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The map label for this gene is icd [H]

Identifier: 21673190

GI number: 21673190

Start: 366383

End: 368608

Strand: Direct

Name: icd [H]

Synonym: CT0351

Alternate gene names: 21673190

Gene position: 366383-368608 (Clockwise)

Preceding gene: 21673189

Following gene: 21673193

Centisome position: 17.0

GC content: 59.66

Gene sequence:

>2226_bases
ATGGCAAGCAAATCAACCATCATTTACACCAAGACCGACGAGGCTCCGGCTTTGGCGACCTACTCGCTGCTTCCGATCAT
CCAGGCCTTCACCCGCGGCACCGGCGTTGATGTCGAGATGAGGGACATCTCCCTTGCCGGCAGGATCATTGCCAACTTCC
CGGAGAATCTTACCGAGGCCCAGAGGATTCCCGACTACCTTAGCCAGCTCGGTGAACTCGTGCTCGCGCCTGAGGCCAAC
ATCATCAAGCTTCCGAATATCAGCGCTTCGATTCCCCAGCTGAAAGCCGCCATCAAGGAGCTTCAGGAGCACGGCTACAA
CGTGCCTGACTATCCCGAAGCCCCGTCGAATGACGAAGAAAAAGCGATTCAGGCCCGTTATGCCAAGGTGCTTGGCAGCG
CCGTGAACCCGGTGCTTCGCGAGGGTAACTCCGACCGCCGTGCTCCGCTCTCCGTCAAAGCCTACGCCAAGAAGCATCCA
CACCGCATGGCTGCATGGAGCGTCAATTCGAAAGCGCACGTTTCGTATATGACCGATGGCGACTTCTACGGCAGCGAGCA
GTCCGTAACCGTGCCTGCCGCCACCACCGTTCGTATCGAATATGTTAACGGCGCCAACGAGGTGACCGTGCTGAAAGAGA
AAACCGCACTGCTCGCCGGTGAAGTGATCGACACGTCAGTTATGAACGTGCGCAAGCTCCGCGAGTTCTACGCCGAGCAG
ATCGAGGATGCCAAATCGCAGGGCGTGCTTTTTTCGCTGCACCTGAAGGCTACCATGATGAAGATTTCCGATCCGGTCAT
GTTCGGCCACGCCGTGTCGGTCTTTTACAAGGATGTGTTTGACAAGCATGGCGCATTGCTCGCCGAGCTTGGCGTGAACG
TCAACAACGGCCTCGGCGATCTCTACGCCAAAATCCAGACCCTACCGGAAGACAAACGTGCCGAGATCGAGGCTGACATC
ATGGCGGTCTACAAGACCCGTCCCGAGCTGGCGATGGTCGATTCCGACAAGGGCATCACCAACCTGCACGTGCCAAACGA
CATCATCATCGATGCTTCCATGCCGGTCGTTGTGCGCGACGGTGGCAAGATGTGGGGCCCCGACGGTCAGCTTCACGACT
GCAAAGCTGTGATTCCGGATCGCTGCTACGCTACCATGTACGGCGAAATCGTGGACGACTGCCGCAAGAACGGCGCGTTC
GATCCTTCCACTATCGGCAGCGTGCCGAACGTGGGCTTGATGGCGCAGAAGGCTGAAGAGTACGGTTCGCACGACAAGAC
CTTCATCGCGCCTGGTGACGGCGTGATCCGCGTGGTCGATGCCGATGGTTCAGTGCTCATGTCGCAGAAGGTCGAGACCG
GCGACATCTTTAGGATGTGCCAGACCAAGGATGCTCCGATTCGCGACTGGGTGAAGCTGGCTGTCCGCCGCGCCAAAGCT
ACCGGTGCTCCGGCAGTCTTCTGGCTCGACAGCAACCGCGCTCATGATGCGCAGATCATCGCCAAGGTGAACGAGTATCT
CAAAGACCTCGACACCGACGGCGTCGAGATCAAGATCATGCCTCCGGTCGAAGCCATGCGCTTCACCCTCGGCCGTTTCC
GTGCCGGACAGGACACCATTTCGGTGACTGGCAACGTGCTTCGTGACTACCTGACCGACCTGTTCCCGATCATCGAGCTC
GGCACCAGCTCCAAGATGCTTTCGATTGTTCCGCTGCTCAACGGTGGTGGCCTGTTTGAAACCGGTGCAGGCGGTTCGGC
TCCCAAGCATGTGCAGCAGTTCCAGAAAGAGGGCTACCTCCGCTGGGATTCGCTCGGCGAGTTCTTGGCTCTGACCGCAT
CGCTGGAGCACCTCGCGCAGACCTTCGGCAACCCGAAAGCGCAGGTGCTGGCCGACACGCTCGACCAGGCGATCGGCAAG
TTCCTCGAAAACCAGAAGTCGCCCGCCCGCAAAGTCGGCCAGATCGACAACCGCGGCAGCCACTTCTATCTCGCCCTCTA
CTGGGCCGAAGCGCTGGCCAGTCAGGACGCCGACGCCGAAATGAAGGCTCGCTTCGCCGGTGTCGCACAGGCGCTCGCCG
AGAAAGAGGAGCTCATCAACGCCGAGCTGATCGCCGCGCAGGGTAGCCCGGTCGATATCGGTGGCTACTACCAGCCCGAT
GACGAGAAGACCACTCGCGCCATGCGCCCGAGCGGCACGCTCAACGCGATCATCAACGCCATGTGA

Upstream 100 bases:

>100_bases
GTTTTTTTCTGACCGGGGGTAATGCGACTCCTGATCGGTGTGTAAGGTTTTCTTTTTCCCAGAAGTCATTTATAACCATA
ATACCTTCAATAGCAACGAT

Downstream 100 bases:

>100_bases
TTTCTGTCGCAAGGCAGCACATCGTAAACGAAGAAGCCCGGTTTATCGCCGGGCTTCGTCATTTCCGGGAGTTATCGTCT
GGTGTTGCCCACGCATAGAT

Product: isocitrate dehydrogenase, NADP-dependent, monomeric type

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 741; Mature: 740

Protein sequence:

>741_residues
MASKSTIIYTKTDEAPALATYSLLPIIQAFTRGTGVDVEMRDISLAGRIIANFPENLTEAQRIPDYLSQLGELVLAPEAN
IIKLPNISASIPQLKAAIKELQEHGYNVPDYPEAPSNDEEKAIQARYAKVLGSAVNPVLREGNSDRRAPLSVKAYAKKHP
HRMAAWSVNSKAHVSYMTDGDFYGSEQSVTVPAATTVRIEYVNGANEVTVLKEKTALLAGEVIDTSVMNVRKLREFYAEQ
IEDAKSQGVLFSLHLKATMMKISDPVMFGHAVSVFYKDVFDKHGALLAELGVNVNNGLGDLYAKIQTLPEDKRAEIEADI
MAVYKTRPELAMVDSDKGITNLHVPNDIIIDASMPVVVRDGGKMWGPDGQLHDCKAVIPDRCYATMYGEIVDDCRKNGAF
DPSTIGSVPNVGLMAQKAEEYGSHDKTFIAPGDGVIRVVDADGSVLMSQKVETGDIFRMCQTKDAPIRDWVKLAVRRAKA
TGAPAVFWLDSNRAHDAQIIAKVNEYLKDLDTDGVEIKIMPPVEAMRFTLGRFRAGQDTISVTGNVLRDYLTDLFPIIEL
GTSSKMLSIVPLLNGGGLFETGAGGSAPKHVQQFQKEGYLRWDSLGEFLALTASLEHLAQTFGNPKAQVLADTLDQAIGK
FLENQKSPARKVGQIDNRGSHFYLALYWAEALASQDADAEMKARFAGVAQALAEKEELINAELIAAQGSPVDIGGYYQPD
DEKTTRAMRPSGTLNAIINAM

Sequences:

>Translated_741_residues
MASKSTIIYTKTDEAPALATYSLLPIIQAFTRGTGVDVEMRDISLAGRIIANFPENLTEAQRIPDYLSQLGELVLAPEAN
IIKLPNISASIPQLKAAIKELQEHGYNVPDYPEAPSNDEEKAIQARYAKVLGSAVNPVLREGNSDRRAPLSVKAYAKKHP
HRMAAWSVNSKAHVSYMTDGDFYGSEQSVTVPAATTVRIEYVNGANEVTVLKEKTALLAGEVIDTSVMNVRKLREFYAEQ
IEDAKSQGVLFSLHLKATMMKISDPVMFGHAVSVFYKDVFDKHGALLAELGVNVNNGLGDLYAKIQTLPEDKRAEIEADI
MAVYKTRPELAMVDSDKGITNLHVPNDIIIDASMPVVVRDGGKMWGPDGQLHDCKAVIPDRCYATMYGEIVDDCRKNGAF
DPSTIGSVPNVGLMAQKAEEYGSHDKTFIAPGDGVIRVVDADGSVLMSQKVETGDIFRMCQTKDAPIRDWVKLAVRRAKA
TGAPAVFWLDSNRAHDAQIIAKVNEYLKDLDTDGVEIKIMPPVEAMRFTLGRFRAGQDTISVTGNVLRDYLTDLFPIIEL
GTSSKMLSIVPLLNGGGLFETGAGGSAPKHVQQFQKEGYLRWDSLGEFLALTASLEHLAQTFGNPKAQVLADTLDQAIGK
FLENQKSPARKVGQIDNRGSHFYLALYWAEALASQDADAEMKARFAGVAQALAEKEELINAELIAAQGSPVDIGGYYQPD
DEKTTRAMRPSGTLNAIINAM
>Mature_740_residues
ASKSTIIYTKTDEAPALATYSLLPIIQAFTRGTGVDVEMRDISLAGRIIANFPENLTEAQRIPDYLSQLGELVLAPEANI
IKLPNISASIPQLKAAIKELQEHGYNVPDYPEAPSNDEEKAIQARYAKVLGSAVNPVLREGNSDRRAPLSVKAYAKKHPH
RMAAWSVNSKAHVSYMTDGDFYGSEQSVTVPAATTVRIEYVNGANEVTVLKEKTALLAGEVIDTSVMNVRKLREFYAEQI
EDAKSQGVLFSLHLKATMMKISDPVMFGHAVSVFYKDVFDKHGALLAELGVNVNNGLGDLYAKIQTLPEDKRAEIEADIM
AVYKTRPELAMVDSDKGITNLHVPNDIIIDASMPVVVRDGGKMWGPDGQLHDCKAVIPDRCYATMYGEIVDDCRKNGAFD
PSTIGSVPNVGLMAQKAEEYGSHDKTFIAPGDGVIRVVDADGSVLMSQKVETGDIFRMCQTKDAPIRDWVKLAVRRAKAT
GAPAVFWLDSNRAHDAQIIAKVNEYLKDLDTDGVEIKIMPPVEAMRFTLGRFRAGQDTISVTGNVLRDYLTDLFPIIELG
TSSKMLSIVPLLNGGGLFETGAGGSAPKHVQQFQKEGYLRWDSLGEFLALTASLEHLAQTFGNPKAQVLADTLDQAIGKF
LENQKSPARKVGQIDNRGSHFYLALYWAEALASQDADAEMKARFAGVAQALAEKEELINAELIAAQGSPVDIGGYYQPDD
EKTTRAMRPSGTLNAIINAM

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 80839; Mature: 80708

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKSTIIYTKTDEAPALATYSLLPIIQAFTRGTGVDVEMRDISLAGRIIANFPENLTEA
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHH
QRIPDYLSQLGELVLAPEANIIKLPNISASIPQLKAAIKELQEHGYNVPDYPEAPSNDEE
HHHHHHHHHHHHEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
KAIQARYAKVLGSAVNPVLREGNSDRRAPLSVKAYAKKHPHRMAAWSVNSKAHVSYMTDG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCCCEEEEEECCCCEEEEEEECC
DFYGSEQSVTVPAATTVRIEYVNGANEVTVLKEKTALLAGEVIDTSVMNVRKLREFYAEQ
CCCCCCCCEEECCEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEDAKSQGVLFSLHLKATMMKISDPVMFGHAVSVFYKDVFDKHGALLAELGVNVNNGLGD
HHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCHHH
LYAKIQTLPEDKRAEIEADIMAVYKTRPELAMVDSDKGITNLHVPNDIIIDASMPVVVRD
HHHHHHCCCCCHHHHHHHHHHEEEECCCCEEEEECCCCCEEEECCCCEEEECCCCEEECC
GGKMWGPDGQLHDCKAVIPDRCYATMYGEIVDDCRKNGAFDPSTIGSVPNVGLMAQKAEE
CCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHH
YGSHDKTFIAPGDGVIRVVDADGSVLMSQKVETGDIFRMCQTKDAPIRDWVKLAVRRAKA
HCCCCCEEEECCCCEEEEEECCCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHC
TGAPAVFWLDSNRAHDAQIIAKVNEYLKDLDTDGVEIKIMPPVEAMRFTLGRFRAGQDTI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCC
SVTGNVLRDYLTDLFPIIELGTSSKMLSIVPLLNGGGLFETGAGGSAPKHVQQFQKEGYL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHCCCE
RWDSLGEFLALTASLEHLAQTFGNPKAQVLADTLDQAIGKFLENQKSPARKVGQIDNRGS
EHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
HFYLALYWAEALASQDADAEMKARFAGVAQALAEKEELINAELIAAQGSPVDIGGYYQPD
EEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCCCCCCC
DEKTTRAMRPSGTLNAIINAM
CCHHHHHCCCCCCHHHHHCCC
>Mature Secondary Structure 
ASKSTIIYTKTDEAPALATYSLLPIIQAFTRGTGVDVEMRDISLAGRIIANFPENLTEA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHH
QRIPDYLSQLGELVLAPEANIIKLPNISASIPQLKAAIKELQEHGYNVPDYPEAPSNDEE
HHHHHHHHHHHHEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
KAIQARYAKVLGSAVNPVLREGNSDRRAPLSVKAYAKKHPHRMAAWSVNSKAHVSYMTDG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHCCCCEEEEEECCCCEEEEEEECC
DFYGSEQSVTVPAATTVRIEYVNGANEVTVLKEKTALLAGEVIDTSVMNVRKLREFYAEQ
CCCCCCCCEEECCEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEDAKSQGVLFSLHLKATMMKISDPVMFGHAVSVFYKDVFDKHGALLAELGVNVNNGLGD
HHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEHHHCCCCCCCHHH
LYAKIQTLPEDKRAEIEADIMAVYKTRPELAMVDSDKGITNLHVPNDIIIDASMPVVVRD
HHHHHHCCCCCHHHHHHHHHHEEEECCCCEEEEECCCCCEEEECCCCEEEECCCCEEECC
GGKMWGPDGQLHDCKAVIPDRCYATMYGEIVDDCRKNGAFDPSTIGSVPNVGLMAQKAEE
CCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHH
YGSHDKTFIAPGDGVIRVVDADGSVLMSQKVETGDIFRMCQTKDAPIRDWVKLAVRRAKA
HCCCCCEEEECCCCEEEEEECCCCEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHC
TGAPAVFWLDSNRAHDAQIIAKVNEYLKDLDTDGVEIKIMPPVEAMRFTLGRFRAGQDTI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCC
SVTGNVLRDYLTDLFPIIELGTSSKMLSIVPLLNGGGLFETGAGGSAPKHVQQFQKEGYL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHCCCE
RWDSLGEFLALTASLEHLAQTFGNPKAQVLADTLDQAIGKFLENQKSPARKVGQIDNRGS
EHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
HFYLALYWAEALASQDADAEMKARFAGVAQALAEKEELINAELIAAQGSPVDIGGYYQPD
EEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCCCCCCC
DEKTTRAMRPSGTLNAIINAM
CCHHHHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]