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The map label for this gene is trx-1

Identifier: 21673615

GI number: 21673615

Start: 754899

End: 755204

Strand: Direct

Name: trx-1

Synonym: CT0785

Alternate gene names: 21673615

Gene position: 754899-755204 (Clockwise)

Preceding gene: 21673614

Following gene: 21673619

Centisome position: 35.03

GC content: 55.56

Gene sequence:

>306_bases
ATGGCTCAAACACTTGACGATCTTATCAGGACAAGCGAACTTCCCGTATTTATCGATTTCTGGGCCGACTGGTGCGGGCC
CTGTAAAATGGTGGCTCCATCCGTCAAACAGCTCGCCAGCGAGTTCAAGGGACGGTTGATCGTGGTCAAGGTCAACGTCG
ATCAGCAGCCTGACGCGGCGGCCCGTTTTCAGGTTCAGGGTATTCCGGCCCTCATGCTTTTTGTTGGTGGTCAGCTCAAA
TGGCGCACTGCCGGAGCGATACCCTACCAGCAAATGCGCCAGGAAGTGCTGAAAGCGATCGGGTGA

Upstream 100 bases:

>100_bases
CGCCAGAGTTGTGTTGAGCGGCTCAGGCAATTTTAGATTTACTCGTCGTGACAGTGGTGTTGCGAAGATTTCATTCACGA
AAAAAACAATTTAACCTCTT

Downstream 100 bases:

>100_bases
CGGAGAGCCATTGCTTTTGTTGATGGACTGGACGAGGTGTACAAAAGGTGGCACAAAAGGTGGCAACAATGAGGGCGCGG
CTACAGTGGCCGCCCTCATT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1

Number of amino acids: Translated: 101; Mature: 100

Protein sequence:

>101_residues
MAQTLDDLIRTSELPVFIDFWADWCGPCKMVAPSVKQLASEFKGRLIVVKVNVDQQPDAAARFQVQGIPALMLFVGGQLK
WRTAGAIPYQQMRQEVLKAIG

Sequences:

>Translated_101_residues
MAQTLDDLIRTSELPVFIDFWADWCGPCKMVAPSVKQLASEFKGRLIVVKVNVDQQPDAAARFQVQGIPALMLFVGGQLK
WRTAGAIPYQQMRQEVLKAIG
>Mature_100_residues
AQTLDDLIRTSELPVFIDFWADWCGPCKMVAPSVKQLASEFKGRLIVVKVNVDQQPDAAARFQVQGIPALMLFVGGQLKW
RTAGAIPYQQMRQEVLKAIG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=30.5263157894737, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI87082331, Length=92, Percent_Identity=38.0434782608696, Blast_Score=94, Evalue=2e-21,
Organism=Escherichia coli, GI1788936, Length=87, Percent_Identity=42.5287356321839, Blast_Score=82, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=98, Percent_Identity=34.6938775510204, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=98, Percent_Identity=34.6938775510204, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=43.6619718309859, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=87, Percent_Identity=34.4827586206897, Blast_Score=68, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=35.632183908046, Blast_Score=64, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639826, Length=72, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=37.8378378378378, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28573567, Length=90, Percent_Identity=32.2222222222222, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17648013, Length=92, Percent_Identity=33.695652173913, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583090, Length=92, Percent_Identity=33.695652173913, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO1_CHLTE (Q8KEA4)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661680.1
- ProteinModelPortal:   Q8KEA4
- SMR:   Q8KEA4
- GeneID:   1006420
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0785
- NMPDR:   fig|194439.1.peg.774
- TIGR:   CT0785
- HOGENOM:   HBG493509
- OMA:   DDLIRTS
- ProtClustDB:   CLSK637470
- BioCyc:   CTEP194439:CT_0785-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11247; Mature: 11116

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTLDDLIRTSELPVFIDFWADWCGPCKMVAPSVKQLASEFKGRLIVVKVNVDQQPDAA
CCCHHHHHHHHCCCCEEEEEHHHHCCCHHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
ARFQVQGIPALMLFVGGQLKWRTAGAIPYQQMRQEVLKAIG
CEEEECCCCEEEEHHCCCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AQTLDDLIRTSELPVFIDFWADWCGPCKMVAPSVKQLASEFKGRLIVVKVNVDQQPDAA
CCHHHHHHHHCCCCEEEEEHHHHCCCHHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCC
ARFQVQGIPALMLFVGGQLKWRTAGAIPYQQMRQEVLKAIG
CEEEECCCCEEEEHHCCCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901