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The map label for this gene is rfbC [H]

Identifier: 21673145

GI number: 21673145

Start: 320292

End: 320849

Strand: Direct

Name: rfbC [H]

Synonym: CT0306

Alternate gene names: 21673145

Gene position: 320292-320849 (Clockwise)

Preceding gene: 21673144

Following gene: 21673146

Centisome position: 14.86

GC content: 54.12

Gene sequence:

>558_bases
ATGCAGATCATCCGGACCTCAATTCCTGACGTTCTTCTGTTCGAACCAGAGGTGTTCGGCGATGAACGCGGCTGGTTTTG
CGAATCTTTCCGTCAGGATATATTCGAGCAACACGCCGGATGCCACCGTTTCGTGCAGGATAACGAATCGTTTTCACGCT
ATGGCGTTGTCCGGGGTTTGCATTACCAGAAACCGCCGCATGTGCAGGGCAAGCTTGTCCGTGTGATCCGGGGTGAGGTG
CTTGATGTGGCTGTCGATATACGCAAGGGTTCTCCAACATTCGGCCATCATACTGCCCAGTTGCTCAATGAGAGCAACCG
CCGGATGATGTGGATTCCGCCCGGATTCGCCCACGGCTTTGCGGTGCTGAGCCAGACAGCGGTGTTCAGTTATAAATGCA
CGGACTATTATGCGCCATCACACGATGCGGGCATCCGGTGGAACGATCCGGCCATTGGCATAGAATGGAGCGTGCCGGAA
AGCGAGATAAGGCTTTCGGATAAGGATCTTCATCATCCGATGCTGCACGAGATTGAAGGTATTGTGCTGGACGCGTAG

Upstream 100 bases:

>100_bases
TCTCGCCTCGCCGCTCCTCAAGAACCAGTATGGGCAGTATCTGCTCAATCTTCTGGAACGGAGAATCTGAACATCAATCC
ATCAAGTAGTACTGTAACCT

Downstream 100 bases:

>100_bases
CATATTTTTCGAACCGCTTATACCGACCAGAGAACAATGAATATTCTTGTCACCGGGAGCCGTGGGCAGCTTGGTTCCGA
ACTGCAAAAACTGCAAGAAG

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MQIIRTSIPDVLLFEPEVFGDERGWFCESFRQDIFEQHAGCHRFVQDNESFSRYGVVRGLHYQKPPHVQGKLVRVIRGEV
LDVAVDIRKGSPTFGHHTAQLLNESNRRMMWIPPGFAHGFAVLSQTAVFSYKCTDYYAPSHDAGIRWNDPAIGIEWSVPE
SEIRLSDKDLHHPMLHEIEGIVLDA

Sequences:

>Translated_185_residues
MQIIRTSIPDVLLFEPEVFGDERGWFCESFRQDIFEQHAGCHRFVQDNESFSRYGVVRGLHYQKPPHVQGKLVRVIRGEV
LDVAVDIRKGSPTFGHHTAQLLNESNRRMMWIPPGFAHGFAVLSQTAVFSYKCTDYYAPSHDAGIRWNDPAIGIEWSVPE
SEIRLSDKDLHHPMLHEIEGIVLDA
>Mature_185_residues
MQIIRTSIPDVLLFEPEVFGDERGWFCESFRQDIFEQHAGCHRFVQDNESFSRYGVVRGLHYQKPPHVQGKLVRVIRGEV
LDVAVDIRKGSPTFGHHTAQLLNESNRRMMWIPPGFAHGFAVLSQTAVFSYKCTDYYAPSHDAGIRWNDPAIGIEWSVPE
SEIRLSDKDLHHPMLHEIEGIVLDA

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=179, Percent_Identity=51.9553072625698, Blast_Score=171, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17550412, Length=169, Percent_Identity=46.1538461538462, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21197; Mature: 21197

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIRTSIPDVLLFEPEVFGDERGWFCESFRQDIFEQHAGCHRFVQDNESFSRYGVVRGL
CCCCCCCCCCEEEECCHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHCC
HYQKPPHVQGKLVRVIRGEVLDVAVDIRKGSPTFGHHTAQLLNESNRRMMWIPPGFAHGF
CCCCCCCHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCHHHHH
AVLSQTAVFSYKCTDYYAPSHDAGIRWNDPAIGIEWSVPESEIRLSDKDLHHPMLHEIEG
HHHHHHHHEEEECCCCCCCCCCCCEEECCCCEEEEECCCHHHEEECCCCCCCHHHHHCCE
IVLDA
EEECC
>Mature Secondary Structure
MQIIRTSIPDVLLFEPEVFGDERGWFCESFRQDIFEQHAGCHRFVQDNESFSRYGVVRGL
CCCCCCCCCCEEEECCHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHCC
HYQKPPHVQGKLVRVIRGEVLDVAVDIRKGSPTFGHHTAQLLNESNRRMMWIPPGFAHGF
CCCCCCCHHHHHHHHHHCCEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCHHHHH
AVLSQTAVFSYKCTDYYAPSHDAGIRWNDPAIGIEWSVPESEIRLSDKDLHHPMLHEIEG
HHHHHHHHEEEECCCCCCCCCCCCEEECCCCEEEEECCCHHHEEECCCCCCCHHHHHCCE
IVLDA
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170390; 8157605; 12384590; 12704152 [H]