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The map label for this gene is ndhD [H]

Identifier: 21673605

GI number: 21673605

Start: 747258

End: 748895

Strand: Direct

Name: ndhD [H]

Synonym: CT0775

Alternate gene names: 21673605

Gene position: 747258-748895 (Clockwise)

Preceding gene: 21673604

Following gene: 21673606

Centisome position: 34.68

GC content: 55.43

Gene sequence:

>1638_bases
ATGCTGAGCTTCATTGTATTTCTGCCGATCATTGCCGGACTTGTCATTTTGGCTGTGCCCTCGTCGCAGAAGCAGATCAT
CAGGATCGTCTCGCTCCTGGCTGCTCTCGGCCAGGGCGTGCTCGCCGTCCTCATCTGGCGCCATTACGACCCGACGATGG
CGGGTATCGTGGCCGCTCCCGGTGGATCGCCTGTCGGCTCCTTCCAGATGATCGAACGGATTCCGTGGATTTCGCTCGAT
CTCGGCTCGTTCGGCCCCCTGAACATCGAGTATTTCCTCGGTGTTGACGGCCTTTCGATCACGATGGTGCTGCTGACCGC
CCTGATTTCAATTATCGGTGTGCTTTCCAGCTGGCCGATCCAGAAGCAGGTCAAGGGCTACTTCATCCTTTACAACCTGC
TCAGCACGGCCATGATGGGCTGTTTCGTGGCGCTCGATTTCTTTCTTTTCTACGTGTTCTGGGAATTGATGCTTCTGCCG
ATGTACTTCCTCATCGGTATCTGGGGTGGTCCGAACCGTGAGTATGCAGCCATCAAGTTCTTCCTTTACACCCTGTTTGG
TTCGGTGTTCATGCTGCTGGTCATGATTGGCCTCTACTTCAGCGTCACCGATCCGCTCACTGGCCATCACACTTTCAGTC
TTGTTGCCATGGCTGACCAGGCAAACTATATCAAGGGCACGATTCTTGGCCCTGACAGCGTCACCTGGAGATATGTTGCC
TTCATTGTGCTCTTCGTCGGCTTTGCCATCAAGGTTCCGATGTTCCCTTTCCACACCTGGCTGCCTGACGCGCACGTTGA
GGCTCCGACTCCGATCTCTGTCATTCTGGCCGGTGTGCTGCTGAAGCTCGGTACTTACGGCATGATGAGGATCAACTTCC
CGCTCTTTCCTGAGGTTTACCAGGCAGGCCTCTATGTGATTGGTGTGTTTGGCGCGATCAACATCATCTACGGTGCCTTC
TGCGCTCTGGCCCAGCAGGATCTGAAGAAAATGGTTGCTTATTCGTCGATCAGTCACATGGGCTATGTGCTGCTCGGCCT
GGCTGCGGCCAACACCGAAGGCATGATCGGCGCGCTCTACCAGATGTTCAACCACGGCACCATCACCGCTATGCTTTTCC
TTCTGGTCGGCGTCATCTACGATCGTGCTCACGCCCGCCAGATCGACAAGTTTGGTGGCCTGGCTACCTATATGCCTGTC
TATACCGGTTTCGTGATCGTCGCATGGTTTGCCTCGCTTGGTCTGCCGGGTCTCTCCGGCTTCATCTCAGAGGCGCTCGT
ATTTGTCGGCGCGTTCAGCGCTCCCGTTACTCGTCCGATCGCTATGGTTTCGGTGCTCGGTATCGTTTTCGGCGCGGCCT
ACCTGCTCTGGTCGTTGCAGCGGATGTTCCTCGGCAAGCGCAAGCCGGACGCTTTGTACGATCTCGAAGTTGATGTCGAT
GGACACGAGCATATTCACTTCCATGACTGGAAAGGCAAGCTCGATCTCGATGCCCGTGAACTGACCATGCTCGTGCCGCT
TGTGATCATCGTCATTGCGCTCGGTATCTATCCAATGCCGGTTATGGGTCTCATTACGACCAGTGTCAACAAACTTGTCC
AGGTTCTCACTCCGGTTGCCATGTCGGCCGTGCATTGA

Upstream 100 bases:

>100_bases
GGTTTTTGCGGTTCTGGGCTGGTTCGCCCTTTACTTTGCGCACCTCGTCAAATAACCGAACGATTTAATTTTTACTCTCC
GAACATAACAGGTATTGAAC

Downstream 100 bases:

>100_bases
TTTGGTGTTCCGTTTAAAAGCATAAACGTTGGAGAAATATGTTTGAAATGCCATCAGGCGCTGAAATACAGAGCATCATC
TCGATCCTCAAGGGTGGTGC

Product: NADH dehydrogenase I, subunit 4

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MLSFIVFLPIIAGLVILAVPSSQKQIIRIVSLLAALGQGVLAVLIWRHYDPTMAGIVAAPGGSPVGSFQMIERIPWISLD
LGSFGPLNIEYFLGVDGLSITMVLLTALISIIGVLSSWPIQKQVKGYFILYNLLSTAMMGCFVALDFFLFYVFWELMLLP
MYFLIGIWGGPNREYAAIKFFLYTLFGSVFMLLVMIGLYFSVTDPLTGHHTFSLVAMADQANYIKGTILGPDSVTWRYVA
FIVLFVGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVYQAGLYVIGVFGAINIIYGAF
CALAQQDLKKMVAYSSISHMGYVLLGLAAANTEGMIGALYQMFNHGTITAMLFLLVGVIYDRAHARQIDKFGGLATYMPV
YTGFVIVAWFASLGLPGLSGFISEALVFVGAFSAPVTRPIAMVSVLGIVFGAAYLLWSLQRMFLGKRKPDALYDLEVDVD
GHEHIHFHDWKGKLDLDARELTMLVPLVIIVIALGIYPMPVMGLITTSVNKLVQVLTPVAMSAVH

Sequences:

>Translated_545_residues
MLSFIVFLPIIAGLVILAVPSSQKQIIRIVSLLAALGQGVLAVLIWRHYDPTMAGIVAAPGGSPVGSFQMIERIPWISLD
LGSFGPLNIEYFLGVDGLSITMVLLTALISIIGVLSSWPIQKQVKGYFILYNLLSTAMMGCFVALDFFLFYVFWELMLLP
MYFLIGIWGGPNREYAAIKFFLYTLFGSVFMLLVMIGLYFSVTDPLTGHHTFSLVAMADQANYIKGTILGPDSVTWRYVA
FIVLFVGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVYQAGLYVIGVFGAINIIYGAF
CALAQQDLKKMVAYSSISHMGYVLLGLAAANTEGMIGALYQMFNHGTITAMLFLLVGVIYDRAHARQIDKFGGLATYMPV
YTGFVIVAWFASLGLPGLSGFISEALVFVGAFSAPVTRPIAMVSVLGIVFGAAYLLWSLQRMFLGKRKPDALYDLEVDVD
GHEHIHFHDWKGKLDLDARELTMLVPLVIIVIALGIYPMPVMGLITTSVNKLVQVLTPVAMSAVH
>Mature_545_residues
MLSFIVFLPIIAGLVILAVPSSQKQIIRIVSLLAALGQGVLAVLIWRHYDPTMAGIVAAPGGSPVGSFQMIERIPWISLD
LGSFGPLNIEYFLGVDGLSITMVLLTALISIIGVLSSWPIQKQVKGYFILYNLLSTAMMGCFVALDFFLFYVFWELMLLP
MYFLIGIWGGPNREYAAIKFFLYTLFGSVFMLLVMIGLYFSVTDPLTGHHTFSLVAMADQANYIKGTILGPDSVTWRYVA
FIVLFVGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVYQAGLYVIGVFGAINIIYGAF
CALAQQDLKKMVAYSSISHMGYVLLGLAAANTEGMIGALYQMFNHGTITAMLFLLVGVIYDRAHARQIDKFGGLATYMPV
YTGFVIVAWFASLGLPGLSGFISEALVFVGAFSAPVTRPIAMVSVLGIVFGAAYLLWSLQRMFLGKRKPDALYDLEVDVD
GHEHIHFHDWKGKLDLDARELTMLVPLVIIVIALGIYPMPVMGLITTSVNKLVQVLTPVAMSAVH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=323, Percent_Identity=33.4365325077399, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI251831117, Length=174, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1788613, Length=541, Percent_Identity=33.641404805915, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1788827, Length=340, Percent_Identity=29.7058823529412, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788614, Length=522, Percent_Identity=28.3524904214559, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788831, Length=425, Percent_Identity=26.3529411764706, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI1788829, Length=300, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI2367154, Length=343, Percent_Identity=26.530612244898, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693160, Length=355, Percent_Identity=27.3239436619718, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 59793; Mature: 59793

