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The map label for this gene is apt [H]

Identifier: 21673132

GI number: 21673132

Start: 304941

End: 305474

Strand: Direct

Name: apt [H]

Synonym: CT0293

Alternate gene names: 21673132

Gene position: 304941-305474 (Clockwise)

Preceding gene: 21673129

Following gene: 21673133

Centisome position: 14.15

GC content: 52.62

Gene sequence:

>534_bases
ATGCCCATCAAATCCAGAATCCGTACTGTTCCCGATTATCCGAAAAAAGGGATCATGTTCCGTGACATTACCACCCTTAT
CAAGGATCCGGTCGGATTCCGTCTGGTGATCGACAACATGACCCAGCATTATCTGTCCAACGGAGTCGATTTTGATGCGA
TCGTGGGTATTGAGTCCAGGGGTTTCATTCTCGGTGGCGCGCTTGCCTATACGCTTGGCAAGGGATTCGTGCCAGTCAGG
AAGCCAGGCAAACTGCCGGCGGATGTGGTGCAGCTCGAATACGAACTCGAGTATGGTACCGACAAGATCGAGATGCATAC
TGACGCTCTTGTTCAAGGGCAGCGCGTGCTTCTGGTTGATGATCTTCTTGCTACGGGCGGCACGGCTCTTGCCGCTGCCG
GACTGGTCGAGAAGCTCGGCGGTGTCGTGGCAAGCATGGCCTTCATCGTCAATCTGCCCGATATTGGCGGCGAAAAGAAG
ATTCGTGAAAAAGGCTATAACATCTACTTCCTGACAGAGTTCGAAGGTGATTGA

Upstream 100 bases:

>100_bases
TCTTAAATTTTTACAAGCAGAAGGCGTCTTTCCGAGGTCTGGCGTCGGTGGTGCCCCGTTTCTGGCAGTTTTCACCAAAT
CAGCAAAACCCTCTACAGTT

Downstream 100 bases:

>100_bases
TACCGTTCGATCTCGAATGACTCATGACTTGTTGCTCTGATTTTTTGAAACGTAGCGCGGTGGCGGCCGCTACCACGCTT
ATTTTTTCTTTGACCGTTCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MPIKSRIRTVPDYPKKGIMFRDITTLIKDPVGFRLVIDNMTQHYLSNGVDFDAIVGIESRGFILGGALAYTLGKGFVPVR
KPGKLPADVVQLEYELEYGTDKIEMHTDALVQGQRVLLVDDLLATGGTALAAAGLVEKLGGVVASMAFIVNLPDIGGEKK
IREKGYNIYFLTEFEGD

Sequences:

>Translated_177_residues
MPIKSRIRTVPDYPKKGIMFRDITTLIKDPVGFRLVIDNMTQHYLSNGVDFDAIVGIESRGFILGGALAYTLGKGFVPVR
KPGKLPADVVQLEYELEYGTDKIEMHTDALVQGQRVLLVDDLLATGGTALAAAGLVEKLGGVVASMAFIVNLPDIGGEKK
IREKGYNIYFLTEFEGD
>Mature_176_residues
PIKSRIRTVPDYPKKGIMFRDITTLIKDPVGFRLVIDNMTQHYLSNGVDFDAIVGIESRGFILGGALAYTLGKGFVPVRK
PGKLPADVVQLEYELEYGTDKIEMHTDALVQGQRVLLVDDLLATGGTALAAAGLVEKLGGVVASMAFIVNLPDIGGEKKI
REKGYNIYFLTEFEGD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=160, Percent_Identity=44.375, Blast_Score=136, Evalue=7e-33,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=48, Blast_Score=121, Evalue=3e-28,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=50, Blast_Score=179, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=162, Percent_Identity=41.9753086419753, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=40.7407407407407, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=34.1176470588235, Blast_Score=92, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136334, Length=166, Percent_Identity=40.9638554216867, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19320; Mature: 19189

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKSRIRTVPDYPKKGIMFRDITTLIKDPVGFRLVIDNMTQHYLSNGVDFDAIVGIESR
CCCHHHCCCCCCCCCCCEEHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEEEEECCC
GFILGGALAYTLGKGFVPVRKPGKLPADVVQLEYELEYGTDKIEMHTDALVQGQRVLLVD
CEEEHHHHHHHHCCCCCCCCCCCCCCHHHEEEEEEECCCCCEEEECHHHHHCCCEEEEEE
DLLATGGTALAAAGLVEKLGGVVASMAFIVNLPDIGGEKKIREKGYNIYFLTEFEGD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHCCCEEEEEEEECCC
>Mature Secondary Structure 
PIKSRIRTVPDYPKKGIMFRDITTLIKDPVGFRLVIDNMTQHYLSNGVDFDAIVGIESR
CCHHHCCCCCCCCCCCEEHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEEEEECCC
GFILGGALAYTLGKGFVPVRKPGKLPADVVQLEYELEYGTDKIEMHTDALVQGQRVLLVD
CEEEHHHHHHHHCCCCCCCCCCCCCCHHHEEEEEEECCCCCEEEECHHHHHCCCEEEEEE
DLLATGGTALAAAGLVEKLGGVVASMAFIVNLPDIGGEKKIREKGYNIYFLTEFEGD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA