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The map label for this gene is ndhB [H]

Identifier: 21673606

GI number: 21673606

Start: 748934

End: 750469

Strand: Direct

Name: ndhB [H]

Synonym: CT0776

Alternate gene names: 21673606

Gene position: 748934-750469 (Clockwise)

Preceding gene: 21673605

Following gene: 21673607

Centisome position: 34.75

GC content: 53.65

Gene sequence:

>1536_bases
ATGTTTGAAATGCCATCAGGCGCTGAAATACAGAGCATCATCTCGATCCTCAAGGGTGGTGCCGGATATTTTGTCCCTGA
AATCTATTTGTCGGCGCTCTTTATGGTGCTGATACTGCTCGATCTCATCACGGGGAAAAAGAATCGCGGATTACTTGCCA
CGGCTACCATCGCCGGTTTGCTCGGCAGTGTCTATTTTATTTTCAAGCAGCAGACGATGCCGGAGGTTCAGTTCTTTTTC
GGCATGTACGCGCTTGACCGCTTCGGTATCTTTTTCAAGTACTTTTTCGTGGTCTCCGGCGTTCTTGCCGTGCTGACCAC
CGTGATCGACGAGCAGCTCAAAAAGCACGAGTCGGGCATGGGTGAGTACTATGCGCTGCTGGTGGCTATGGTGGTCGGCA
TGATGATGATGGCATCCTCGACTGATCTGTTAATGATGTTCCTTTCGATGGAGCTTGTTAGTCTTTCGGCTTACGCGCTG
ACCGGTTACCTGAAGCGCGAACCTCGCTCCTCGGAAGCGGCCCTGAAATACCTGGTGTACGGCGCAGTCTCCTCGGGAAT
GCTCCTGTATGGCTTCTCGCTCTTGTACGGTATGACCGCCGAAACCAATCTTACCCGCATCAGCATGGTGCTTGCCGCGC
ATGGCTACGATCCGCTGGCGATGATACTTGCCGTGCTGCTCATCATGGCAGGTCTCGGCTACAAGATGGGCGCGGTACCG
TTCCACTTCTGGAGCCCCGACGTTTACGAGGGCGCACCTACTCCGGTCACCGCCTATCTTTCGGTTGCCTCCAAGGCTGC
CGGTTTCGCCATGCTCATGCGTTTCTTTTTCGTGGCTGTGCCTCACGGCTTCGATATGTATGTCAGCCCGCTGCACATTG
ACTGGCTCTCGATCCTGATACTGGTCTCCGCGGCTTCGATGATCTACGGTAACGTCGTGGCTATTTGGCAGAAGAACGTC
AAACGTCTGCTTGCTTACTCCTCGATCGCCCACGCCGGTTATCTCTTGCTCGGCATCATCACCATGGATCAGCTCGGCAC
ACAGGCGGTTCTGGTCTATCTCGCCGCTTATCTCCTGATGAACTATGGCGCTTTCTATGTGGTGATTCTCATCGCCAACC
ACACCGGAAGCGAAAACCTTGATGACTACAAAGGTCTTGGCAAAAGAATGCCGTTGCTCGGTGCTGCCCTGACGGTGTTC
CTCATCTCGCTGGTCGGTCTGCCGCCGACCTTCGGCTTCATCGGCAAGCTGATGATCTTCTCAGCGCTGCTCGCCAAAGG
CAGCCTCTTCATGTGGCTGGCTCTGATCGGTATCCTGACCAGTGTTATTTCGCTCTATTACTACATGCTGATTCCGCTCA
ACATGTATCTGAGAGAGTCGAACACTCCCGAAGAGGGCGTGATCGCGACCGGCATGGGCGCGAAGATCGTCACCGCTTCG
CTGATGATTCTGACGTTGTGGTTTGGTCTGTTTTTCCAGCCAATTGCCAACTATGCAAGATATTCAACGTCTATTTTCGG
AGCGTTTCTGAACTGA

Upstream 100 bases:

>100_bases
CGACCAGTGTCAACAAACTTGTCCAGGTTCTCACTCCGGTTGCCATGTCGGCCGTGCATTGATTTGGTGTTCCGTTTAAA
AGCATAAACGTTGGAGAAAT

Downstream 100 bases:

