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The map label for this gene is clpC [H]

Identifier: 21673032

GI number: 21673032

Start: 199397

End: 201961

Strand: Direct

Name: clpC [H]

Synonym: CT0191

Alternate gene names: 21673032

Gene position: 199397-201961 (Clockwise)

Preceding gene: 21673030

Following gene: 21673034

Centisome position: 9.25

GC content: 58.25

Gene sequence:

>2565_bases
ATGGAAGGAAATTTCTCGAATAGAGTTCAGGACGTGATCAGGCTCAGCCGCGAAGAGGCGCTGCGTCTGGGGCACGACTA
TATCGGCACCGAACATCTTCTGCTCGGACTGATCCGGGAAGGAGAGGGCATAGGAGCCAAAATTCTCAAAAACCTCAAAG
TCGATCTTTTCCAGCTGAAGCAAAAGATCGAGGAGAACACCCATCCCAAGGTTCCGGCCACGCAGATGGGCAATGTGCCG
CTAACCAAGCAGGCTGAAAAGGTGCTCAAGATCACTTATTTGGAGGCCAAGATCTGCAAGTCAACCATCATCGGCACGGA
GCATCTGTTGCTCTCGATTCTCAAGGGTGACGACAACATTGCCGCCCAGATTCTCGAACAGTTCGGTGTCACCTATGACC
AGGTGCGCGACGAGCTGATGACCATTACGACCGGGCGCAGCGAGGCTTACGAGCCGCCGATGGAGGGTTCCTATTCGTCG
GGTTCGGGAAGCCCCGCGCGTCCGTCGAAAAAGTCCGAGACGAAGCGCGGTGAACGCACCAAAACGCCGGTGCTCGACAA
TTTCGGGCGCGACATCACGCGCTTGGCGATGGAGGACAAGCTCGACCCGATCATCGGGCGCGAAAAGGAGATCGAGCGCG
TGGCGCAGGTGCTCAGCCGCCGCAAGAAAAACAATCCGGTGCTGATCGGCGAGCCTGGCGTTGGCAAAACGGCCATCGCC
GAAGGGCTGGCGCTCAAGATCGTGCAGCGCAAGGTTTCGCGCGTGCTTTACGACAAGCGCGTCGTGGCGCTCGACCTCGC
GGCGCTCGTCGCGGGCACGAAGTACCGCGGCCAGTTTGAGGAGCGCATGAAGGCGCTCATGAATGAGCTGGAGCGTTCGC
GTGACGTGATCCTCTTCATCGACGAGCTGCACACCATCATCGGTGCTGGCGGCGCTTCGGGTTCGCTCGATGCGAGCAAC
ATCTTCAAACCCGCGCTCGCTCGCGGCGAGTTGCAGTGCATCGGCGCGACCACGCTCGATGAGTACCGCCAGTACATCGA
GAAGGATGGTGCGCTGGATCGCCGTTTCCAAAAGATCATGGTTGAGCCGACCTCGGTCGAGGAGACCATCCAGATTCTGA
ACAACATCAAAAACAAGTACGAAGCGCATCACCACGTGCATTACTCGGAGGATGCCATCGAGAAGGCGGTCAAGCTCTCG
GAGCGCTACATCACCGACCGTTTTCTGCCTGACAAGGCGATCGACGTCATGGACGAGGCGGGCGCGAGAGTGCACCTGAG
CAACATCCACGTGCCGCAGGAGATTCTCGAACTTGAGAAGTCCATCGAGGAGATCAAGAGCGAGAAGAACAAAGTGGTCA
AGATGCAGAACTTCGAGGAGGCGGCACGCCTGCGCGACAAGGAGAAGAACATGCTTGAAGCGCTCGACCACGCCAAGCAG
GAGTGGGAAGAGCAGTCGATGGAGAGCGTTTACGACGTGACCGAAGCCGACATCACCTCGGTGATCGCGATGATGACCGG
CATTCCGGTGGCGAAGGTGGCGCAGTCCGAATCGAAGAAGTTGCTCACCATGGAGGCGGAGCTGAAAAAGGAAGTCATCG
GCCAGGACGAGGCGATCAAGAAGATCACCAAAGCGATCCAGCGCACCCGTGCGGGCCTCAAGGATCCGTCGCGCCCCATC
GGCTCGTTCATCTTCCTCGGCCCGACCGGCGTCGGCAAGACCGAGCTGGCCAAGGCGCTGACCCGTTATCTGTTCGACAG
CGAGGATGCGCTGATCCGCGCCGACATGAGTGAGTACATGGAGAAGTTCTCGGTAAGCCGCCTGGTTGGAGCGCCTCCCG
GATACGTTGGCTACGAAGAGGGCGGCCAGCTCACCGAAAAGGTGCGCCGCAAACCCTATTCGGTGGTGCTGATCGACGAG
ATCGAAAAGGCGCATCCCGACGTGTTTAACATTCTGCTCCAGGTGCTCGACGAGGGCGTGCTGACCGACGGACTTGGCCG
CAAGGTCGATTTCCGCAACACGATCATCATCATGACCTCGAACATCGGTGCCAAGGAGATCAAGAGCTTCAGCACCGGCG
GAGGCATGGGCTTCGCGCCGCCTTCGGATGCGACGGGTGATTACAAGGCGATGAAGTCCACCATCGAGGATGCATTGAAG
CGCGTGTTCAATCCGGAGTTCCTGAACCGCATCGACGACACGATCGTGTTCCACCAGCTCGAAAAGTCGGATATCTTCAA
GATTATCGACATCACGGCAGGCAAGCTCTTCAAGCGCCTGAAGGAGATGGGCATCGAGGTTGAGATCGACGAGAAAGCCA
AGGAGTTCCTTGTCGAGAAGGGTTACGACCAGAAGTACGGAGCACGCCCGCTGAAACGCGCGTTGCAGAAATATGTCGAG
GATCCGCTCGCGGAGGAGATGCTCAAGGGCCGCTTCACCGAGGGCAGCGTGATTCAGATCACCTTCGACGAAAAGGAGAA
GGAGCTGCGCTTTCTTGATGGCGCGTCTTCCGCCGAACCGACTCCCAAAAAGAGCAAGAAAGAGGAGACGCTCGACAAAG
AGTGA

Upstream 100 bases:

>100_bases
GTAGCGATAACAGATTGGTTGTGCCCACTCGTACTTCATAGCCAGAGTTACAGCGCATTTCAGGGAGCTTCCCGTCAATT
TTAGCGATACAGGATCATAA

Downstream 100 bases:

>100_bases
TGCCCCGGATCGCAAGATTTTAATTTCTCCCGAAGCCCCGCTGAAACGATGATTTCAGCGGGGCTTTTTTTGGGGGGGTA
TTTCGTACAAGTGTCTGAAC

Product: ATP-dependent Clp protease, ATP-binding subunit ClpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 854; Mature: 854

Protein sequence:

>854_residues
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIGAKILKNLKVDLFQLKQKIEENTHPKVPATQMGNVP
LTKQAEKVLKITYLEAKICKSTIIGTEHLLLSILKGDDNIAAQILEQFGVTYDQVRDELMTITTGRSEAYEPPMEGSYSS
GSGSPARPSKKSETKRGERTKTPVLDNFGRDITRLAMEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIA
EGLALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDELHTIIGAGGASGSLDASN
IFKPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVEPTSVEETIQILNNIKNKYEAHHHVHYSEDAIEKAVKLS
ERYITDRFLPDKAIDVMDEAGARVHLSNIHVPQEILELEKSIEEIKSEKNKVVKMQNFEEAARLRDKEKNMLEALDHAKQ
EWEEQSMESVYDVTEADITSVIAMMTGIPVAKVAQSESKKLLTMEAELKKEVIGQDEAIKKITKAIQRTRAGLKDPSRPI
GSFIFLGPTGVGKTELAKALTRYLFDSEDALIRADMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDE
IEKAHPDVFNILLQVLDEGVLTDGLGRKVDFRNTIIIMTSNIGAKEIKSFSTGGGMGFAPPSDATGDYKAMKSTIEDALK
RVFNPEFLNRIDDTIVFHQLEKSDIFKIIDITAGKLFKRLKEMGIEVEIDEKAKEFLVEKGYDQKYGARPLKRALQKYVE
DPLAEEMLKGRFTEGSVIQITFDEKEKELRFLDGASSAEPTPKKSKKEETLDKE

Sequences:

>Translated_854_residues
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIGAKILKNLKVDLFQLKQKIEENTHPKVPATQMGNVP
LTKQAEKVLKITYLEAKICKSTIIGTEHLLLSILKGDDNIAAQILEQFGVTYDQVRDELMTITTGRSEAYEPPMEGSYSS
GSGSPARPSKKSETKRGERTKTPVLDNFGRDITRLAMEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIA
EGLALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDELHTIIGAGGASGSLDASN
IFKPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVEPTSVEETIQILNNIKNKYEAHHHVHYSEDAIEKAVKLS
ERYITDRFLPDKAIDVMDEAGARVHLSNIHVPQEILELEKSIEEIKSEKNKVVKMQNFEEAARLRDKEKNMLEALDHAKQ
EWEEQSMESVYDVTEADITSVIAMMTGIPVAKVAQSESKKLLTMEAELKKEVIGQDEAIKKITKAIQRTRAGLKDPSRPI
GSFIFLGPTGVGKTELAKALTRYLFDSEDALIRADMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDE
IEKAHPDVFNILLQVLDEGVLTDGLGRKVDFRNTIIIMTSNIGAKEIKSFSTGGGMGFAPPSDATGDYKAMKSTIEDALK
RVFNPEFLNRIDDTIVFHQLEKSDIFKIIDITAGKLFKRLKEMGIEVEIDEKAKEFLVEKGYDQKYGARPLKRALQKYVE
DPLAEEMLKGRFTEGSVIQITFDEKEKELRFLDGASSAEPTPKKSKKEETLDKE
>Mature_854_residues
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIGAKILKNLKVDLFQLKQKIEENTHPKVPATQMGNVP
LTKQAEKVLKITYLEAKICKSTIIGTEHLLLSILKGDDNIAAQILEQFGVTYDQVRDELMTITTGRSEAYEPPMEGSYSS
GSGSPARPSKKSETKRGERTKTPVLDNFGRDITRLAMEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIA
EGLALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFIDELHTIIGAGGASGSLDASN
IFKPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIMVEPTSVEETIQILNNIKNKYEAHHHVHYSEDAIEKAVKLS
ERYITDRFLPDKAIDVMDEAGARVHLSNIHVPQEILELEKSIEEIKSEKNKVVKMQNFEEAARLRDKEKNMLEALDHAKQ
EWEEQSMESVYDVTEADITSVIAMMTGIPVAKVAQSESKKLLTMEAELKKEVIGQDEAIKKITKAIQRTRAGLKDPSRPI
GSFIFLGPTGVGKTELAKALTRYLFDSEDALIRADMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDE
IEKAHPDVFNILLQVLDEGVLTDGLGRKVDFRNTIIIMTSNIGAKEIKSFSTGGGMGFAPPSDATGDYKAMKSTIEDALK
RVFNPEFLNRIDDTIVFHQLEKSDIFKIIDITAGKLFKRLKEMGIEVEIDEKAKEFLVEKGYDQKYGARPLKRALQKYVE
DPLAEEMLKGRFTEGSVIQITFDEKEKELRFLDGASSAEPTPKKSKKEETLDKE

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=342, Percent_Identity=36.5497076023392, Blast_Score=209, Evalue=1e-53,
Organism=Escherichia coli, GI1788943, Length=888, Percent_Identity=44.8198198198198, Blast_Score=697, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=820, Percent_Identity=40.7317073170732, Blast_Score=576, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6320464, Length=701, Percent_Identity=46.9329529243937, Blast_Score=599, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6323002, Length=900, Percent_Identity=35, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 95864; Mature: 95864

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIGAKILKNLKVDLFQLK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QKIEENTHPKVPATQMGNVPLTKQAEKVLKITYLEAKICKSTIIGTEHLLLSILKGDDNI
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHH
AAQILEQFGVTYDQVRDELMTITTGRSEAYEPPMEGSYSSGSGSPARPSKKSETKRGERT
HHHHHHHHCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
KTPVLDNFGRDITRLAMEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIA
CCCCHHHHCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
EGLALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEH
DELHTIIGAGGASGSLDASNIFKPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIM
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHH
VEPTSVEETIQILNNIKNKYEAHHHVHYSEDAIEKAVKLSERYITDRFLPDKAIDVMDEA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
GARVHLSNIHVPQEILELEKSIEEIKSEKNKVVKMQNFEEAARLRDKEKNMLEALDHAKQ
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
EWEEQSMESVYDVTEADITSVIAMMTGIPVAKVAQSESKKLLTMEAELKKEVIGQDEAIK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEHHHHHHHHHHHCCHHHHH
KITKAIQRTRAGLKDPSRPIGSFIFLGPTGVGKTELAKALTRYLFDSEDALIRADMSEYM
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDEIEKAHPDVFNILLQVLDEGV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHHCCHHHHHHHHHHHCCH
LTDGLGRKVDFRNTIIIMTSNIGAKEIKSFSTGGGMGFAPPSDATGDYKAMKSTIEDALK
HCCCCCCCEECCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RVFNPEFLNRIDDTIVFHQLEKSDIFKIIDITAGKLFKRLKEMGIEVEIDEKAKEFLVEK
HHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHC
GYDQKYGARPLKRALQKYVEDPLAEEMLKGRFTEGSVIQITFDEKEKELRFLDGASSAEP
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCCC
TPKKSKKEETLDKE
CCCCCHHHHCCCCC
>Mature Secondary Structure
MEGNFSNRVQDVIRLSREEALRLGHDYIGTEHLLLGLIREGEGIGAKILKNLKVDLFQLK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QKIEENTHPKVPATQMGNVPLTKQAEKVLKITYLEAKICKSTIIGTEHLLLSILKGDDNI
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHH
AAQILEQFGVTYDQVRDELMTITTGRSEAYEPPMEGSYSSGSGSPARPSKKSETKRGERT
HHHHHHHHCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
KTPVLDNFGRDITRLAMEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIA
CCCCHHHHCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
EGLALKIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKALMNELERSRDVILFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEH
DELHTIIGAGGASGSLDASNIFKPALARGELQCIGATTLDEYRQYIEKDGALDRRFQKIM
HHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHH
VEPTSVEETIQILNNIKNKYEAHHHVHYSEDAIEKAVKLSERYITDRFLPDKAIDVMDEA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
GARVHLSNIHVPQEILELEKSIEEIKSEKNKVVKMQNFEEAARLRDKEKNMLEALDHAKQ
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
EWEEQSMESVYDVTEADITSVIAMMTGIPVAKVAQSESKKLLTMEAELKKEVIGQDEAIK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEHHHHHHHHHHHCCHHHHH
KITKAIQRTRAGLKDPSRPIGSFIFLGPTGVGKTELAKALTRYLFDSEDALIRADMSEYM
HHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLIDEIEKAHPDVFNILLQVLDEGV
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECHHHHCCHHHHHHHHHHHCCH
LTDGLGRKVDFRNTIIIMTSNIGAKEIKSFSTGGGMGFAPPSDATGDYKAMKSTIEDALK
HCCCCCCCEECCCEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RVFNPEFLNRIDDTIVFHQLEKSDIFKIIDITAGKLFKRLKEMGIEVEIDEKAKEFLVEK
HHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHC
GYDQKYGARPLKRALQKYVEDPLAEEMLKGRFTEGSVIQITFDEKEKELRFLDGASSAEP
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCCC
TPKKSKKEETLDKE
CCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]