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFIVFLPIIAGLVILAVPSSQKQIIRIVSLLAALGQGVLAVLIWRHYDPTMAGIVAAP
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHCEEECC
GGSPVGSFQMIERIPWISLDLGSFGPLNIEYFLGVDGLSITMVLLTALISIIGVLSSWPI
CCCCCCHHHHHHHCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
QKQVKGYFILYNLLSTAMMGCFVALDFFLFYVFWELMLLPMYFLIGIWGGPNREYAAIKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FLYTLFGSVFMLLVMIGLYFSVTDPLTGHHTFSLVAMADQANYIKGTILGPDSVTWRYVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHH
FIVLFVGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVY
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHH
QAGLYVIGVFGAINIIYGAFCALAQQDLKKMVAYSSISHMGYVLLGLAAANTEGMIGALY
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QMFNHGTITAMLFLLVGVIYDRAHARQIDKFGGLATYMPVYTGFVIVAWFASLGLPGLSG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
FISEALVFVGAFSAPVTRPIAMVSVLGIVFGAAYLLWSLQRMFLGKRKPDALYDLEVDVD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
GHEHIHFHDWKGKLDLDARELTMLVPLVIIVIALGIYPMPVMGLITTSVNKLVQVLTPVA
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MSAVH
HHHCC
>Mature Secondary Structure
MLSFIVFLPIIAGLVILAVPSSQKQIIRIVSLLAALGQGVLAVLIWRHYDPTMAGIVAAP
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHCEEECC
GGSPVGSFQMIERIPWISLDLGSFGPLNIEYFLGVDGLSITMVLLTALISIIGVLSSWPI
CCCCCCHHHHHHHCCCEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
QKQVKGYFILYNLLSTAMMGCFVALDFFLFYVFWELMLLPMYFLIGIWGGPNREYAAIKF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FLYTLFGSVFMLLVMIGLYFSVTDPLTGHHTFSLVAMADQANYIKGTILGPDSVTWRYVA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHH
FIVLFVGFAIKVPMFPFHTWLPDAHVEAPTPISVILAGVLLKLGTYGMMRINFPLFPEVY
HHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHH
QAGLYVIGVFGAINIIYGAFCALAQQDLKKMVAYSSISHMGYVLLGLAAANTEGMIGALY
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
QMFNHGTITAMLFLLVGVIYDRAHARQIDKFGGLATYMPVYTGFVIVAWFASLGLPGLSG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
FISEALVFVGAFSAPVTRPIAMVSVLGIVFGAAYLLWSLQRMFLGKRKPDALYDLEVDVD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
GHEHIHFHDWKGKLDLDARELTMLVPLVIIVIALGIYPMPVMGLITTSVNKLVQVLTPVA
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MSAVH
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]