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The map label for this gene is ndhK [H]

Identifier: 21673599

GI number: 21673599

Start: 741062

End: 742168

Strand: Direct

Name: ndhK [H]

Synonym: CT0769

Alternate gene names: 21673599

Gene position: 741062-742168 (Clockwise)

Preceding gene: 21673598

Following gene: 21673600

Centisome position: 34.39

GC content: 56.01

Gene sequence:

>1107_bases
ATGGTGCTCAGCATGGGGCCGCAGCACCCGTCAACGCACGGCGTGCTCCGTCTCGAATGCATCACCGACGGTGAAGTGGT
CGTCGAGGCCGAGCCGTACCTCGGCTATCTCCACCGCTGTTTCGAGAAGCATTGCGAAAAGATTGACTATCCGGCCATCG
TGCCCTATACCGACAGGATGGACTACCTTGCCGGCATGAACAACGAGCTGGCTTACTGCATCACCGTCGAGAAGTTGCTT
GACATCGAAATTCCCCGCCGTGTCGAATTTATCCGTGTCATCGTCGCTGAGCTGAACAGGATCGCTTCGCACCTGGTGGC
CATTGGCACTTACGCTATAGACCTTGGCGCTTTCACACCGTTCCTCTTCTGCTTCCGCGATCGAGAGCACATCATGAGCC
TGCTCGAATGGATCTCCGGTGCGCGTATGCTCTATAACTATATCTGGATCGGTGGTCTTGCCTATGATGTTCCTGCCGAT
TTCAAGACGCGTGTTGCCGAGTTTGTCACCTACTTCAGGCCGAAAGCCAAAGAGTTGTACCAGCTCTTGACAGAGAACGA
GATTTTCGTCAAGCGCACGTACGACATTGGCATCATGCCTGCCGACGTAGCGATCAACTATGGCTGGAGCGGTCCGATGC
TTCGTGGTTCCGGCGTCAAGTGGGATCTGCGCCGCAACGATCCCTATTCGGTCTATCCCGAACTTGATTTCGATGTTCCG
GTACCGGACGGCAAGTTCTCCGTTGTCGGTGACTGCCTGTCGCGCCATCTGGTTCGCGCGCTCGAAATGGAGGAGAGTCT
CAAAATCATCGAGCAGTGTCTCGACAAAATGCCGGAAGAGCCGAACTTCAACTCGCGGGCGCTTATTCCCAAGAAGATTA
GGCCCAAGGCTGGCGAGGTCTATGGCCGTGCCGAGAATCCGCGTGGAGAGCTTGGCTACTACATCGTCAGCGATGGAAAA
TCGACCAGCCCGGTGCGCTGCAAGGCCCGTTCGTCGTGCTTCGTCAACCTGTCGGCGATGAAGGATCTTTCGAAGGGGCA
GCTGATTCCCGATCTGGTGGCCATCATTGGCAGCATCGATATCGTGCTGGGTGAAGTTGACCGCTGA

Upstream 100 bases:

>100_bases
AGTCATGCAGGAATTAGGCAAAGCTGAAACGAACTCCACCAGGATCATCCGTCAGGACGACAAGCGCGTCACTATCGAAA
AGGATCTCGATACCGAACAT

Downstream 100 bases:

>100_bases
CCGTTTTCAAGACAACACTTTTATTTCAAGAAGGTTCGCCTATTGATATGAGTTCATCACCATCTCTCAATACCTGGTCC
GACGCCCTTTCAGGTTTCTC

Product: NADH dehydrogenase I, 49 kDa subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MVLSMGPQHPSTHGVLRLECITDGEVVVEAEPYLGYLHRCFEKHCEKIDYPAIVPYTDRMDYLAGMNNELAYCITVEKLL
DIEIPRRVEFIRVIVAELNRIASHLVAIGTYAIDLGAFTPFLFCFRDREHIMSLLEWISGARMLYNYIWIGGLAYDVPAD
FKTRVAEFVTYFRPKAKELYQLLTENEIFVKRTYDIGIMPADVAINYGWSGPMLRGSGVKWDLRRNDPYSVYPELDFDVP
VPDGKFSVVGDCLSRHLVRALEMEESLKIIEQCLDKMPEEPNFNSRALIPKKIRPKAGEVYGRAENPRGELGYYIVSDGK
STSPVRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR

Sequences:

>Translated_368_residues
MVLSMGPQHPSTHGVLRLECITDGEVVVEAEPYLGYLHRCFEKHCEKIDYPAIVPYTDRMDYLAGMNNELAYCITVEKLL
DIEIPRRVEFIRVIVAELNRIASHLVAIGTYAIDLGAFTPFLFCFRDREHIMSLLEWISGARMLYNYIWIGGLAYDVPAD
FKTRVAEFVTYFRPKAKELYQLLTENEIFVKRTYDIGIMPADVAINYGWSGPMLRGSGVKWDLRRNDPYSVYPELDFDVP
VPDGKFSVVGDCLSRHLVRALEMEESLKIIEQCLDKMPEEPNFNSRALIPKKIRPKAGEVYGRAENPRGELGYYIVSDGK
STSPVRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR
>Mature_368_residues
MVLSMGPQHPSTHGVLRLECITDGEVVVEAEPYLGYLHRCFEKHCEKIDYPAIVPYTDRMDYLAGMNNELAYCITVEKLL
DIEIPRRVEFIRVIVAELNRIASHLVAIGTYAIDLGAFTPFLFCFRDREHIMSLLEWISGARMLYNYIWIGGLAYDVPAD
FKTRVAEFVTYFRPKAKELYQLLTENEIFVKRTYDIGIMPADVAINYGWSGPMLRGSGVKWDLRRNDPYSVYPELDFDVP
VPDGKFSVVGDCLSRHLVRALEMEESLKIIEQCLDKMPEEPNFNSRALIPKKIRPKAGEVYGRAENPRGELGYYIVSDGK
STSPVRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSIDIVLGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=390, Percent_Identity=44.1025641025641, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI260898743, Length=384, Percent_Identity=43.2291666666667, Blast_Score=301, Evalue=6e-82,
Organism=Escherichia coli, GI145693162, Length=390, Percent_Identity=37.1794871794872, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789076, Length=369, Percent_Identity=28.9972899728997, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1788832, Length=370, Percent_Identity=29.7297297297297, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17555284, Length=390, Percent_Identity=42.0512820512821, Blast_Score=321, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI17568379, Length=390, Percent_Identity=42.3076923076923, Blast_Score=320, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24638644, Length=390, Percent_Identity=43.3333333333333, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI221459469, Length=389, Percent_Identity=41.3881748071979, Blast_Score=315, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 41765; Mature: 41765

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSMGPQHPSTHGVLRLECITDGEVVVEAEPYLGYLHRCFEKHCEKIDYPAIVPYTDRM
CCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHCCCCEECCCCCCH
DYLAGMNNELAYCITVEKLLDIEIPRRVEFIRVIVAELNRIASHLVAIGTYAIDLGAFTP
HHHHCCCCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLFCFRDREHIMSLLEWISGARMLYNYIWIGGLAYDVPADFKTRVAEFVTYFRPKAKELY
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCHHHHH
QLLTENEIFVKRTYDIGIMPADVAINYGWSGPMLRGSGVKWDLRRNDPYSVYPELDFDVP
HHHCCCCEEEEEEECCCEEEHHEEEECCCCCCEECCCCCEEEECCCCCCEECCCCCCCCC
VPDGKFSVVGDCLSRHLVRALEMEESLKIIEQCLDKMPEEPNFNSRALIPKKIRPKAGEV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
YGRAENPRGELGYYIVSDGKSTSPVRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSID
CCCCCCCCCCCCEEEEECCCCCCCEEEEECCCEEEEHHHHHCCCCCCHHHHHHHHHCCHH
IVLGEVDR
EEEECCCC
>Mature Secondary Structure
MVLSMGPQHPSTHGVLRLECITDGEVVVEAEPYLGYLHRCFEKHCEKIDYPAIVPYTDRM
CCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHCCCCEECCCCCCH
DYLAGMNNELAYCITVEKLLDIEIPRRVEFIRVIVAELNRIASHLVAIGTYAIDLGAFTP
HHHHCCCCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLFCFRDREHIMSLLEWISGARMLYNYIWIGGLAYDVPADFKTRVAEFVTYFRPKAKELY
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCHHHHH
QLLTENEIFVKRTYDIGIMPADVAINYGWSGPMLRGSGVKWDLRRNDPYSVYPELDFDVP
HHHCCCCEEEEEEECCCEEEHHEEEECCCCCCEECCCCCEEEECCCCCCEECCCCCCCCC
VPDGKFSVVGDCLSRHLVRALEMEESLKIIEQCLDKMPEEPNFNSRALIPKKIRPKAGEV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
YGRAENPRGELGYYIVSDGKSTSPVRCKARSSCFVNLSAMKDLSKGQLIPDLVAIIGSID
CCCCCCCCCCCCEEEEECCCCCCCEEEEECCCEEEEHHHHHCCCCCCHHHHHHHHHCCHH
IVLGEVDR
EEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA