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The map label for this gene is dxs [H]

Identifier: 21673176

GI number: 21673176

Start: 353020

End: 354954

Strand: Reverse

Name: dxs [H]

Synonym: CT0337

Alternate gene names: 21673176

Gene position: 354954-353020 (Counterclockwise)

Preceding gene: 21673177

Following gene: 21673170

Centisome position: 16.47

GC content: 61.5

Gene sequence:

>1935_bases
ATGGCAGACCTCGTCTCCGCTCCGGCTATGATTTCGCAGGCCTATCCACTGCTTTCGTCCATCCACTCTCCCGCCGACCT
CAAGAAACTGAGTCTTCACGAACTCGAACTGGTGGCTGCCGAGTGCCGGAAAAAGGTGATCGAGCTGGTGTCGCAGAACG
GGGGACACTTCGGTTCGAGCCTCGGAGTCGTGGAGCTGACCGTGGCGCTGCACTACGTCTACCAGAGCCCGACCGACCGG
ATCATCTGGGACGTGGGCCATCAAGCGTACGTGCACAAAATCCTCACCGGGCGGCTGGCGCAGATGGAGACCAACCGCCG
CTACCACGGCCTGGCGGGCTTCCCGAAGCGCAGCGAAAGCCCGCACGACGCCTTCGGCACCGGCCACGCCTCGACCTCGA
TCTCGGCGGCGGCAGGACTGGCGGCAGCACGAGACCTTGCCGGACGAAAGGAGAAGGTAGTGGCGATCATCGGCGACGGC
AGCCTGACAGGCGGCATGGCCTTCGAGGCGATGAACCATCTCGGCGATACGAAGTCCGACGTACTGGTCATCCTCAACGA
CAACCAGATGGCGATTTCGCCAAGCACCGGAGGCTTGAAGAACTATCTGGTCAACCTCACCCTGAACAAAACCTACAACC
GCTTGCGCAAGTTTGTATGGGACAGCCTCTCCCTGCTGCACAACGAAATAGGCGAAACAGCCAAAACCGCCGTGCACCGC
ATCGAGGATGGCATCAAGGCCGCCTTCACGCCCGGCGCGTATTTCGAGGCGCTCGGTTTCCGCTACTTCGGCCCCATCGA
CGGCCACAACATGGAGCAGCTCATCAAGGCGCTCCGCGAAATGCGCCAGCTCCACCACCCCAAGCTGCTACACGTCATTA
CCACCAAGGGCAAGGGGTTCAAGCCCGCCGAGGAGAACCAGCCCAAGTGGCACGCCAGTGTTGGAGGCTTTGACATCGAG
ACAGGCAAGAACGTCAAGGCTCCCGGCAAACCGGCCAAGCCGAAGTATCAGGAGGTGTTCGGCGAAGCGCTGGTCGAGCT
GGCGCTGAAAGACCCGACCATCACGGCGATCACGGCAGCCATGCCGAGCGGCACCTCGCTCGACCTGTTCCAGCAGGCTA
TTCCGTCGAGATGCTTCGACGTGGGCATCGCCGAGCAGCACGCTGTCACCTTCGCAGCAGGACTCGCCTGCGGCGGCTTC
AAACCGGTATTCGCCGTTTATTCCACCTTTTTGCAACGCGCCTACGACCAGCTCATCCACGACGTGGCGCTGCAAAACCT
GCACGTGGTGTTCGCCATCGACCGCGCTGGCCTGGTCGGCGAGGATGGCCCGACCCACCATGGCGCGTTCGACCTGTCGT
ACCTCAACGTCGTGCCGAATTTGACCATCATGGCCCCCGGCGACGAACAGGAGCTGCGAAACATGCTCTACACGGCACTG
TACGATATCAAAGGCCCGGTGGCGATCCGCTATCCTCGAGGCAGCGGCAGCGGCGCGACGCTGCACAAGGAGTTCACGCC
TGTTCCGGTCGGCAGGGGGCGAATTCTGCGGGATGGCAAATCGGTGGCGCTGCTTGGCATCGGCACCATGAGCAACCGCG
CGCTCGAAACCGCTGCACTGCTTGAAGCGGCAGGCCTCGATCCGCTGGTGTGCGACATGCGCTTCCTCAAGCCGCTCGAC
ACCGAGATAATCGACATGGCGGCATCACGCTGTACGCACATCGTCACCATCGAGGAGAACAGCATCATCGGCGGCTTCGG
CAGCAACGTGGTCAACTATCTGCACCACGCCCATCCCGGAATCAAATGCATTTCGTTCGGCCTGCCCGATGCCTTCGTCA
CCCACGGCAGCATGGATGAGCTGTACCGTGAAGTCGGCCTCGACGCCGAAAGTCTGTCGGGAAAGATTCTGGAGTTTTAC
AAGGATAAGCCGTAA

Upstream 100 bases:

>100_bases
TCGATTCAGAACAAGGAAATCCCCCCATCCCGGAACGGTAGGCTGATCCGGGAGGTTAGAAAAAAAACGTACTTTCATCT
GAACATCATCCCCCTAACCT

Downstream 100 bases:

>100_bases
GGCAGCATCGGAAGGGCAAGCATCACGAGACGAAGTAACAGGTTGGCCAGAATTCCGGCCAGCACGTCGTCGGCCATGAT
GCCCCAGCCGCCGGGGAGGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 644; Mature: 643

Protein sequence:

>644_residues
MADLVSAPAMISQAYPLLSSIHSPADLKKLSLHELELVAAECRKKVIELVSQNGGHFGSSLGVVELTVALHYVYQSPTDR
IIWDVGHQAYVHKILTGRLAQMETNRRYHGLAGFPKRSESPHDAFGTGHASTSISAAAGLAAARDLAGRKEKVVAIIGDG
SLTGGMAFEAMNHLGDTKSDVLVILNDNQMAISPSTGGLKNYLVNLTLNKTYNRLRKFVWDSLSLLHNEIGETAKTAVHR
IEDGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLIKALREMRQLHHPKLLHVITTKGKGFKPAEENQPKWHASVGGFDIE
TGKNVKAPGKPAKPKYQEVFGEALVELALKDPTITAITAAMPSGTSLDLFQQAIPSRCFDVGIAEQHAVTFAAGLACGGF
KPVFAVYSTFLQRAYDQLIHDVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNVVPNLTIMAPGDEQELRNMLYTAL
YDIKGPVAIRYPRGSGSGATLHKEFTPVPVGRGRILRDGKSVALLGIGTMSNRALETAALLEAAGLDPLVCDMRFLKPLD
TEIIDMAASRCTHIVTIEENSIIGGFGSNVVNYLHHAHPGIKCISFGLPDAFVTHGSMDELYREVGLDAESLSGKILEFY
KDKP

Sequences:

>Translated_644_residues
MADLVSAPAMISQAYPLLSSIHSPADLKKLSLHELELVAAECRKKVIELVSQNGGHFGSSLGVVELTVALHYVYQSPTDR
IIWDVGHQAYVHKILTGRLAQMETNRRYHGLAGFPKRSESPHDAFGTGHASTSISAAAGLAAARDLAGRKEKVVAIIGDG
SLTGGMAFEAMNHLGDTKSDVLVILNDNQMAISPSTGGLKNYLVNLTLNKTYNRLRKFVWDSLSLLHNEIGETAKTAVHR
IEDGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLIKALREMRQLHHPKLLHVITTKGKGFKPAEENQPKWHASVGGFDIE
TGKNVKAPGKPAKPKYQEVFGEALVELALKDPTITAITAAMPSGTSLDLFQQAIPSRCFDVGIAEQHAVTFAAGLACGGF
KPVFAVYSTFLQRAYDQLIHDVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNVVPNLTIMAPGDEQELRNMLYTAL
YDIKGPVAIRYPRGSGSGATLHKEFTPVPVGRGRILRDGKSVALLGIGTMSNRALETAALLEAAGLDPLVCDMRFLKPLD
TEIIDMAASRCTHIVTIEENSIIGGFGSNVVNYLHHAHPGIKCISFGLPDAFVTHGSMDELYREVGLDAESLSGKILEFY
KDKP
>Mature_643_residues
ADLVSAPAMISQAYPLLSSIHSPADLKKLSLHELELVAAECRKKVIELVSQNGGHFGSSLGVVELTVALHYVYQSPTDRI
IWDVGHQAYVHKILTGRLAQMETNRRYHGLAGFPKRSESPHDAFGTGHASTSISAAAGLAAARDLAGRKEKVVAIIGDGS
LTGGMAFEAMNHLGDTKSDVLVILNDNQMAISPSTGGLKNYLVNLTLNKTYNRLRKFVWDSLSLLHNEIGETAKTAVHRI
EDGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLIKALREMRQLHHPKLLHVITTKGKGFKPAEENQPKWHASVGGFDIET
GKNVKAPGKPAKPKYQEVFGEALVELALKDPTITAITAAMPSGTSLDLFQQAIPSRCFDVGIAEQHAVTFAAGLACGGFK
PVFAVYSTFLQRAYDQLIHDVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNVVPNLTIMAPGDEQELRNMLYTALY
DIKGPVAIRYPRGSGSGATLHKEFTPVPVGRGRILRDGKSVALLGIGTMSNRALETAALLEAAGLDPLVCDMRFLKPLDT
EIIDMAASRCTHIVTIEENSIIGGFGSNVVNYLHHAHPGIKCISFGLPDAFVTHGSMDELYREVGLDAESLSGKILEFYK
DKP

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=679, Percent_Identity=24.0058910162003, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI4507521, Length=679, Percent_Identity=24.0058910162003, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI225637463, Length=422, Percent_Identity=24.8815165876777, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI225637459, Length=422, Percent_Identity=24.8815165876777, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI225637461, Length=422, Percent_Identity=24.8815165876777, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI133778974, Length=375, Percent_Identity=24.8, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI156564403, Length=246, Percent_Identity=23.5772357723577, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786622, Length=629, Percent_Identity=48.3306836248013, Blast_Score=569, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17539652, Length=435, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24645119, Length=588, Percent_Identity=25.5102040816327, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45551847, Length=588, Percent_Identity=25.5102040816327, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45550715, Length=588, Percent_Identity=25.5102040816327, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24666278, Length=604, Percent_Identity=25.3311258278146, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358145, Length=266, Percent_Identity=24.0601503759398, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24650940, Length=266, Percent_Identity=24.0601503759398, Blast_Score=70, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69740; Mature: 69609

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLVSAPAMISQAYPLLSSIHSPADLKKLSLHELELVAAECRKKVIELVSQNGGHFGSS
CCCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LGVVELTVALHYVYQSPTDRIIWDVGHQAYVHKILTGRLAQMETNRRYHGLAGFPKRSES
CCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PHDAFGTGHASTSISAAAGLAAARDLAGRKEKVVAIIGDGSLTGGMAFEAMNHLGDTKSD
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCC
VLVILNDNQMAISPSTGGLKNYLVNLTLNKTYNRLRKFVWDSLSLLHNEIGETAKTAVHR
EEEEECCCEEEECCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEDGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLIKALREMRQLHHPKLLHVITTKGKGF
HHHCHHEECCCCHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
KPAEENQPKWHASVGGFDIETGKNVKAPGKPAKPKYQEVFGEALVELALKDPTITAITAA
CCCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEC
MPSGTSLDLFQQAIPSRCFDVGIAEQHAVTFAAGLACGGFKPVFAVYSTFLQRAYDQLIH
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNVVPNLTIMAPGDEQELRNMLYTAL
HHHHCCEEEEEEEECCCCCCCCCCCCCCEEEEHHHHHCCCEEEECCCCHHHHHHHHHHHH
YDIKGPVAIRYPRGSGSGATLHKEFTPVPVGRGRILRDGKSVALLGIGTMSNRALETAAL
HHCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHH
LEAAGLDPLVCDMRFLKPLDTEIIDMAASRCTHIVTIEENSIIGGFGSNVVNYLHHAHPG
HHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECCCEECCHHHHHHHHHHHCCCC
IKCISFGLPDAFVTHGSMDELYREVGLDAESLSGKILEFYKDKP
CEEEEECCCHHHHCCCCHHHHHHHHCCCHHHHCCHHHHHHCCCC
>Mature Secondary Structure 
ADLVSAPAMISQAYPLLSSIHSPADLKKLSLHELELVAAECRKKVIELVSQNGGHFGSS
CCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
LGVVELTVALHYVYQSPTDRIIWDVGHQAYVHKILTGRLAQMETNRRYHGLAGFPKRSES
CCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PHDAFGTGHASTSISAAAGLAAARDLAGRKEKVVAIIGDGSLTGGMAFEAMNHLGDTKSD
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCC
VLVILNDNQMAISPSTGGLKNYLVNLTLNKTYNRLRKFVWDSLSLLHNEIGETAKTAVHR
EEEEECCCEEEECCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEDGIKAAFTPGAYFEALGFRYFGPIDGHNMEQLIKALREMRQLHHPKLLHVITTKGKGF
HHHCHHEECCCCHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
KPAEENQPKWHASVGGFDIETGKNVKAPGKPAKPKYQEVFGEALVELALKDPTITAITAA
CCCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEC
MPSGTSLDLFQQAIPSRCFDVGIAEQHAVTFAAGLACGGFKPVFAVYSTFLQRAYDQLIH
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DVALQNLHVVFAIDRAGLVGEDGPTHHGAFDLSYLNVVPNLTIMAPGDEQELRNMLYTAL
HHHHCCEEEEEEEECCCCCCCCCCCCCCEEEEHHHHHCCCEEEECCCCHHHHHHHHHHHH
YDIKGPVAIRYPRGSGSGATLHKEFTPVPVGRGRILRDGKSVALLGIGTMSNRALETAAL
HHCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCEEECCCEEEEEEECCCCCHHHHHHHH
LEAAGLDPLVCDMRFLKPLDTEIIDMAASRCTHIVTIEENSIIGGFGSNVVNYLHHAHPG
HHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEECCCEECCHHHHHHHHHHHCCCC
IKCISFGLPDAFVTHGSMDELYREVGLDAESLSGKILEFYKDKP
CEEEEECCCHHHHCCCCHHHHHHHHCCCHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]