSDGKPAKNVVFLQCAGQRDKDHVPY
CSTVCCNVSLKQAKYVRESDPDAGAFIVYKDMRTTGLYENFYKSAQDDEGIFLTKGEILGLSEESDGSLVIEIDNQLLGR
KMKVKADLLVLATGMVSNMVPDGMSVNNLTPEYIGKMVQRETSDGVIEALEPESLILNLKYRQGPEMPHHKWGFPDSHFI
CFPYETRRTGIYSAGAVRHPMDAVQASADATGAALKAIQCMELTAQGRAVHPRTWDRTYPEIRFESCTQCRRCTVECPFG
AYNEKADGTPLEFPSRCRRCGVCMGACPQRVISFRDYSVDMISAMIKSIEVPDEGTFVIGFVCENDAYPAFDMVGLNRIG
MNTNFRFIPLRCLGGLNLAWIADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLEAERVEQVQL
AINEWDKLPGILEEFSKKIKDIGDNPYKGF
>Mature_749_residues
ADDKKIGVYLCTDCGIGEALNVDELEAVAKKEFKVPVCKQHPNLCSNEGVQIIKDDLNNGEVNKIVIAACSQRVNNDVFN
FDPLTYVTERVNLREQVVWTAPKGDDAKEGTQLMAADYLRMGITRVQKSEVPIPKIADVNRTVLVVGGGVTGLTAALEAS
QTGYKVVLVEKAQELGGWAKKMHRVFPTKPPFAEIEQPAIGNKIEAVKKDGNITVHTGTTIASIEGGPGEYTVTIDRNGT
TETFPAGAIVLAAGWKPYDASKLGHLGYGKHRNVVTNLEFEQNVAKTGGKVTRPSDGKPAKNVVFLQCAGQRDKDHVPYC
STVCCNVSLKQAKYVRESDPDAGAFIVYKDMRTTGLYENFYKSAQDDEGIFLTKGEILGLSEESDGSLVIEIDNQLLGRK
MKVKADLLVLATGMVSNMVPDGMSVNNLTPEYIGKMVQRETSDGVIEALEPESLILNLKYRQGPEMPHHKWGFPDSHFIC
FPYETRRTGIYSAGAVRHPMDAVQASADATGAALKAIQCMELTAQGRAVHPRTWDRTYPEIRFESCTQCRRCTVECPFGA
YNEKADGTPLEFPSRCRRCGVCMGACPQRVISFRDYSVDMISAMIKSIEVPDEGTFVIGFVCENDAYPAFDMVGLNRIGM
NTNFRFIPLRCLGGLNLAWIADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLEAERVEQVQLA
INEWDKLPGILEEFSKKIKDIGDNPYKGF

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR003813
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4; PF02662 FlpD [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 82602; Mature: 82471

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDKKIGVYLCTDCGIGEALNVDELEAVAKKEFKVPVCKQHPNLCSNEGVQIIKDDLNN
CCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEECCCCC
GEVNKIVIAACSQRVNNDVFNFDPLTYVTERVNLREQVVWTAPKGDDAKEGTQLMAADYL
CCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
RMGITRVQKSEVPIPKIADVNRTVLVVGGGVTGLTAALEASQTGYKVVLVEKAQELGGWA
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHH
KKMHRVFPTKPPFAEIEQPAIGNKIEAVKKDGNITVHTGTTIASIEGGPGEYTVTIDRNG
HHHHHHCCCCCCHHHCCCCCCCCHHHHEECCCCEEEEECCEEEEECCCCCCEEEEEECCC
TTETFPAGAIVLAAGWKPYDASKLGHLGYGKHRNVVTNLEFEQNVAKTGGKVTRPSDGKP
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCCC
AKNVVFLQCAGQRDKDHVPYCSTVCCNVSLKQAKYVRESDPDAGAFIVYKDMRTTGLYEN
CCCEEEEEECCCCCCCCCCCHHHHEECCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
FYKSAQDDEGIFLTKGEILGLSEESDGSLVIEIDNQLLGRKMKVKADLLVLATGMVSNMV
HHHCCCCCCCEEEECCEEEECCCCCCCEEEEEECCHHHCCEEEEECCEEEEEHHHHHHCC
PDGMSVNNLTPEYIGKMVQRETSDGVIEALEPESLILNLKYRQGPEMPHHKWGFPDSHFI
CCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCEE
CFPYETRRTGIYSAGAVRHPMDAVQASADATGAALKAIQCMELTAQGRAVHPRTWDRTYP
EEECHHCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
EIRFESCTQCRRCTVECPFGAYNEKADGTPLEFPSRCRRCGVCMGACPQRVISFRDYSVD
CCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHCCHHHCCHHHHHHHCCCCHH
MISAMIKSIEVPDEGTFVIGFVCENDAYPAFDMVGLNRIGMNTNFRFIPLRCLGGLNLAW
HHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHCCCEEECCCCCEEEEEEEECCCCCHHH
IADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLEAERVEQVQL
HHHHHHCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AINEWDKLPGILEEFSKKIKDIGDNPYKGF
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADDKKIGVYLCTDCGIGEALNVDELEAVAKKEFKVPVCKQHPNLCSNEGVQIIKDDLNN
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEECCCCC
GEVNKIVIAACSQRVNNDVFNFDPLTYVTERVNLREQVVWTAPKGDDAKEGTQLMAADYL
CCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
RMGITRVQKSEVPIPKIADVNRTVLVVGGGVTGLTAALEASQTGYKVVLVEKAQELGGWA
HHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHCCCCCCEEEEEECHHHHHHHH
KKMHRVFPTKPPFAEIEQPAIGNKIEAVKKDGNITVHTGTTIASIEGGPGEYTVTIDRNG
HHHHHHCCCCCCHHHCCCCCCCCHHHHEECCCCEEEEECCEEEEECCCCCCEEEEEECCC
TTETFPAGAIVLAAGWKPYDASKLGHLGYGKHRNVVTNLEFEQNVAKTGGKVTRPSDGKP
CCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCCCC
AKNVVFLQCAGQRDKDHVPYCSTVCCNVSLKQAKYVRESDPDAGAFIVYKDMRTTGLYEN
CCCEEEEEECCCCCCCCCCCHHHHEECCCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHH
FYKSAQDDEGIFLTKGEILGLSEESDGSLVIEIDNQLLGRKMKVKADLLVLATGMVSNMV
HHHCCCCCCCEEEECCEEEECCCCCCCEEEEEECCHHHCCEEEEECCEEEEEHHHHHHCC
PDGMSVNNLTPEYIGKMVQRETSDGVIEALEPESLILNLKYRQGPEMPHHKWGFPDSHFI
CCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCEE
CFPYETRRTGIYSAGAVRHPMDAVQASADATGAALKAIQCMELTAQGRAVHPRTWDRTYP
EEECHHCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCCCC
EIRFESCTQCRRCTVECPFGAYNEKADGTPLEFPSRCRRCGVCMGACPQRVISFRDYSVD
CCCHHHHHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHCCHHHCCHHHHHHHCCCCHH
MISAMIKSIEVPDEGTFVIGFVCENDAYPAFDMVGLNRIGMNTNFRFIPLRCLGGLNLAW
HHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHCCCEEECCCCCEEEEEEEECCCCCHHH
IADALSRGVDGILLLGCKYGDDYQCHYVKGSQMANERLGKVQETLDRLMLEAERVEQVQL
HHHHHHCCCCEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AINEWDKLPGILEEFSKKIKDIGDNPYKGF
HHHHHHCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]