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The map label for this gene is ilvC

Identifier: 21673451

GI number: 21673451

Start: 617604

End: 618596

Strand: Reverse

Name: ilvC

Synonym: CT0616

Alternate gene names: 21673451

Gene position: 618596-617604 (Counterclockwise)

Preceding gene: 21673452

Following gene: 21673450

Centisome position: 28.71

GC content: 59.11

Gene sequence:

>993_bases
ATGAATATCTATTACGAGCAGGATGCCGATCTTGCGGTACTGCAGAACAAGAATATCGCCATTCTCGGCTACGGCAGCCA
GGGCCACGCTCATGCGCTGAACCTGAAGGACAGCGGCATGAACGTCTGCGTCGGCCTCAAGACCGACAGCGCCTCCTGCG
CCAAGGCACGCGAAGCGGGCCTGAAGGTTGACACTGTGGCCGAAGCGGTCAAATGGGCCGATATCGTCATGATTCTCCTG
CCGGATCAGACCCAGAAAAGCGTTTACGACAACGAAATCGCGCCGAACCTGAAATCGGGCGCGACGCTCGCTTTCGGCCA
CGGCTTCAATATTCACTACAAGCAGATCGTGCCGCCGGCTGACGTGAACGTCATCATGATCGCGCCCAAAAGCCCCGGCC
ACCTCGTTCGCCGCACCTACACCGAAGGCAACGGCGTGCCCTGCCTCATCGCGGTGCACCAGGACGCTACCGGCGACGCC
AAGGCAATTGCGCTCGCATGGGCAAAAGGCATCGGCGGCACCAAGGCTGGCGTGATCGAGACCAGCTTCAAGGATGAAAC
TGAAACCGACCTCTTCGGTGAACAGGCCGTCTTGTGCGGCGGTTCGGCTGAACTCATCAAGGCCGGATTCGAGACCCTCA
CCGAGGCGGGCTATCCTGCCGAGCTGGCCTACTTCGAGTGCATGCACGAGCTGAAGCTCATCGTTGACCTTTACTACGAA
GGCGGCCTGTCGCGCATGAACTACTCGGTCAGCGACACCGCCGAGTACGGCGGCATGACCCGCGGCCCGCGCGTCGTCAC
TTCCGCCGCGAAAGCCGAGATGAAGAAGATTCTCGAAGAGATTCAGGACGGTCGCTTCGCAAAAGAGTTCATCGACGAAT
GCAACTCCGGTTACAAGAAGATGAACGAGTTGCGTGAGAGCAACCGCAACCACCCCATCGAAGTCGTCGGCGCGAAGCTG
CGCGGCATGATGAGCTGGCTGAAAAAGAAATAA

Upstream 100 bases:

>100_bases
GGCATCCGTGAACTCGCCCGTTCCGGCGCGGTAGCCATCCATCGCGGCGAGAGCTGAAGTTTTTTATGTACGTCCAAAAC
CAGTCAACACGAATATGTCA

Downstream 100 bases:

>100_bases
GCGGGAGGATGATGTATAAAATTGTCTCTATCCCCGGCGACGGCATCGGCCCCGAAGTGGTAGCCGGTGCGCTCGACGTG
CTGAACGCCGTCGCGAAAAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNIYYEQDADLAVLQNKNIAILGYGSQGHAHALNLKDSGMNVCVGLKTDSASCAKAREAGLKVDTVAEAVKWADIVMILL
PDQTQKSVYDNEIAPNLKSGATLAFGHGFNIHYKQIVPPADVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDATGDA
KAIALAWAKGIGGTKAGVIETSFKDETETDLFGEQAVLCGGSAELIKAGFETLTEAGYPAELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRVVTSAAKAEMKKILEEIQDGRFAKEFIDECNSGYKKMNELRESNRNHPIEVVGAKL
RGMMSWLKKK

Sequences:

>Translated_330_residues
MNIYYEQDADLAVLQNKNIAILGYGSQGHAHALNLKDSGMNVCVGLKTDSASCAKAREAGLKVDTVAEAVKWADIVMILL
PDQTQKSVYDNEIAPNLKSGATLAFGHGFNIHYKQIVPPADVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDATGDA
KAIALAWAKGIGGTKAGVIETSFKDETETDLFGEQAVLCGGSAELIKAGFETLTEAGYPAELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRVVTSAAKAEMKKILEEIQDGRFAKEFIDECNSGYKKMNELRESNRNHPIEVVGAKL
RGMMSWLKKK
>Mature_330_residues
MNIYYEQDADLAVLQNKNIAILGYGSQGHAHALNLKDSGMNVCVGLKTDSASCAKAREAGLKVDTVAEAVKWADIVMILL
PDQTQKSVYDNEIAPNLKSGATLAFGHGFNIHYKQIVPPADVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDATGDA
KAIALAWAKGIGGTKAGVIETSFKDETETDLFGEQAVLCGGSAELIKAGFETLTEAGYPAELAYFECMHELKLIVDLYYE
GGLSRMNYSVSDTAEYGGMTRGPRVVTSAAKAEMKKILEEIQDGRFAKEFIDECNSGYKKMNELRESNRNHPIEVVGAKL
RGMMSWLKKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=306, Percent_Identity=35.9477124183007, Blast_Score=150, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=330, Percent_Identity=33.6363636363636, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CHLTE (Q8KER7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661516.1
- ProteinModelPortal:   Q8KER7
- SMR:   Q8KER7
- GeneID:   1007141
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0616
- NMPDR:   fig|194439.1.peg.610
- TIGR:   CT0616
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   CTEP194439:CT_0616-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 35858; Mature: 35858

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYYEQDADLAVLQNKNIAILGYGSQGHAHALNLKDSGMNVCVGLKTDSASCAKAREAG
CCEEECCCCCEEEEECCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHCC
LKVDTVAEAVKWADIVMILLPDQTQKSVYDNEIAPNLKSGATLAFGHGFNIHYKQIVPPA
CCHHHHHHHHHHEEEEEEEECCCHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCC
DVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDATGDAKAIALAWAKGIGGTKAGVIE
CCCEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCEEE
TSFKDETETDLFGEQAVLCGGSAELIKAGFETLTEAGYPAELAYFECMHELKLIVDLYYE
CCCCCCCCHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRVVTSAAKAEMKKILEEIQDGRFAKEFIDECNSGYKK
CCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
MNELRESNRNHPIEVVGAKLRGMMSWLKKK
HHHHHHCCCCCCEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIYYEQDADLAVLQNKNIAILGYGSQGHAHALNLKDSGMNVCVGLKTDSASCAKAREAG
CCEEECCCCCEEEEECCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHCC
LKVDTVAEAVKWADIVMILLPDQTQKSVYDNEIAPNLKSGATLAFGHGFNIHYKQIVPPA
CCHHHHHHHHHHEEEEEEEECCCHHHHHHCCCCCCCCCCCCEEEECCCCCEEEEECCCCC
DVNVIMIAPKSPGHLVRRTYTEGNGVPCLIAVHQDATGDAKAIALAWAKGIGGTKAGVIE
CCCEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCEEE
TSFKDETETDLFGEQAVLCGGSAELIKAGFETLTEAGYPAELAYFECMHELKLIVDLYYE
CCCCCCCCHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
GGLSRMNYSVSDTAEYGGMTRGPRVVTSAAKAEMKKILEEIQDGRFAKEFIDECNSGYKK
CCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
MNELRESNRNHPIEVVGAKLRGMMSWLKKK
HHHHHHCCCCCCEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901