>100_bases
ACGGTCTGACATAAACGCTTTTTGACGGCCTTAAAAAACCTGGTAAATCTTTTTGATTGCCAGGTTTTTTTATTTGAAGC
TTTTTGATTAGTTAATAAAT

Product: NADH dehydrogenase I, subunit 2

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MFEMPSGAEIQSIISILKGGAGYFVPEIYLSALFMVLILLDLITGKKNRGLLATATIAGLLGSVYFIFKQQTMPEVQFFF
GMYALDRFGIFFKYFFVVSGVLAVLTTVIDEQLKKHESGMGEYYALLVAMVVGMMMMASSTDLLMMFLSMELVSLSAYAL
TGYLKREPRSSEAALKYLVYGAVSSGMLLYGFSLLYGMTAETNLTRISMVLAAHGYDPLAMILAVLLIMAGLGYKMGAVP
FHFWSPDVYEGAPTPVTAYLSVASKAAGFAMLMRFFFVAVPHGFDMYVSPLHIDWLSILILVSAASMIYGNVVAIWQKNV
KRLLAYSSIAHAGYLLLGIITMDQLGTQAVLVYLAAYLLMNYGAFYVVILIANHTGSENLDDYKGLGKRMPLLGAALTVF
LISLVGLPPTFGFIGKLMIFSALLAKGSLFMWLALIGILTSVISLYYYMLIPLNMYLRESNTPEEGVIATGMGAKIVTAS
LMILTLWFGLFFQPIANYARYSTSIFGAFLN

Sequences:

>Translated_511_residues
MFEMPSGAEIQSIISILKGGAGYFVPEIYLSALFMVLILLDLITGKKNRGLLATATIAGLLGSVYFIFKQQTMPEVQFFF
GMYALDRFGIFFKYFFVVSGVLAVLTTVIDEQLKKHESGMGEYYALLVAMVVGMMMMASSTDLLMMFLSMELVSLSAYAL
TGYLKREPRSSEAALKYLVYGAVSSGMLLYGFSLLYGMTAETNLTRISMVLAAHGYDPLAMILAVLLIMAGLGYKMGAVP
FHFWSPDVYEGAPTPVTAYLSVASKAAGFAMLMRFFFVAVPHGFDMYVSPLHIDWLSILILVSAASMIYGNVVAIWQKNV
KRLLAYSSIAHAGYLLLGIITMDQLGTQAVLVYLAAYLLMNYGAFYVVILIANHTGSENLDDYKGLGKRMPLLGAALTVF
LISLVGLPPTFGFIGKLMIFSALLAKGSLFMWLALIGILTSVISLYYYMLIPLNMYLRESNTPEEGVIATGMGAKIVTAS
LMILTLWFGLFFQPIANYARYSTSIFGAFLN
>Mature_511_residues
MFEMPSGAEIQSIISILKGGAGYFVPEIYLSALFMVLILLDLITGKKNRGLLATATIAGLLGSVYFIFKQQTMPEVQFFF
GMYALDRFGIFFKYFFVVSGVLAVLTTVIDEQLKKHESGMGEYYALLVAMVVGMMMMASSTDLLMMFLSMELVSLSAYAL
TGYLKREPRSSEAALKYLVYGAVSSGMLLYGFSLLYGMTAETNLTRISMVLAAHGYDPLAMILAVLLIMAGLGYKMGAVP
FHFWSPDVYEGAPTPVTAYLSVASKAAGFAMLMRFFFVAVPHGFDMYVSPLHIDWLSILILVSAASMIYGNVVAIWQKNV
KRLLAYSSIAHAGYLLLGIITMDQLGTQAVLVYLAAYLLMNYGAFYVVILIANHTGSENLDDYKGLGKRMPLLGAALTVF
LISLVGLPPTFGFIGKLMIFSALLAKGSLFMWLALIGILTSVISLYYYMLIPLNMYLRESNTPEEGVIATGMGAKIVTAS
LMILTLWFGLFFQPIANYARYSTSIFGAFLN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=312, Percent_Identity=23.3974358974359, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI145693160, Length=477, Percent_Identity=32.2851153039832, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=26.7241379310345, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788614, Length=356, Percent_Identity=28.0898876404494, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788613, Length=376, Percent_Identity=25, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788829, Length=352, Percent_Identity=25.2840909090909, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788827, Length=333, Percent_Identity=24.024024024024, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56058; Mature: 56058

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA