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The map label for this gene is hisB

Identifier: 21673565

GI number: 21673565

Start: 715946

End: 716530

Strand: Reverse

Name: hisB

Synonym: CT0735

Alternate gene names: 21673565

Gene position: 716530-715946 (Counterclockwise)

Preceding gene: 21673566

Following gene: 21673558

Centisome position: 33.25

GC content: 57.26

Gene sequence:

>585_bases
ATGACCCAGCGCATCGCATCTCACAGCCGCAAAACTGCTGAAACGGACATTTCCGCCACCGTCAATCTCGACGGTTCAGG
AACGTCGGCCATCGAGACCGGCGTGGTTTTTCTCGATCACATGCTCACCAACTTCAGCCGCCACTCCGGCATCGACGTGC
AGTTACGGTGCAGCGGCGATCTGGAAGTTGACGACCACCACACCGTAGAAGATGTAGCGCTGGTGCTCGGCAAAGCCATC
GTGGACGCGCTTGGCGACAAAAAAGGTATCGGACGCTACGGCTGGGCGATCATCCCGATGGACGAAGCGCTGGCACAGTG
CTCGATCGACCTCGGTGGGCGTAGCTATTGCGTCTTCAGGGCAGAATTTCAGCGCCCGGTGATCCAGGGGCTTTCAACCG
AGATGGTAGAGCACTTCTTTGTGTCGCTCTCGCGAACGATGAACGCAAACCTGCACCTCGCGGTTCTGGAGGGCCGGAAT
ACGCACCATATGATCGAGGCGCTCTTTAAGTCGCTGGCCTACGCGATGAAGCAGGCAGTGAAGGTCGAAAGCACAGAAAT
CAAATCGACCAAAGGGGCAATCTGA

Upstream 100 bases:

>100_bases
CGCTCGGAAGCTCCATCGTCCTGTCAATCATCCTGAGCCTCGTCATTGGCCTTATCAACAAATTTTTCAGATAGCATCAT
TCATGTCAGAATCAACACCC

Downstream 100 bases:

>100_bases
GATAAGAAGTACAACACAAATAAAAAAGGCTGCCCAGTATTTTCCCGAAGCAGCCTTTTTTATTCGATCAGTCAGATTTT
TTACTTTGCAAAGGCGACCG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MTQRIASHSRKTAETDISATVNLDGSGTSAIETGVVFLDHMLTNFSRHSGIDVQLRCSGDLEVDDHHTVEDVALVLGKAI
VDALGDKKGIGRYGWAIIPMDEALAQCSIDLGGRSYCVFRAEFQRPVIQGLSTEMVEHFFVSLSRTMNANLHLAVLEGRN
THHMIEALFKSLAYAMKQAVKVESTEIKSTKGAI

Sequences:

>Translated_194_residues
MTQRIASHSRKTAETDISATVNLDGSGTSAIETGVVFLDHMLTNFSRHSGIDVQLRCSGDLEVDDHHTVEDVALVLGKAI
VDALGDKKGIGRYGWAIIPMDEALAQCSIDLGGRSYCVFRAEFQRPVIQGLSTEMVEHFFVSLSRTMNANLHLAVLEGRN
THHMIEALFKSLAYAMKQAVKVESTEIKSTKGAI
>Mature_193_residues
TQRIASHSRKTAETDISATVNLDGSGTSAIETGVVFLDHMLTNFSRHSGIDVQLRCSGDLEVDDHHTVEDVALVLGKAIV
DALGDKKGIGRYGWAIIPMDEALAQCSIDLGGRSYCVFRAEFQRPVIQGLSTEMVEHFFVSLSRTMNANLHLAVLEGRNT
HHMIEALFKSLAYAMKQAVKVESTEIKSTKGAI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=48.1675392670157, Blast_Score=187, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=37.2727272727273, Blast_Score=145, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CHLTE (Q8KEF4)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661630.1
- ProteinModelPortal:   Q8KEF4
- SMR:   Q8KEF4
- GeneID:   1006367
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0735
- NMPDR:   fig|194439.1.peg.724
- TIGR:   CT0735
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   PRK00951
- BioCyc:   CTEP194439:CT_0735-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21189; Mature: 21058

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRIASHSRKTAETDISATVNLDGSGTSAIETGVVFLDHMLTNFSRHSGIDVQLRCSGD
CCCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
LEVDDHHTVEDVALVLGKAIVDALGDKKGIGRYGWAIIPMDEALAQCSIDLGGRSYCVFR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEEE
AEFQRPVIQGLSTEMVEHFFVSLSRTMNANLHLAVLEGRNTHHMIEALFKSLAYAMKQAV
HHHCCHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
KVESTEIKSTKGAI
HHHHHHHCCCCCCC
>Mature Secondary Structure 
TQRIASHSRKTAETDISATVNLDGSGTSAIETGVVFLDHMLTNFSRHSGIDVQLRCSGD
CCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
LEVDDHHTVEDVALVLGKAIVDALGDKKGIGRYGWAIIPMDEALAQCSIDLGGRSYCVFR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCEEEEEE
AEFQRPVIQGLSTEMVEHFFVSLSRTMNANLHLAVLEGRNTHHMIEALFKSLAYAMKQAV
HHHCCHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
KVESTEIKSTKGAI
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901