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The map label for this gene is accC [H]

Identifier: 21672998

GI number: 21672998

Start: 164878

End: 166221

Strand: Reverse

Name: accC [H]

Synonym: CT0157

Alternate gene names: 21672998

Gene position: 166221-164878 (Counterclockwise)

Preceding gene: 21672999

Following gene: 21672985

Centisome position: 7.71

GC content: 57.29

Gene sequence:

>1344_bases
TTGTTTAAAAAAATACTCATAGCAAACCGTGGGGAGATCGCCTTGCGGGTCATGCATACCTGCCGCGAGATGGGCATTTG
CACCGTGGCCGTCTATTCGACCGCCGATGCCGATTCCCTTCATGTCAGGTACGCAGACGAAGCGGTCTGCATCGGACCGC
CGCTTTCGAGAGAAAGCTACCTGAATATTCCGCGCATCATCGCCGCTGCCGAGGTCACCAACGCTGACGCGATTCATCCT
GGCTACGGCTTTCTGGCCGAAAACGCCGATTTTGCGGAAGTATGCAGCTCCTCGAACATCAAGTTCATTGGCCCTTCCGC
GGAGATGATCAACAAGATGGGCGACAAAAACACCGCCAAATCGACCATGATTGCTGCAGGCGTGCCAGTCGTCCCGGGAA
GTGAAGGTCTGGTCGAAGATGTGGCTCACGCCATTGAGACCGCCAAAAAGATCGGCTATCCCGTCATCATCAAACCGACA
GCTGGGGGTGGCGGAAAAGGGATGCGGGTGGTACACGAAGAGAGCCAGCTCGAAAAAAACCTTAAGACCGCCCAGAGCGA
GGCCGGCATGGCCTTCGGCAACAGCGGCGTCTATATCGAGAAGTTCCTTGAAAATCCCCGCCACATCGAAATTCAGATTC
TGGCCGACCAGCACGGCAACGTGGTGCACCTCGGCGAACGCGACTGCACCGTGCAGCGCCGCCACCAGAAGCTGATCGAG
GAGACTCCCTCACCGGTAGTCGATGAAGCCCTGCGCACGAAGATGGGCGAAGCGGCCGTGGCCGCCGCCAAGGCGATCAA
CTACGAAGGCGCCGGCACCATCGAGTTCCTGCTCGACAAGCACAAAAACTTCTACTTCATGGAGATGAACACCCGCATCC
AAGTGGAGCATCCCATAACCGAGCAGCGCTACGACGTCGATATCGTCAGGGAACAGATCAGCATCGCCGCTGGAGGAAGC
CTGGAAGGGAAAACCTTCATTCCGAGAGGCCACTCCATCGAGTGCCGCATCAATGCCGAAGACCCTGAGCACATGTTCAG
GCCTTCGCCGGGAGAGATTCAGGTCTTTCATACGCCCGGAGGCCCCGGCGTCAGGATCGACTCGCACTGCTACGCAAGCT
ACGTCGTGCCATCGAACTACGACTCGATGATCGGCAAGCTCATCGTCACTGCCCACAACCGTGACGAAGCGATCGCCCGC
ATGTCGAGGGCTCTCGACGAGTTCATCATCATGGGCATCAAAACCACCATCCCTTTCCACAAGCAGGTGATGCACGATCC
GGTGTTCAGAAGCGGAGAGTTCGACACGAGCTTCCTCGACAGCTTCAGGTTCGAGAAACCGTAA

Upstream 100 bases:

>100_bases
TCAGGAACCATTGTCGAGATTCTCGTCGAAAACGGCCAGCCGGTCGAATACAATCAGGCTCTCTTCCGAGTCAAGCCATA
ACTTCAATACTCACTGCACC

Downstream 100 bases:

>100_bases
CCCTGAACAAAGAGAACGCCGCTCCTCTCTTCATAGTGCACCCGACCATTTTCAAACCCTGTAATGTAATAACCATTTGT
TTACTAAATGGCTGCAGGGT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADADSLHVRYADEAVCIGPPLSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCSSSNIKFIGPSAEMINKMGDKNTAKSTMIAAGVPVVPGSEGLVEDVAHAIETAKKIGYPVIIKPT
AGGGGKGMRVVHEESQLEKNLKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVVHLGERDCTVQRRHQKLIE
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPITEQRYDVDIVREQISIAAGGS
LEGKTFIPRGHSIECRINAEDPEHMFRPSPGEIQVFHTPGGPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHNRDEAIAR
MSRALDEFIIMGIKTTIPFHKQVMHDPVFRSGEFDTSFLDSFRFEKP

Sequences:

>Translated_447_residues
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADADSLHVRYADEAVCIGPPLSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCSSSNIKFIGPSAEMINKMGDKNTAKSTMIAAGVPVVPGSEGLVEDVAHAIETAKKIGYPVIIKPT
AGGGGKGMRVVHEESQLEKNLKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVVHLGERDCTVQRRHQKLIE
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPITEQRYDVDIVREQISIAAGGS
LEGKTFIPRGHSIECRINAEDPEHMFRPSPGEIQVFHTPGGPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHNRDEAIAR
MSRALDEFIIMGIKTTIPFHKQVMHDPVFRSGEFDTSFLDSFRFEKP
>Mature_447_residues
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADADSLHVRYADEAVCIGPPLSRESYLNIPRIIAAAEVTNADAIHP
GYGFLAENADFAEVCSSSNIKFIGPSAEMINKMGDKNTAKSTMIAAGVPVVPGSEGLVEDVAHAIETAKKIGYPVIIKPT
AGGGGKGMRVVHEESQLEKNLKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVVHLGERDCTVQRRHQKLIE
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPITEQRYDVDIVREQISIAAGGS
LEGKTFIPRGHSIECRINAEDPEHMFRPSPGEIQVFHTPGGPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHNRDEAIAR
MSRALDEFIIMGIKTTIPFHKQVMHDPVFRSGEFDTSFLDSFRFEKP

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=48.9749430523918, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=47.6404494382022, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=47.6404494382022, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=47.6404494382022, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=47.737556561086, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=47.737556561086, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=47.737556561086, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=31.496062992126, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.8447937131631, Blast_Score=239, Evalue=5e-63,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=56.4334085778781, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=48.1818181818182, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.7589285714286, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.8325791855204, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=488, Percent_Identity=30.7377049180328, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=30.5882352941176, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=30.5882352941176, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=448, Percent_Identity=41.9642857142857, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=45.3125, Blast_Score=361, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=46.2053571428571, Blast_Score=353, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6323863, Length=483, Percent_Identity=31.8840579710145, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6324343, Length=518, Percent_Identity=30.3088803088803, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI281363050, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652224, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652222, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652220, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652218, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652212, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652210, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652214, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI19921944, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652216, Length=456, Percent_Identity=47.5877192982456, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=46.2585034013605, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=44.9382716049383, Blast_Score=347, Evalue=8e-96,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.2186878727634, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.2186878727634, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.2186878727634, Blast_Score=228, Evalue=9e-60,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.2186878727634, Blast_Score=228, Evalue=9e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49181; Mature: 49181

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADADSLHVRYADEAVCIGPPLSRESY
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCC
LNIPRIIAAAEVTNADAIHPGYGFLAENADFAEVCSSSNIKFIGPSAEMINKMGDKNTAK
CCCCHHEEEHCCCCCCCCCCCCCEEECCCCHHHHHCCCCEEEECCCHHHHHHCCCCCCHH
STMIAAGVPVVPGSEGLVEDVAHAIETAKKIGYPVIIKPTAGGGGKGMRVVHEESQLEKN
HEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEHHHHHHHH
LKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVVHLGERDCTVQRRHQKLIE
HHHHHHHCCCEECCCCCCHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPIT
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEECCEEEEECCCC
EQRYDVDIVREQISIAAGGSLEGKTFIPRGHSIECRINAEDPEHMFRPSPGEIQVFHTPG
CCCCCHHHHHHHHHEEECCCCCCCEECCCCCEEEEEECCCCHHHHCCCCCCCEEEEECCC
GPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHNRDEAIARMSRALDEFIIMGIKTTIPFH
CCCEEECCCEEEEEEECCCHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHH
KQVMHDPVFRSGEFDTSFLDSFRFEKP
HHHHHCCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MFKKILIANRGEIALRVMHTCREMGICTVAVYSTADADSLHVRYADEAVCIGPPLSRESY
CCCEEEEECCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCC
LNIPRIIAAAEVTNADAIHPGYGFLAENADFAEVCSSSNIKFIGPSAEMINKMGDKNTAK
CCCCHHEEEHCCCCCCCCCCCCCEEECCCCHHHHHCCCCEEEECCCHHHHHHCCCCCCHH
STMIAAGVPVVPGSEGLVEDVAHAIETAKKIGYPVIIKPTAGGGGKGMRVVHEESQLEKN
HEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEHHHHHHHH
LKTAQSEAGMAFGNSGVYIEKFLENPRHIEIQILADQHGNVVHLGERDCTVQRRHQKLIE
HHHHHHHCCCEECCCCCCHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
ETPSPVVDEALRTKMGEAAVAAAKAINYEGAGTIEFLLDKHKNFYFMEMNTRIQVEHPIT
HCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEECCEEEEECCCC
EQRYDVDIVREQISIAAGGSLEGKTFIPRGHSIECRINAEDPEHMFRPSPGEIQVFHTPG
CCCCCHHHHHHHHHEEECCCCCCCEECCCCCEEEEEECCCCHHHHCCCCCCCEEEEECCC
GPGVRIDSHCYASYVVPSNYDSMIGKLIVTAHNRDEAIARMSRALDEFIIMGIKTTIPFH
CCCEEECCCEEEEEEECCCHHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHH
KQVMHDPVFRSGEFDTSFLDSFRFEKP
HHHHHCCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]