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The map label for this gene is hisS

Identifier: 21673075

GI number: 21673075

Start: 247867

End: 249159

Strand: Direct

Name: hisS

Synonym: CT0236

Alternate gene names: 21673075

Gene position: 247867-249159 (Clockwise)

Preceding gene: 21673074

Following gene: 21673076

Centisome position: 11.5

GC content: 59.71

Gene sequence:

>1293_bases
ATGACACAGTTCCAAGGAGTGAAAGGGACGAGAGATATTTTTCCTGATGAGATTTCGAGATGGCACTATGTCGAGGGGGT
TGTCCACTCGGTAGCCGCGCTGTACGGATTCAGCGAAATCCGTACGCCTGTTTTCGAGTACACCGAGCTCTTTCAGCGCG
GCATAGGAGCGACCACCGATATCGTCGGCAAGGAGATGTTCACCTTTCTTCCCGATCCCAATGGCCGCTCCCTGACGCTT
CGTCCCGAGATGACCGCAGGCGTGATGCGCGCCTGCTTGCAGAAGAACCTGCTCTCGCAAGCGCCAGTGCACAAGCTCTG
GTACATTAGCGATCTGTTCCGCAAGGAGCGCCCGCAGGCTGGCCGTCAGCGCCAGTTCACGCAGTTCGGCGCGGAGCTGC
TCGGTGTATCCAACCCGGCGGCGGTGGCCGAAGTGCTTACCCTCATGATGCAGGTGTTTGAAACGCTCGGGCTGCACGGC
TTGCGACTGCGCATCAACTCGCTTGGCGACCTCGACGACCGTGCGCGGTATCGCGAGGCGCTCCGGGCCTACTTCCAGCC
TTACGAGGCCGACCTCGACGAGTTGTCGAAGGAGCGGCTTAAAAAGAATCCGTTGCGCATCCTCGATTCGAAAAATCCCG
CTTTGCAGGAGATGATCATGGGCGCGCCGAGGCTCTACCATTCGCTCAAGCCGGAGTCTGTGGCCGAATTCGAGCAGGTG
CTCGCCTATCTCGACGACAGGCAAATCGCCTACAACGTCGATCACCTGCTGGTGCGCGGACTCGATTATTACTGCCACAC
GGCTTTCGAGGTGACCAGCTCCGAGCTTGGCGCGCAGGACGCTATTGGCGGCGGCGGGCGCTACGACGGCTTGGCGCGTG
AACTTGGAGCTTCCGCTGATCTGCCCGCCGTGGGTTTCGCCGTCGGCATGGAGCGGCTCATGATTGTCATGGAGAAGCAG
GGGCTGTTCGCGACGCTCAATCCGCATGGTCCTCTTGTTTCTGTCATCATACAGCAAAAGGAGCTTGCCGGGCATGCCAT
GCAGGTCGCTTTCCATTTGCGCAAGGCAGGCATCAAAACCGAGATCGATCTTGCCGAACGGAGCATGAAGGCGCAGATGC
GTGACGCCAACCGAATGGGTTCGGCCTACGCGCTCTTCGTTGGCCAGTCGGAATTCGAGTCGGGCATCTATGCGCTCAAG
AATCTCGTCACTTCCGAGCAGACCTCGCTCGATCTTGACGCCATCATCGAGGTGTTGCGCGAACCGGCGGCGCGGGAGTC
GCTCAGGCCATGA

Upstream 100 bases:

>100_bases
CAAGCTCATCGACGCGGCAACCCCCGCAGATGTGCTCGAACTTTTCAAGCAGGAGGAGAGGGATCTCCCCCAGATTTAAT
TTGATGACCGCAAGGCAGCT

Downstream 100 bases:

>100_bases
GGCCGCAAGTGACCATCTACGGCAAGCCGGAGTGCTGCCTCTGCGACGATGCGCTCAAAGTGCTCGAAGCAGTGCGTAAG
CGGATTCCGTTCGATATCGA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTQFQGVKGTRDIFPDEISRWHYVEGVVHSVAALYGFSEIRTPVFEYTELFQRGIGATTDIVGKEMFTFLPDPNGRSLTL
RPEMTAGVMRACLQKNLLSQAPVHKLWYISDLFRKERPQAGRQRQFTQFGAELLGVSNPAAVAEVLTLMMQVFETLGLHG
LRLRINSLGDLDDRARYREALRAYFQPYEADLDELSKERLKKNPLRILDSKNPALQEMIMGAPRLYHSLKPESVAEFEQV
LAYLDDRQIAYNVDHLLVRGLDYYCHTAFEVTSSELGAQDAIGGGGRYDGLARELGASADLPAVGFAVGMERLMIVMEKQ
GLFATLNPHGPLVSVIIQQKELAGHAMQVAFHLRKAGIKTEIDLAERSMKAQMRDANRMGSAYALFVGQSEFESGIYALK
NLVTSEQTSLDLDAIIEVLREPAARESLRP

Sequences:

>Translated_430_residues
MTQFQGVKGTRDIFPDEISRWHYVEGVVHSVAALYGFSEIRTPVFEYTELFQRGIGATTDIVGKEMFTFLPDPNGRSLTL
RPEMTAGVMRACLQKNLLSQAPVHKLWYISDLFRKERPQAGRQRQFTQFGAELLGVSNPAAVAEVLTLMMQVFETLGLHG
LRLRINSLGDLDDRARYREALRAYFQPYEADLDELSKERLKKNPLRILDSKNPALQEMIMGAPRLYHSLKPESVAEFEQV
LAYLDDRQIAYNVDHLLVRGLDYYCHTAFEVTSSELGAQDAIGGGGRYDGLARELGASADLPAVGFAVGMERLMIVMEKQ
GLFATLNPHGPLVSVIIQQKELAGHAMQVAFHLRKAGIKTEIDLAERSMKAQMRDANRMGSAYALFVGQSEFESGIYALK
NLVTSEQTSLDLDAIIEVLREPAARESLRP
>Mature_429_residues
TQFQGVKGTRDIFPDEISRWHYVEGVVHSVAALYGFSEIRTPVFEYTELFQRGIGATTDIVGKEMFTFLPDPNGRSLTLR
PEMTAGVMRACLQKNLLSQAPVHKLWYISDLFRKERPQAGRQRQFTQFGAELLGVSNPAAVAEVLTLMMQVFETLGLHGL
RLRINSLGDLDDRARYREALRAYFQPYEADLDELSKERLKKNPLRILDSKNPALQEMIMGAPRLYHSLKPESVAEFEQVL
AYLDDRQIAYNVDHLLVRGLDYYCHTAFEVTSSELGAQDAIGGGGRYDGLARELGASADLPAVGFAVGMERLMIVMEKQG
LFATLNPHGPLVSVIIQQKELAGHAMQVAFHLRKAGIKTEIDLAERSMKAQMRDANRMGSAYALFVGQSEFESGIYALKN
LVTSEQTSLDLDAIIEVLREPAARESLRP

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=452, Percent_Identity=24.1150442477876, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI15029520, Length=441, Percent_Identity=23.8095238095238, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788861, Length=426, Percent_Identity=41.0798122065728, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI71993693, Length=473, Percent_Identity=27.4841437632135, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71993686, Length=473, Percent_Identity=27.4841437632135, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24643061, Length=479, Percent_Identity=24.2171189979123, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24643059, Length=495, Percent_Identity=23.6363636363636, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_CHLTE (Q8KFT6)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661140.1
- ProteinModelPortal:   Q8KFT6
- SMR:   Q8KFT6
- GeneID:   1007724
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0236
- NMPDR:   fig|194439.1.peg.234
- TIGR:   CT0236
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   CTEP194439:CT_0236-MONOMER
- BRENDA:   6.1.1.21
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48132; Mature: 48001

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFQGVKGTRDIFPDEISRWHYVEGVVHSVAALYGFSEIRTPVFEYTELFQRGIGATTD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVGKEMFTFLPDPNGRSLTLRPEMTAGVMRACLQKNLLSQAPVHKLWYISDLFRKERPQA
HHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
GRQRQFTQFGAELLGVSNPAAVAEVLTLMMQVFETLGLHGLRLRINSLGDLDDRARYREA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
LRAYFQPYEADLDELSKERLKKNPLRILDSKNPALQEMIMGAPRLYHSLKPESVAEFEQV
HHHHHCCHHCCHHHHHHHHHHCCCHHEECCCCHHHHHHHHCCHHHHHCCCCHHHHHHHHH
LAYLDDRQIAYNVDHLLVRGLDYYCHTAFEVTSSELGAQDAIGGGGRYDGLARELGASAD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCC
LPAVGFAVGMERLMIVMEKQGLFATLNPHGPLVSVIIQQKELAGHAMQVAFHLRKAGIKT
CCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EIDLAERSMKAQMRDANRMGSAYALFVGQSEFESGIYALKNLVTSEQTSLDLDAIIEVLR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EPAARESLRP
CCHHHCCCCC
>Mature Secondary Structure 
TQFQGVKGTRDIFPDEISRWHYVEGVVHSVAALYGFSEIRTPVFEYTELFQRGIGATTD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVGKEMFTFLPDPNGRSLTLRPEMTAGVMRACLQKNLLSQAPVHKLWYISDLFRKERPQA
HHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
GRQRQFTQFGAELLGVSNPAAVAEVLTLMMQVFETLGLHGLRLRINSLGDLDDRARYREA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHH
LRAYFQPYEADLDELSKERLKKNPLRILDSKNPALQEMIMGAPRLYHSLKPESVAEFEQV
HHHHHCCHHCCHHHHHHHHHHCCCHHEECCCCHHHHHHHHCCHHHHHCCCCHHHHHHHHH
LAYLDDRQIAYNVDHLLVRGLDYYCHTAFEVTSSELGAQDAIGGGGRYDGLARELGASAD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHCCCCC
LPAVGFAVGMERLMIVMEKQGLFATLNPHGPLVSVIIQQKELAGHAMQVAFHLRKAGIKT
CCHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EIDLAERSMKAQMRDANRMGSAYALFVGQSEFESGIYALKNLVTSEQTSLDLDAIIEVLR
HHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EPAARESLRP
CCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901