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The map label for this gene is groEL [H]

Identifier: 21673365

GI number: 21673365

Start: 536712

End: 538349

Strand: Direct

Name: groEL [H]

Synonym: CT0530

Alternate gene names: 21673365

Gene position: 536712-538349 (Clockwise)

Preceding gene: 21673364

Following gene: 21673367

Centisome position: 24.91

GC content: 57.75

Gene sequence:

>1638_bases
ATGACTGCTAAAGATATTCTCTTTGACGCCGAGGCGAGGACCAAACTCAAGGTTGGCGTCGATAAACTTGCCAATGCCGT
AAAAGTGACCCTTGGCCCAGCCGGTCGTAACGTGCTTATCGATAAAAAATTCGGTGCTCCAACCTCCACCAAGGACGGCG
TGACCGTTGCAAAAGAGATCGAACTTGTCGATCCGGTTGAGAACATGGGCGCCCAGATGGTTCGCGAAGTGGCTTCCAAA
ACCAGCGATGTCGCTGGCGACGGCACCACCACAGCCACCGTGCTCGCCCAGGCCATCTACCGCGAAGGTCTGAAGAACGT
CACCGCCGGTGCTCGCCCGATCGACCTGAAGCGTGGCATCGACCGCGCCGTGAAAGAGGTCGTCGCCGAGCTGCGCAACA
TCAGCCGCTCTATCTCCGGCAAGAAAGAGATCGCCCAGGTTGGCACCATTTCGGCCAACAACGATCCGGAAATCGGTGAG
CTGATCGCCGAGGCGATGGACAAGGTCGGCAAGGACGGCGTCATCACCGTCGAAGAGGCAAAGGGCATGGAGACCGAGCT
GAAAGTTGTCGAGGGTATGCAATTCGACCGCGGCTACCTCTCTCCTTACTTCGTGACCAACTCGGAGACCATGGAAGCCG
AGCTTGACGAGGCGCTCATCCTGATCCACGACAAGAAGATCAGCAACATGAAAGAGCTGCTTCCGATTCTCGAAAAAGCC
GCACAGTCCGGTCGTCCGCTGCTCATCATTGCCGAGGACATCGAGGGTGAAGCGCTGGCCACCCTTGTGGTCAACAAGCT
CCGTGGCACCCTGAAAGTCGCCGCCGTCAAGGCTCCTGGCTTCGGTGACCGCCGTAAGGCCATGCTCGAAGACATCGCCA
TCCTCACCGGTGGCACTGTTATCTCCGAAGAGAAGGGCTACAAACTCGAGAACGCTACCATGGCTTATCTTGGCCAGGCT
GCCCGTATCACTATCGACAAGGACAATACCACCATCGTTGAAGGCAAAGGCAAGCAGGAAGAGATCAAGGCCCGTATCAA
CGAGATCAAAGGCCAGATCGAGAAATCGACCTCCGATTACGACACCGAGAAGCTCCAGGAACGCCTGGCCAAGCTCTCCG
GCGGTGTTGCCGTGCTGAAAATCGGTGCATCGACCGAAGTCGAGATGAAAGAGAAAAAAGCTCGCGTTGAAGATGCTCTG
CACGCAACCCGTGCAGCCGTTCAGGAAGGCATCGTGGTTGGCGGTGGCGTTGCGCTCATCCGCGCAGCCAAAGGTCTCGC
CAAGGCTGTTGCCGACAACGAAGACCAGAAGACCGGTATCGAGATCATCCGCCGTGCGCTCGAAGAGCCGCTCCGCCAGA
TCGTTGCCAACACCGGCACGACCGATGGCGCCGTCGTTCTCGAGAAGGTGAAGAACGCTGAAGGCGATTACGGCTTCAAT
GCTCGCACCGAGCAGTACGAGAACCTCATCGAGGCTGGCGTTGTTGATCCGACCAAGGTGACCCGTAGCGCGCTCGAGAA
CGCCGCTTCGGTTGCCAGCATCCTGCTTACCACGGAAGCTGCAATCACCGATGTCAAGGAAGACAAGGCTGATATGCCTG
CAATGCCTCCGGGTGGCATGGGTGGTGGCATGTACTGA

Upstream 100 bases:

>100_bases
CGAGGACTACCTGATCATGCGCGAGTCCGATATCTTCGCGATTCTTGGCTGACCAATTCACAAACAGTTTTTTTAAATCT
TTAAGGAGGAACGCTTTACA

Downstream 100 bases:

>100_bases
TCACCGATTGTTCATGACAACAAAAAAGGCCTGCGAAAGCGGGCCTTTTTTGTTGGGTGAATGGACTGGATTTTCATTTC
TCCTCGTTTATCGCTGGTGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTAKDILFDAEARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASK
TSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSISGKKEIAQVGTISANNDPEIGE
LIAEAMDKVGKDGVITVEEAKGMETELKVVEGMQFDRGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKA
AQSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATMAYLGQA
ARITIDKDNTTIVEGKGKQEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARVEDAL
HATRAAVQEGIVVGGGVALIRAAKGLAKAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNAEGDYGFN
ARTEQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITDVKEDKADMPAMPPGGMGGGMY

Sequences:

>Translated_545_residues
MTAKDILFDAEARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASK
TSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSISGKKEIAQVGTISANNDPEIGE
LIAEAMDKVGKDGVITVEEAKGMETELKVVEGMQFDRGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKA
AQSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATMAYLGQA
ARITIDKDNTTIVEGKGKQEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARVEDAL
HATRAAVQEGIVVGGGVALIRAAKGLAKAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNAEGDYGFN
ARTEQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITDVKEDKADMPAMPPGGMGGGMY
>Mature_544_residues
TAKDILFDAEARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASKT
SDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSISGKKEIAQVGTISANNDPEIGEL
IAEAMDKVGKDGVITVEEAKGMETELKVVEGMQFDRGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKAA
QSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATMAYLGQAA
RITIDKDNTTIVEGKGKQEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARVEDALH
ATRAAVQEGIVVGGGVALIRAAKGLAKAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNAEGDYGFNA
RTEQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITDVKEDKADMPAMPPGGMGGGMY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=50, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=50, Blast_Score=518, Evalue=1e-147,
Organism=Escherichia coli, GI1790586, Length=533, Percent_Identity=66.2288930581613, Blast_Score=688, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=50.8506616257089, Blast_Score=530, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI193210679, Length=209, Percent_Identity=51.1961722488038, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=53.1309297912713, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=54.3560606060606, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=54.3560606060606, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=51.3358778625954, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=51.3358778625954, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=51.3358778625954, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=546, Percent_Identity=45.4212454212454, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=524, Percent_Identity=37.9770992366412, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI19921262, Length=524, Percent_Identity=37.9770992366412, Blast_Score=322, Evalue=4e-88,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58080; Mature: 57949

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKDILFDAEARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEI
CCCHHHEECCCCCHHHHHCHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHH
ELVDPVENMGAQMVREVASKTSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGI
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DRAVKEVVAELRNISRSISGKKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGMETELKVVEGMQFDRGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKA
CCCHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
AQSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEKGYKLENATMAYLGQAARITIDKDNTTIVEGKGKQEEIKARINEIKGQIEKSTSDY
EECCCCCEECCCHHHHCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARVEDALHATRAAVQEGIVVGGGVALI
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHH
RAAKGLAKAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNAEGDYGFN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
ARTEQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITDVKEDKADMPAMPPGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GGGMY
CCCCC
>Mature Secondary Structure 
TAKDILFDAEARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEI
CCHHHEECCCCCHHHHHCHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHH
ELVDPVENMGAQMVREVASKTSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGI
HHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DRAVKEVVAELRNISRSISGKKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITVEEA
HHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGMETELKVVEGMQFDRGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKA
CCCHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHH
AQSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEEKGYKLENATMAYLGQAARITIDKDNTTIVEGKGKQEEIKARINEIKGQIEKSTSDY
EECCCCCEECCCHHHHCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARVEDALHATRAAVQEGIVVGGGVALI
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHH
RAAKGLAKAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNAEGDYGFN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
ARTEQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITDVKEDKADMPAMPPGGM
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
GGGMY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA